The Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) announced today the discovery that DnaK, a protein of the bacterium mycoplasma, interferes with the mycoplasma-infected cell’s ability to respond to and repair DNA damage, a known origin of cancer.
A new study has been launched Burkina Faso for Bharat Biotech’s typhoid conjugate vaccine (TCV). It is the second clinical study underway in Africa for the vaccine and the first in West Africa.
An international group of researchers, led by Ronna Hertzano, MD, PhD, Associate Professor, Department of Otorhinolaryngology-Head & Neck Surgery, Anatomy and Neurobiology, at the University of Maryland School of Medicine (UMSOM), and Michael Bowl, Ph.D., Programme Leader Track Scientist, Mammalian Genetics Unit, MRC Harwell Institute, UK, have identified the gene that acts as a key regulator for special cells needed in hearing.
In a new study, researchers have found that the gut microbiome appears to play a key role in how well the body accepts a transplanted heart. The scientists found a causal relationship between the presence of certain microbes and transplant outcome.
Researchers at the University of Maryland School of Medicine have made a surprising discovery: during fetal development, a particular immune cell seems to play a key role in determining the male or female characteristics of the brain.
This week, to better understand this microbiome, scientists will be collecting bacteria from monuments at Gettysburg Battlefield and Fort McHenry in Baltimore.
Exposing newborn mice to vaginal microbes from stressed female mice may transfer the effects of stress to the newborns, according to a new study by researchers at the University of Maryland School of Medicine. These changes resemble those seen specifically in the male offspring of moms that were stressed during pregnancy.
Sex plays a role in hypertension, diabetes, arthritis – and in many neurological and psychiatric disorders. To better understand the molecular underpinnings of this disparity, Tracy Bale of the University of Maryland School of Medicine, along with several colleagues, focused on a molecule that plays a key role in placental health. In a study of mice, they found that the molecule, O-linked N-acetylglucosamine transferase (OGT) works by establishing sex-specific patterns of gene expression.
The University of Maryland School of Medicine held the ceremonial opening of the Fannie Angelos Cellular Therapeutics Laboratory, a state-of-the-art facility that will allow scientists to create the next generation of cancer cures — cells that help a patient’s immune system attack and eliminate cancer.
Scientists have for the first time found evidence that a microbe in the human gut is associated with protection from typhoid fever infection. If the research is borne out, it could offer an exciting new way to reduce these infections.
Saladin may not be well known in the West, but even 800 years after his death, he remains famous in the Middle East. During his illustrious life, he successfully led armies against the invading Crusaders and conquered several kingdoms. But his death remains a mystery. Now an expert disease detective has a new theory about what may have killed him.
Renowned New York Times journalist Nicholas Kristof will speak on May 3 at the Peabody Library in Baltimore on the need to build a fairer society.
Scientists have for the first time found direct causal links between the neurotransmitter dopamine and avoidance – behavior related to pain and fear. Researchers have long known that dopamine plays a key role in driving behavior related to pleasurable goals, such as food, sex and social interaction. In general, increasing dopamine boosts the drive toward these stimuli. But dopamine’s role in allowing organisms to avoid negative events has remained mysterious.
An international research group studying 520,000 people from around the world has identified 22 new genetic risk factors for stroke, tripling the number of gene regions known to affect stroke risk. These results provide new clues on stroke mechanisms and could help scientists identify drug targets for treatment. The work is the largest genetic study on stroke ever.
Every year, approximately 12 million adults in the U.S. are diagnosed with Chronic Obstructive Pulmonary Disease, and 120,000 die from it. For people with COPD, Haemophilus influenzae, a bacterium, can be particularly dangerous. Now, researchers have unraveled how the bacterium adapts quickly, which may open new avenues for therapy for COPD and other diseases such as ear infections or pneumonia.
A new study has found that although radiology research by women has increased significantly over the past five decades, the rate of this increase has leveled off since 2000.
Researchers from the University of Maryland School of Medicine and the University of Maryland A. James Clark School of Engineering have developed a new military vehicle shock absorbing device that may protect troops from traumatic brain injury after a land mine blast. Over the past 18 years of conflicts in Iraq and Afghanistan, more than 250,000 troops have suffered such injuries.
New research in mice has found that a father’s stress affects the brain development of his offspring. This stress changes the father’s sperm, which can then alter the brain development of the child. This new research provides a much better understanding of the key role that fathers play in the brain development of offspring.
Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side effects. A team of computational biologist has developed a way to identify the features that distinguish one enzyme from similar enzymes. This research has the potential to significantly accelerate drug discovery, allowing scientists to develop more effective drugs, more quickly.
Researchers have identified significant mitochondrial changes that take place in cocaine addiction, and they blocked them.
A new study is the first to identify a mechanism that could explain an early link between sound input and cognitive function, often called the “Mozart effect.”
Researchers have found a two-way link between traumatic brain injury and intestinal changes. These interactions may contribute to increased infections in these patients, and may also worsen chronic brain damage.
Nearly half of all US medical care is delivered by emergency departments, according to a new study by researchers at the University of Maryland School of Medicine. In recent years, the percentage of care delivered by emergency departments has grown. The paper highlights the major role played by emergency rooms in U.S. health care.
A new study by researchers has identified an innovative strategy for treating influenza, and perhaps other infectious diseases as well. Scientists showed that a small protein called retrocyclin-101 (RC-101) could potentially improve the symptoms and mortality associated with the flu and possibly other types of infectious illness as well.
Many people with schizophrenia have trouble with learning and memory. A new study has found intriguing links between sleep, cognition and a compound called kynurenine. These links could illuminate the mechanism that causes cognitive problems among those with the disease, and could point the way to new treatments to reduce some of the disease’s symptoms.
A new study of the human microbiome has uncovered millions of previously unknown genes from microbial communities in the human gut, skin, mouth, and vaginal microbiome, allowing for new insights into the role these microbes play in human health and disease.
A new study has uncovered how inflammation contributes to a key feature of diabetes, the body’s inability to metabolize glucose, a condition known as insulin resistance.
Depression affects more than 300 million people annually. Now, a new study has pinpointed how one particular gene plays a central role – either protecting from stress or triggering a downward spiral, depending on its level of activity.
Although the basic outlines of human hearing have been known for years – sensory cells in the inner ear turn sound waves into the electrical signals that the brain understands as sound – the molecular details have remained elusive. Now, new research has identified a crucial protein in this translation process.
Although lifestyle contributes to heart disease, genetics play a major role. This genetic facet has remained largely mysterious. But new research by scientists at the University of Maryland School of Medicine has identified what may be a key player: a mutated gene that leads to irregular heartbeat, which can lead to a dangerously inefficient heart.
Under normal conditions, the CHD4 protein is one of the good guys: it stops cells from transcribing faulty DNA, thereby eliminating potential mutation. But in colon cancer and perhaps other kinds of cancer as well, it appears that this protein becomes a kind of double agent, working for the enemy.
Researchers have identified a gene that plays a key role in the formation of neural tube defects, a problem commonly found in infants of pregnant women with diabetes. This is the first time the gene has been shown to play this role; it opens up a new way to understand these defects, and may one day lead to new treatments that could prevent the problem or decrease its incidence.
Award-winning science journalist Gina Kolata will be the graduation speaker at this year's graduation.
Francisco Goya is the most important Spanish artist of the 19th century. In 1793, Goya, then 46, came down with a severe, undiagnosed illness. His hearing never returned. Now, a hearing expert at the University of Maryland School of Medicine has developed a diagnosis.
The University of Maryland School of Medicine has been awarded a $9 million seven-year grant to develop new tools against drug-resistant malaria in Southeast Asia and other regions where the disease is common.
A new study has found a link between neurological birth defects in infants commonly found in pregnant women with diabetes and several neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Huntington’s diseases. This is the first time this link has been identified; it may indicate a new way to understand, and perhaps treat, both neural tube defects and these neurodegenerative diseases.
An experimental malaria vaccine protected healthy subjects from infection with a malaria strain different from that contained in the vaccine, according to a study published today. The Phase 1 clinical trial is important because in places where malaria is common, there is usually more than one strain of malaria.
Researchers have identified a new mechanism by which inflammation can spread throughout the brain after injury. This mechanism may explain the widespread and long-lasting inflammation that occurs after traumatic brain injury, and may play a role in other neurodegenerative diseases.
Stephen Davis, MBBS, FRCP, MACP, the Theodore E. Woodward Endowed Chair and the Professor and Chairman of the Department of Medicine at the University of Maryland School of Medicine (UM SOM); Director of the General Clinical Research Center and the Clinical Translational Science Institute; and Vice-President of Clinical Translational Science for the University of Maryland, Baltimore campus, has received the Mary Betty Stevens Award for Outstanding Clinical Research from the Maryland Chapter of the American College of Physicians (ACP).
For hundreds of millions of years, ticks have survived on Earth by sucking blood from their victims for days, often leaving behind terrible diseases as a thank-you note. But no one has ever looked at why ticks, themselves, are able to survive while harboring bacteria, viruses and parasites. Now, for the first time, scientists have decoded how the ingenious tick immune system fights a myriad of microbes.
A new study by University of Maryland School of Medicine researchers has found that in mice, adjusting levels of a compound called kynurenic acid can have significant effects on schizophrenia-like behavior. The study appeared in the latest issue of the journal Biological Psychiatry.
The University of Maryland School of Medicine announced that it has hired several top scientists in a range of fields, including orthopaedics and brain science.
Over the course of their lives, about 80 percent of Americans will suffer from back pain at one time or another. For millions of people this pain is chronic. A new study has concluded that yoga may be helpful for low back pain.
Every year in India, about 20,000 people die from rabies. Most of the victims are children. Nearly all of the deaths occur after victims are bitten by rabid dogs. For years, experts have debated the best strategy to reduce this burden. Now, a new study has identified a cost-effective way to reduce death due to rabies.
A new study has for the first time identified seven key proteins in the virus that may be the culprits behind this damage. The study is the first comprehensive description of the Zika virus genome.
An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, according to a new study that included researchers from the University of Maryland School of Medicine.
In a new study, researchers have modified a rabies virus, so that it has a protein from the MERS virus; this altered virus works as a 2-for-1 vaccine that protects mice against both Middle East Respiratory Syndrome (MERS) and rabies.
Typhoid fever remains a serious global problem: it kills almost a quarter of a million people annually. To help promote typhoid vaccines, the Bill & Melinda Gates Foundation has given a $36.9 million grant to the University of Maryland School of Medicine Center for Vaccine Development (CVD). The project is a partnership with the Oxford Vaccine Group and PATH.
– Every year, more than 32,000 Americans die from gunshot wounds. A significant proportion of these deaths involve head wounds. Despite this massive public health burden, researchers know little about the variables that determine whether a victim of these injuries will live or die. Now, for the first time ever, researchers have developed a system to help answer this question. The system has created a way to better understand the variables involved in survival from these wounds.
The University of Maryland in College Park and the University of Maryland, Baltimore today unveiled ambitious plans for the Center for Sports Medicine, Health and Human Performance.
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