Latest News from: Joslin Diabetes Center

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Released: 5-Mar-2024 3:05 PM EST
Weight-loss surgery provides superior long-term benefits for patients with Type 2 diabetes, study finds
Joslin Diabetes Center

A landmark study conducted at four sites, including Joslin Diabetes Center, reports that people with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to people who received medical management plus lifestyle interventions. Participants who underwent bariatric surgery, also called metabolic or weight-loss surgery, were also more likely to stop needing diabetes medications and had higher rates of diabetes remission up to 12 years post-surgery. The findings, published in JAMA, suggest that weight loss surgery may carry benefits for people with diabetes, even those who are below the traditional BMI threshold of 35 for bariatric surgery.

23-Feb-2024 3:05 PM EST
Shifting focus: Investigators describe changes to pancreatic β cell at onset of Type 1 Diabetes
Joslin Diabetes Center

About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced “beta”) in the pancreas, leading to a lack of insulin and inability to regulate blood sugar. It’s not known why the body suddenly perceives its own β-cells as the enemy; some lines of evidence suggest environmental factors such as viral infections may trigger the onset of T1D, others suggest genetics may also play some role. Groundbreaking research by investigators at Joslin Diabetes Center sheds new light on the specific changes β-cells go through at the onset of T1D. Their findings—published in Nature Cell Biology—offer new avenues for targeted interventions for the chronic autoimmune condition.

Released: 23-Feb-2023 2:55 PM EST
Phase 3 Trial Finds Oral Empagliflozin Provided Safe Glycemic Control in Children with Type 2 Diabetes
Joslin Diabetes Center

Researchers recently completed a phase 3 clinical trial that assessed the efficacy and safety of two different classes of oral agents for the treatment of type 2 diabetes in young people aged 10-17 years.

Released: 5-Jan-2023 1:55 PM EST
Researchers Shed Light on How Exercise Preserves Physical Fitness During Aging
Joslin Diabetes Center

Researchers investigated the role of one cellular mechanism in improving physical fitness by exercise training and identified one anti-aging intervention that delayed the declines that occur with aging in the model organism.

Released: 5-Oct-2022 2:15 PM EDT
Exercise and obesity have opposite impact on muscle, fat tissues, researchers demonstrate
Joslin Diabetes Center

First-of-its-kind dissection of adipose and muscle tissues reveal single-cell changes in metabolic tissues

Released: 5-Aug-2022 10:35 AM EDT
Study Reverses Long-Held Ideas About Relationship Among Diabetes, Fat and Cardiovascular Disease
Joslin Diabetes Center

In a paper published in Circulation Research, scientists describe a series of studies designed to determine the relationship among insulin, fats and the vascular system.

Released: 25-Jul-2022 5:40 PM EDT
Gut Microbe Peptide Implicated in Triggering Type 1 Diabetes
Joslin Diabetes Center

Researchers have identified a species of human gut bacterium that makes a protein containing a sequence of amino acids that mimics the insulin peptide targeted by the immune system in type 1 diabetes.

Released: 20-Jan-2022 2:05 PM EST
Crosstalk between pancreatic cells may drive rare form of diabetes
Joslin Diabetes Center

Joslin researchers show how one form of the rare inherited disease known as mature onset diabetes of the young (MODY) is driven by mutated digestive enzymes generated in pancreatic exocrine cells that are then taken up by neighboring insulin-secreting beta cells.

   
Released: 22-Dec-2021 4:10 PM EST
Cracking the code for a new system of cell-to-cell signaling
Joslin Diabetes Center

Joslin discovery about exosomes (cell fragments that regulate other cells) may help to advance RNA gene therapies for many diseases.

Released: 20-Sep-2021 7:05 AM EDT
Insulin resistance pinned to cell signaling defects that could act as therapy targets
Joslin Diabetes Center

Insulin resistance in the general population seems likely to be caused by a series of cell-specific signaling defects some of which appear to be sex-specific. In addition, only a portion of the defects are shared with those seen in diabetes, pointing towards the existence of novel pathways behind insulin resistance in the general population. According to researchers, this could also be the starting point for new therapeutics to tackle insulin resistance, which is the major driver of type 2 diabetes and metabolic syndrome and is present in 20-30% of the general population in the United States.

