Feature Channels: Stem Cells

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Released: 18-Apr-2022 12:00 PM EDT
Prevalence of Anti-HLA Antibodies in Haploidentical Hematopoietic Stem Cell Transplantation in Pediatric Patients : A Single-Center Experience
Preprints

Muhammad Ameen, Sadia Khan, Ali Al-Ahmari, Muhab Ayas, Aya Kattih, Amani Alkofide, Mohamad Walid Ballourah, Muheeb Al-Awami

Released: 18-Apr-2022 12:00 PM EDT
Commensal Oral Microbiota Influences Ulcerative Oral Mucositis Clinical Course in Allogeneic Stem Cell Transplant Recipients
Preprints

Julia Bruno, Vitor Heidrich, Franciele H. Knebel, Vinícius Campos de Molla, Claudia Joffily Parahyba, Wanessa Miranda-Silva, Paula Fontes Asprino, Luciana Tucunduva, Vanderson Rocha, Yana Novis, Celso Arrais-Rodrigues, Anamaria Aranha Camargo, Eduardo Rodrigues Fregnani

Released: 16-Apr-2022 12:00 PM EDT
Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells.
Preprints

Thulaj Meharwade, Loick Joumier, Maxime Parisotto, Vivian Huynh, Edroaldo Lummertz da Rocha, Mohan Malleshaiah

Released: 16-Apr-2022 12:00 PM EDT
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Preprints

Kris G Alavattam, Katie A Mitzelfelt, Giancarlo Bonora, Paul A Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J Palpant, William S Noble, Charles E Murry

Released: 16-Apr-2022 12:00 PM EDT
Chromatin remodeler developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders
Preprints

Pauliina Auvinen, Jussi Vehviläinen, Heidi Marjonen, Vijayachitra Modhukur, Joonas Sokka, Essi Wallén, Karita Rämö, Laura Ahola, Andres Salumets, Timo Otonkoski, Heli Skottman, Miina Ollikainen, Ras Trokovic, Hanna Kahila, Nina Kaminen-Ahola

Released: 15-Apr-2022 12:00 PM EDT
Whole-embryonic identification of maternal microchimeric cell types in mouse using single-cell RNA sequencing
Preprints

Kana Fujimoto, Akira Nakajima, Shohei Hori, Yumiko Tanaka, Yoshitaka Shirasaki, Sotaro Uemura, Naoki Irie

Released: 14-Apr-2022 12:00 PM EDT
Predicting the risk of acute kidney injury after hematopoietic stem cell transplantation: development of a new predictive nomogram
Preprints

Zhaoping Gan, Liyi Chen, Meiqing Wu, Lianjin Liu, Lingling Shi, Qiaochuan Li, Zhongming Zhang, Yongrong Lai

Released: 14-Apr-2022 12:00 PM EDT
A congenital hydrocephalus causing mutation in Trim71 results in stem cell differentiation defects through inhibiting Lsd1 mRNA translation
Preprints

Qiuying Liu, Mariah K Novak, Rachel Pepin, Katharine Maschhoff, Xiaoli Chen, Shaojie Zhang, Wenqian Hu

Released: 14-Apr-2022 12:00 PM EDT
Efficacy of inhaled tiotropium add-on to budesonide/formoterol in patients with bronchiolitis obliterans developing after hematopoietic stem cell transplantation
Preprints

Jeong Uk Lim, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chin Kook Rhee

Released: 14-Apr-2022 12:00 PM EDT
Identification of Protective, Metabolite-producing Bacterial and Viral Consortia in Allogeneic Stem Cell Transplantation Patients
Preprints

Erik Thiele Orberg, Elisabeth Meedt, Andreas Hiergeist, Jinling Xue, Sakhila Ghimire, Melanie Tiefgraber, Sophia Göldel, Tina Eismann, Alix Schwarz, Sebastian Jarosch, Katja Steiger, Michael Gigl, Karin Kleigrewe, Julius Fischer, Klaus-Peter Janssen, Michael Quante, Simon Heidegger, Peter Herhaus, Mareike Verbeek, Jürgen Ruland, Daniela Weber, Daniel Wolff, Matthias Edinger, Dirk Busch, Wolfgang Herr, Florian Bassermann, André Gessner, Li Deng, Ernst Holler, Hendrik Poeck

