Over three decades, a world-recognized medical team at UC San Diego Medical Center has spurred the evolution of a complex surgery to destroy dangerous clusters of arteries and veins in the brain. Integrating innovative approaches in radiology, anesthesia, and surgery, the team has perfected a method to systematically starve these abnormal brain lesions, artery by artery, vein by vein.
A team of scientists from the UC San Diego School of Medicine and Osaka University in Japan have identified a protein switch that helps prevent liver damage, including inflammation, fibrosis and cancer. The findings suggest that a better understanding of how the protein, TAK1, works could lead to new insights into the development of liver disease and cancer.
The recent shootings at the Ft. Hood, Texas army base, allegedly by an army psychiatrist, have placed much-needed focus on mental health care in the army. In an article published in the December issue of the journal CNS Spectrum, renowned psychopharmacology expert Stephen M. Stahl, MD, PhD, calls for increased mental health staffing at Fort Hood and other army bases.
Researchers at the UC San Diego School of Medicine have pinpointed a mechanism that may help explain how chromosomal translocations – the supposedly random shuffling of large chunks of DNA that frequently lead to cancer – aren’t so random after all.
A study by neuroscientist William C. Mobley, MD, PhD, chair of the Department of Neurosciences at the UCSD, School of Medicine, and colleagues at Stanford University Medical School has demonstrated a possible new approach to slowing the inevitable progression of cognitive decline found in Down’s syndrome.
A new study finds that atherosclerosis, hardening of the arteries, was common in ancient Egyptians, challenging a belief that vascular disease is a modern affliction caused by current-day risk factors such as stress and sedentary lifestyles.
In a study that promises to improve diagnosis and monitoring of Alzheimer’s disease, scientists at the University of California, San Diego have developed a fast and accurate method for quantifying subtle, sub-regional brain volume loss using magnetic resonance imaging (MRI). The study will be published the week of November 16 in the Proceedings of the National Academy of Science (PNAS).
Igor Grant, MD, professor of psychiatry at the University of California, San Diego School of Medicine, and colleagues have been awarded a $17 million grant from the National Institute on Drug Abuse to establish the Translational Methamphetamine AIDS Research Center (TMARC) at UC San Diego.
UC San Diego Medical Center recently launched a website dedicated to offering families and the medical community valuable information about the best way to provide human milk to premature and underweight infants.
To find a long-term, permanent solution for GERD, the Center for the Future of Surgery at UC San Diego Medical Center is leading a multicenter clinical trial to test the safety and effectiveness of a new incisionless treatment.
The University of California, San Diego will lead a new Center of Expertise on Migration and Health as one of three multi-campus initiatives launched by the University of California system under the auspices of the new UC Global Health Institute.
Using imaging mass spectrometry, researchers at the University of California, San Diego have developed tools that will enable scientists to visualize how different cell populations of cells communicate. Their study shows how bacteria talk to one another – an understanding that may lead to new therapeutic discoveries for diseases ranging from cancer to diabetes and allergies.
Researchers led by Moores UCSD Cancer Center Director Dennis A. Carson, MD, professor of medicine, and Catriona Jamieson, MD, PhD, assistant professor of medicine and director of the Cancer Stem Cell Research Program at the Moores UCSD Cancer Center have been awarded $20 million over four years to develop novel drugs against leukemia stem cells.
Scientists at the University of California, San Diego School of Medicine report that regeneration of central nervous system axons can be achieved in rats even when treatment delayed is more than a year after the original spinal cord injury.
Distinguished transplant and cancer surgeon, Alan Hemming, MD, has been recruited to the University of California, School of Medicine to launch a multidisciplinary center for the treatment of advanced liver disease at the UC San Diego Medical Center and Moores UCSD Cancer Center.
Researchers at the University of California, San Diego, have identified a key protein that promotes the development of pulmonary arterial hypertension in humans and mice. This groundbreaking discovery has implications for future drug therapies that may extend the life of patients with pulmonary arterial hypertension and prevent the need for lung transplantation, currently the only cure for this debilitating disease.
Funding for two research projects at the University of California, San Diego School of Medicine are among the 76 grants announced by the Bill & Melinda Gates Foundation in the third funding round of Grand Challenges Explorations, an initiative to help scientists around the world explore bold and largely unproven ways to improve health in developing countries.
A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig’s disease, in mice. The results offer a bit of good news in efforts to develop a therapy to stop or slow the progression of a disease that generally kills its victims within just a few years.
A study by researchers at the University of California, San Diego School of Medicine reports a significant breakthrough in explaining gaps in scientists’ understanding of human brain function. The study – which provides a picture of language processing in the brain with unprecedented clarity – will be published in the October 16 issue of the journal Science.
Researchers at the Moores UCSD Cancer Center have received $6 million from the National Institutes of Health to spend the next five years looking for, testing and developing chemicals called “adjuvants” that they hope will make current vaccines more effective.
More than four million babies are born in the United States every year. A growing number of these infants, more than 10 percent, are “caught” by midwives. This year, UC San Diego Medical Center celebrates the 10th anniversary of its Birth Center—California’s only in-hospital unit dedicated to natural childbirth.
The UCSD/Salk Center for Academic Research and Training in Anthropogeny (CARTA), an organized research unit of the University of California, San Diego, today announced the launch of its online Museum of Comparative Anthropogeny (MOCA), available at http://carta.anthropogeny.org/moca/about.
An international team, led by researchers from the University of California, San Diego School of Medicine and the National Eye Institute, has discovered gene variants for glaucoma in a black population. The finding could lead to future treatments or a cure for this disease, which leads to blindness in two million Americans each year.
Researchers from the University of California, San Diego School of Medicine and the Salk Institute for Biological Studies in La Jolla have developed a safe strategy for reprogramming cells to a pluripotent state without use of viral vectors or genomic insertions.
