Feature Channels: Stem Cells

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Rahul Naithani

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Kseniia Sarieva, Theresa Kagermeier, Shokoufeh Khakipoor, Ezgi Atay, Zeynep Yentuer, Katharina Becker, Simone Mayer

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Ruisong Wang, Ziyi Qin, Long Huang, Huiling Luo, Han Peng, Xinyu Zhou, Zhixiang Zhao, Mingyao Liu, Pinhong Yang, Tieliu Shi

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Joana Rodrigues Dantas, Débora Batista Araújo, Karina Ribeiro Silva, Débora Lopes Souto, Maria De Fátima Carvalho Pereira, RonirRaggio LUIZ, Cesar Claudio-Da-Silva, Carlos Eduardo Barra Couri, Angelo Maiolino, Carmen Lúcia Kuniyoshi Rebelatto, Débora Regina Daga, Alexandra Cristina Senegaglia,

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Zesheng Peng, Yuxi Wu, Jiajing Wang, Sujie Gu, Yihao Wang, Bingzhou Xue, Peng Fu, Wei Xiang

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Devanjan Dey, Vadanya Shrivastava, Diksha Joshi, Chitra Mohinder Singh Singal, Sagar Tyagi, Muzaffer Ahmed Bhat, Paritosh Jaiswal, Jai Bhagwan Sharma, Jayanth Kumar Palanichamy, Subrata Sinha, Pankaj Seth, Sudip Sen

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Vahedeh Hosseini, Mahdi Paryan, Ameneh Koochaki, Henry Manuel Cesaire, Samira Mohammadi-Yeganeh

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Fan-Yan Wei, Asuka Inoue, Akiko Ogawa, Seiya Ohira, Tatsuya Ikuta, Yuri Kato, Shota Yanagida, Yukina Ishii, Yasunari Kanda, Motohiro Nishida

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Yu-Ki Lee, Yue Hao, Zhonghua Xi, Woongbae Kim, Youngmin Park, Kyu-Jin Cho, Jyh-Ming Lien, In-Suk Choi

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Wenjing Wan, Yuyang Miao, Yuwei Niu, Kunyuan Zhu, Yingwan Ma, Menghao Pan, Baohua Ma, Qiang Wei

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Yulong Qiao, Qiang Sun, Xiaona Chen, Di Wang, Ruibao Su, Yuanchao Xue, Hao Sun, Huating Wang

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Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y. Kwon, Fen-Biao Gao, Raymond Roos, Paschalis Kratsios

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Katsuhiro Tomofuji, Jumpei Kondo, Kunishige Onuma, Koki Oyama, Eiji Miyoshi, Ken Fukumitsu, Takamichi Ishii, Etsuro Hatano, Masahiro Inoue

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Charlotte Jaloux, Maxime Bonnet, Marie Vogtensperger, Marie Witters, Julie Veran, Laurent Giraudo, Florence Sabatier, Justin Michel, Romaric Lacroix, Corinne Chareyre, Regis Legre, Gaelle Guiraudie Capraz, Francois Feron

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Fenghua Qian, Brooke E Arner, Shaneice K Nettleford, Robert F Paulson, K. Sandeep Prabhu

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Catherine Thieblemont, Bettina Altmann, Fabian Frontzek, Loïc Renaud, Loic Chartier, Nicolas Ketterer, Christian Recher, Viola Poeschel, Olivier Fitoussi, Gerhard Held, René-Olivier Casasnovas, Corinne Haioun, Franck Morschhauser, Be

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Qiang Feng, Yushang Wang, Lihua Wang, Tianyong Sun, Song Shen, Zixuan Li, Xiaomei Ma, Xiufeng Gu, Xiumei Zhang, Ai Peng, Xin Xu

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Xiang Xu, Shidan Li, Wei Xing, Shaochuan Wang, Youbin Li, Hao Jiang, Hanxuan Zheng, XiaoMing Li, Jing Yang, Debin Guo, Xiaoyu Xie, Renqing Jiang, Chao Fan, Lei Li, Jun Fei

