Scientists from the Vienna BioCenter have pushed SARS-CoV-2 detection to a new level. Their approach is as sensitive and robust, yet cheaper, simpler and faster to implement than conventional tests. 'bead-LAMP' and 'HomeDip-LAMP' could be game-changers for population-wide screening, especially in disadvantaged environments, such as developing countries.
Neurobiologists solve long-standing question over how brains orchestrate complex behaviours. The scientists from the lab of Manuel Zimmer showed that such behaviours are controlled by hierarchical neural activity, as they now reported in the journal Neuron.
New insights into the process of DNA-looping change our view of how the genome is organised within cells. The discoveries by IMP-researchers elucidate a fundamental mechanism of life and settle a decade long scientific dispute.
The immune system relies on B cells and their ability to make antibodies against an extremely broad range of pathogens. This broad responsiveness bears some risk, as B cells can also turn against healthy tissue - a phenomenon called autoimmunity. Scientists from the lab of Meinrad Busslinger now reported in the journal "Nature Immunology" how the protein lkaros orchestrates the fine balance between B cell silencing and activation - and thereby controls autoimmunity.
Emily Bayer of Columbia University, Mohamed El-Brolosy of the Max Planck Institute for Heart and Lung Research, and Justin Silpe of Princeton University: three exceptional young scientists were chosen to be the first laureates of the new International Birnstiel Award for Doctoral Studies in the Molecular Life Sciences.
Scientists at IMBA - Institute of Molecular Biotechnology at the Austrian Academy of Sciences - together with the Boston Children's Hospital at Harvard, demonstrate a completely new way of combating autoimmune diseases and cancer.
Scientists have long argued over which cells enable salamanders to grow back lost limbs. By tracking lineages and characterising individual cells, researchers could now show that connective tissue cells develop stem-cell-like properties and underlie the regeneration of legs. The findings were published in the journal “Science”.
Fertilisation is a pivotal process underlying all sexual reproduction, yet its molecular mechanisms are poorly understood. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna have now identified a protein they called “Bouncer” as a crucial factor for sperm entry into the egg. Remarkably, this protein is sufficient to allow fertilization between different species. The study is published in the current issue of the journal Science.
Scientists from two institutes at the Vienna BioCenter (VBC) have developed a method to identify and characterise microRNAs in individual cells of living animals.
Scientists in Vienna, Dresden and Heidelberg have decoded the entire genetic information of the Mexican salamander axolotl, the largest genome ever to be sequenced. This will be a powerful tool to study the molecular basis of regeneration. The journal NATURE publishes the news today.
Neuroscientist Manuel Zimmer, a group leader at the Research Institute of Molecular Pathology (IMP) in Vienna, has been selected as HHMI-Wellcome International Research Scholar. His work on C. elegans worms aims to uncover how the brain processes information to generate behaviour.
DNA molecules in the cells‘ nuclei are neatly folded into loops. This serves to wrap them up tightly, but also to bring distant gene regulatory sequences into close contact. In a paper published this week by NATURE, scientists at the Research Institute of Molecular Pathology (IMP) in Vienna describe how cohesin might do the trick.
The Research Institute of Molecular Pathology (IMP) opens its new building: IMP sponsor Boehringer Ingelheim has constructed a new flagship for the Vienna Biocenter, the Life Science cluster in Vienna, with an investment of 52 million euros. Representatives from politics, industry and science celebrated the opening.
Applications by the IMP, the Research Institute of Molecular Pathology in Vienna, were 100% successful in the latest call of the European Research Council ERC. Over the coming five years, projects by Senior Scientists Meinrad Busslinger and Elly Tanaka will be funded with 4.8 million euros.
No single neuron produces a thought or a behavior; anything the brain accomplishes is a vast collaborative effort between cells. When at work, neurons talk rapidly to one another, forming networks as they communicate. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna and the Rockefeller University in New York are developing technology that would make it possible to record brain activity as it plays out across these networks.
Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as “the molecular kiss of death”. Tim Clausen’s group at the Research Institute of Molecular Pathology (IMP) in Vienna identified an analogous system in gram-positive bacteria, where the role of a degradation tag is fulfilled by a little known post-translational modification: arginine phosphorylation. The discovery, which is published online by the journal Nature, opens new avenues for designing antibacterial therapies.
Scientists discovered a new way in which microRNAs can determine the fate of cells in the course of their development. This could be a key to understanding how complex organisms are built, say researchers from the Institute of Molecular Pathology (IMP) in Vienna.
An international team of scientists from Austria, Germany and the US has combined newly developed techniques in electron microscopy and protein assembly to elucidate how cells regulate one of the most important steps in cell division. The latest paper in a series of four is now published online in Molecular Cell.
Biologists develop a new method for analyzing brain images and demonstrate it with a study on fruit flies.
Jan-Michael Peters and Tim Clausen of the Research Institute of Molecular Pathology (IMP) and Jürgen Knoblich of the Institute of Molecular Biotechnology (IMBA) each receive an Advanced Grant by the European Research Council ERC. That means a success rate of 100 percent for the two institutes. Researchers at the Vienna Biocenter have received a total of 36 ERC-Grants so far.
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