Feature Channels: Stem Cells

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Released: 21-Sep-2022 12:00 PM EDT
The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury
Preprints

Kenichiro Eshima, Hiroki Ohzono, Masafumi Gotoh, Hidehiro Nakamura, Takahiro Okawa, Naoto Shiba

Released: 21-Sep-2022 12:00 PM EDT
ESDR556 - Functional and proliferative melanocyte-derived pluripotent stem cells: from developmental studies to clinical perspectives
Preprints

Manoubia Saidani, Annabelle Darle, Margot Jarrige, Hélène Polveche, Sévenine Julie, Sandrine Bessou Touya, Lemaitre Gilles, Cécile Martinat, Christine Baldeschi, Jennifer Allouche

Released: 21-Sep-2022 12:00 PM EDT
Genome instability underlies an augmented DNA damage response in familial and sporadic ALS human iPSC-derived motor neurons
Preprints

Oliver Ziff, Jacob Neeves, Jamie Mitchell, Guilia Tyzack, Carlos Ruiz, Nicholas McGranahan, Raphaelle Luisier, Anob Chakrabarti, Simon Boulton, Gavin Kelly, Jack Humphrey, Rickie Patani

Released: 21-Sep-2022 12:00 PM EDT
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
Preprints

Teresa Emmilie Knudsen, William Hamilton, Martin Proks, Maria Lykkegaard, Alexander Valentin Nielsen, Ala Trusina, Joshua M Brickman

Newswise: A Consistent Lack of Sleep Negatively Impacts Immune Stem Cells, Increasing Risk of Inflammatory Disorders and Heart Disease
20-Sep-2022 8:05 AM EDT
A Consistent Lack of Sleep Negatively Impacts Immune Stem Cells, Increasing Risk of Inflammatory Disorders and Heart Disease
Mount Sinai Health System

Mount Sinai study also shows catching up on sleep doesn’t reverse possible negative effects on cellular level

Released: 20-Sep-2022 12:00 PM EDT
Differential elasticity in lineage segregation of embryonic stem cells
Preprints

Christine M. Ritter, Natascha Leijnse, Younes Farhangi Barooji, Joshua M. Brickman, Amin Doostmohammadi, Lene B. Oddershede

Released: 20-Sep-2022 12:00 PM EDT
Intensity of Induction Regimen and Outcomes Among Adults with Ph+ ALL Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Preprints

Marlise Luskin, Hari Raman, Se Eun Kim, Daniel DeAngelo, Kristen Stevenson, Donna Neuberg, Eric Winer, Martha Wadleigh, Jacqueline Garcia, Annette Kim, Richard Stone, Vincent Ho

Released: 20-Sep-2022 12:00 PM EDT
Integrated analysis of next generation sequencing minimal residual disease (MRD) and PET scan in transplant eligible myeloma patients
Preprints

Rodrigo Fonseca, Mariano Arribas, Julia E. Wiedmeier-Nutor, Yael N. Kusne, Miguel Gonzalez-Velez, Heidi Kosiorek, Richard J. Butterfield, Ilan Kirsch, Joseph Mikhael, A. Keith Stewart, Craig Reeder, Jeremy Larsen, P. Bergsagel, Rafael Fonseca

Released: 20-Sep-2022 12:00 PM EDT
Autophagy inhibits inflammation via down-regulation of p38 MAPK/mTOR signaling cascade in endothelial cells
Preprints

Ling Zhou, Juanjuan Wang, Hui Hou, Jiao Li, Juan Li, Jiannan Liang, Junqin Li, Xuping Niu, Ruixia Hou, Kai-Ming Zhang

Released: 20-Sep-2022 12:00 PM EDT
Presence of cells in the polyaneuploid cancer cell (PACC) state predicts risk of recurrence in prostate cancer
Preprints

Levent Trabzonlu, Kenneth J Pienta, Bruce J Trock, Angelo Michael De Marzo, Sarah R Amend

Released: 20-Sep-2022 12:00 PM EDT
mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells
Preprints

Musashi Kubiura-Ichimaru, Christopher Penfold, Kazuaki Kojima, Constance Dollet, Haruka Yabukami, Katsunori Semi, Yasuhiro Takashima, Thorsten Boroviak, Hideya Kawaji, Knut Woltjen, Aki Minoda, Erika Sasaki, Toshiaki Watanabe

