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Released: 1-Nov-2004 2:30 PM EST
Grants to Develop Health Promotion, Prevention Programs in the Work Place
Dana-Farber Cancer Institute

The Center for Disease Control has awarded researchers at Dana-Farber Cancer Institute two grants totaling $3 million to develop workplace-based health promotion and prevention programs.

Released: 20-Oct-2004 1:00 PM EDT
Children’s Book Illustrators Decorate Snowflakes to Benefit Cancer Research
Dana-Farber Cancer Institute

It will be snowing art in November and December when original works"” decorated snowflakes"” by some of the best-known award-winning children's book illustrators will be auctioned online in a charity event, Robert's Snow: for Cancer's Cure.

14-Oct-2004 3:00 PM EDT
Childhood Cancer Survivors at Increased Risk of Breast Cancer
Dana-Farber Cancer Institute

Young women who were treated for cancer as children have a greater chance of developing breast cancer if their treatment included chest radiation, if they initially had cancer of the bones, muscles, or connective tissue, or had a family history of breast cancer, according to a new study.

Released: 20-Sep-2004 1:50 PM EDT
Leukemia Eliminated in Mice, Demonstrating New Cancer Drug Therapy
Dana-Farber Cancer Institute

Scientists at Dana-Farber Cancer Institute have corrected a flaw in cancer cells that lets them evade the normal cell-death process, and as a result they eliminated leukemia cells from mice.

Released: 30-Aug-2004 1:30 PM EDT
Lance Armstrong Foundation’s Gift Launches Adult Cancer Survivorship Clinic
Dana-Farber Cancer Institute

The Lance Armstrong Foundation has given a $1 million gift to Dana-Farber Cancer Institute to establish the Lance Armstrong Foundation Adult Survivorship Clinic. The clinic, which will be part of the Perini Family Survivors' Center, will expand Dana-Farber's commitment to serving cancer survivors of all ages.

Released: 19-Aug-2004 4:10 PM EDT
Cell-cycle Triggers Might be Cancer Drug Targets
Dana-Farber Cancer Institute

Dana-Farber Cancer Institute researchers have found that removing three key proteins believed essential to cell division and growth had little impact on normal tissue development of a mouse embryo.

12-Aug-2004 1:50 PM EDT
Hormonal Therapy Improves Survival in Prostate Cancer Patients
Dana-Farber Cancer Institute

Researchers have found that adding only six months of hormone therapy to external beam radiation therapy for localized prostate cancer increased patients' likelihood of surviving to five years by 10 percent.

15-Jul-2004 6:10 AM EDT
Study Suggests Broader Chemotherapy Attack in Breast Cancer
Dana-Farber Cancer Institute

In the first comprehensive survey of gene activity in each cell type composing normal and malignant breast tissue, scientists at Dana-Farber Cancer Institute have identified genes in non-cancerous supporting cells that can spur the growth of breast cancer cells.

6-Jul-2004 1:20 PM EDT
Drug Reduces Heart Damage Caused by Childhood Leukemia Treatment
Dana-Farber Cancer Institute

A potent chemotherapy that is highly effective in treating the most common form of childhood leukemia can significantly harm the heart, but findings from a multi-center study suggest that adding an experimental drug to the therapy can reduce or prevent the damage.

7-Jun-2004 2:00 PM EDT
Proteins Offer Insights Into Organization of Biological Networks
Dana-Farber Cancer Institute

Research into the many-sided interactions of proteins in yeast cells is revealing that such networks may have something in common with other kinds of systems, from the World Wide Web to the country's electric-power grid.

Released: 8-Jun-2004 8:50 AM EDT
Strong Familial Tendency in Rare Form of Lymphoma
Dana-Farber Cancer Institute

Scientists at Dana-Farber Cancer Institute have uncovered new evidence that Waldenstrom's macroglobulinemia can run in families. Investigators will document these findings, as well as their discovery that certain markings on the surface of Waldenstrom's tumor cells may indicate a subtype of the disease.

4-Jun-2004 2:10 PM EDT
Encouraging Results for Drug That Steps Up When Gleevec Fails
Dana-Farber Cancer Institute

A new pill that targets several molecules implicated in the growth of cancer has shown promise in combating gastrointestinal tumors that no longer respond to the targeted drug Gleevec.

4-Jun-2004 2:00 PM EDT
Attitudes May Deter African Americans from Receiving Surgery for Non-small Cell Lung Cancer
Dana-Farber Cancer Institute

Do African Americans with early-stage non-small cell lung cancer (NSCLC) have a lower overall survival rate than Caucasians with the disease because they have less access to adequate medical care, or because they are less likely to agree to lung surgery when offered? A study offers evidence that both factors may play a role.