Released: 14-Apr-2022 12:00 PM EDT
Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of Pyroptosis Related Genes in Human Cancers
Preprints

Zhi-Na Wang, Hong-Ming Ma, Zi-Yi Chen, Jia-Wen Chen, Xu-Wen Yang, Nan Zhang, Fanjie Meng

Released: 14-Apr-2022 12:00 PM EDT
Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas based technology
Preprints

Alessandro Umbach, Giulia Maule, Eyemen Kheir, Alessandro Cutarelli, Marika Foglia, Luca Guarrera, Luca Fava, Luciano Conti, Enrico Garattini, Mineko Terao, Anna Cereseto

Released: 14-Apr-2022 5:15 AM EDT
Generation and characterization of stable pig pregastrulation epiblast stem cell lines
Cell Research

… Despite ongoing attempts since the 1990s, no stably defined pig epiblast-derived stem cell line has been established. Here, guided by … in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 …

Released: 13-Apr-2022 12:00 PM EDT
Discovery of zerumbone as a new agent for cardiac hypertrophy by high-throughput screening using human embryonic stem cell-derived cardiomyocytes
Preprints

Jie Huang, Haiyan Chen, Shujue Lan, Le Qin, Zixuan Xun, Shuai Han, Hongwei Zhao, Yunqing Ci, Chen Xu, Wenjia Zhu, Xinya Lu, Jiaxin Chen, Qiuyi Zheng, Ermin Li, Xinyun Chen, Chao Lu, Ruizhe Qian, Sifeng Chen, Xiaobo Li, Ning Sun

Newswise: The ethics of research on conscious artificial brains
Released: 12-Apr-2022 3:25 PM EDT
The ethics of research on conscious artificial brains
Kyoto University

One way in which scientists are studying how the human body grows and ages is by creating artificial organs in the laboratory.

Released: 12-Apr-2022 12:00 PM EDT
Paeoniflorin drives immunomodulation of mesenchymal stem cells via regulating Th1/Th2 cytokines in oral lichen planus
Preprints

Zhihui Zhang, Yan Zhang, Zhongfang Zhao, Pei Li, Danyang Chen, Wei Wang, Ying Han, Shiqi Zou, Xin Jin, Jianling Zhao, Hongwei Liu, Xiao Wang, Weili Zhu

Released: 12-Apr-2022 12:00 PM EDT
Exploring Health Behaviors and the Feasibility of a Lifestyle Intervention for Patients with Multiple Myeloma
Preprints

Allen Hodge, Patricia Sheean, Paula O’Connor, Kiley Tyler, Abigail Kerschner, Alexis Williams, Kathleen Jensik, Alexis Visotcky, Anita D’Souza, Parameswaran Hari, Binod Dhakal, Saurabh Chhabra, Kathryn E. Flynn, Patrick Hagen, Melinda Stolley

Released: 12-Apr-2022 4:00 AM EDT
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges
Trends in Molecular Medicine

Stem cell-based therapy for retinal degeneration is transitioning from the research stage to the clinical stage and is being developed as a treatment across the globe. In clinical studies on induced pluripotent stem cell (iPSC)-… of stem cell-based therapy …

Released: 12-Apr-2022 4:00 AM EDT
Impact of the multiscale viscoelasticity of Quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces
Biomaterials

… and cell types and correlate interfacial mechanical properties with stem cell expansion. Correlations suggest an impact of … stem cell proliferation, we determined the interfacial shear moduli of corresponding interfaces and correlated …

Released: 11-Apr-2022 12:00 PM EDT
A combination of Granulocyte-macrophage colony-stimulating factor with the R2 regimen in elderly high-risk B cell lymphoma maintenance therapy improves survival by modulating natural killer cells
Preprints

