Researchers at Washington University School of Medicine in St. Louis have developed a way to attack synovial sarcoma — a rare tumor of soft tissues, such as ligaments and muscles — using an investigational drug that triggers cell death.
Tree beta diversity — a measure of site-to-site variation in the composition of species present within a given area — matters more for ecosystem functioning than other components of biodiversity at larger scales. The finding has implications for conservation planning.
Children who were prescribed antibiotics inappropriately were more likely to develop complications such as diarrhea and skin rashes than children who were treated according to medical guidelines, according to a new study from Washington University School of Medicine in St. Louis and The Pew Charitable Trusts. This misuse of antibiotics resulted in at least $74 million in excess health-care costs in the U.S. in 2017.
A $2.3 million National Institutes of Health (NIH) grant will fund Jianjun Guan and Fuzhong Zhang’s effort to develop and deliver therapeutic proteins to help treat injured limbs.
The McKelvey School of Engineering’s Lan Yang has been selected to receive the Friedrich Wilhelm Bessel Research Award. Given by the Alexander von Humboldt Foundation, the award recognizes distinguished scientists in any discipline.
Vaccinated people with mild breakthrough COVID-19 infections can experience debilitating, lingering symptoms that affect the heart, brain, lungs and other parts of the body, according to researchers at Washington University School of Medicine in St. Louis and the Veterans Affairs St. Louis Health Care System. However, a new study of more than 13 million veterans also found that vaccination against the virus that causes COVID-19 reduced the risk of death by 34% and the risk of getting long COVID-19 by 15%, compared with unvaccinated patients infected with the virus.
Researchers at Washington University School of Medicine in St. Louis and the University of Wisconsin–Madison identified the genetic causes of three mitochondrial diseases by figuring out what dozens of poorly understood mitochondrial proteins do.
People with neurofibromatosis type 1 (NF1) develop tumors on nerves throughout their bodies. Researchers at Washington University School of Medicine in St. Louis have discovered that nerve cells with the mutation that causes NF1 are hyperexcitable and that suppressing this hyperactivity with the epilepsy drug lamotrigine stops tumor growth in mice.
Researchers at Washington University School of Medicine in St. Louis have identified a previously unknown function for the fragile X protein, the loss of which is the leading inherited cause of intellectual disability. The researchers showed that the protein modulates how neurons in the brain’s memory center process information, a central part of learning and memory.
Microbial communities shape our health and the health of our planet. Some are familiar to humans, like the microbes that reside in the gut, known as our microbiome. Others keep fermenting along mostly under the radar.
Research from the lab of Calvin Lai, assistant professor of psychological and brain sciences in Arts & Sciences, suggests demographics, not bias, is the best predictor of racial discrepancy when it comes to who gets pulled over by police.
The forthcoming study conducted by researchers at the Olin Business School at Washington University in St. Louis and UCLA shows abortion ruling leak did little to change Americans’ voting intentions.
Using the properties of a unique class of materials, researchers, including Aravind Nagulu at the McKelvey School of Engineering, may have found a way to dramatically increase the bandwidth available for wireless communications.
Researchers at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis have found a way to help more patients who want to stop smoking. The successful strategy involves using electronic medical records to help identify smokers when they visit their oncologists and offering help with quitting during such visits.
While having a child attend a private school or school with above-average instructional quality was associated with better mental health of parents during the COVID-19 pandemic, hybrid school was associated with worse parental mental health, as was working from home, finds a new study from the Brown School at Washington University in St. Louis.
Researchers at Washington University School of Medicine in St. Louis and Saint Louis University found that less than half of Americans who received treatment for opioid use disorder over a five-year period were offered a potentially lifesaving medication. The numbers were even lower for those with what’s known as polysubstance use disorder — when opioid users also misuse other substances.
Deer, caribou, bison and other similar animals are often infected by a range of internal parasites, including worms called helminths. Although many of these infections are not lethal, they can still impact health or animal behavior.
Researchers at Washington University School of Medicine in St. Louis have received a $6 million grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) to harness new understandings of the immune system to develop innovative therapies for heart failure and the prevention of organ rejection following heart transplantation.
A study by researchers at Washington University School of Medicine in St. Louis and the Broad Institute of MIT and Harvard suggests that women who get recurrent urinary tract infections (UTIs) may be caught in a vicious cycle in which antibiotics given to eradicate one infection predispose them to develop another.
Researchers from the Washington University Center for the Study of Itch and Sensory Disorders have identified a specific neuropeptide and a neural circuit that transmit pleasant touch from the skin to the brain. The findings eventually may help scientists better understand and treat disorders characterized by touch avoidance and impaired social development.
If Florida’s action to strip Walt Disney World of its status as a special tax district is indeed retaliatory against the company for its opposition to the state’s “Don’t Say Gay” law, as critics call it, then Florida has plainly violated the First Amendment, said a constitutional law expert at Washington University in St.
Three of four blood tests used to identify people in early stages of Alzheimer’s disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis. Such differences may put Black patients at risk of misdiagnosis.
By scanning the genomes of nearly 6,000 stroke patients, researchers at Washington University School of Medicine in St. Louis identified two genes associated with recovery. Both are involved in regulating neuronal excitability, suggesting that targeting overstimulated neurons may help promote recovery in the pivotal first 24 hours.