Released: 30-Jun-2021 2:55 PM EDT
Newly Discovered Proteins Provide Protection Against Progression of Kidney Disease in Diabetes
Joslin Diabetes Center

Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center in Boston.

Released: 12-May-2021 11:20 AM EDT
Ancient gut microbiomes may offer clues to modern diseases
Joslin Diabetes Center

Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases.

Released: 12-Apr-2021 1:05 PM EDT
Pain Receptors Linked to the Generation of Energy-Burning Fat Cells: Implications for Obesity Therapy
Joslin Diabetes Center

A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism >on 12 March 2021, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) -- a protein known to sense noxious stimuli, including pain and temperature.

Released: 30-Mar-2021 11:30 AM EDT
Kids’ metabolic health can be improved with exercise during pregnancy: here’s why
Joslin Diabetes Center

BOSTON – (March 25, 2021) – A mechanism has been identified that explains how physical exercise in pregnancy confers metabolic health benefits in offspring. According to researchers, the key lies with a protein called SOD3, vitamin D and adequate exercise, with the outcomes possibly forming the first steps to designing rational diet and exercise programs to use during pregnancy and particularly when mothers may also be overweight or obese.

Released: 4-Jan-2021 1:20 PM EST
Routine eye scans may give clues to cognitive decline in diabetes
Joslin Diabetes Center

In older people with type 1 diabetes, damage to the retina may be linked to memory problems and other cognitive conditions.BOSTON – (December 31, 2020) – As they age, people with diabetes are more likely to develop Alzheimer's disease and other cognitive disorders than are people without diabetes. Scientists at Joslin Diabetes Center now have shown that routine eye imaging can identify changes in the retina that may be associated with cognitive disorders in older people with type 1 diabetes.

Released: 16-Dec-2020 2:55 PM EST
CAN risk in diabetes reduced with intensive control of blood glucose and blood pressure
Joslin Diabetes Center

BOSTON – (December 16, 2020) – Intensive interventions to reduce blood glucose and blood pressure levels in type 2 diabetes reduce the risk of developing cardiovascular autonomic neuropathy (CAN), a frequent but underdiagnosed complication of diabetes that can be life-threatening. In a study led by Alessandro Doria , MD, PhD, MPH, from the Joslin Diabetes Center and Harvard Medical School, and Rodica Pop Busui, MD, PhD, of the University of Michigan, published online in Diabetes Care , researchers found that intensive glycemic control reduced CAN risk by 17%, while intensive blood pressure control reduced risks by 22%.

Released: 8-Dec-2020 1:10 PM EST
Lipid component identified in breast milk may play an important role in early childhood weight development
Joslin Diabetes Center

A lipid metabolite called 12,13-diHOME has been identified in human breast milk and appears to be associated with beneficial infant weight gain and body Study suggests that when new mothers exercise, they likely improve newborn’s longer term metabolic health.

Released: 3-Sep-2020 11:45 AM EDT
Diabetes-in-a-dish model uncovers new insights into the cause of type 2 diabetes
Joslin Diabetes Center

Researchers have developed a novel ‘disease-in-a-dish’ model to study the basic molecular factors that lead to the development of type 2 diabetes, uncovering the potential existence of major signaling defects both inside and outside of the classical insulin signaling cascade, and providing new perspectives on the mechanisms behind insulin resistance in type 2 diabetes and possibly opportunities for the development of novel therapeutics for the disease.

Released: 26-Aug-2020 2:15 PM EDT
Transplanted brown-fat-like cells hold promise for obesity and diabetes
Joslin Diabetes Center

A potential therapy for obesity would transplant HUMBLE (human brown-like) fat cells, human white fat cells that have been genetically modified using CRISPR to become similar to heat-generating brown fat cells.

Released: 20-Jul-2020 12:45 PM EDT
Increased blood sugar levels may decrease benefits of aerobic exercise
Joslin Diabetes Center

Researchers at Joslin Diabetes Center have discovered that some benefits of aerobic exercise may be dampened by higher-than-normal blood sugar levels, and that this is independent of obesity and insulin levels in the blood.



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