Xu et al. profiled the genome-wide H3K9me3 distribution in human oocytes and early embryos. They found the function and mechanism of H3K9me3 modification on long terminal repeat (LTR) regulation and provide a detailed map of the sequential reprogram
Your gut is a wondrous place. A special layer of cells that coats the insides of your small and large intestines takes in nutrients and water from what you ate while keeping anything bad out of your system.
Recombination-activating genes (RAG1 and RAG2) are critical in lymphoid cell development and function for initiating the V(D)J-recombination process to generate polyclonal lymphocytes with broad antigen-specificity.
The examination of post-mortem brain tissue suggests synaptic loss as a central pathological hallmark of schizophrenia.
Lebers Congenital Amaurosis (LCA16) is caused by point mutations in KCNJ13 gene, which encodes for an inward-rectifying potassium channel, Kir7.1.
Single nucleotide polymorphism rs6903956 has been identified as one of the genetic risk factors for coronary artery disease (CAD).
We investigated the potential correlation between the fluid shear stress and the proliferation of bone prostate cancer cells on the surface of nanoclay-based scaffolds in a perfusion bioreactor.
In a previous work, we presented a model that integrates cancer cell differentiation and immunotherapy, analysing a particular therapy against cancer stem cells by cytotoxic cell vaccines.
مدينة روتشستر، ولاية مينيسوتا— في إحدى الدراسات الأولى من نوعها، حللت مايو كلينك مجموعة كبيرة من المرضى لفهم دوافعهم للبحث عن علاجات بالخلايا الجذعية وما إذا كانت التوقعات مبنية على العلم. ويمكن أن تساعد هذه النتائج خبراء الرعاية الصحية على التعامل مع الادعاءات المضللة وتقديم المشورة للمرضى بشكل أفضل.
p53 is one of the most important proteins in cancer biology. Often referred to as a “guardian of the genome,” p53 becomes activated in response to various cellular stressors like DNA damage.
Allogeneic hematopoietic cell transplantation between female donors and male recipients (female-to-male allo-HCT) is a well-established risk factor for inferior survival outcomes due to a higher incidence of graft-versus-host disease (GVHD).
To ensure faultless duplication of the entire genome, eukaryotic replication initiates from thousands of replication origins.
Suspension cultures are widely used for cell expansion in regenerative medicine and production.
Germ cells are the vehicle of human reproduction, arising early in embryonic development and developing throughout adult life until menopause onset in women.
YES-associated protein (YAP) is a transcriptional cofactor with a key role in the regulation of several cellular processes, including proliferation, differentiation and epithelial-to-mesenchymal transition (EMT), by integrating multiple cell autonomous and microenvironmental cues.
We report a case of 7-year old female patient. She had recurrent pneumonia since infancy and she was hospitalized several times. She had persistant lymphopenia with normal immunoglobulin levels and lymphocyte subsets.
Motivation: Clarifying how hematopoietic stem cells differentiate into mature cell types is important for understanding how they attain specific functions and offers the potential for therapeutic manipulation.
Although model organisms have provided insight into the earliest stages of cardiac vascularization, we know very little about this process in humans.
Experimental approaches for measuring single-cell gene expression can observe each cell at only one time point, requiring computational approaches for reconstructing the dynamics of gene expression during cell fate transitions.
Transforming growth factor-beta (TGFβ) is released from cells as part of a trimeric latent complex consisting of TGFβ, the TGFβ propeptides, and either a latent TGFβ binding protein (LTBP) or glycoprotein-A repetitions predominant (GARP) protein.
Intermittent fasting (IF) is a promising non-pharmacological strategy to counteract ageing which has been shown to increase the number of adult-born neurons in the dentate gyrus of mice.
Cancer alters both local and distant tissue by influencing the microenvironment.
Efficiently delivering nucleic acid into mammalian cells is essential to overexpress genes for assessing gene functions.
Scientists have long puzzled over the gap in the fossil record that would explain the evolution of invertebrates to vertebrates. Vertebrates, including fishes, amphibians, reptiles, birds, mammals, and humans, share unique features, such as a backbone and a skull. Invertebrates are animals without backbones.
We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) scaffolds that can be repopulated with various cell types to interrogate cell-ECM interactions.
In the process of caner recovery, Huaier simultaneously promotes significant hair growth and restoration as a typical evidence of its efficacy on induced tissue regeneration and repair function.
