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Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment for clinical trials, and treatment decision-making. Researchers at Icahn School of Medicine at Mount Sinai, part of the International Committee on Clinical Trials of MS, collaborated to re-examine the standardized MS clinical course descriptions originally published in 1996 and recommend refined phenotype descriptions that include improved clinical descriptive terminology, MRI and other imaging techniques, analysis of fluid biomarkers and neurophysiology. The proposed 2013 revisions will appear in the May 28, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Immune Response to Prostate-Specific Antigen, Live Birth Rate Adversely Affected by Increasing Paternal Age, Comparison of Treatment Modalities for Benign Prostatic Hyperplasia, Understanding Psychosocial and Supportive Needs Following Cystectomy

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Mount Sinai Beth Israel receives the 2014 American Heart Association’s Get With The Guidelines®–Heart Failure Gold Quality Achievement Award.

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Mount Sinai Health System Experts Offer Important Tips on Having a Healthy and Safe Memorial Day Holiday

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Even if treated, hypertension and high cholesterol are increasingly common for people with human immunodeficiency virus (HIV), according to a new study from researchers at Mount Sinai St. Luke’s and Mount Sinai Roosevelt hospitals in New York and the University of California, Davis.

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–– A research team from the Friedman Brain Institute of the Icahn School of Medicine at Mount Sinai published evidence showing that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. This is the first study to demonstrate the critical links between the levels of the trafficking protein, the potassium channels’ effect on neuronal activity and a mouse’s response to cocaine. Results from the study were published in the peer-reviewed journal Neuron earlier this month.

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Mount Sinai study shows the socioeconomic status of congestive heart failure patients does not influence hospital rankings for heart failure readmissions.

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Mount Sinai is pleased to announce today that James C. Tsai, MD, MBA has been appointed President of New York Eye and Ear Infirmary of Mount Sinai and Chair of Ophthalmology for the Mount Sinai Health System, effective September 2014.

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A research team from the Friedman Brain Institute of the Icahn School of Medicine at Mount Sinai has published evidence that shows that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. This is the first study to demonstrate the critical links between the levels of the trafficking protein, the potassium channels’ effect on neuronal activity and a mouse’s response to cocaine. Results from the study are published in the peer-reviewed journal Neuron on May 7, 2014.

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Vivek Reddy, MD, Director of Arrhythmia Services for The Mount Sinai Hospital, reported his promising12-month follow-up data showing the world’s first leadless pacemaker is demonstrating overall device performance comparable to conventional pacemakers. Dr. Reddy presented the one-year LEADLESS study data findings during his late-breaking clinical trial presentation on May 9 at Heart Rhythm 2014, the Heart Rhythm Society’s 35th Annual Scientific Sessions in San Francisco, CA.

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The Mount Sinai Health System and Mount Sinai Beth Israel are pleased to announce the appointments of Blase A. Carabello, MD, as Chair of Cardiology and John D. Puskas, MD, as Chair of Cardiothoracic Surgery at Mount Sinai Beth Israel.

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Adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems cells to generate in greater numbers making them more useful in adult transplantation.

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The Cardiac Catheterization Laboratory of Mount Sinai Heart at The Mount Sinai Hospital has once again received the highest “two-star” safety rating from the New York State Department of Health for its percutaneous coronary interventions (PCI) overall and in non-emergency cases.

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In the largest family study on autism spectrum disorder (ASD) to date, researchers from the Icahn School of Medicine at Mount Sinai, along with a research team from the Karolinska Institutet in Stockholm Sweden and King’s College in London found that individual risk of ASD and autistic disorder increased with greater genetic relatedness in families – that is, persons with a sibling, half-sibling or cousin diagnosed with autism have an increased likelihood of developing ASD themselves. Furthermore, the research findings showed that “environmental” factors unique to the individual (birth complications, maternal infections, etc.) were more of a determinant for ASD than previously believed.

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Many patients with throat cancer associated with oral human papillomavirus (HPV) have anxiety about transmitting the virus to their partners’ and increasing their cancer risk. However, a multi-center prospective study co-led by researchers at Icahn School of Medicine at Mount Sinai suggests that cancer risk in partners remain low. The research is reported in the Journal of Clinical Oncology (JCO).

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The Mount Sinai Health System has announced Pércio S. Gulko, MD, as Chief of the Division of Rheumatology in the Samuel Bronfman Department of Medicine. An expert in rheumatoid arthritis and author of over sixty leading peer-reviewed publications, Dr. Gulko will play a key role in advancing patient care, expanding research and developing comprehensive and innovative treatments for patients suffering from rheumatological disorders.