4-Jun-2004 1:50 PM EDT
Velcade TM a Major Improvement Over Standard Therapy
Dana-Farber Cancer Institute

Early results from a major, international Phase III clinical trial decisively show that recurrent multiple myeloma is more effectively treated with the drug bortezomib (trade name: Velcade TM) than with dexamethasone, a drug that for decades has been the standard therapy for relapsed disease.

Released: 1-Apr-2004 4:20 PM EST
Center for Applied Cancer Science Launched
Dana-Farber Cancer Institute

The establishment of the Center for Applied Cancer Science, a far-reaching initiative designed to convert basic molecular discoveries into new therapies for cancer, is announced.

12-Mar-2004 3:40 PM EST
Scientists Identify Crucial Gene for Blood Development
Dana-Farber Cancer Institute

Researchers have pinpointed a crucial gene on which the normal development of the body's entire blood system depends. If the gene is absent, even the most basic blood stem cells cannot be generated. In a mutated form, this gene can cause a rare and devastating form of leukemia.

2-Feb-2004 10:00 AM EST
Benefit in Stop-Smoking Programs Targeted for Working-Class Groups
Dana-Farber Cancer Institute

A study suggests that a person's occupation is a distinct and significant factor - in addition to education, income, race/ethnicity, and gender - in determining which groups of adults bear the greatest burden of smoking, and which may especially benefit from smoking-cessation efforts.

29-Jan-2004 12:20 PM EST
Scientists Identify a Human Antibody That Blocks SARS Virus Infection
Dana-Farber Cancer Institute

An antibody plucked from a "library" of human antibodies has powerfully blocked infection by the SARS virus in laboratory tests. This discovery could expedite the development of an antibody drug for the prevention or early treatment of SARS.

21-Jan-2004 2:10 PM EST
Do Cancer Patients in Clinical Trials Have Better Outcomes than Non-Participants?
Dana-Farber Cancer Institute

Some oncologists contend that patients in cancer trials experience better outcomes than non-participants - a benefit known as a "trial effect." Researchers reviewed 26 published cancer studies and found little convincing evidence that a trial effect exists.

Released: 9-Dec-2003 2:00 PM EST
Scientists Announce Long-Sought Mouse Model of Human Pancreatic Cancer
Dana-Farber Cancer Institute

Researchers have created bioengineered mice that develop aggressive, fatal pancreatic cancer through the same genetic mishaps that cause the disease in humans.

4-Dec-2003 1:40 PM EST
Fertility Worries Common in Young Breast Cancer Survivors
Dana-Farber Cancer Institute

A survey of young breast cancer survivors found that more than half likely overestimated their risk for developing treatment related infertility, according to researchers. The study is the largest to date that addresses fertility and menopausal concerns among young women with breast cancer.

3-Dec-2003 11:20 AM EST
Surgery without Radiation Inadequate for DCIS
Dana-Farber Cancer Institute

Women who chose not to receive radiation therapy following surgery for Ductal Carcinoma In Situ experienced recurrences at a surprisingly high rate. This suggests that surgery alone is inadequate in treating these small, very early breast cancers.

Released: 31-Oct-2003 10:40 AM EST
Novel Enzyme with Key Role in Leukemia Protein's Normal Function
Dana-Farber Cancer Institute

Scientists have discovered an enzyme they say accounts for a cancer-causing protein's Jekyll-and-Hyde personality. Normally, the protein regulates when and how body parts develop, but when mutated, it triggers a rare, often-lethal infant leukemia called mixed lineage leukemia.

Released: 2-Sep-2003 2:00 PM EDT
Study Raises Prospect of Practical Vaccine for Metastatic Melanoma
Dana-Farber Cancer Institute

In a step toward a practical vaccine for advanced melanoma, a notoriously difficult-to-treat form of cancer, researchers have demonstrated the effectiveness of a vaccine that is safer and easier to produce than earlier versions.

27-Mar-2003 12:00 AM EST
Rare Blood Disease Shown to be a Form of Treatable Cancer
Dana-Farber Cancer Institute

In the process of figuring out why an anti-cancer drug is effective in treating patients with the rare blood disorder hypereosinophilic syndrome, researchers at Brigham and Women's Hospital and Dana-Farber Cancer Institute have shown that it is a form of cancer.