Shunrong Sun, Wulipan Fulati, Lin Shen, Min Wu, Zilan Huang, Wensi Qian, Pingping Chen, Yingwei Hu, Mingyue Chen, Yu Xu, Hongdi Zhang, Jiexian Ma, Yanhui Xie

Released: 11-Apr-2022 12:00 PM EDT
Placental mesenchymal stem cells improve ovarian function in a rat model of premature ovarian insufficiency by inhibiting NLRP3 inflammasome activity
Preprints

Huiming Ma, Na Hu, Shasha Xing, Shudan Liu, Songlin Guo, Feiyan Zhang, Xiaona Ma, Xueyun Liang, Dongmei Chen

Released: 11-Apr-2022 12:00 PM EDT
A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target
Preprints

Hongorzul Davaapil, Madeline McNamara, Alessandra Granata, Robyn G. C. Macrae, Mei Hirano, Martina Fitzek, Jose Antonio Aragon-Martin, Anne Child, David M. Smith, Sanjay Sinha

Released: 10-Apr-2022 12:00 PM EDT
Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium
Preprints

Nicolette M Johnson, Louis R Parham, Jeeyoon Na, Keara E Monaghan, Hannah M Kolev, Alena Klochkova, Melissa S Kim, Charles H Danan, Zvi Cramer, Lauren A Simon, Kaitlyn E Naughton, Stephanie Adams-Tzivelekidis, Yuhua Tian, Patrick A Williams, Nicolae A Leu, Simone Sidoli, Kelly A Whelan, Ning Li, Christopher J Lengner, Kathryn E Hamilton

Released: 10-Apr-2022 12:00 PM EDT
Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D
Preprints

Mirko Hh Schmidt, Verica Vasic, Kathrin Barth, Frank Bicker, Ulrike Schumann, Christine Maurer, Nora Heinig, Cora Roehlecke, Ute Nimtschke, Lana Schumann, Matthias Meinhardt, Thomas Mittmann, Konstantin Radyushkin, Jan Baumgart, Stefan Tenzer, Frauke Zipp, Irmgard Tegeder

7-Apr-2022 12:00 PM EDT
NK Cells Combined with Bispecific Antibody Showed Strong Response for Patients with Lymphoma
University of Texas MD Anderson Cancer Center

Researchers from The University of Texas MD Anderson Cancer Center showed that natural killer (NK) cells derived from donated umbilical cord blood, combined with a novel bispecific antibody known as AFM13 that targets CD16A and CD30, achieved effective responses in patients with pretreated and refractory CD30+ lymphoma. The study was presented today at the American Association for Cancer Research (AACR) Annual Meeting 2022.

Released: 9-Apr-2022 12:00 PM EDT
How to Heal the Gut’s Brain: Regeneration of the Enteric Nervous System
Preprints

The neural-crest derived enteric nervous system (ENS) is the intrinsic nervous system of the gastrointestinal (GI) tract and controls all gut functions, including motility.

Released: 8-Apr-2022 12:00 PM EDT
Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases
Preprints

Mohamad Karaky, Gabrielle Boucher, Saraï Mola, Sylvain Foisy, Claudine Beauchamp, Marie-Eve Rivard, Melanie Burnette, Hugues Gosselin, iGenoMed Consortium, Alain Bitton, Guy Charron, Philippe Goyette, John D. Rioux

Released: 8-Apr-2022 12:00 PM EDT
Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma
Preprints

Christian E. Badr, Katharina Eyme, Alessandro Sammarco, Roshani Jha, Hayk Mnatsakanyan, Rudolph Neustadt, Charlotte Moses, Ahmad Alnasser, Daniel Tardiff, Baolong Su, Kevin Williams, Steven Bensinger, Chee Yeun Chung

Released: 8-Apr-2022 12:00 PM EDT
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs
Preprints