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A 30-second Public Service Announcement (PSA) for the Mount Sinai Ovarian Cancer Risk Assessment program aired for the first time yesterday, May 1, on the iconic Toshiba Vision LED signboards in the heart of Times Square, New York City. The PSA will continue to broadcast every six minutes, 24-hours per day through May 15th. David Fishman, MD, Director and Founder of the Mount Sinai Ovarian Cancer Risk Assessment Program, Valisia LeKae, Broadway actress and ovarian cancer survivor and Toshiba executives unveiled the PSA with a countdown yesterday afternoon.

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Scientists at Icahn School of Medicine at Mount Sinai, along with collaborators at institutions in India, Italy, and Japan, have identified the first gene linked to childhood-onset familial dilated cardiomyopathy (DCM), one of the most common heart muscle diseases in children. It is a progressive and potentially fatal heart condition resulting from an enlarged and weakened heart muscle.

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A substantial proportion of risk for developing autism spectrum disorders (ASD), resides in genes that are part of specific, interconnected biological pathways, according to researchers from the Icahn School of Medicine at Mount Sinai, who conducted a broad study of almost 2,500 families in the United States and throughout the world.

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Skin cancer is the most common form of cancer in the United States, with one in five Americans developing it over the course of their lives. It’s also one of the most preventable types of cancers. In recognition of May’s Skin Cancer Awareness Month and Melanoma Monday on May 5th, Mount Sinai Health System experts are arming the public with vital tips on prevention and offering FREE skin cancer screenings.

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New research uncovers a conceptually novel approach to treating depression. Instead of dampening neuron firing found with stress-induced depression, researchers demonstrated for the first time that further activating these neurons opens a new avenue to mimic and promote natural resilience.

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Researchers from Mount Sinai Demonstrate Proof of Concept for New, Rapidly-Acting Pharmacotherapy for Treatment of PTSD

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Cardiologists and cancer experts at The Mount Sinai Hospital have joined forces to establish its first Cardio-Oncology Clinic at The Tisch Cancer Institute at The Mount Sinai Hospital.

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Seasonal influenza causes approximately 30,000 deaths yearly in the US, despite the availability of vaccines and antivirals. During pandemic years, these numbers can increase significantly. To insure pandemic preparedness, the National Institutes of Health has awarded $26 million to five institutions, including the Icahn School of Medicine at Mount Sinai. The multimillion dollar award is part of an international collaboration of Centers of Excellence for Influenza Research and Surveillance (CEIRS) network.

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A research team from the Icahn School of Medicine at Mount Sinai published the first controlled evidence showing that an intranasal ketamine spray conferred an unusually rapid antidepressant effect –within 24 hours—and was well tolerated in patients with treatment-resistant major depressive disorder.

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The new President of the Association of Black Cardiologists (ABC) is Icilma V. Fergus, MD, Director of the Cardiovascular Disparities at Mount Sinai Heart at The Mount Sinai Hospital.

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Mark G. Lebwohl, MD, was named President-elect of the American Academy of Dermatology (AAD) during the last day of the annual meeting on March 25. The AAD is the world’s largest dermatologic society, representing more than 17,000 physicians specializing in the diagnosis and medical, surgical, and cosmetic treatment of skin, hair, and nail conditions. He will hold the office of president for one year.

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Ash Tewari, MBBS, MCh, Kyung Hyun Kim, MD Chair in Urology, Icahn School of Medicine at Mount Sinai and Chairman, Milton and Carroll Petrie Department of Urology at the Mount Sinai Hospital, was the recipient of the Physician Blue Ribbon Award at the Blue Ribbon Awards Gala hosted by the Integrated Medical Foundation held on March 20th, 2014 at the Village Club in Lake Success, New York. Dr. Tewari was recognized for his commitment to the early detection of prostate cancer.

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Mount Sinai researchers have linked high levels of exposure to inhaled particulate matter by first responders at Ground Zero to the risk of obstructed sleep apnea and post-traumatic stress disorder (PTSD), both conditions that may impact cardiovascular health.

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In recognition of a generous $10 million gift to the Icahn School of Medicine at Mount Sinai, made by benefactors Patty and Jay Baker, school leadership today announced the formation of ‘The Patty and Jay Baker National Palliative Care Center at Mount Sinai.’

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A new, non-invasive, stool-based screening test detected 92% of colorectal cancer (CRC), according to a multicenter trial published online today in the New England Journal of Medicine. The new test, which is not yet approved by the FDA, allows patients to collect a sample at home without the need for bowel preparation or diet restrictions.

