Feature Channels: Alzheimer's and Dementia

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People who have been hospitalized for a major traumatic brain injury (TBI) may have a higher risk of developing dementia when compared to people who do not have a TBI, according to a new study published in the May 11, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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A suite of complimentary tests can quantify changes in dogs suspected of suffering from cognitive decline. The approach could benefit dogs and serve as a model for evaluating cognitive decline progression in – and treatments for – humans with Alzheimer’s disease.

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It’s often said that a little stress can be good for you. Now scientists have shown that the same may be true for cells, uncovering a newly-discovered mechanism that might help prevent the build-up of tangles of proteins commonly seen in dementia.

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Cedars-Sinai geriatrics experts will present their latest advances in research and care in person at the annual scientific meeting of the American Geriatrics Society (AGS) in Orlando May 12-14, sharing innovations to improve both the quality of patient care and quality of life for older adults.

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People with higher levels of antioxidants in their blood may be less likely to develop dementia, according to a study published in the May 4, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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A new nationally representative study published online in the Journal of Alzheimer’s Disease Reports found hearing impairment and vision impairment to be independently associated with cognitive impairment.

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Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.

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妙佑医疗国际(Mayo Clinic) 研究人员提出了一种新的计算模型，用于在阿尔茨海默病症状与脑解剖结构之间建立起映射关系。该模型是通过将机器学习技术应用于患者大脑成像数据而开发的。这个模型利用大脑的完整功能，而不是特定的大脑区域或网络来解释脑解剖结构与心理过程之间的关系。研究结果已发表在《自然通讯》杂志上。

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Pesquisadores da Mayo Clinic propuseram um novo modelo para mapear os sintomas da doença de Alzheimer na anatomia do cérebro. Esse modelo foi desenvolvido aplicando o processo de aprendizagem de uma máquina a dados de imagens de cérebros de pacientes.

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Los investigadores de Mayo Clinic propusieron un nuevo modelo para hacer un mapa de los síntomas de la enfermedad de Alzheimer en la anatomía cerebral. El modelo se creó mediante la aplicación de aprendizaje automático a los datos de imágenes cerebrales de los pacientes.

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This research in mice provides evidence for how dynamics in the default mode network of the brain are altered by activating the locus coeruleus region – a small nucleus in the brainstem that releases norepinephrine. It also suggests new targets for treatment to restore DMN function.

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UC San Diego researchers developed a smartphone app that could allow people to screen for Alzheimer's disease, ADHD and other neurological diseases and disorders—by recording closeups of their eye. The app uses a smartphone's built-in near-infrared camera and selfie camera to track how a person's pupil changes in size. These pupil measurements could be used to assess a person's cognitive condition.

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Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain. The scientists say this discovery in mice of a new function by cells known as astrocytes opens a whole new direction for neuroscience research that might one day lead to treatments for many disorders ranging from epilepsy to Alzheimer’s to traumatic brain injury.