Vitamin D supplements may help patients with chronic obstructive pulmonary disease (COPD) get more from their pulmonary rehabilitation programs, according to a study conducted by researchers from Belgium.
Researchers have linked a variant in the vitamin D receptor gene (VDR) with the onset of chronic obstructive pulmonary disease (COPD) in Caucasian men. The study population consisted of participants in the Veterans Administration Normative Aging Study, a multidisciplinary study of aging that began in 1963.
The six-minute walking distance test (6MWD), a test that measures a patient’s ability to tolerate exercise and physical activity, is an effective tool for understanding disease severity in patients with chronic obstructive pulmonary disease (COPD), according to a three-year global study of patients with COPD sponsored by drug manufacturer GlaxoSmithKline.
Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers in France.
A simple, minimally-invasive technique using cells from the interior of the nose could help clinicians detect lung cancer in its earliest – and most treatable – stages, according to a study conducted by researchers in Boston.
Continuous positive airway pressure, or CPAP, can increase alertness and even improve quality of life for sufferers of obstructive sleep apnea (OSA), even if their symptoms are minimal, according to a study conducted by researchers in Europe. Patients enrolled in the study reported an improvement in daytime sleepiness within six months of beginning CPAP treatment.
Continuous positive airway pressure (CPAP) effectively decreases the risk of cardiovascular death in elderly patients who suffer from obstructive sleep apnea (OSA), according to a study conducted by researchers in Spain. The study is the first large-scale study to assess the impact of OSA and the effectiveness of CPAP treatment in cardiovascular mortality in the elderly.
Researchers in Baltimore have identified new compounds which relax airway muscles and may provide relief from shortness of breath for patients with COPD and asthma. The bitter-tasting compounds are at least as, if not more, effective than currently available agents used to manage these diseases, and may present new options for treatment.
Hospital patients with pneumonia may be at risk of experiencing sudden cardiac arrest, often with few or no warning signs, according to research from the University of Chicago Medical Center under the auspices of the American Heart Association’s Get with the Guidelines project.
New research on mice has shown that pulmonary administration of granulocyte macrophage-colony stimulating factor (GM-CSF) significantly reduces flu symptoms and prevents death after a lethal dose influenza virus. While GM-SCF therapy for humans as a flu prophylaxis or treatment may be years away, the study results were striking: All of the mice treated with GM-SCF survived after being infected with the influenza virus, whereas untreated mice all died from the same infection.
Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized for pneumonia and treated with inhaled corticosteroids (ICS) have decreased mortality when compared to those who are not treated with ICS, according to a retrospective analysis of almost 16,000 COPD patients admitted to VA hospitals.
Patients who receive intensive care services are very different in the United States than in the United Kingdom, according to a new study that compared admission and mortality statistics from ICUs in each country. The study found that U.K. patients are much sicker upon ICU admission, whereas U.S. patients are more likely to require continuing care after discharge and are often sent to skilled care facilities instead of home.
A new study has demonstrated no significant benefit of taking the drug bosentan for idiopathic pulmonary fibrosis (IPF).
March 24, 2011, marks World TB Day. On this day around the world, the public health and scientific community will raise public awareness about tuberculosis and the challenges that remain in controlling it globally, such as preventing the spread of drug resistant TB and as the urgent need to develop new TB diagnostic, treatment and prevention tools.
Changes that occur in the airways of asthma patients are in part caused by the naturally occurring protein interleukin-13 (IL-13) which stimulates invasion of airway cells called fibroblasts, according to a study conducted by researchers at Duke University. The study is the latest effort by researchers to better understand the processes that are involved in airway remodeling that can cause breathing difficulties in patients with asthma.
The American Thoracic Society has released new official clinical guidelines on the diagnosis and management of idiopathic pulmonary fibrosis (IPF). The statement replaces ATS guidelines published in 2000, and reviews current knowledge in the epidemiology, etiology, diagnosis and management of IPF, as well as available treatment options, including pharmacologic and non-pharmacologic therapies and palliative care.
American Thoracic Society President, Dean Schraufnagel, M.D.'s statement in support of the EPA’s Power Plant Air Toxics Rule.
Four novel biomarkers have been identified which may aid in the diagnosis and management of asthma and chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers in Australia, who determined the biomarkers may be used in different combinations to successfully identify patients with either of the airway diseases. In conducting the study, the researchers relied on proteomics, an emerging field of science that focuses on the structure and functions of an organism’s proteins.
Monitoring blood for tiny particles released by cells lining the lungs may help clinicians diagnose emphysema in its earliest stages, according to researchers from Weill Cornell Medical College. The particles, called endothelial microparticles (EMPs), are shed during the disease process as tiny blood vessels in the lungs, called pulmonary capillaries, are injured and die.
American Thoracic Society President Dean E. Schraufnagel, MD, expressed his opposition to legislation introduced today by Senator James Inhofe (R-OK) and Representative Fred Upton (R-MI) to prohibit the U.S. Environmental Protection Agency from issuing rules on carbon pollution and other greenhouse gases.
The American Thoracic Society has released a new official report recommending research priorities in incorporating ambulatory management of adults with obstructive sleep apnea (OSA) into healthcare systems. The report identifies barriers preventing incorporation of portable monitor testing into clinical management pathways and recommends research and development needed to address those barriers.
The American Thoracic Society has released a new report detailing recent global changes in the management of human immunodeficiency virus (HIV)-associated pulmonary disease. The report examines the evolving landscape of HIV and its associated diseases in areas where combination antiretroviral therapies (ART) are available, as well as offering insight into the trends occurring in areas of the world where ART use is limited.
Acute viral infection does not appear to be a primary cause of acute exacerbation of idiopathic pulmonary fibrosis (IPF), a progressive, deadly disease resulting in thickening and scarring of the lungs, according to a study conducted by researchers from the U.S., Korea and Japan. Previous studies had suggested viral infection might cause exacerbation of IPF in a majority of patients who have the condition, which occurs most often in people between 50 and 70 years of age.
Use of the blood clot-inhibiting medication tifacogin does not appear to improve outcomes of patients with severe community-acquired pneumonia (sCAP), according to a study conducted by researchers from North and South America, Europe, Asia and Africa. The drug had shown some potential benefit in the sCAP subgroup of an earlier trial involving sepsis patients.
Cigarette smoking has been linked with overproduction of mucus associated with chronic bronchitis, according to a study conducted by researchers in New Mexico. The study indicates cigarette smoke suppresses a protein that causes the natural death of mucus-producing cells in the airways of bronchitis patients.
Resistance to leptin, a protein that plays a key role in regulating metabolism and appetite, may help prevent the development of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) in individuals with type II diabetes, according to a study conducted by researchers in Chicago. The study indicates leptin resistance, a common characteristic of diabetes, may help prevent the formation of inflexible, fibrous tissue that develops in ALI and ARDS.
American Thoracic Society President Dean E. Schraufnagel, MD, today expressed “grave concerns” with legislation released by House Energy and Commerce Committee chairman Fred Upton (R-MI) and Senate Environment and Public Works Chairman Jim Inhofe (R-OK) to make changes to the Clean Air Act.
Previously linked to the severity of asthma and chronic obstructive pulmonary disease (COPD) in humans, vitamin D deficiency has now been shown to alter lung structure and function in young mice. The new study, conducted by researchers in Australia, offers the first concrete evidence linking vitamin D deficiency with deficits in lung function and altered lung structure.
Using inexpensive air filters may help reduce cardiovascular disease risk that results from exposure to air pollution, according to researchers from Canada, who studied healthy adultsliving in a small community in British Columbia where wood burning stoves are the main sources of pollution. The researchers found that high efficiency particle air (HEPA)filters reduced the amount of airborne particulate matter, resulting in improved blood vessel health and reductions in blood markers that are associated with an increased risk of cardiovascular disease.
Patients suffering from chronic obstructive pulmonary disease (COPD) who are on long-term oxygen therapy (LTOT) have more to worry about than breathing difficulties. According to a new study by researchers in Sweden, COPD patients on LTOT today face an increased risk of death from cardiovascular disease and other non-respiratory ailments. The study’s results suggest physicians need to carefully monitor for these conditions and treat them to help decrease the risk of mortality in these patients.
Identifying tuberculosis patients in Africa using passive methods is leaving many cases undiagnosed, according to researchers from the Netherlands, Kenya and the United States, who studied case detection methods in HIV-prone western Kenya. Tuberculosis (TB) occurs commonly in men and women with HIV, but in these patients TB can be more difficult to detect.
The American Thoracic Society has released a new official clinical policy statement on the treatment of fungal infections in adult pulmonary and critical care patients. The statement replaces ATS guidelines published in 1988, and takes into account new medications and treatment approaches, as well as provides an overview of emerging fungi.
Cystic fibrosis (CF) patients with normal to mildly impaired lung function may benefit from a new investigational drug designed to help prevent formation of the sticky mucus that is a hallmark of the disease, according to researchers involved in a phase 3 clinical trial of the drug. Called denufosol, the investigational medication can be given early in the CF disease process, and may help delay the progression of lung disease in these patients, the researchers found.