Nathaniel R. Kastan, Sanyukta Oak, Rui Liang, Leigh Baxt, Robert W. Myers, John Ginn, Nigel Liverton, David J. Huggins, John Pichardo, Matthew Paul, Thomas S. Carroll, Aaron Nagiel, Ksenia Gnedeva, A. J. Hudspeth

Released: 8-Apr-2022 12:00 PM EDT
CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons
Preprints

Wah Chiu, Gong-Her Wu, Jesús Galaz-Montoya, Michael Schmid, Lydia Joubert, Patrick Mitchell, Cristina Danita, Serena Yeung, Sanket Gupte, Joy Hsu, Judith Frydman, Ranen Aviner, William Mobley, Chengbiao Wu, Yingli Gu, Charlene Smith-Geater, Leslie Thompson, Ricardo Miramontes, Keona Wang, Nicolette Geller

Released: 8-Apr-2022 12:00 PM EDT
Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response
Preprints

Gustavo Garcia, Yijie Wang, Joseph Ignatius Irudayam, Arjit Vijey Jeyachandran, Sebastian Castillo Cario, Chandani Sen, Shen Li, Yunfeng Li, Ashok Kumar, Karin Nielsen-Saines, Samuel W. French, Priya S. Shah, Kouki Morizono, Brigitte Gomperts, Arjun Deb, Arunachalam Ramaiah, Vaithilingaraja Arumugaswami

Released: 8-Apr-2022 12:00 PM EDT
A method for stabilising the XX karyotype in female mESC cultures
Preprints

Andrew Keniry, Natasha Jansz, Peter F Hickey, Kelsey Breslin, Megan Iminitoff, Tamara Beck, Matthew E Ritchie, Marnie E Blewitt

Released: 8-Apr-2022 12:00 PM EDT
Rapid Recovery of Male Cats with Postrenal Acute Kidney Injury by Treating with Allogeneic Adipose Mesenchymal Stem Cell-derived Exosomes
Preprints

Weihui Li, Wei Wang, Xin He, Zheng Liao, Aili Aierken, Jinlian Hua, Yan Wang, Dezhang Lu, Shiqiang Zhang

Released: 8-Apr-2022 12:00 PM EDT
Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells
Preprints

Irene Zorzan, Riccardo Massimiliano Betto, Giada Rossignoli, Mattia Arboit, Andrea Drusin, Paolo Martini, Graziano Martello

Released: 8-Apr-2022 12:00 PM EDT
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
Preprints

Emily Gruber, Joan So, Alexander C Lewis, Rheana Franich, Rachel Cole, Luciano G Martelotto, Amy J Rogers, Eva Vidacs, Peter Fraser, Kym Stanley, Lisa Jones, Anna S Trigos, Niko Thio, Jason Li, Brandon Nicolay, Scott Daigle, Adriana E Tron, Marc L Hyer, Jake Shortt, Ricky W Johnstone, Lev M Kats

Released: 8-Apr-2022 12:00 PM EDT
Single Ion Channel Recording in 3D Culture of Stem Cells Using Patch-Clamp Technique
Preprints

Vladislav I. Chubinskiy-Nadezhdin, Anastasia V. Sudarikova, Mariia A. Shorokhova, Valeria Y. Vasileva, Zuleikha M. Khairullina, Yuri A. Negulyaev

Released: 8-Apr-2022 12:00 PM EDT
A Comprehensive Roadmap of Human Placental Development in vitro
Preprints

Jaroslav Slamecka, Carlos A. Tristan, Seumgmi Ryu, Pei-Hsuan Chu, Claire Weber, Tao Deng, Yeliz Gedik, Pinar Ormanoglu, Sam Michael, Ty C. Voss, Anton Simeonov, İlyas Singec

Released: 7-Apr-2022 12:00 PM EDT
Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders
Preprints

Federica Forlanini, Alice Chan, Jasmeen Dara, Christopher C. Dvorak, Morton J. Cowan, Jennifer M. Puck, Morna J. Dorsey



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