In the largest study of its kind, researchers from Mount Sinai School of Medicine have discovered five new genetic mutations associated with Crohn’s disease in Jews of Eastern European descent, also known as Ashkenazi Jews.
For the first time in a new U.S. clinical trial, researchers at Mount Sinai School of Medicine have used the HeartLight Endoscopic Ablation System (EAS) to correct abnormal electrical signals inside the heart of a patient affected by atrial fibrillation (AFib), one of the nation’s most common heart ailments. The device is the first catheter ablation system to incorporate a camera that allows doctors to see a direct, real-time image of the patient’s heart tissue during ablation.
Researchers from Mount Sinai School of Medicine have found that post-operative radiation therapy (PORT), a controversial yet frequently administered treatment for lung cancer, may not prolong life in older people with locally advanced disease.
Researchers from Mount Sinai School of Medicine have found that laws permitting children to stay on their parents’ health insurance through age 26 result in improved access to health care compared to states without those laws. This analysis indicates the potential positive impact of a key provision of the Patient Protection and Affordable Care Act of 2010 (ACA). The study appears in the March issue of the journal Pediatrics, the official journal of the American Academy of Pediatrics.
Dr. Dan Iosifescu offers tips and tricks on beating the winter doldrums.
In an animal study, Mount Sinai researchers found that decaffeinated coffee may improve glucose utilization in the brain, reducing the risk for Type 2 diabetes and the brain dysfunction associated with some neurological disorders.
Researchers from the Children’s Environmental Health Center at The Mount Sinai Medical Center in New York have found an association between exposure to the chemical group known as phthalates and obesity in young children – including increased body mass index (BMI) and waist circumference.
In the first study of its kind, researchers at Queens College and Mount Sinai School of Medicine have found that low socioeconomic status (SES) and maternal gestational diabetes together may cause a 14-fold increased risk of attention deficit hyperactivity disorder (ADHD) in six year olds.
Researchers from Mount Sinai School of Medicine, have identified the pattern of cell signaling induced by antipsychotic drugs in a complex composed of two brain receptors linked to schizophrenia. The discovery should allow researchers to predict the effectiveness of novel compounds for the treatment of schizophrenia and other serious mental disorders and may accelerate the development of better antipsychotic drugs. The findings are published in the November 23 issue of Cell.
In the first study using magnetic resonance imaging (MRI) to evaluate cardiovascular risk in World Trade Center (WTC) first responders, researchers from Mount Sinai School of Medicine have found that the responders who experienced high levels of exposure to the initial dust cloud on September 11, 2001, demonstrate high-risk features of atherosclerosis (plaque in arteries).
Researchers from Mount Sinai School of Medicine have discovered the therapeutic benefit of fetal stem cells in helping the maternal heart recover after heart attack or other injury. The research marks a significant advancement in cardiac regenerative medicine.
Steven H. Feinsilver, MD, Director, Center for Sleep Medicine, Mount Sinai School of Medicine, provides advice and tips on adjusting to the end of Daylight Savings Time and getting a good night's sleep year-round.
In a first-of-its-kind study, researchers from Mount Sinai School of Medicine have discovered several gene variants contributing to early stent thrombosis (ST), a devastating and often deadly complication after coronary stent implantation in people with coronary artery disease.
Researchers at Mount Sinai School of Medicine have found that conflicts of interest (COI) are prevalent and potentially underreported among individuals participating in the development of clinical practice guidelines, which inform standards of patient care.
Excessive food AGEs, through both maternal blood transmission and baby formula, could together significantly increase children’s risk for diseases such as diabetes from a very young age. A second study of AGEs in adults found that cutting back on processed, grilled, and fried foods may improve insulin resistance in people with diabetes.
Researchers at Mount Sinai School of Medicine have found that $6.7 billion was spent in one year performing unnecessary tests or prescribing unnecessary medications in primary care, with 86 percent of that cost attributed to the prescription of brand-name statins to treat high cholesterol. The findings are published in a research letter in the October 1 Online First issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Eric Schadt, PhD, a visionary in the use of computational biology in genomics, has joined The Mount Sinai Medical Center to lead the Institute for Genomics and Multiscale Biology. The Institute is the hub of genomics research at Mount Sinai School of Medicine, collaborating with 13 other disease-oriented and core-technology-based institutes.
Findings represent a significant advance in understanding the causes of schizophrenia and bipolar disorder.
Researchers at Mount Sinai School of Medicine have found that thyroid-stimulating hormone (TSH), a hormone produced in the anterior pituitary gland that regulates endocrine function in the thyroid gland, can promote bone growth independent of its usual thyroid functions. The research suggests that TSH, or drugs that mimic its affect on bone, may be key to possible future treatments for osteoporosis and other conditions involving bone loss, such as cancer. The findings were published online this week in the National Academy of Sciences journal PNAS.
Researchers from Mount Sinai School of Medicine have for the first time used several imaging techniques to prove the efficacy of a promising new treatment for atherosclerosis—the build-up of plaque in artery walls that can lead to a heart attack.
Researchers at Mount Sinai School of Medicine have identified a new drug target that may treat and/or prevent heart failure, published in this week's Nature.
Mount Sinai School of Medicine has been awarded a $3.4 million grant over four years from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) to begin the largest study of its kind, in which a patient’s genomic risk for disease is revealed in a lab, and then entered into an electronic medical record for use in determining treatment in the clinical care setting.
A team of researchers comparing the two leading treatment approaches for the eye condition uveitis, which is the fifth leading cause of blindness in the US, have found that a time-release corticosteroid implant placed surgically in the eye is similarly effective in treating the disease as anti-inflammatory corticosteroids and immunosuppressive drugs taken orally. The report was published online this week in the journal Ophthalmology.
A study led by Mount Sinai School of Medicine researchers of 192 pharmaceutical advertisements in biomedical journals found that only 18 percent were compliant with Food and Drug Administration (FDA) guidelines, and over half failed to quantify serious risks including death. The study, is published online today in the journal Public Library of Science (PLoS) One.
Mount Sinai Leaders of WTC Clinical Center of Excellence available to discuss health of First Responders surrounding 9/11 anniversary.
An international team of researchers led by scientists at Mount Sinai School of Medicine have found that motion sickness on tilting trains can be essentially eliminated by adjusting the timing of when the cars tilt as they enter and leave the curves. They found that when the cars tilt just at the beginning of the curves instead of while they are making the turns, there was no motion sickness.
The Mount Sinai Medical Center has become the first hospital on the east coast to perform a cardiac ablation procedure using the Thermocool Smarttouch Contact Force-Sensing Catheter for the treatment of symptomatic, paroxysmal atrial fibrillation (AF), or periodic rapid and irregular heartbeats. The catheter, combined with 3D mapping and navigation software, gives physicians a real-time, objective measure of tip-to-tissue contact force during the catheter ablation procedure and will hopefully allow physicians to more safely and effectively treat AF, which affects more than two million Americans.
Sexual transmission of hepatitis C virus (HCV) is considered rare. But a new study by researchers at Mount Sinai School of Medicine, working with the Centers for Disease Control (CDC), provides substantial evidence that men with the HIV virus who have sex with other men are at increased risk for contracting HCV through sexual transmission. The results of the study are published in the CDC’s Morbidity and Mortality Weekly Report.
Researchers at Mount Sinai School of Medicine have identified how a gene for a protein that can cause Type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer’s disease.
Researchers at Mount Sinai School of Medicine have found that grape seed polyphenols—a natural antioxidant—may help prevent the development or delay the progression of Alzheimer’s disease.
Introducing increasing amounts of foods that contain baked milk into the diets of children who have milk allergies helped a majority of them outgrow their allergies, according to a study conducted at Mount Sinai School of Medicine’s Jaffe Food Allergy Institute. The data are reported in the May 23 issue of the Journal of Allergy and Clinical Immunology.
Researchers at Mount Sinai School of Medicine have found in a Phase II trial that a gene therapy developed at Mount Sinai stabilized or improved cardiac function in people with severe heart failure. Patients receiving a high dose of the therapy, called SERCA2a, experienced substantial clinical benefit and significantly reduced cardiovascular hospitalizations, addressing a critical unmet need in this population. The data are published online in the June 27 issue of the American Heart Association journal Circulation.
With the decline in volunteers for clinical trials, how do we achieve the medical breakthroughs of tomorrow? Leading researchers and policy experts from across the country will come together June 27 and June 28 at Mount Sinai School of Medicine in New York to examine the issue of declining enrollment in clinical trials. The two-day workshop is co-sponsored by Mount Sinai’s Institute of Translational Sciences through the Department of Health Evidence and Policy and the Institute of Medicine of the National Academies.
