Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer.
Researchers at Mount Sinai School of Medicine have shown for the first time in an animal model that vitamin C actively protects against osteoporosis, a disease affecting large numbers of elderly women and men in which bones become brittle and can fracture. The findings are published in the October 8 online edition of PLoS ONE.
Chronic morphine exposure has the opposite effect on the brain compared to cocaine in mice, providing new insight into the basis of opiate addiction, according to Mount Sinai School of Medicine researchers.
In the first study of its kind, a research team led by Mount Sinai School of Medicine and Albert Einstein College of Medicine of Yeshiva University discovered 12 genetic markers associated with the development of erectile dysfunction (ED) in prostate cancer patients who were treated with radiation.
Researchers from Mount Sinai School of Medicine have identified reliable predictors of pain by surveying patients throughout their hospital stays about the severity of their pain and their levels of satisfaction with how their pain was managed by hospital staff. Using this data, interdisciplinary teams treating patients were able to identify patients at higher risk for pain prior to, or immediately upon, their admission to the hospital, and create and implement intervention plans resulting in patients reporting lower levels of pain and higher levels of satisfaction with their pain management. The study is published online in the American Journal of Medical Quality.
Mount Sinai School of Medicine has signed an agreement with Coursera.org that will make Mount Sinai graduate and medical school courses freely available online.
Two Mount Sinai School of Medicine researchers are among a select group of scientists from around the world who have been recognized by the National Cancer Institute (NCI) for their quest to answer the most pressing questions about cancer.
Scientists at Mount Sinai School of Medicine have discovered a subpopulation of cells that display cancer stem cell properties and resistance to chemotherapy, and participate in tumor progression. This breakthrough could lead to the development of new tests for early cancer diagnosis, prognostic tests, and innovative therapeutic strategies, as reported in Cancer Cell.
As many as a quarter of Medicare recipients spend more than the total value of their assets on out-of-pocket health care expenses during the last five years of their lives, according to researchers at Mount Sinai School of Medicine. They found that 43 percent of Medicare recipients spend more than their total assets minus the value of their primary residences. The findings appear online in the current issue of the Journal of General Internal Medicine.
A new study suggests that a polyclonal antibody that blocks follicle-stimulating hormone (FSH) in mice without ovaries might offer a more effective way to prevent or arrest osteoporosis than currently available treatments.
Researchers at Mount Sinai School of Medicine have identified a common compound in the modern diet that could play a major role in the development of abdominal obesity, insulin resistance, and type 2 diabetes.
Latrepirdine, which failed in U. S. Clinical trials of alzheimer’s disease, is showing new potential in an animal model.
Finding provides new drug development opportunity in this hard-to-treat disease.
Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role for an oncogenic signaling pathway in embryonic stem cell (ESC) self-renewal and in reprogramming adult cells into an ESC-state, which will aid in the development of future cancer therapies.
An international team of scientists led by researchers at Mount Sinai School Medicine have discovered that a drug that had previously yielded conflicting results in clinical trials for Alzheimer’s disease effectively stopped the progression of memory deterioration and brain pathology in mouse models of early stage Alzheimer’s disease.
Predictors of disease severity in human papillomavirus-derived head and neck cancer, tobacco use, and the dramatic benefits of robotic surgery in people with head and neck cancer are among landmark research presented by Mount Sinai School of Medicine at the Eighth International Conference on Head and Neck Cancer.
Researchers from Mount Sinai School of Medicine have developed a new computational method that will help organize scientific data, making it easier for scientists to identify and prioritize genes, drug targets, and connections between drugs.
A team of researchers have found that schizophrenia or bipolar disorder seen in parents or siblings was associated with increased risk of autism spectrum disorder (ASD). The study was published online by Archives of General Psychiatry on Monday, July 2.
A patient registry is proving invaluable in cataloging the clinical features, symptoms, severity, and outcomes of fibromuscular dysplasia (FMD), a non-inflammatory vascular disease that can cause narrowing of arteries in the carotid (neck) and renal (kidney) arteries, which can result in headache, strokes, and aneurysms. Registry data revealed that 91 percent of patients are women diagnosed in the prime of their lives. As a result, physicians are developing best practices that can lead to early diagnosis and treatment with the goal of improved outcomes and fewer adverse vascular events.
A lifestyle that features fresh foods and limited use of products likely to contain environmental chemicals has been shown to reduce exposure to endocrine-disrupting chemicals (EDCs), such as BPA and phthalates, in a small population study. EDCs are linked to a number of adverse health complications including neuro-developmental delays, behavioral issues and fertility problems. They are produced by the millions of pounds per year and found extensively in a range of products that contain certain plastics.
The Center for Minimally Invasive and Robotic Surgery at The Mount Sinai Medical Center—a pioneer in robotic surgery—now offers the procedure to patients with sleep apnea, whose obstructive breathing prevents them from sleeping normally.
