Study Finds E-Cigarette Nicotine Labels Not Always Accurate

Published in the July-August issue of the Journal of Pediatric Nursing, the study examined products purchased from North Dakota retail stores selling e-cigarettes, but not required to have a tobacco retail license. The research team noted that 23 e-liquid containers claimed to have no nicotine, but 43 percent did, in fact, contain nicotine. Levels of nicotine in those e-cigs averaged 0.19 mg/mL, with the highest level found at 0.48 mg/mL.

The NDSU research team includes Kelly Buettner-Schmidt, associate professor of nursing; Donald R. Miller, professor of pharmacy practice; and research scientist Narayanaganesh Balasubramanian.

Of 93 e-liquid containers examined, 70 claimed to contain nicotine ranging from 3-24 mg/mL. Among those containers, 51 percent had nicotine outside the labeled amount, with 34 percent having less nicotine and 17 percent having more than labels specified. Actual content of nicotine ranged from 66 percent under the labeled concentrations to 172 percent over the labeled concentrations.

The Core Synthesis & Analytical Services Facility at NDSU measured the contents of the containers, using a high-performance liquid chromatography method. Results allowed for +/- 10 percent variation in nicotine concentration.

The study also found that 65 percent of the e-liquid containers were not child-resistant, with the potential to be easily ingested by a curious child.

“Mislabeling of nicotine in e-liquids exposes the user to the harmful effects of nicotine,” said study author Kelly Buettner-Schmidt, associate professor of nursing at NDSU. “In areas without child-resistant packaging requirements, children may be exposed to harmful nicotine.”

Depending on the size of a child, even small levels of ingested liquid nicotine could severely impact a child, according to Buettner-Schmidt, and result in nicotine toxicity, accidental poisoning or death.

The cross-sectional study of e-liquids included products purchased between June 9 and June 26, 2015 from 16 North Dakota retail stores that sell electronic nicotine devices, but are not required to hold a tobacco retail license. The study was conducted prior to new state requirements covering e-cigarettes. The North Dakota Center for Tobacco Prevention and Control Policy funded the study titled “Electronic Cigarette Refill Liquids: Child-Resistant Packaging, Nicotine Content, and Sales to Minors.”

In August 2015, North Dakota banned the sale of e-cigarettes and tobacco for those under 18 and now requires child-resistant e-liquid containers, although the amount of nicotine content remains unregulated. In August 2016, the U.S. Food and Drug Administration is scheduled to ban sale of e-cigarette products to those under 18, and prohibit free samples, false or misleading advertising of e-cigarette products. By 2018, the FDA is scheduled require warning labels for e-cigarette products. Detailed information about the study can be found in the Journal of Pediatric Nursing, National Center for Biotechnology Information and at Science Direct.An additional study available online in the journal Tobacco Control, examined whether 16 retail stores selling e-cigarette products were compliant with North Dakota’s smoke-free law. Use of e-cigarettes or evidence of use was observed in 50 percent of stores associated with the study, making them non-compliant with state law. Only 6 percent of stores in the study complied with indoor smoke-free requirements and 44 percent of stores complied with outdoor smoke-free requirements of the state. About NDSUAs a student-focused, land grant, research institution, NDSU serves the citizens of North Dakota. NDSU is listed in the top 100 research universities in the U.S. for R&D in agricultural sciences, chemistry, computer science, physical sciences, psychology, and social sciences, based on research expenditures reported to the National Science Foundation. Researchers in the College of Health Professions at NDSU conduct research in nursing, public health, pharmacy practice and pharmaceutical sciences, covering a wide variety of areas including tobacco, cancer, and drug delivery systems to combat disease. www.ndsu.edu/researchAbout the Journal of Pediatric NursingThe Journal of Pediatric Nursing: Nursing Care of Children and Families (JPN) is the official journal of the Society of Pediatric Nurses and the Pediatric Endocrinology Nursing Society. Journal content covers the life span from birth to adolescence.

About the Journal of Tobacco ControlTobacco Control is an international peer review journal covering the nature and consequences of tobacco use worldwide; tobacco's effects on population health, the economy, the environment, and society; efforts to prevent and control the global tobacco epidemic through population level education and policy changes; the ethical dimensions of tobacco control policies; and the activities of the tobacco industry and its allies.