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This research revealed that inflammation in the gut GM-CSF is produced in the normal gut in response to microbiota signals by specialized cells, requires sufficient GM-CSF to protect against gut inflammation. Deletion of GM-CSF gene in the mouse impaired gut regulatory function and compromised oral tolerance, and increased susceptibility to IBD.

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With approximately a 90% death rate and no treatment yet available, Marburg virus research and development are a top priority. This cell culture research reveals the molecular details of how Marburg virus and host protein interact, providing a potential disease target.

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Cardiovascular researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai, Sanford-Burnham Medical Research Institute, and University of California, San Diego have identified a small, but powerful, new player in the onset and progression of heart failure. Their findings, published in the journal Nature on March 12, also show how they successfully blocked the newly discovered culprit to halt the debilitating and chronic life-threatening condition in its tracks.

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Investigators studying chronic kidney disease have uncovered abnormal molecular signaling pathways from disease initiation to irreversible kidney damage, kidney failure, and death. Their results point to new drug targets for the disease.

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Using a transgenic mouse model, a Mount Sinai research team found that development of intestinal tumors depends on bacteria in the gut and that eradicating the bacteria with antibiotics also prevented polyp formation. They propose that gut bacteria may cross into the intestine, spurring inflammation and tumor growth.

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The kidneys, two very important organs located in your back, help to continuously clean out wastes and extra fluid from your body. One in 10 Americans develops kidney disease due to diabetes, high blood pressure or a family history of kidney failure. For March’s Kidney Awareness month, doctors from the Mount Sinai Health System discuss risk factors associated with the disease and offer ways to help protect your kidneys.

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Opiate use triggers changes in the protein RGS9-2 in neurons in the brain's reward center. Repeated use affects analgesic relief and tolerance, as well as addiction.

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Colorectal cancer, cancer of the colon or rectum affecting both men and women, is the third leading cause of cancer deaths in the United States. Although highly treatable and preventable, about 140,000 Americans are still diagnosed and more than 50,000 people die a year. Here, experts from the Mount Sinai Health System offer eight tips to help ward off the disease.

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Researchers at Mount Sinai find cognitive behavioral therapy plus hypnosis (CBTH) reduces fatigue in radiotherapy breast cancer patients

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Appendicitis, the most common potential surgical problem for kids seen in the emergency department, can be visualized with a high degree of accuracy using point-of-care ultrasound. Using it as 1st-line imaging study of choice also reduces kids' exposure to ionizing radiation.

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This February during American Heart Month, Vivek Reddy, MD, of Mount Sinai Heart at The Mount Sinai Hospital implanted the United States’ first miniature-sized, leadless cardiac pacemaker directly inside a patient’s heart without surgery.

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Alex D. Federman, MD, Associate Professor in the Department of Medicine, General Internal Medicine at the Icahn School of Medicine at Mount Sinai, has been approved for funding by the Patient-Centered Outcomes Research Institute (PCORI) for his research, “Clinic-Based vs. Home-Based support to improve care and outcomes for older asthmatics.” Dr. Federman will lead 1 of 82 research projects approved for PCORI funding to help patients and those who care for them make better-informed healthcare decisions.

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February is American Heart Month reminding all Americans that promotion of heart health is the most critical prevention tool we have available today. Dr. Valentin Fuster shares his top three prevention tips for adults and children.

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Mount Sinai researchers generated their engineered cardiac tissue from human embryonic stem cells with the resulting muscle having remarkable similarities to native heart muscle, including the ability to beat and contract like the human heart. This research breakthrough study was highlighted as the cover story of the February 2014 issue of The FASEB Journal.

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Prostate cancer is the second leading cause of cancer death in American men. One in six men will be diagnosed with prostate cancer and 230,000 new cases are diagnosed annually. Overall, the five-year survival rate is 100 percent for men with the disease confined to the prostate or nearby tissue.

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Using a zebrafish model of liver cancer and patient data, UHRF1 was identified as a novel oncogene involved in the pathogenesis of hepatocellular cancer. It is overexpressed in about 40% to 50% of liver cancers and predicts poor outcome.This finding might point to target for new treatments.

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February is American Heart Month. “Top 10 Things Women Need to Do to Protect their Hearts,” from cardiovascular disease by leading female cardiovascular experts of Mount Sinai Heart at The Mount Sinai Hospital.

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Two studies, which account for the largest DNA sequencing efforts to date on schizophrenia, reveal that the disorder is caused by far more rare genetic mutations than previously suspected.

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Teen marijuana use may have repercussions in unexposed progeny. This rodent study found that parental use of marijuana/THC was linked to molecular and neurobiological disturbances and increased motivation to get drugs.