Released: 26-Mar-2003 12:00 AM EST
U.S. Minorities Face "Unequal Burden of Cancer"
Dana-Farber Cancer Institute

Barriers to healthy lifestyles, early detection services and good medical care contribute to higher cancer incidence and mortality rates for African Americans and other medically underserved minorities in this country, when compared with white U.S. citizens.

Released: 14-Mar-2003 12:00 AM EST
Therapeutic Antibody Research and Engineering Center Launched
Dana-Farber Cancer Institute

The Dana-Farber Cancer Institute and the National Foundation for Cancer Research announced today the establishment of the NFCR Center for Therapeutic Antibody Engineering at Dana-Farber to assist scientists in developing new antibodies for cancer research.

Released: 5-Mar-2003 12:00 AM EST
March is National Colorectal Cancer Awareness Month
Dana-Farber Cancer Institute

March is national colorectal cancer awareness month, and Dana-Farber Cancer Institute physicians and nurses are encouraging people who are age 50 and older to be screened regularly for the disease.

28-Feb-2003 12:00 AM EST
Screening Test Helps Identify Cancer Survivors at Risk for Emotional Distress
Dana-Farber Cancer Institute

A relatively brief screening test can give caregivers a good indication of which cancer survivors are emotionally distressed and may benefit from further psychological evaluation, according to new research by a team of Dana-Farber Cancer Institute investigators.

20-Feb-2003 12:00 AM EST
Drug Combo Improves Survival in Aggressive Bone Cancer
Dana-Farber Cancer Institute

A multi-institutional study has shown that adding two experimental drugs to the standard four-drug chemotherapy regimen significantly improved survival in patients with non-metastatic Ewing's sarcoma, a highly malignant bone cancer of children and young adults.

14-Feb-2003 12:00 AM EST
Vaccine Technique Shows Potential against Common Form of Lung Cancer
Dana-Farber Cancer Institute

In a demonstration of a vaccine therapy's potential for treating lung cancer, Dana-Farber Cancer Institute scientists report that a prototype vaccine boosted the natural immune response to tumors in a small group of patients with advanced non-small cell lung cancer.

Released: 31-Jan-2003 12:00 AM EST
How the Sun Causes Skin Cancer
Dana-Farber Cancer Institute

Dana-Farber researchers have made a discovery that could help explain how a child's sunburn can develop into a deadly tumor decades later. The findings may lead to a means of distinguishing, at an early stage, cancerous moles from non-cancerous ones.

Released: 5-Sep-2002 12:00 AM EDT
Drug Shows Promise in Treating Severe Complications of Stem Cell Transplants
Dana-Farber Cancer Institute

A study led by researchers at Dana-Farber Cancer Institute has shown that a drug extracted from porcine intestinal tissue reduced the risk of death in patients who experienced severe veno-occlusive disease, an often-fatal complication of stem cell transplants.

4-Sep-2002 12:00 AM EDT
High-Starch Diet Linked to Pancreatic Cancer in Overweight, Sedentary Women
Dana-Farber Cancer Institute

Research has shown that a diet high in starchy foods may increase the risk of pancreatic cancer in women who are overweight and sedentary. The study suggests that excess insulin can promote the development of pancreatic cancer.

Released: 20-Jul-2002 12:00 AM EDT
Worksite Program to Stop Smoking Among Blue-Collar Workers Yields Notable Success
Dana-Farber Cancer Institute

Blue-collar workers are more likely to quit smoking when workplace smoking cessation programs are combined with other occupational health and safety messages rather than when singled out, according to a study headed by Dana-Farber Cancer Institute researchers. The findings may lead to a new approach to improving working-class people's health.

17-Jul-2002 12:00 AM EDT
Post-surgery Chemotherapy Questioned for Certain Breast Cancer Patients
Dana-Farber Cancer Institute

An international study questions the value of chemotherapy following breast surgery in postmenopausal women with lymph node-negative tumors that are responsive to estrogen. However, patients whose tumors were unresponsive to estrogen did benefit from chemotherapy.

14-Jun-2002 12:00 AM EDT
Discovery of Six New Breast Cancer-Susceptibility Genes
Dana-Farber Cancer Institute

A decade of research into one of the world's least-known diseases has resulted in a major advance against one of the best-known: the discovery of six genes linked to inherited breast cancer. Dana-Farber Cancer Institute researchers and colleagues report that an error in any of six Fanconi anemia genes can increase a person's risk of developing breast cancer.

Released: 24-Apr-2002 12:00 AM EDT
Women Treated for Hodgkin's Disease Often Are Unaware of Future Risk of Breast Cancer
Dana-Farber Cancer Institute

Many young women treated with chest radiation for Hodgkin's disease are not aware that they have an increased risk of developing breast cancer later in life. Moreover, among those who are aware of their increased risk, many fail to have regular mammograms, according to a new study led by researchers at Dana-Farber Cancer Institute.