A new delivery method for levodopa/carbidopa, a common dual-drug Parkinson’s disease (PD) regimen, significantly improved the duration of the drugs’ effectiveness in people with advanced PD.
The Mount Sinai Medical Center is the first institution in New York State to use in the clinical setting a newly approved imaging technique to detect Alzheimer’s disease (AD) in people who are cognitively impaired. Until now, physicians have been limited in their ability to diagnose AD, guided almost exclusively by a patient’s mental and behavioral symptoms and family history.
David Samadi, MD, Vice-Chair of Urology at Mount Sinai School of Medicine, knows that many men put off caring for their health, even when they have a family. But just a loving nudge from his family can help keep Dad on track for long-term prostate health, prostate cancer prevention, and prostate cancer awareness.
Researchers from Mount Sinai School of Medicine developed a cancer model built in the fruit fly Drosophila, then used it to create a whole new approach to the discovery of cancer treatments. The result is an investigational compound AD80 that precisely targets multiple cancer genes. Tested in mouse models, the drug proved far more effective and less toxic than standard cancer drugs, which generally focus on a single target. This is the first time that whole-animal screening has been used in a rational, step-wise approach to polypharmacology. The study appears online today in the journal Nature.
New York magazine named 129 Mount Sinai physicians to its “Best Doctors” list, more than any individual hospital in New York City. The recent issue also lists 59 additional doctors who serve at hospitals within Mount Sinai’s affiliate network.
Researchers from Mount Sinai School of Medicine are pioneering new ultrasound techniques that provide the first characterization of multidirectional blood flow in the heart. By focusing on fluid dynamics – specifically, the efficiency with which blood enters and exits the heart’s left ventricle – the researchers believe they can detect heart disease even when traditional measures show no sign of trouble.
Mount Sinai School of Medicine researchers will present several landmark studies, including data on treatment trends in late-stage cancer, a promising multiple myeloma vaccine, and predictive models of soft tissue sarcomas, prostate and bladder cancer, at the 2012 American Society of Clinical Oncology (ASCO) meeting June 1-5, 2012 in Chicago.
Researchers at Mount Sinai School of Medicine in New York have found new clues in the pathogenesis of skull and skin birth defects associated with a rare genetic disorder, Beare-Stevenson cutis gyrata syndrome (BSS).
Mount Sinai School of Medicine researchers have succeeded in developing a biosynthetic polyphenol that improves cognitive function in mice with Alzheimer’s disease (AD). The findings, published in a recent issue of the Journal of Neuroscience, provide insight in determining the feasibility of biosynthetic polyphenols as a possible therapy for AD in humans, a progressive neurodegenerative disease for which there is currently no cure.
Researchers at Mount Sinai School of Medicine have gained insight into the mechanism by which a pathological brain protein called tau contributes to the progression of Alzheimer’s disease (AD) and other neurodegenerative disorders. This finding, published in the most recent issue of the Journal of Biological Chemistry, may provide the basis for future investigations on how to prevent tau from damaging brain circuits involved in cognitive function.
Patients find “cloud” technology a faster, more efficient way to store and distribute their medical images than current options, according to the preliminary findings of an image sharing project led by The Mount Sinai Medical Center in conjunction with four other academic medical institutions. The Phase I results of the Radiological Society of North America (RSNA) Image Share project are being presented today at the American Roentgen Ray Society Annual Meeting in Vancouver, Canada.
A cutting-edge procedure called seed localization is improving patient satisfaction at The Mount Sinai Medical Center. In patients undergoing lumpectomy for cancers that are small and cannot be felt in the breast, a tiny radioactive seed is guided into the breast and implanted at the site of the tumor. The seed allows surgeons to better target and remove small breast tumors.
Since May is Skin Cancer Awareness Month and Melanoma Monday is May 7, Mount Sinai experts are sharing tips on prevention and insight on the new FDA labeling requirements on sunscreen. Patients are also available to discuss their experience with melanoma.
An editorial published today in the prestigious journal Environmental Health Perspectives calls for increased research to identify possible environmental causes of autism and other neurodevelopmental disorders in America's children and presents a list of ten target chemicals including which are considered highly likely to contribute to these conditions.
Dr. Mark Green, director of the Headache Center at Mount Sinai School of Medicine, provides insight into new guidelines released by the American Academy of Neurology on migraine treatments.
In an important test of one of the first drugs to target core symptoms of autism, researchers at Mount Sinai School of Medicine are undertaking a pilot clinical trial to evaluate insulin-like growth factor (IGF-1) in children who have SHANK3 deficiency (also known as 22q13 Deletion Syndrome or Phelan-McDermid Syndrome), a known cause of autism spectrum disorder (ASD).