Crows and ravens are well known for their black color and the harsh “caw” sound they make. They are intelligent birds that use tools, solve complex abstract problems and speak a volume of words. But what is less well appreciated is how diverse they are. Their diversity is accompanied by their ability to live all over the world in a variety of habitats.
Up to half of older adults may have sleep apnea, a condition in which breathing and sleep are briefly interrupted many times a night. A new study from researchers at Washington University School of Medicine in St. Louis shows that this chronic tiredness can have serious implications for road safety.
Using Gallup survey data from 2000-2019 spanning across four presidential administrations, political scientists at Washington University in St. Louis find anxiety about crime, race and the president’s political party influence whether Americans hold presidents accountable for crime.
Follow the pollen. Warmer temperatures brought plants -- and then came even warmer temperatures, according to new model simulations published April 15 in Science Advances.
Scanning the brains of newborns, researchers at Washington University School of Medicine in St. Louis have found that maternal exposure to poverty and crime can influence the structure and function of young brains even before babies make their entrances into the world.
Demand for new kinds of antibiotics is surging, as drug-resistant and emerging infections are becoming an increasingly serious global health threat. Researchers are racing to reexamine certain microbes that serve as one of our most successful sources of therapeutics: the actinomycetes.
A new resonator system discovered in the labs of Lan Yang and Xuan “Silvia” Zhang at the McKelvey School of Engineering can interact with never-before-accessible ranges in the electromagnetic spectrum. The research was published in the journal Nature Nanotechnology.
In the wake of the slap heard ‘round the world — actor Will Smith’s blow to comedian Chris Rock’s left cheek — scholars in the business of entertainment in the Olin Business School at Washington University in St. Louis say the situation is shot through with reputational risk.But not where you might think.
Researchers at Washington University School of Medicine have found that many people who tested positive for the coronavirus in the early months of the pandemic also experienced peripheral neuropathy — pain, tingling and numbness in the hands and feet — during and following their bouts with COVID-19.
On March 21, President Biden issued an urgent warning to American business leaders to strengthen their companies’ cyber defenses immediately. In recent weeks, experts have been surprised by the lack of full-scale cyberattacks by Russia. But the threat of devastating cyberattacks is still very real and American companies and individuals must remain vigilant, warned Liberty Vittert, professor of practice of data science at Washington University’s Olin Business School.
Biologists have developed a new method to measure the extent to which regional geographic features — including barriers between regions, like mountains or water — affect local rates of speciation, extinction and dispersal for species. As a test case, they successfully used their model to delineate the movement and diversification of neotropical anole lizards.
The United States Senate’s passing of a resolution supporting a war crimes investigation into Russian President Vladimir Putin for his invasion of Ukraine adds to an international call to hold Putin accountable for Russia’s actions.The invasion gives rise to a real concern not only about breaches of international law for which the Russian Federation might be liable, but about liability of individuals for international crimes, said Leila Sadat, the James Carr Professor of International Criminal Law and Special Adviser on Crimes Against Humanity to the International Criminal Court prosecutor.
International business experts John Horn and Patrick Moreton offer their perspectives on the developing situation with China, including challenges facing the country and what impact their actions could have on the Chinese and global economies.
Alzheimer’s disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study by researchers at Washington University School of Medicine in St. Louis has shown that targeting astrocytes — an inflammatory cell in the brain — reduces tau-related brain damage and inflammation in mice.
Analyzing more than 200 years of conflicts, David Carter at Washington University in St. Louis finds revisionist states — like Russia — have made territorial claims when the great powers that dominate the international system are embroiled in crisis.
Researchers at Washington University School of Medicine in St. Louis have found that people with severe alcohol use disorder miss more than double the number of workdays missed by individuals without alcohol use disorder. The total number of missed workdays due to alcohol use disorder was 232 million.
A research team led by Chao Zhou at the McKelvey School of Engineering has used a safe, noninvasive imaging technique to observe the development of a human heart organoid over 30 days.
Scientists rely on brainwide association studies to measure brain structure and function — using brain scans — and link them to mental illness and other complex behaviors. But a study by researchers at Washington University School of Medicine in St. Louis and the University of Minnesota, published March 16 in Nature, shows that most published brainwide association studies are performed with too few participants to yield reliable findings.
The Senate approved on March 10 a $1.5 trillion bipartisan spending package, which Senate Majority Leader Chuck Schumer called “the strongest, boldest and most significant government funding package we’ve seen in a long time.” The spending package, which is expected to be signed by President Joe Biden, includes $18.
The COVID-19 pandemic has exacerbated risks of violence for refugee and migrant girls and women, finds a new report from the Brown School at Washington University in St. Louis and UNICEF.
A new study — in mice — from Washington University School of Medicine in St. Louis suggests that blocking a major inflammatory pathway that is activated in pancreatic cancer makes the tumors sensitive to chemotherapy and a type of immunotherapy that prompts the immune system’s T cells to attack the cancer cells. The therapy more than doubled survival in a mouse model of pancreatic cancer.
Scientists from Washington University in St. Louis are helping to recover gases from a container of lunar soil that astronauts collected and sealed under vacuum on the surface of the Moon in 1972. The effort is part of NASA’s Apollo Next Generation Sample Analysis (ANGSA) initiative. Preliminary science results will be discussed during the Lunar and Planetary Science Conference, which will be held in Houston March 7-11.