… reside in the RZ, a known location for stem cells 5,11 , and that FoxA2+ cells are located in close proximity to the SOC, which is viewed as a signaling center of RZ stemness 10 , we asked whether FoxA2+ cells are different than the previously …
… stem cell … stem cell state, accompanied by altered niche requirements and a mature chief cell/secretory phenotype. Following the constitutive expression of p57 in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …
… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …
Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid …
… programs maintaining stem cell integrity have been identified, safety mechanisms eliminating malignant HSPCs from the stem cell pool … HSPCs and antigen-specific CD4 + T cells, causing stem cell proliferation, differentiation, and specific exhaustion …
By developing a 3D spheroid system for hPSC-hepatocytes differentiation and combining it with genomic approaches, Jaenisch and colleagues identified a role for THRB in regulating hPSC-hepatocytes maturation through chromatin-remodeling complex pBAF.
Xu et al. demonstrated feasibility of modeling early heart failure using induced pluripotent stemcell-derived cardiomyocytes from patients with HLHS. They observed that heart failure is linked to increased apoptosis, mitochondrial dysfunction, redox
Theunissen et al. describe a methodology for deriving self-renewing 3D trophoblast organoids from naive human pluripotent stem cells. They demonstrate that stem-cell-derived trophoblast organoids model human placental development, X chromosome inact
… In order to obtain the highest yield of mesenchymal stem cell-derived nanovesicles (MSC-NVs), we employed a serial extrusion approach using polycarbonate membrane filters with 5 μm, 1 μm, 0.4 μm, and 0.2 μm pore sizes …
Cardiovascular diseases (CVDs) are globally known to be important causes of mortality and disabilities. Common treatment strategies for CVDs, such as pharmacological therapeutics impose serious challenges due to the failure of …
The high mortality rate of malignant pleural mesothelioma led to study the mechanisms for chemoresistance. The cancer stem cell (CSC) model has been proposed to explain chemoresistance. CSCs are characterized by self-renewal …
In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells.
bstract: Placenta-derived stem cells (PDSCs) offer the advantages of possessing mesenchymal and embryonic traits, broad differentiation potential, large-scale availability, and no ethical constraints in their utilization in therapeutic applications. Elevated protein synthesis and consequently enhanced protein maintenance networks become necessary both due to the requirement to maintain stemness and respond to different stresses.
The presence of Cervical Cancer Stem Cells (CCSCs) in cases of Cervical Cancer (CC) represent a small subpopulation of tumor cells with a high potential for resistance to conventional treatments.
In this issue of Cell Stem Cell, a new study by Rostovskaya et al. (2022) uses human stem cells to understand the formation of the amnion, a vital extraembryonic tissue that encircles the fetus during gestation. They provide insight into human amnio
In this review, Shao and Fu outline recent progress in reconstructing multiscale structural orders in embryoids and organoids and discuss conceptual and technological frameworks useful for innovating bioengineering-directed approaches to achieve next
In this review, Qazi et al. describe advances in the engineering of hydrogels to explore complex biological processes, such as development, disease, and wound healing. They specifically highlight the spatiotemporal control over hydrogel biochemical
The intrahepatic bile ducts consist of a complex branching morphology. Here, Roos et al. demonstrate that a branching tubular architecture can be induced in human adult intrahepatic cholangiocyte organoids. These BRCOs faithfully recapitulate aspect
In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition,
Antigen presentation is typically regarded as the domain of immune cells such as dendritic cells and B cells. Hernandez-Malmierca et al. (2022) upend this notion by observing that hematopoietic stem and progenitor cells process and present antigen v
The success of stem cell transplantation depends upon the coordinated sequence of stem cell renewal, differentiation, assembly, and maintenance of long-term function. Advances in biomaterials can improve pre-/post-transplantation outcomes by integrat
Haas and colleagues show that hematopoietic stem cells (HSCs) act as antigen-presenting cells. The presentation of immunogenic antigens triggers a bidirectional interaction with antigen-specific CD4+ T cells, resulting in the rapid exhaustion of dis
Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes.
Zhongyue Lv, Ying Li, Yachen Wang, Fengyu Cong, Xiaoyan Li, Wanming Cui, Chao Han, Yushan Wei, Xiaojun Hong, Yong Liu, Luyi Ma, Yang Jiao, Chi Zhang, Huanjie Li, Mingyan Jin, Liang Wang, Shiwei Ni, Jing Liu
Xiaowei Gu, Anna Heinrich, Tony DeFalco
Isaline Bontemps, Celine Lallemand, Denis Biard, Nathalie Dechamps, Thierry Kortulewski, Emmanuelle Bourneuf, Capucine Siberchicot, Francois Boussin, Sylvie Chevillard, Anna Campalans, Jerome Lebeau
In this paper, we describe a platform for modeling LGMD based on the use of human induced pluripotent stem cells (hiPSC).
latelets are a uniquely mammalian physiologic attribute. As the only non-marine vertebrate class to experience menopause, humans have a substantial post-reproductive lifespan and are believed to have a limited, non-renewable oocyte supply. Ovarian reserve typically declines after about age 35yrs, marking losses which cannot be recovered by available fertility medications.
Yizhuo Zhou, Ying Yang, Jun Qian, Jian Ge, Debora I Sinner, Hongxu Ding, Andrea Califano, Wellington V Cardoso
Yoshitaka Tamaki, Jay P Ross, Paria Alipour, Helene Catoire, Daniel Rochefort, Makoto Urushitani, Ryosuke Takahashi, Joshua A Sonnen, Stefano Stifani, Patrick A Dion, Guy A Rouleau
… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell proliferation and differentiation, leading to notable changes in mouse body weight and muscle morphology during development. We further assayed the genome-wide …
Bryce LaFoya, Ken Prehoda
Congjuan Luo, Feng Luo, Lin Che, Long Zhao, Hui Zhang, Xiaofei Man, Quandong Bu, Haiyan Zhou, Yan Xu
Wout J. Weuring, Nina Dirkx, Els De Vriendt, Noor Smal, Bobby P.C. Koeleman, Joep van de Vondervoort, Martijn Koetsier, Sarah Weckhuysen
… related to complications of hematopoietic stem cell transplantation. This highlights a non-… The most frequent ocular complication of autologous hematopoietic stem cell transplantation is … periorbital edema in a patient after hematopoietic stem cell …
… This article provides a review of the most frequently used CSCs and stem cell markers. … of stem cells, because they play a role in stem cell pluripotency and their interactions with various co-… Indeed, the functional role of stem cell factors in …
… the multitude of stem cell types (adipose derived, bone marrow derived, embryonic and induced pluripotent) and techniques employed to induce stem cell proliferation and differentiation … Here, we curate several studies on stem cell …
… Instead, using stem cell models, it is possible to recapitulate neurodevelopment in vitro, essentially observing risk in a laboratory dish. We … The first human embryonic stem cell lines were grown in 1998, with the theoretical capability to …
PO-660-03 OPTICAL CONTROL OF ARRHYTHMIA MORPHOLOGY IN HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED … To develop a method for the induction of morphologically and physiologically defined arrhythmias in human …
Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang
Chuyu Li, Jiazi Xie, Juan Dong, Chao Gao, Meng Xia, Yuting Lin, Yugui Cui, Lianju Qin, Wei Wu
Yajuan Shi, Hyosung Kim, Catherine A Hamann, Elizabeth M Rhea, Jonathan M Brunger, Ethan S Lippmann
UC San Diego scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.
Ovarian cancer is a deadly disease attributed to late-stage detection as well as recurrence and development of chemoresistance. Ovarian cancer stem cells (OCSCs) are hypothesized to be largely responsible for emergence of chemoresistant tumors.
Dongni Lin, Kaihao Yan, Lingyun Chen, Junxiong Chen, Jianing Xu, Zhijing Xie, Zhujun Li, Shuo Lin, Jinghuan Li, Zhenzhou Chen
Much has been learned about the genes and pathways that contribute to a diverse array of hematopoietic malignancies and other hematopoietic diseases. However, for many of these diseases, an allogeneic hematopoietic stem cell (HSC) transplant …
… Here, we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs from differentiating into leukemia progenitors and promote their differentiation into non-leukemic cells, thus …
… In summary, our study demonstrated that NSE promoted stem cell-like characteristics of SCLC via NBL1 and the activation of the BMP2/… , which promotes stem cell-like characteristics [20, 21]. Thus, we aimed to determine …
… For example, in the repair phase after bacteria (Pseudomonas aeruginosa)-induced lung injury, 30–70% of the AT2s acquire the expression of a stem cell surface marker Sca-1 (stem cell antigen 1, or Ly6a) [15, 16]. The Sca-1 + AT2s are likely to …
Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient …
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