Newswise: Anti-sedative could alleviate cancer therapy side effects, study suggests
Released: 20-Sep-2022 11:05 AM EDT
Anti-sedative could alleviate cancer therapy side effects, study suggests
The Rockefeller University Press

Researchers in China have discovered that inhibiting a protein called the GABAA receptor can protect intestinal stem cells from the toxic effects of chemotherapy and radiotherapy. The study, published September 20 in the Journal of Experimental Medicine (JEM), suggests that the FDA-approved anti-sedative flumazenil, which targets GABAA receptors, could alleviate some of the common gastrointestinal side effects, such as diarrhea and vomiting, induced by many cancer treatments.

Released: 19-Sep-2022 12:00 PM EDT
Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system
Preprints

Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka, Christopher Wittwer, Kenta Kikuchi, Takatoshi Iijima, Yu Kakimoto, Kenichi Hirabayashi, Daisuke Kurotaki, Henning Jacob Jessen, Adolfo Saiardi, Eiichiro Nagata

Released: 19-Sep-2022 12:00 PM EDT
Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming
Preprints

Kangyun Wu, Yong Zhang, Stephen R Austin, Huqing Yin Declue, Derek E Byers, Erika C Crouch, Michael J Holtzman

Released: 19-Sep-2022 12:00 PM EDT
Weight Loss Post Allogeneic Stem Cell Transplant is Associated with Increased Transplant Related Mortality
Preprints

Kayla Madsen, Katherine Lee, Shiyi Chen, Carol Chen, Arjun Law, Armin Gerbitz, Rajat Kumar, Dennis Kim, Wilson Lam, Ivan Pasic, Auro Viswabandya, Fotios Michelis, Ram Vasudevan Nampoothiri, Jeffrey Lipton,

Released: 18-Sep-2022 12:00 PM EDT
Within-host virus evolution during the extended treatment of RSV infection with mutagenic drugs
Preprints

Christopher Jr Illingworth, Alexandra Y Kreins, Adriana Margarit Soler, Tim Best, Patricia Dyal, Giovanna Lucchini, Kanchan Rao, Rachel Williams, Austen Jj Worth, Judith Breuer

Released: 18-Sep-2022 12:00 PM EDT
Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
Preprints

Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam Mondal, Gregory Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop

Released: 17-Sep-2022 12:00 PM EDT
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Preprints

Tianchi Xin, Sara Gallini, David Gonzalez, Lauren E. Gonzalez, Sergi Regot, Valentina Greco

Released: 15-Sep-2022 12:00 PM EDT
The downstream PPARγ target LRRC1 participates in early-stage adipocytic differentiation
Preprints

Xinping Wang, Jianyun Liu, Ting Wang, Baicheng Ma, Ping Wu, Xiaoyuan Xu, Jianjun Xiong

Released: 14-Sep-2022 12:00 PM EDT
NOTCH-pathway inactivation reprograms oral-stem-like cancer cells to JAK-STAT dependent state and provides the opportunity of synthetic lethality
Preprints

Subhashis Ghosh, Paromita Mitra, Uday Saha, Arnab Ghosh, Nidhan Kumar Biswas, Shantanu Saha Roy, Moulinath Acharya, Sandeep Singh

Released: 14-Sep-2022 12:00 PM EDT
Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function
Preprints

Emma Partiot, Aurelie Hirschler, Sophie Colomb, Willy Lutz, Tine Claeys, Francois Delalande, Maika S Deffieu, Judith Roels, Joanna Bons, Domitille Callon, Laurent Andreoletti, Marc Labrousse, Frank Mj Jacobs, Valerie Rigau,

Released: 13-Sep-2022 11:45 AM EDT
The blood stem cell research that could change medicine of the future
University of New South Wales

Biomedical engineers and medical researchers at UNSW Sydney have independently made discoveries about embryonic blood stem cell creation that could one day eliminate the need for blood stem cell donors.

Released: 12-Sep-2022 12:00 PM EDT
Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes
Preprints

Carlos Bernal-Mizrachi, Jisu Oh, Amy E Riek, Kevin T Bauerle, Adriana Dusso, Kyle McNerney, Ruteja Barve, Isra Darwech, Jennifer Sprague, Clare Moynihan, Rong M Zhang, Ting Wang, Xiaoyun Xing, Daofeng Li,

Released: 10-Sep-2022 12:00 PM EDT
Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue
Preprints

Gregor Andelfinger, Andrew Song, Renata H.M. Sindeaux, Yuanyi Li, Hicham Affia, Tapan Agnihotri, Severine Leclerc, Patrick Piet van Vliet, Mathieu Colas, Jean-Victor Guimond, Natasha Patey, Jean-Sebastien Joyal, Elie Haddad, Luis Barreiro

Released: 9-Sep-2022 12:00 PM EDT
Unselfish traits and social decision-making patterns characterize six populations of real-world extraordinary altruists
Preprints

Shawn A Rhoads, Kruti Vekaria, Katherine O'Connell, Hannah S Elizabeth, David Gertler Rand, Megan Kozak Williams, Abigail Marsh

Released: 9-Sep-2022 12:00 PM EDT
Identification of the Metaphyseal Skeletal Stem Cell
Preprints

Guan Yang, Qi He, Xiaoxiao Guo, Rong-Yu Li, Jingting Lin, Wanyu Tao, Wenjia Liu, Huisang Lin, Mingchuan Tang, Shilai Xing, Yini Qi, Yanli Peng, Lei Dong, Jing-Dong J Han, Bin

Released: 9-Sep-2022 12:00 PM EDT
p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation
Preprints

Justine Creff, Ada Nowosad, Anne Prel, Anne Pizzocaro, Marion Aguirrebengoa, Nicolas Duquesnes, Caroline Callot, Thomas Jungas, Christine Dozier, Arnaud Besson

Released: 9-Sep-2022 12:00 PM EDT
Stem Cell Therapy Improves Human Islet Graft Survival in Mice via Regulation of Macrophages
Preprints

Wenyu Gou, Wei Hua, Lindsay Swaby, Wanxing Cui, Erica Green, Katherine Morgan, Charlie Strange, Hongjun Wang

Released: 9-Sep-2022 12:00 PM EDT
Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics
Preprints

Roman Thaler, Keigo Yoshizaki, Thai Nguyen, Satoshi Fukumoto, Pamela DenBesten, Daniel D Bikle, Yuko Oda

Released: 9-Sep-2022 12:00 PM EDT
Placental mesenchymal stem cells ameliorate NLRP3 inflammasome induced ovarian insufficiency by modulating macrophage M2 polarization
Preprints

Dongmei Chen, Na Hu, Shasha Xing, Li Yang, Feiyan Zhang, Songlin Guo, Shudan Liu, Xiaona Ma, Xueyun Liang, Huiming Ma

Released: 9-Sep-2022 12:00 PM EDT
Impact of pretransplant donor-specific anti-HLA antibodies in HLA-mismatched peripheral blood stem cell transplantation
Preprints

Takeshi Hagino, Kazuhiro Ikegame, Hidenori Tanaka, Yoshinobu Kanda, Katsuji Kaida, Takahiro Fukuda, Yukio Kondo, Maho Sato, Noriko Doki, Hirohisa Nakamae, Ken-Ichi Matsuoka, Yasuo Mori, Hideki Sano, Tetsuya Eto,

Released: 9-Sep-2022 12:00 PM EDT
Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway
Preprints

Hao Liu, Qiwei Zhang, Ranli Gu, Wei Li, Yunsong Liu, Yongsheng Zhou

Released: 9-Sep-2022 12:00 PM EDT
Engineering High-Quality Cartilage Microtissues using Hydrocortisone Functionalised Microwells
Preprints

Ross Burdis, Gabriela Soares Kronemberger, Daniel J Kelly

Released: 9-Sep-2022 12:00 PM EDT
Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators
Preprints

Saptarshi Mallick, Jayati Chakrabarti, Jennifer Eschbacher, Andreas G Moraitis, Andrew E Greenstein, Jared Churko, Kelvin W Pond, Antonia Livolsi, Curtis A Thorne, Andrew S Little, Kevin Cj Yuen, Yana Zavros

Released: 9-Sep-2022 12:00 PM EDT
Macromolecular crowding facilitates rapid fabrication of intact, robust cell sheets
Preprints

Shuwen Guan, Shipeng Wu, Gang Li, Jiangwei Xiao, Botao Gao



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