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Lola Reid, Wencheng Zhang, Giacomo Lanzoni, Eliane Wauthier, Sean Simpson, Amanda Allen, Carolyn Suitt, Juan Dominguez-Bendala, Vincenzo Cardinale, Domenico Alvaro, Diletta Overi, Eugenio Gaudio, Guido Carpino, Kyle Mathews,

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Jian Zhang, Xiao Hu, Qiao Wu, Shangqin Guo

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Haruka Miyata, Masakazu Ishii, Fumio Suehiro, Naohiro Komabashiri, Nao Ikeda, Tomoaki Sakurai, Masahiro Nishimura

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Ana Gutierrez-Franco, Mohamed N. Hassan, Loris Mularoni, Mireya Plass

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One of the hallmarks of Alzheimer’s disease is a reduction in the firing of some neurons in the brain, which contributes to the cognitive decline that patients experience. A new study from MIT shows how a type of cells called microglia contribute to this slowdown of neuron activity.

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A small-molecule cocktail reprograms human cord blood erythroblasts into induced megakaryocytes with ex vivo functionality. The four small molecules extensively remodel the chromatin and induce the dynamic network transition from erythroid master ge

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In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors.

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In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes

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In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importan

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Talbott et al. discuss the current state of knowledge in fibroblast biology and heterogeneity, primarily focusing on fibroblasts in skin wound repair. They also consider emerging techniques in the field and evaluate limitations of existing methodolo

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Tsai and colleagues explored the impact of the Alzheimer’s disease-associated risk gene APOE4 onto the cellular communication of neurons and microglia. Through combinatorial experiments with cells derived from CRISPR-edited APOE isogenic lines, thi

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Goto and colleagues identify lymphatic endothelial cells (LECs) and RSPO3+GREM1+ fibroblasts (RGFs) as stromal niche components of intestinal stem cells (ISCs). LECs and RGFs sustain ISCs through the production of RSPO3 and GREM1 in homeostasis. In i

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Palikuqi et al. employ imaging of cleared intestinal tissue, transcriptional analyses, and genetic mouse models to investigate the role of lymphatic endothelial cells in the intestinal stem cell niche. The authors demonstrate that lymphatic endothel

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Inflammation and infection acutely suppress HSC function. However, the long-term ramifications of such challenges are unclear. This study demonstrates that murine HSCs fail to recover functional potency up to 1 year post-inflammatory/infection challe

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Jing et al. combine a stroma-free differentiation system with EZH1-repression-mediated epigenetic reprogramming to generate developmentally mature iPSC-derived CAR T cells with enhanced antitumor activities.

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I Gde Rurus Suryawan, Andrianto Andrianto, Arisya Agita, Anudya Kartika Ratri, Ricardo Adrian Nugraha

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Yoshimitsu Shimomura, Masashi Nishikubo, Hayato Maruoka, Seiko Nasu, Tomomi Nishioka, Kenji Sakizono, Satoshi Mitsuyuki, Tomoyo Kubo, Naoki Okada, Daishi Nakagawa, Kimimori Kamijo, Hiroharu Imoto, Ryusuke Yamamoto, Yuya Nagai,

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Michael Herriges, Maria Yampolskaya, Bibek R Thapa, Jonathan Lindstrom-Vautrin, Feiya Wang, Cheng-Lun Na, Liang Ma, McKenna M Montminy, Jessie Huang, Carlos Villacorta-Martin, Pankaj Mehta, Darrell N. Kotton

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Helena G Asenjo, Maria Alcazar-Fabra, Mencia Espinosa, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugan, Pedro Carmona-Saez, Antonio Sanchez-Pozo, Alvaro Rada-Iglesias, Robert J Klose, David

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Raly James Custodio, Hee Jin Kim, Jiyeon Kim, Darlene Mae Ortiz, Mikyung Kim, Danilo Buctot, Leandro Val Sayson, Hyun Jun Lee, Bung-Nyun Kim, Eugene Yi, Jae Hoon Cheong

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Adam Stabell, Shuxiong Wang, Grace Lee, Ji Ling, Sandrine Nguyen, George Sen, Qing Nie, Scott Atwood

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Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda