Cleveland Clinic Study Shows High Remission Rates of Diabetic Kidney Disease Five Years After Bariatric Surgery

Article ID: 590367

Released: 14-Jun-2012 9:00 AM EDT

Source Newsroom: American Society for Metabolic and Bariatric Surgery (ASMBS)

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Newswise — SAN DIEGO, CA – JUNE 20, 2012 – In many obese diabetic patients, one of the most dreaded complications of Type 2 diabetes can be put into remission or prevented entirely with bariatric surgery, according to a new study* from the Cleveland Clinic presented here at the 29th Annual Meeting of the American Society for Metabolic & Bariatric Surgery (ASMBS).

The study found that nearly 60 percent of obese patients with diabetic nephropathy, the leading cause of end-stage kidney disease, no longer had the condition five years after surgery. Additionally, only 25 percent of obese diabetics without nephropathy at the time of surgery eventually developed this complication. Researchers noted this incidence rate after surgery is about 50 percent less than what occurs in the non-surgically treated diabetes population. The five-year remission and improvement rates for Type 2 diabetes were 44 percent and 33 percent, respectively.

“When we started this study, we thought bariatric surgery may just halt the progression of diabetic nephropathy, instead over half of the patients who had diabetic nephropathy prior to undergoing bariatric surgery experienced remission. This is a remarkable finding that warrants greater consideration of bariatric surgery in this patient population,” said lead study author Helen M. Heneghan, MD, a bariatric surgery fellow at the Cleveland Clinic Bariatric and Metabolic Institute in Ohio.

About seven million Americans have diabetic kidney disease, which jumped 34 percent in the last two decades, despite a substantial increase in the use of medications to treat the disease. Diabetes is the most common cause of kidney disease, a condition that independently increases the risk of heart disease and death.1

The study included 52 patients, mostly female, who suffered from obesity and Type 2 diabetes for almost nine years. They had an average body mass index (BMI) of 49 before undergoing bariatric surgery, which was primarily gastric bypass surgery. Nearly 40 percent had diabetic nephropathy prior to undergoing surgery, a complication of diabetes caused by uncontrolled blood sugar which, in severe cases, can require dialysis or lead to kidney failure. In the United States, diabetic nephropathy accounts for about 40 percent of new cases of end-stage renal disease.2

“No medical therapy has been as effective in achieving an effect of this magnitude on diabetic nephropathy,” said study co-author Philip R. Schauer, MD, professor of surgery and director of the Cleveland Clinic Bariatric and Metabolic Institute. Dr. Schauer published a study earlier this year in the New England Journal of Medicine that showed bariatric surgery can put Type 2 diabetes into remission even before substantial weight loss occurs. In addition to remission or improvement of Type 2 diabetes and its complications in the current study, patients were able to maintain 50 percent excess weight loss after five years, and also achieved significant improvements in blood pressure and cholesterol levels.

According to the World Health Organization, 90 percent of people with Type 2 diabetes worldwide are obese or overweight.3 The federal government estimates about 10.7 percent (23.5 million) of people age 20 years or older in the United States have Type 2 diabetes.4 According to the study authors, given these striking figures, the importance of trying to control obesity and diabetes, and prevent diabetic complications, is even more apparent. In addition to Dr. Heneghan and Dr. Schauer, study co-authors include Neil Orzech, MD, Kalman Bencsath, MD, Derrick Cetin, DO, and Stacy A. Brethauer, MD.

About Obesity and Metabolic and Bariatric SurgeryObesity is one of the greatest public health and economic threats facing the United States.5 Approximately 72 million Americans are obese6 and, according to the ASMBS, about 18 million have morbid obesity. Obese individuals with a BMI greater than 30 have a 50 to 100 percent increased risk of premature death compared to healthy weight individuals as well as an increased risk of developing more than 40 obesity-related diseases and conditions including Type 2 diabetes, heart disease and cancer.7,8 The federal government estimated that in 2008, annual obesity-related health spending reached $147 billion, double what it was a decade ago, and projects spending to rise to $344 billion each year by 2018. 10