A new study from Mount Sinai School of Medicine has found that a cellular signaling pathway governs the differentiation of cells into fat tissue or smooth muscle, which lines the vascular system. Engaging this signaling pathway and its capacity to govern cell differentiation has important implications in preventing obesity and cardiovascular disease. The study is published in the June issue of Developmental Cell.
Researchers at Mount Sinai School of Medicine have published new data on why the aging brain is less resilient and less capable of learning from life experiences. The findings provide further insight into the cognitive decline associated with aging and neurodegenerative diseases like Alzheimer’s.
Researchers from Mount Sinai School of Medicine have discovered a protein signaling pathway that becomes hyperactivated in human sarcoma cells, suggesting that medications to inhibit this pathway may be effective in the treatment of human sarcomas. The research is published in the current issue of the journal Cancer Cell.
Researchers at Mount Sinai School of Medicine have made a critical discovery that may lead scientists to abandon the use of broad conventional ethnic labels—African-American, Hispanic, and Caucasian—to estimate a patient’s genetic risk for disease. This first-of-its kind study conducted with diverse patients receiving care at a single urban academic medical center, marks an important step in the clinical application of personalized medicine. The data are published online in the peer-reviewed journal PLoS ONE.
In three new studies published in the May issue of the journal Health Affairs, Mount Sinai School of Medicine researchers reveal the staggering economic impact of toxic chemicals and air pollutants in the environment, and propose new legislation to mandate testing of new chemicals and also those already on the market.
Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in people with Type 1 and Type 2 diabetes.
The new Dubin Breast Center of The Tisch Cancer Institute at Mount Sinai opened today, bringing a range of multidisciplinary services under one roof and marking a great leap forward in care of breast cancer patients throughout the region.
Researchers at Mount Sinai School of Medicine have found that patients with Alzheimer’s disease have lower glucose utilization in the brain than those with normal cognitive function, and that those decreased levels may be detectable approximately 20 years prior to the first symptoms of Alzheimer’s disease. This new finding could lead to the development of novel therapies to prevent the eventual onset of Alzheimer’s. The study is published online in the journal Translational Neuroscience.
Sometimes acne isn't really acne... More than 85 percent of Americans suffer from acne at some point in their lives. It’s one of the most common reasons that patients visit their dermatologist. Still, according to Joshua Zeichner, MD, Director of Cosmetic and Clinical Research at Mount Sinai School of Medicine’s Department of Dermatology, sometimes what looks like acne simply isn’t.
Researchers at Mount Sinai School of Medicine have discovered a way that mutations in a gene called LRRK2 may cause the most common inherited form of Parkinson’s disease.
The Mount Sinai Medical Center has become the first hospital in the United States to perform a cardiac catheterization procedure using the TactiCath force-sensing ablation catheter for the treatment of symptomatic paroxysmal atrial fibrillation (AF), or periodic rapid and irregular heartbeats. The new procedure will allow physicians to more safely and effectively treat AF, which affects more than two million Americans.
Researchers from Mount Sinai School of Medicine have found that lactate, a type of energy fuel in the brain, plays a critical role in the formation of long-term memory. These findings have important implications for common illnesses like Alzheimer’s disease, other neurodegenerative disorders, aging-related memory impairment and diabetes. The research is published in the March 4th issue of the journal Cell.
Researchers from Mount Sinai School of Medicine have discovered a novel function of brain insulin, indicating that impaired brain insulin action may be the cause of the unrestrained lipolysis that initiates and worsens type 2 diabetes in humans.
Researchers at Mount Sinai School of Medicine have found that even small amounts of damage to heart muscle during coronary artery bypass grafting (CABG) is associated with an increased risk of death, even among patients who initially do well following surgery.
Mount Sinai’s Cardiac Catheterization Laboratory has been awarded New York State’s highest “two-star” safety rating in every category of case the state tracks for percutaneous coronary intervention (PCI), according to new data released this month that examine patient discharges from 2006 – 2008. This is the first time since New York State began public reporting of statistics for cardiac labs that any hospital has been awarded the two-star safety rating across the board.
Researchers from Mount Sinai School of Medicine have identified a therapy that may enhance memory and prevent the loss of long-term memory. The research is published in the January 27th issue of Nature.
Mount Sinai researchers coordinating the largest clinical study to date of ”Sarcoid Like” Granulomatous Pulmonary Disease in World Trade Center (WTC) responders have found that the rate of the condition was increased in this group as compared to the records of pre-9/11 FDNY personnel.
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