A newly developed equation produces more accurate estimates of the glomerular filtration rate (GFR)"”a key indicator of kidney function in patients with chronic kidney disease (CKD), according to research being presented at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania.
Several recent studies have suggested that common gene variations may be responsible for much of the elevated risk of kidney disease in African Americans. New research on the MYH9 gene"”and its implications for the screening and possible prevention of kidney disease in the African American population"”will be summarized in a press briefing to be held at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia, PA.
The end-stage renal disease (ESRD) Medicare reform measures recently passed by Congress represent the most significant ESRD reforms in decades. These measures and how they will impact the practice of nephrology and patient care will be the topic of a session during the American Society of Nephrology (ASN) 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania.
Depending on where they live in the United States, patients needing a kidney transplant can wait just one year for a deceased donor's kidney or up to 10 years. The causes and implications of these inequities will be discussed at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia.
For most patients with chronic kidney disease (CKD), the risk of experiencing a cardiovascular related death is greater than the risk of progressing to end-stage renal disease (ESRD). According to research being presented at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania, African Americans with CKD caused by high blood pressure (hypertensive nephrosclerosis) demonstrated a higher risk of progressing to ESRD than dying from heart disease related events.
For patients with end stage renal disease (ESRD) on dialysis who also must be treated for heart disease, stents provide the best one-year survival compared with other revascularization treatments, but bypass surgery provides the best long-term survival, according to a paper being presented at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania.
Individuals with kidney disease often suffer from cognitive impairment, but kidney transplantation can improve their mental performance, according to a paper being presented at the American Society of Nephrology's 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania.
The Halpin Foundation and the American Society of Nephrology (ASN) proudly announce the recipient of the Halpin Foundation-ASN Research Grant for 2008, which was created to provide funding for young faculty to foster evolution to an independent research career by providing transition funding toward successful application for an RO1 grant.
African American kidney disease patients in both Canada and the United States are less likely than Caucasian Americans to have access to kidney transplants, but only African-Americans in the United States have worse health outcomes than Caucasians after a transplant is performed, according to a study appearing in the January 2009 issue of the Journal of the American Society Nephrology (JASN). The results could further open the debate about what has driven the disparities seen only in the United States.
Modification of the current screening criteria are needed for diagnosing patients with autosomal dominant polycystic disease (ADPKD), according to a study appearing in the January 2009 issue of the Journal of the American Society Nephrology (JASN). The results suggest that some patients with a milder form of the disease may otherwise be misdiagnosed.
People traveling to other countries to receive kidney transplants experience more severe post-transplant complications with a higher incidence of acute rejection and severe infections, according to a study appearing in the November 2008 issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings suggest that such "transplant tourism" by Americans may not be as safe as receiving transplants in the United States.
Kidneys from older donors often do not survive long after transplantation because of certain structural dysfunctions that can occur as the kidney ages, according to a study appearing in the January 2009 issue of the Journal of the American Society Nephrology (JASN). The findings indicate that the number of functioning glomeruli"”the filtering units of the kidney"”drops significantly with age, leading to a self-perpetuating injury in the rest of the kidney.
Elevated uric acid levels in the blood indicate an increased risk of new-onset kidney disease, according to a study appearing in the December 2008 issue of the Journal of the American Society Nephrology (JASN). The results suggest that it may be appropriate to prescribe uric acid"“lowering drugs, such as allopurinol and probenecid, to these otherwise healthy individuals.
Hospitalized patients with chronic kidney disease (CKD) are at higher risk for adverse consequences of medical care compared with those without the disease, according to a study appearing in the December 2008 issue of the Journal of the American Society Nephrology (JASN).
All countries should take steps to govern organ donation and transplantation, thereby ensuring patient safety and prohibiting unethical practices, according to an article appearing in the September 2008 issue of the Clinical Journal of the American Society of Nephrology (CJASN). The document is a consensus of more than 150 representatives of scientific and medical bodies from around the world, government officials, social scientists, and ethicists, who met in Istanbul, Turkey, this spring.
The discovery of "complementary" antibodies against plasminogen in patients with blood vessel inflammation caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs) may lead to new approaches to research, testing, and treatment of ANCA vasculitis and other autoimmune diseases, suggests a paper in the December Journal of the American Society of Nephrology (JASN).
The drug rituximab causes considerable kidney injury healing in patients with membranous nephropathy, a common form of kidney disease, according to a study appearing in the November 2008 issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that this condition, previously destined to progress to kidney failure in 30-40 percent of cases, can actually be healed in some patients.
Among patients receiving dialysis for chronic kidney disease (CKD), high levels of alkaline phosphatase"”a routinely measured laboratory marker of bone disease"”may signal an increased risk of death, reports a study in the November Journal of the American Society of Nephrology (JASN).
A routinely available laboratory result called the estimated glomerular filtration rate (eGFR) provides a simple indicator of kidney function and may increase early diagnoses of chronic kidney disease (CKD). However, widespread use of eGFR for this purpose may have inherent flaws and dangers"”including a risk that large numbers of elderly patients will be misclassified as having CKD.
Kidneys donated after individuals die from cardiovascular causes may be one of the best options for black patients in need of transplants, according to a study appearing in the October 2008 issue of the Journal of the American Society Nephrology (JASN). The research reveals that utilization of these organs should be expanded in order to reduce racial disparities that exist in renal transplantation.
For patients receiving kidney transplants, treatment with cholesterol-lowering "statin" drugs may lead to longer survival, reports a study in the November 2008 Journal of the American Society of Nephrology (JASN).
A medication called cinacalcet"”an important part of treatment to control high levels of parathyroid hormone (PTH) in patients receiving dialysis for end-stage renal disease (ESRD)"”works by resetting the balance between calcium and PTH levels, according to a study in the November Journal of the American Society of Nephrology (JASN).
More frequent hemodialysis sessions might improve the health of patients with end-stage renal disease (ESRD), but under reasonable assumptions of expected benefit, the overall costs are likely to increase, according to a study appearing in the September 2008 issue of the Journal of the American Society Nephrology (JASN).
Patients with kidney disease"”especially end-stage renal disease (ESRD) requiring dialysis"”are less likely to receive recommended medications after a heart attack, reports a study in the September 2008 Clinical Journal of the American Society of Nephrology (CJASN).
A new treatment using a combination of drugs targeting different parts of the immune system improves the recovery rate for patients with severe lupus involving the kidneys, according to a report in the October Journal of the American Society of Nephrology (JASN).
Consistently maintaining certain blood levels of markers of bone metabolism and disease can prolong the lives of patients on hemodialysis, according to a study appearing in the September 2008 issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that keeping parathyroid hormone, calcium, and phosphorous levels in control is critically important for dialysis patients with chronic kidney disease (CKD).
Healthy individuals with higher levels of albumin excretion, even levels considered normal, are at increased risk of developing hypertension (high blood pressure), according to a study appearing in the October 2008 issue of the Journal of the American Society Nephrology (JASN). The study suggests that to prevent cardiovascular disease, the definition of "normal" urinary albumin excretion should be reconsidered.
Healthy individuals who gain weight, even to a weight still considered normal, are at risk for developing chronic kidney disease (CKD), according to a study appearing in the September 2008 issue of the Journal of the American Society Nephrology (JASN). The study suggests that CKD should be added to the list of conditions that are associated with weight gain, including diabetes and hypertension.
Withdrawing certain immunosuppressive drugs following kidney transplantation prolongs survival and saves money compared with keeping patients on these medications for life, according to a study appearing in the September 2008 issue of the Journal of the American Society Nephrology (JASN).
Many patients with chronic kidney disease (CKD) have mild reductions in thyroid function, or subclinical hypothyroidism"”a condition that becomes more common as kidney function declines, according to a study in the September 2008 issue of Clinical Journal of the American Society of Nephrology (CJASN).
A number of biological, societal, and health care"“related issues contribute to disparities in the outcomes of US patients with kidney disease, according to two articles appearing in the July 2008 issue of the Journal of the American Society Nephrology (JASN). The articles indicate that immediate and substantial efforts on a number of fronts are needed to provide better health care for affected Americans.
For patients with type 2 diabetes, a condition called non-alcoholic fatty liver disease (NAFLD) may be an important risk factor for diabetes-related chronic kidney disease (CKD), according to a study in the August Journal of the American Society of Nephrology (JASN).
Radiographic procedures such as computed tomography (CT) scans that use intravenous dye rarely cause clinically significant acute kidney injury in patients with mild baseline kidney disease, according to a study appearing in the September 2008 issue of CJASN. The findings reveal that these procedures are safe for the large and growing number of individuals who undergo them as well as give physicians reassuring information on patient risk.
For patients undergoing kidney transplantation, treatment with the anti-rejection drug sirolimus may lead to an increased risk of diabetes, reports a study in the July Journal of the American Society of Nephrology (JASN).
For patients with type 1 diabetes and end-stage renal disease (ESRD), simultaneous kidney-pancreas transplantation increases the chances of long-term survival compared to kidney transplantation alone, reports a study in the August 2008 issue of Journal of the American Society of Nephrology (JASN).
Black patients have a higher risk of dying in the early stages of chronic kidney disease (CKD) than whites, according to a study appearing in the July 2008 issue of the Journal of the American Society Nephrology. The findings may explain why blacks have better survival rates once they reach advanced stages of the disease"”in essence, because only the healthiest blacks are surviving long enough to develop later stages of the disease.
An often asymptomatic condition"”systolic dysfunction, or decreased pumping of the heart"”poses an increased risk of death for patients on kidney transplant waiting lists, according to a study appearing in the June 2008 issue of the Journal of the American Society Nephrology (JASN). The findings reveal that a clinical indicator beyond well-known risk factors for cardiovascular mortality should be considered when caring for patients waiting for kidney donations.
Health care in the United States is expensive, but its funding is crucial because it also is a major contributor to the economy and can better lives, according to an essay appearing in the June 2008 issue of the Journal of the American Society Nephrology (JASN). Because of the cost of health care, this is not time to shrink the budget at the National Institutes of Health, which funds medical research that leads to potentially curative therapy.
For patients with moderate to severe chronic kidney disease (CKD), treatment with activated vitamin D may reduce the risk of death by approximately one-fourth, suggests a study in the August Journal of the American Society of Nephrology.
Why do black patients with advanced kidney disease have higher levels of creatinine, a standard indicator of kidney function, than whites? Contrary to what doctors have thought, the difference may not necessarily reflect differences in muscle mass related to younger age or differences in body composition, reports a study in the July 2008 issue of the Clinical Journal of the American Society of Nephrology (CJASN).
The osteoporosis drug raloxifene increases bone mineral density and reduces the risk of vertebral fractures among postmenopausal women with mild to moderate chronic kidney disease (CKD), according to a study appearing in the July 2008 issue of the Journal of the American Society Nephrology.
A recent look at what is known about the health effects of drinking water reveals that most supposed benefits are not backed by solid evidence. The findings indicate that most people do not need to worry about drinking their recommended 8 glasses of 8 ounces ("8x8") of water per day. The editorial is published in the June 2008 issue of the Journal of the American Society of Nephrology (JASN).
A family of small molecules called CFTR inhibitors show promising effects in slowing the progression of polycystic kidney disease (PKD), the most common genetic disease of the kidneys, according to preliminary research reported in the July 2008 issue of the Journal of the American Society Nephrology.
For patients with type 1 diabetes, increased levels of uric acid in the blood may be an early sign of diabetic kidney disease"”appearing before any significant change in urine albumin level, the standard screening test, reports a study in the May 2008 issue of the Clinical Journal of the American Society of Nephrology.
The American Society of Nephrology (ASN), in partnership with the National Kidney Foundation (NKF) and The American Society of Pediatric Nephrology (ASPN), will celebrate the third annual World Kidney Day Thursday, March 13. Physicians and patient advocates from across the nation will hold meetings with members of Congress and their staff to raise awareness of chronic kidney disease (CKD) as a growing public health problem and to advocate for increased funding for research.
A simple laboratory test may provide a new way for doctors to identify patients at risk of developing potentially severe acute kidney injury (AKI) after surgery"”up to three days before the problem would otherwise be detected, reports a pilot study in the May 2008 issue of the Clinical Journal of the American Society of Nephrology.
For patients with acute kidney injury (AKI), an external device containing human kidney cells promotes recovery of the injured kidneys and significantly reduces the risk of death, according to a preliminary clinical study published in the May Journal of the American Society of Nephrology.
Universal access to health care might help to overcome racial and ethnic barriers to treatment for kidney disease, suggest two studies in the March 2008 issue of Clinical Journal of the American Society of Nephrology.
Transplantation of kidneys from older donors is followed by increased stiffening of the recipient's aorta"”which may help to explain the higher rates of cardiovascular disease and death in patients receiving kidneys from "expanded criteria" donors, reports a study in the April Journal of the American Society of Nephrology.
For critically ill patients, intensive insulin therapy (IIT) to keep blood sugar (glucose) at normal levels reduces the risk of acute kidney injury, reports a study in the March Journal of the American Society of Nephrology.
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