New research from Mount Sinai Medical Center in New York reveals that repeated exposure to cocaine decreases the activity of a protein necessary for normal functioning of the brain’s reward system, thus enhancing the reward for cocaine use, which leads to addiction. Investigators were also able to block the ability of repeated cocaine exposure, to induce addiction. The findings, published online April 22 in the journal Nature Neuroscience, provide the first evidence of how cocaine changes the shape and size of neuron rewards in a mouse model.
Mount Sinai School of Medicine researchers have found that targeted swallowing exercises can help alleviate swallowing dysfunction – a debilitating side effect in people undergoing chemoradiation therapy (CRT) for head and neck cancer. The study, published in the April issue of Archives of Otolaryngology – Head & Neck Surgery, a JAMA Network publication, suggests that clinicians should consider giving all patients undergoing CRT an exercise regimen to improve their quality of life after treatment.
Recognizing significant health disparities in the local community, these students joined together to develop a curriculum in which select students participate in community service and research projects with the help of a faculty mentor to acquire the skills they need to pursue social justice work in their careers.
Through a groundbreaking new gene sequencing technology, researchers have demonstrated that the gene FLT3 is a valid therapeutic target in Acute Myeloid Leukemia, AML, one of the most common types of leukemia. The technique, developed by Pacific Biosciences, allows for the rapid and comprehensive detection of gene mutations in patients with AML. The findings, published online April 15 in Nature, are a result of collaboration among scientists at the University of California, San Francisco, Pacific Biosciences and Mount Sinai School of Medicine. The discovery may help lead to the development of new drugs to treat AML.
David H. Koch, Executive Vice President of Koch Industries, has committed $10 million to the Jaffe Food Allergy Institute at The Mount Sinai Medical Center. The gift is one of the largest in the Institute's history and will create the David H. and Julia Koch Research Program in Food Allergy Therapeutics. The program will serve as a hub for drug discovery and vaccine development related to food allergy, and build upon the promising work already underway at the Institute. The donation will also be used to further the Institute's recruitment of leading researchers dedicated to the discovery of new food allergy therapeutics.
Researchers from Mount Sinai School of Medicine have developed a method to derive enough DNA information from non-DNA sources—such as RNA—to clearly identify individuals whose biological data are stored in massive research repositories. The approach may raise questions regarding the ability to protect individual identity when high-dimensional data are collected for research purposes. A paper introducing the technique appears in the April 8 online edition of Nature Genetics.
Mutations in three new genes have been linked to autism, according to new studies including one with investigators at Mount Sinai School of Medicine. The findings, in a trio of papers revealing new genetic targets in autism, are published in the April 4th online issue of the journal Nature. The studies provide new insights into important genetic changes and the many biological pathways that lead to autism spectrum disorders (ASD).
A new study led by researchers at Mount Sinai School of Medicine indicates that CT scans are more effective than traditional lung cancer detection methods at identifying aggressive lung cancers in their most treatable stages. The data, published online March 27 in the journal Radiology, demonstrate that lung cancers found through annual CT screening are similar to those found in routine practice, both in terms of tumor growth rates and cell-type distribution. In fact, the report showed that 79 percent of the cases diagnosed through annual repeat CT scans were detected at clinical Stage I, the earliest and most treatable stage, compared to only 15 percent detected through traditional methods.
Mount Sinai School of Medicine researchers presented 86 abstracts and plenary sessions at the American College of Cardiology’s (ACC) 61st Annual Scientific Session, including ground-breaking research on aggressive statin therapy, the prevalence of unrecognized cardiovascular disease symptoms in women, and morbidity associated with non-adherence to medication after stent implantation.
Mount Sinai School of Medicine researchers have discovered that marijuana-like chemicals trigger receptors on human immune cells that can directly inhibit a type of human immunodeficiency virus (HIV) found in late-stage AIDS.
A new topical gel now available by prescription significantly decreases the amount of time needed to treat actinic keratosis, a skin condition that is a common precursor to skin cancer, according to a multi-center trial led by researchers at Mount Sinai School of Medicine. The gel, called ingenol mebutate, is applied to the skin for just a few days, making it quicker and even more effective as current therapies require weeks to months to apply. The Phase III study results of the trial are published in the March 15, 2012 issue of the The New England Journal of Medicine.
Researchers at Mount Sinai School of Medicine have found that 92 percent of more than 1,000 gastroenterologists responding to a survey believed that pressures to increase the volume of colonoscopies adversely impacted how they performed their procedures, which could potentially affect the quality of colon cancer screening. The findings, based on responses from members of the American Society for Gastrointestinal Endoscopy (ASGE), are published in the March 2012 issue of Gastrointestinal Endoscopy.
Researchers from Mount Sinai School of Medicine have identified a regulator protein that plays a crucial role in kidney fibrosis, a condition that leads to kidney failure. Finding this regulator provides a new therapeutic target for the millions of Americans affected by kidney failure.
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