Cerebral malaria-associated over expression of pro-inflammatory cytokines and chemokines ultimately results in the up-regulation of adhesion molecules in the brain endothelium leading to sequestration of mature parasitized RBCs in the brain.
Bioengineers at the University of Notre Dame have shown that a new strategy can restore damaged stem cells and enable them to grow new tissues again.
Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. The RNA-binding protein Musashi-1 (MSI1) is a neural stem cell marker, characterized as a gene translation regulator and associated with high oncogenicity in several human cancers.
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Homozygous TREM2 mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). Despite extensive investigation, the role of TREM2 in NHD pathogenesis remains poorly understood.
All living cells maintain a charge distribution across their cell membrane (membrane potential) by carefully controlled ion fluxes. These bioelectric signals regulate cell behavior (such as migration, proliferation, differentiation) as well as higher-level tissue and organ patterning. Thus, voltage gradients represent an important parameter for diagnostics as well as a promising target for therapeutic interventions in birth defects, injury, and cancer. However, despite much progress in cell and molecular biology, little is known about bioelectric states in human stem cells.
Lung adenocarcinoma is the most common and aggressive type of lung cancer with the highest incidence of bone metastasis. Epidermal growth factor‐like domain multiple 6 (EGFL6) is an exocrine protein, and the expression of EGFL6 is correlated with survival of patient with lung adenocarcinoma. However, the association between EGFL6 expression in lung adenocarcinoma and bone metastasis has not been investigated.
Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumours in patients with tuberous sclerosis complex (TSC).
Introduction: Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival. Human adipose-derived stem cells were added into filling materials.
Background Graphene quantum dots (GQDs) have been broadly applied in biomedicine in recent years, and their environmental exposure and toxicological impacts have raised increasing concerns.
The failure of diseased adult heart to regenerate is a major burden to our societies. Besides patients with ischemia and left ventricular (LV) dysfunction, progress in pediatric surgery to repair cardiac malformations has led to a growing population of now adult congenital heart diseases (CHD) patients with right ventricular (RV) failure.
Rett syndrome (RTT) is a rare disease and one of the most abundant causes for intellectual disa-bilities in females. Single mutations in the gene coding for methyl-CpG-binding protein 2 (MECP2), are responsible for the disease.
Intratumoral heterogeneity can exist along multiple axes: Cancer Stem Cells (CSCs)/non-CSCs, drug-sensitive/drug-tolerant states and a spectrum of epithelial-hybrid-mesenchymal phenotypes.
WNT binding to Frizzleds (FZD) is a crucial step that leads to the initiation of signalling cascades governing multiple processes during embryonic development, stem cell regulation and adult tissue homeostasis. Recent efforts have enabled us to shed light on WNT-FZD pharmacology in overexpressed HEK293 cell systems.
Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for muscle stem cells (MuSCs) during muscle regeneration.
Nonsense-mediated mRNA decay (NMD) is a highly conserved post-transcriptional gene expression regulation mechanism in eukaryotic cells.
Cartilage progenitor cells (CPCs) are a small but highly proliferative cell population that resides within cartilage.
Sanfilippo syndrome type B (Mucopolysaccharidosis type IIIB or MPS IIIB) is a recessive genetic disorder that severely affects the brain due to a deficiency in the enzyme α-N-acetylglucosaminidase (NAGLU), leading to intralysosomal accumulation of partially degraded heparan sulfate.
Mavacamten (MAVA), Blebbistatin (BLEB), and Omecamtiv mecarbil (OM) are promising drugs directly targeting sarcomere dynamics, with demonstrated efficacy against hypertrophic cardiomyopathy (HCM) in clinical trials.
Woranop Sukparangsi, Ampika Thongphakdee, Santhita Karoon, Nattakorn Suban Na Ayuttaya, Intira Hengkhunthod, Rachapon Parkongkeaw, Rungnapa Bootsri, Wiewaree Sikaeo
Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes.
Clonal hematopoiesis resulting from enhanced fitness of mutant hematopoietic stem cells (HSCs) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear.
Metazoan chromosomes are organized into discrete domains (TADs), believed to contribute to the regulation of transcriptional programs.
Mesenchymal stem cell (MSC) transplantation was suggested as a promising approach to treat spinal cord injury (SCI).
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