The president of the American Thoracic Society today criticized the Environmental Protection Agency for seeking a six-month delay in issuing a final rule for ozone pollution.
Patients aged 65 and older who survive an episode of mechanical ventilation during a hospitalization are more likely to suffer from long-term disabilities after leaving the hospital than those who survive hospitalization without mechanical ventilation, according to researchers at the University of Pittsburgh. These results were borne out even though the levels of functional disability prior to hospitalization were similar in both groups.
A school-based intervention program designed for adolescents with asthma significantly improves asthma management and quality of life for the students who participate, and reduces asthma morbidity, according to researchers in New York City, who studied the effect of the program aimed at urban youth and their medical providers. The Asthma Self-Management for Adolescents (ASMA) program is an eight-week intervention geared toward helping adolescents learn more effective ways of managing their symptoms and controlling their asthma.
The US Department of Health and Human Services and the Critical Care Societies Collaborative have established a new national awards program. The National Awards Program to Recognize Achievements in Eliminating Healthcare-Associated Infections will annually recognize teams of critical care professionals and healthcare institutions that achieve excellence and notable, sustained improvements in preventing healthcare-associated infections, specifically infections in critical care.
Moderate to severe chronic obstructive pulmonary disease (COPD) may be an auto-immunity problem, according to researchers in Spain, who studied the presence of auto-antibodies in patients with COPD and compared them to levels of control subjects. They found that a significant number of patients with COPD had significant levels of auto-antibodies circulating in their blood, about 5 to 10 times the level in controls.
Patients with obstructive sleep apnea (OSA) may blame their daytime difficulties on simple sleepiness, but new research suggests that their brains may be to blame. Specifically, their cognitive challenges may be caused by structural deficits in gray matter, brought on by the intermittent oxygen deprivation that comes with OSA.
The decision to stop life-support for incapacitated and critically ill patients is, for surrogate decision makers, often fraught with moral and ethical uncertainty, and long-term emotional consequences. But as difficult as these decisions are, more than half of surrogate decision makers prefer to have full authority over the choice than to share or cede that power to physicians, according to a recent study out of the University of Pittsburgh School of Medicine.
Long term exposure to low-level air pollution may increase the risk of severe chronic obstructive pulmonary disease (COPD), according to researcher s in Denmark. While acute exposure of several days to high level air pollution was known to be a risk factor for exacerbation in pre-existing COPD, until now there had been no studies linking long-term air pollution exposure to the development or progression of the disease.
In the largest human study to date on the topic, researchers have uncovered evidence of the possible influence of human sex hormones on the structure and function of the right ventricle (RV) of the heart.
Exacerbations in cystic fibrosis (CF) may be linked to chronic infection with a bacterium called Stenotrophomonas maltophilia, which was previously thought to simply colonize the CF lung. The finding that chronic infection with S. maltophilia is independently linked with an increased risk of exacerbations gives clinicians and researchers a new potential measure of the health status of CF patients, as well as a new potential target in fighting their disease.
Even children of a healthy weight who have an imbalanced metabolism due to poor diet or exercise may be at increased risk of asthma, according to new research, which challenges the widespread assumption that obesity itself is a risk factor for asthma.
There may be no simple one-size-fits-all approach to improving end-of-life care in ICU settings, according to a recent study from some of the world’s leading researchers in palliative care.
New evidence linking the use of acetaminophen to development of asthma and eczema suggests that even monthly use of the drug in adolescents may more than double risk of asthma in adolescents compared to those who used none at all; yearly use was associated with a 50 percent increase in the risk of asthma.
Smokers who are exposed to wood smoke, either through home heating and cooking or through ambient neighborhood pollution, are not only at increased risk of COPD, but are also more likely to have epigenetic changes in the DNA that further increase their risk of COPD and related pulmonary problems.
Patients with cystic fibrosis (CF) recover from exacerbations equally well if they are treated at home or in a hospital, according to researchers from Johns Hopkins University. Furthermore, longer treatment with antibiotics does not appear to offer any additional benefit over shorter courses.
A new study from researchers in Ottawa and Toronto suggests that a commonly used type of bone marrow stem cell may be able to help treat sepsis, a deadly condition that can occur when an infection spreads throughout the body.
Exposure to high levels of fungus may increase the risk of severe asthma attacks among people with certain chitinase gene variants, according to a study from Harvard Medical School, Harvard Pilgrim Health Care Institute and Brigham and Women’s Hospital.
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