In populations with a low prevalence of tuberculosis (TB), the majority of positives with the three tests commercially available in the U.S for the diagnosis of TB are false positives, according to a new study.
Hypoglossal nerve stimulation (HGNS) produced marked dose-related increases in airflow in obstructive sleep apnea (OSA) patients without arousing them from sleep, according to a new study from the Johns Hopkins Sleep Disorders Center. The study suggests the potential therapeutic efficacy of HGNS across a broad range of sleep apnea severity and offers an alternative to continuous positive airway pressure (CPAP), the current mainstay of treatment for moderate to severe OSA. The effectiveness of CPAP is often limited by poor patient adherence.
Heart rate recovery at one minute after a six-minute walking distance (6MWD) test is highly predictive of clinical worsening and time to clinical worsening in patients with idiopathic pulmonary arterial hypertension (IPAH), according to a new study.
Metabolic syndrome biomarkers predict subsequent decline in lung function after particulate exposure, according to new research involving rescue personnel exposed to World Trade Center (WTC) dust.
Researchers at the University of Chicago have found important new relationships between obesity, sleep-disordered breathing (SDB) and cognitive processing among elementary school children.
Vitamin D levels are not related to acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in patients with severe COPD, according to a large prospective cohort study involving 973 North American patients. The findings were published online ahead of the print edition of the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
Measuring specific, exercise-related responses can help physicians determine who may be more at risk for severe high altitude illness (SHAI), according to a study conducted by researchers in France. The researchers also found that taking acetazolamide (ACZ), a drug frequently prescribed to prevent altitude illness, can reduce some of the risk factors associated with SHAI.
Although increased use of noninvasive positive-pressure ventilation (NIPPV) nationwide has helped decrease mortality rates among patients hospitalized with chronic obstructive pulmonary disease (COPD), a small group of patients requiring subsequent treatment with invasive mechanical ventilation (IMV) have a significantly higher risk of death than those placed directly on IMV, according to researchers in the United States who studied patterns of NIPPV use
The American Thoracic Society (ATS), originally founded as the American Sanatorium Association at the turn of the twentieth century, welcomes the news that deaths worldwide from tuberculosis are falling and, with the exception of Africa, all world regions are on target to halve TB mortality by 2015.
Treatment with the calcium-sensitizing drug levosimendan may be effective in improving muscle function in patients with respiratory muscle weakness, which often accompanies chronic diseases such as chronic obstructive pulmonary disease (COPD) and congestive heart failure, according to researchers in the Netherlands, who studied the effects of the drug on healthy volunteers. The drug, which is normally prescribed in patients with acute heart failure,increases the sensitivity of muscle tissue to calcium, improving the muscle’sability to contract.
Children with severe therapy-resistant asthma (STRA) may have poorer lung function and worse symptoms compared to children with moderate asthma, due to lower levels of vitamin D in their blood, according to researchers in London. Lower levels of vitamin D may cause structural changes in the airway muscles of children with STRA, making breathing more difficult. The study provides important new evidence for possible treatments for the condition.
Dear reporters, The ten-year anniversary of the 2001 attacks on the World Trade Center is upon us. The American Thoracic Society has experts on hand to assist you with reporting on the health effects from exposure to the airborne pollutants released in the attacks. Please contact me, Keely Savoie, or Brian Kell should you need any additional information.
Today, the White House issued a press release stating they would not move to issue a final standard on ozone pollution. The American Thoracic strongly condemns this decision. “This is not change we believe in,” said ATS President-Elect Monica Kraft, MD, professor of medicine and director of the Asthma, Allergy and Airway Center at Duke University.
The American Thoracic Society has issued the first-ever guidelines on the use of fractional exhaled nitric oxide (FENO) address when to use FENO and how to interpret FENO levels in different clinical settings. The guidelines, which appear in the September 1 American Journal of Respiratory and Critical Care Medicine, are graded based on the available evidence in the literature.
A higher proportion of female nurses among intensive care teams may decrease individuals’ risk of professional burnout, according to Swiss researchers who studied the factors related to burnout in the high-stress setting of the intensive care unit (ICU).
The benefits of continuous positive airway pressure machines (CPAP) for patients with obstructive sleep apnea (OSA) are quickly reversed when the therapy is withdrawn, according to Swiss research.
Wearing compression stockings may be a simple low-tech way to improve obstructive sleep apnea in patients with chronic venous insufficiency, according to French researchers.