Metabolic/bariatric surgery has been shown to be the most effective and long lasting treatment for morbid obesity and many related conditions and results in significant weight loss.11,12,13 In the United States, about 200,000 adults have metabolic/bariatric surgery each year.14 The Agency for Healthcare Research and Quality (AHRQ) reported significant improvements in the safety of metabolic/bariatric surgery due in large part to improved laparoscopic techniques.15 The risk of death is about 0.1 percent16 and the overall likelihood of major complications is about 4 percent.17

About the ASMBSThe ASMBS is the largest organization for bariatric surgeons in the world. It is a non-profit organization that works to advance the art and science of bariatric surgery and is committed to educating medical professionals and the lay public about bariatric surgery as an option for the treatment of morbid obesity, as well as the associated risks and benefits. It encourages its members to investigate and discover new advances in bariatric surgery, while maintaining a steady exchange of experiences and ideas that may lead to improved surgical outcomes for morbidly obese patients. For more information, visit

###*PL-116: Effects of Bariatric Surgery on Diabetic Nephropathy After 5 Years Follow-up Dr. Helen M. Heneghan; Dr. Philip R. Schauer; Neil Orzech, MD; Kalman Bencsath, MD; Derrick Cetin, DO; Stacy A. Brethauer, MDREFERENCES

1 de Boer, I. H., Rue, T. C., Hall, Y. N., et al. (2011). Temporal trends in the prevalence of diabetic kidney disease in the United States. Journal of the American Medical Association. 305(24) pp. 2532-2539. Access May 2012 from

2 American Diabetes Association. (2004). Nephropathy in diabetes. Diabetes Care. Accessed May 2012 from

3 Global Strategy on Diet, Physical Activity and Health – World Health Organization. (2012). Obesity and overweight. Accessed May 2012 from

4 National Diabetes Information Clearinghouse - U.S. Department of Health and Human Services. (2008). Diabetes Overview. Accessed May 2012 from

5 Flegal, K. M., Carroll, M. D., Ogden, C. L., et al. (2002). Prevalence and trends in obesity among US adults, 1999-2000. Journal of the American Medical Association. 288(14) pp. 1723-1727. Accessed March 2012 from

6 Chronic Disease Prevention and Health Promotion – Centers for Disease Control and Prevention. (2011). Obesity; halting the epidemic by making health easier at a glance 2011. Accessed February 2012 from

7 Office of the Surgeon General – U.S. Department of Health and Human Services. Overweight and obesity: health consequences. Accessed March 2012 from

8 Kaplan, L. M. (2003). Body weight regulation and obesity. Journal of Gastrointestinal Surgery. 7(4) pp. 443-51. Doi:10.1016/S1091-255X(03)00047-7. Accessed March 2012 from

9 Finkelstein, E. A., Trogdon, J. G., Cohen, J. W., et al. (2009). Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Affairs. 28(5) pp. w822-w831. Accessed February 2012 from

10 Thorpe, K (2009). The future costs of obesity: national and state estimates of the impact of obesity on direct health care expenses. America’s Health Rankings. Accessed June 2012 from

11 Weiner, R. A. (2010). Indications and principles of metabolic surgery. U.S. National Library of Medicine. 81(4) pp.379-394.

12 Chikunguw, S., Patricia, W., Dodson, J. G., et al. (2009). Durable resolution of diabetes after roux-en-y gastric bypass associated with maintenance of weight loss. Surgery for Obesity and Related Diseases. 5(3) p. S1

13 Torquati, A., Wright, K., Melvin, W., et al. (2007). Effect of gastric bypass operation on framingham and actual risk of cardiovascular events in class II to III obesity. Journal of the American College of Surgeons. 204(5) pp. 776-782. Accessed March 2012 from

14 American Society for Metabolic & Bariatric Surgery. (2009). All estimates are based on surveys with ASMBS membership and bariatric surgery industry reports.

15 Poirier, P., Cornier, M. A., Mazzone, T., et al. (2011). Bariatric surgery and cardiovascular risk factors. Circulation: Journal of the American Heart Association. 123 pp. 1-19. Accessed March 2012 from

16 Agency for Healthcare Research and Quality (AHRQ). Statistical Brief #23. Bariatric Surgery Utilization and Outcomes in 1998 and 2004. Jan. 2007.

17 Flum, D. R. et al. (2009). Perioperative safety in the longitudinal assessment of bariatric surgery. New England Journal of Medicine. 361 pp.445-454. Accessed June 2012 from


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