29-Mar-2002 12:00 AM EST
Mechanism Behind Tamoxifen Side Effect
Dana-Farber Cancer Institute

Dana-Farber researchers have identified the underlying mechanism that causes one of tamoxifen's side effects. The findings may lead to new medications that reduce the risk of certain types of breast cancer, but don't carry tamoxifen's potential downside.

15-Mar-2002 12:00 AM EST
Dietary Changes Can Lower Colon Cancer Risk in Families with a History of the Disease
Dana-Farber Cancer Institute

People who have a parent or sibling with colon cancer can markedly reduce their own chances of developing the disease by taking a daily multivitamin that includes folic acid and limiting their intake of alcohol, per a Dana-Farber, Brigham and Women's, and HSPH study.

Released: 20-Feb-2002 12:00 AM EST
News Tips from Dana-Farber Cancer Institute
Dana-Farber Cancer Institute

1) Social influences in the workplace contribute to occupational differences in quitting smoking; 2) Childhood cancer patients find survival is the first step in lifelong battle.

14-Jan-2002 12:00 AM EST
Human Genome Sequence Yields New Tool for Microbe-Hunting
Dana-Farber Cancer Institute

Dana-Farber researchers have developed a powerful method for detecting foreign bacteria and viruses in human tissue samples, even if the organisms haven't previously been encountered. The microbe-hunting method relies on DNA sequence data.

Released: 3-Jan-2002 12:00 AM EST
News Tips from Dana-Farber Cancer Institute
Dana-Farber Cancer Institute

1) Study upends earlier thinking about immune cells' readiness against disease; 2) Drawing a new map of cancer: gene chips help sort out cancer types; 3) Researchers to examine disparity in cancer care among minorities.

3-Dec-2001 12:00 AM EST
Scientists Using Gene Chips Identify a Unique Form of Leukemia
Dana-Farber Cancer Institute

Dana-Farber Cancer Institute scientists have discovered that a rare but lethal blood cancer that strikes infants in their first year is a genetically distinct type of leukemia that might someday be treatable with designer drugs specifically targeted to it.

23-Nov-2001 12:00 AM EST
Mixed Report Card on Informed Consent to Cancer Clinical Trials
Dana-Farber Cancer Institute

While most cancer patients enrolled in clinical trials understand the primary purpose of the research, nearly one quarter of the participants do not realize that clinical trials are conducted mainly to benefit future patients, not themselves.

Released: 13-Nov-2001 12:00 AM EST
Gene Chips Bring New Order to Lung Cancer Types
Dana-Farber Cancer Institute

Using miniaturized chips that make snapshots of the activity of thousands of genes at once, Dana-Farber Cancer Institute scientists have divided lung cancers into new categories based on their gene functions rather than the cells' appearance under a microscope.

13-Nov-2001 12:00 AM EST
Immune System Discovery May Lead to Preventive Therapy for Diabetes
Dana-Farber Cancer Institute

By manipulating a cell that controls the immune system's response to infections, researchers at Dana-Farber Cancer Institute and their colleague have prevented the onset of diabetes in mice predisposed to the disease. The finding one day may lead to the development of a preventive therapy for people at risk for type 1 diabetes.

Released: 13-Sep-2001 12:00 AM EDT
Finding of Key Blood Sugar Controller Could Yield New Diabetes Drugs
Dana-Farber Cancer Institute

Dana-Farber Cancer Institute researchers have discovered the long-sought molecular "switch" that regulates the liver's production of glucose, the sugar that fuels the brain but which builds up dangerously in the bloodstream of diabetics because this switch doesn't turn off. Researchers say it may be possible to design new drug treatments for diabetes as a result of the work.

Released: 11-Sep-2001 12:00 AM EDT
AIDS Virus's Ability to Mimic Other Infections Blunts Immune System
Dana-Farber Cancer Institute

New, three-dimensional images from researchers at Dana-Farber Cancer Institute provide the fullest picture yet of how the AIDS virus blunts the immune system's ability to mount an attack against infections and cancer.

26-Jul-2001 12:00 AM EDT
New Consortium Aims to Reduce Tobacco's Toll on Working Families
Dana-Farber Cancer Institute

Dana-Farber Cancer Institute and the University of Massachusetts Lowell announced a new national partnership between labor unions and tobacco control groups to reduce tobacco use and exposure to secondhand smoke among working families.



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