Cigarette smoke exposure fundamentally alters airway tissue from people with chronic obstructive pulmonary disease (COPD) at the cellular level, laying the groundwork for airway thickening and even precipitating precancerous changes in cell proliferation that may be self-perpetuating long after cigarette smoke exposure ends, according to Australian researchers.
Patients with idiopathic pulmonary fibrosis (IPF) who report treatment for gastroespophageal reflux (GER) appear to have longer survival than IPF patients who are not treated for GERD, according to a new study from the University of California, San Francisco.
Telomeres, the body’s own cellular clocks, may be a crucial factor underlying the development of emphysema, according to research from Johns Hopkins University.
The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X (u-EPX), a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years.
Psychosocial stress appears to enhance the lung-damaging effects of traffic-related pollution (TRP) in children, according to new research from the Keck School of Medicine of the University of Southern California (USC) in Los Angeles.
Noninvasive ventilation (NIV) used as a weaning technique for mechanically ventilated patients can shorten intubation time and may reduce the risk of post-extubation acute respiratory failure (ARF), according to French researchers. They also found that NIV used as a post-intubation rescue therapy could significantly reduce the risk of reintubation and death.
Despite their beneficial effects in treating heart disease, neither aspirin nor simvastatin appear to offer benefit to patients suffering from pulmonary artery hypertension (PAH), according to a National Institutes of Health (NIH)-funded study conducted at four U.S. medical centers. This was the first NIH-funded randomized clinical trial (RCT) in PAH.
Children whose mothers or grandmothers smoked during pregnancy are at increased risk of asthma in childhood, but the underlying causes of this are not well understood. Now a new study indicates changes in a process called DNA methylation that occurs before birth may be a root cause.
Researchers have described a new respiratory disease in soldiers returning from Iraq and Afghanistan.
Face masks worn by patients infected with tuberculosis (TB) may be able to significantly cut transmission rates to non-infected patients, according to a new study by researchers from the U.S. and South Africa. The study was conducted in a specialized airborne infections research facility in South Africa, which was designed to allow study of methods to control the spread of TB. Transmission rates were measured using healthy guinea pigs exposed to infected patients.
Results from C91 “Late-Breaking Clinical Trials” on Tuesday afternoon, May 17, will bring new light to clinical problems and potential treatments. While five examine possible new therapies for people with asthma (pregnant women), emphysema, lymphangioleiomyomatosis (LAM), TB and chronic obstructive pulmonary disease (COPD), a sixth looks at the safety of physician- vs. nurse-led transport teams for critically ill patients,
A new study links the intermittent interruption of breathing that occurs in patients with obstructive sleep apnea (OSA) to enhanced proliferation of melanoma cancer cells and increased tumor growth in mice, according to researchers in Spain. The study also found tumor cells of OSA mouse models tended to contain more dead cells, indicating a more aggressive type of cancer.
Patients with chronic obstructive pulmonary disease (COPD) are more likely to increase physical activity on a day-to-day basis when exercises classes are combined with a confidence-building program, according to researchers from Michigan and Illinois. Those improvements, however, are only short-term and patients return to their original levels of activity once the confidence-building program ends, the study found.
Workplace smoking bans are gaining ground globally, and one study has shown that they may have significant health effects. The study, conducted by researchers in Dublin, found that emergency room admissions due to respiratory illness dropped significantly in Ireland after the implementation of a workplace smoking ban, compared to admissions that took place before the ban went into effect.
According to a new study conducted by researchers in Connecticut, the Wii Fit™ offers patients with chronic obstructive pulmonary disease (COPD) an effective workout – and one that, because it is enjoyable, patients are more likely to use.
A traditional Chinese herbal paste known as Xiao Chuan, or XCP, may help reduce winter exacerbations of chronic obstructive pulmonary disease (COPD), according to a new study conducted by researchers in Beijing. The paste has been used to treat breathing difficulties in China for more than a thousand years.
A miniature, easy-to-carry ventilation system with a simple nasal mask may help patients with chronic obstructive pulmonary disease (COPD) become more active, according to research conducted at medical centers in California and Utah. The compact design offers an attractive alternative to currently available larger, less comfortableventilators and masks.
An impaired ability to handle oxidative stress that arises from exposure to secondhand smoke and other environmental triggers may contribute to the development of asthma, according to results obtained from the Shanghai Women’s Health Asthma and Allergy Study. The results of the study suggest regulating the body’s antioxidant defense system may play an important role in asthma prevention.
Concern over vaccine safety is one of the primary factors preventing parents from having their asthmatic children vaccinated for influenza, or flu, according to Michigan researchers. Parents who do not vaccinate their children are also less likely to view flu as a“trigger” for their child’s asthma, the researchers noted.
ATS 2011, DENVER – Waiting to seek emergency medical care for asthma exacerbations can result in worse outcomes, including hospitalization, according to a study conducted by researchers from New York. Patients who delay regular medical care also were sicker when finally seen by a doctor than patients who sought care when asthma exacerbations first occurred.
African-American children are more likely to report previous emergency room visits, hospitalizations and need for intensive care unit (ICU) management for asthma than Caucasian children on their first visit to an asthma specialist, according to a study conducted by researchers at Johns Hopkins University. The study also indicated that African-American children have poorer lung function at their initial visit to an asthma specialist than their Caucasian counterparts.
ATS 2011, DENVER – The antibiotic linezolid may be more effective than vancomycin in treating ventilated patients who develop methicillin-resistant Staphylococcus aureus (MRSA) pneumonia as a result of their ventilation, according to a study conducted globally by American and French researchers.
Researchers at the University of Chicago Medical Center attempting to identify the vital signs that best predict those hospitalized patients at greatest risk for cardiac arrest found that a composite index used in some hospitals to activate a rapid response team and by emergency room physicians to assess the likelihood of a patient dying was a better predictor of cardiac arrest than any single vital sign.
Surrogate decision-makers faced with the difficult task of overseeing loved ones’ medical care may find help thanks to a new decision aid aimed at patients with prolonged mechanical ventilation. According to a study conducted by researchers in North Carolina, Pennsylvania and Washington who developed and tested the aid, surrogates reported the aid significantly improved the often daunting decision-making process.
Inhaling small amounts of hydrogen in addition to concentrated oxygen may help stem the damage to lung tissue that can occur when critically ill patients are given oxygen for long periods of time, according to a rat model study conducted by researchers in Pittsburgh. The study also found hydrogen initiates activation of heme-oxygenase (HO-1), an enzyme that protects lung cells.
Removing enlarged tonsils and adenoids may help prevent high blood pressure and heart damage in children who suffer from obstructive sleep apnea (OSA), according to a study conducted at Cincinnati Children’s Hospital Medical Center. In some children with OSA, adenotonsillectomy can result in significantly lower blood pressure within 24 months of the procedure.
Telemonitoring may offer promise for patients in remote locations without access to specially trained intensive care physicians. However, a recent study indicates telemonitoring does not offer improved clinical outcomes compared to patients who receive standard care.
A new program developed by researchers at Pennsylvania State College of Medicine and Pennsylvania State University may make it easier for patients with moderate/severe chronic obstructive pulmonary disease (COPD) to make critical decisions regarding their care as their disease worsens. The computer-based decision aid (CDA) is designed to educate patients about planning for end-of-life decisions without diminishing hope, according to the researchers.
Researchers have demonstrated the effectiveness of a novel treatment that stimulates the nerve that controls the diaphragm to normalize the breathing of patients who suffer from both heart failure and central sleep apnea.
Although so-called clot-busting drugs are commonly used in the treatment of some patients with blood clots in the lungs, a new study conducted by researchers in Spain and the U.S. indicates the agents do not appear to be any more effective than traditional blood thinners for the majority of these patients. Clot-busters, or thrombolytic agents, also appear to increase the risk of death in patients with normal blood pressure.
Children with cystic fibrosis (CF) who have poor lung function early in life are more likely also to have poor lung function in adolescence, regardless of whether they are exposed to a common infection caused by the bacteria Pseudomonas aeruginosa in early childhood. Earlier studies had indicated infection with the bacteria early in life was strongly associated with poor lung function later on.
Clinicians consistently fall short in discussing end-of-life care with patients with chronic obstructive pulmonary disorder (COPD), according to a study completed by researchers in Washington. The study focused on the communication skills of staff physicians, physician trainees and advanced practice nurses.
Sleep problems among urban minority children, including resistance to going to bed, shortened sleep duration, and daytime sleepiness are much more common than previously thought, according to a study conducted by researchers in New York.
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