A molecular signature that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a particular anti-cancer drug.
UC San Diego Medical Center has once again excelled in the “Physicians of Exceptional Excellence” survey, which will appear in the October issue of San Diego Magazine. Eighty University of California, San Diego physicians in 30 specialties were rated the best doctors in the region by their peers, and more than any other health care system or medical group in San Diego County.
A study from the Center for Molecular Genetics at the University of California, San Diego School of Medicine shows that a gene called HPRT plays an important role in setting the program by which primitive or precursor cells decide to become normal nerve cells in the human brain.
A specific protein on the surface of a common bacterial pathogen allows the bacteria to leave the bloodstream and enter the brain, initiating the deadly infection known as meningitis. The new finding, which may guide development of improved vaccines to protect those most vulnerable, including young infants and the elderly, is now available online in the Journal of Experimental Medicine.
Officials of the University of California, San Diego Health Sciences and the Indian Institute of Technology (IIT) Kharagpur today signed a historic preliminary agreement to collaborate in the development of an International Medical Center (IMC) at IIT Kharagpur.
Surgeons at the University of California, San Diego Medical Center have performed the next in a series of groundbreaking single-incision surgeries. Through one small port in the navel, surgeons removed a kidney and ureter and reconstructed a patient’s bladder as part of an innovative cancer surgery.
An international group of researchers is the first to show that common variations in a gene – previously shown to be associated with Retts Syndrome, autism, and mental retardation – are associated with differences in brain structure in both healthy individuals and patients with neurological and psychiatric disorders.
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies. Their findings, which may lead to new therapies for these diseases, will appear in the online edition of Nature Genetics on August 9.
Researchers at the Shiley-Marcos Alzheimer's Disease Research Center at the University of California San Diego are about to launch a Phase 2 clinical trial to test a gene therapy treatment for Alzheimer's disease (AD) called CERE-110. Previously, CERE-110 was carefully studied in animals as well as in a small study to assess safety in humans.
An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop gene therapy for treating a rare, hereditary retinal disease. The therapy has been shown to restore lost vision in animal models of retinitis pigmentosa (RP). Their work is being funded in part by a $1.5 million grant from the Prince Salman Center for Disability Research in Saudi Arabia, where the recessive gene mutation that leads to the eye disease RP has been found in children from several families.
New imaging technology provides insight into abnormalities in the brain circuitry of patients with anorexia nervosa (commonly known as anorexia) that may contribute to the puzzling symptoms found in people with the eating disorder.
Group B Streptococcus (GBS), a bacterial pathogen that causes sepsis and meningitis in newborn infants, is able to shut down immune cell function in order to promote its own survival, according to researchers at the University of California, San Diego School of Medicine and the Skaggs School of Pharmacy and Pharmaceutical Sciences. Their study, published online July 13 in the Journal of Experimental Medicine, offers insight into GBS infection.
Veterans with post-traumatic stress disorder (PTSD) are more likely to have metabolic syndrome than veterans without PTSD, according to a study led by Pia Heppner, Ph.D., psychologist with the University of California, San Diego School of Medicine and Veterans Affairs of San Diego, VA Center of Excellence for Stress and Mental Health (CESAMH).
Patients suffering from severe arthritis now have an option for total ankle replacement that offers increased mobility and pain relief without permanent metal implants. Pioneered by Daniel K. Lee, D.P.M., F.A.C.F.A.S., at UC San Diego Medical Center, this technique is the first in the U.S to offer arthritis sufferers a non-metal, biological ankle replacement.
The University of California, San Diego Medical Center's Hyperbaric Medicine Center is part of a nationwide effort to compile and evaluate data in order to validate whether cancer patients being treated for radiation-related wounds heal more quickly and more thoroughly with hyperbaric oxygen therapy.
In a first-of-its-kind study, research results show that toenail nicotine levels can help predict risk of coronary heart disease (CHD) in women. Researchers at UCSD School of Medicine, in collaboration with colleagues from Harvard University, showed that the higher the level of nicotine in the toenails, the higher the risk of coronary heart disease.
New analysis of a drug approved for osteoporosis prevention and treatment has provided definitive evidence that the medication is also effective as a breast cancer preventative for certain cancers. Women who took the drug raloxifene were less likely to develop invasive, estrogen-receptor (ER) positive breast cancer compared with women who did not take the drug.
Sun exposure and vitamin D levels may play a strong role in risk of type 1 diabetes in children, according to new findings by researchers at the Moores Cancer Center at University of California, San Diego and the Department of Family and Preventive Medicine. This association comes on the heels of similar research findings by this same group regarding vitamin D levels and several major cancers.
New research from the University of California, San Diego Department of Medicine, Division of Nephrology, shows that the anti-rejection drug sirolimus (brand name Rapamune) may help prolong the clinical benefit of transplanted kidneys and delay rejection, especially in patients who do not regularly take their prescribed medications (are "non-compliant").
Through an advanced minimally-invasive procedure called laparoscopy, Andrew M. Lowy, M.D., chief of surgical oncology at Moores UCSD Cancer Center, has completely removed a cancerous tumor without the need for a large 8-12 inch incision.
Every year more than 100,000 U.S. patients undergo gastric bypass surgery for the treatment of obesity. 20 percent of these patients will regain weight within a few years after the surgery and will be at renewed risk for diseases. The Center for the Treatment of Obesity at UC San Diego Medical Center now offers a new incision-free procedure to reverse weight gain after gastric bypass surgery.
Researchers at UC San Diego School of Medicine are challenging conventional thinking with a study showing that modest wine consumption, defined as one glass a day, may not only be safe for the liver, but may actually decrease the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD).
"Every week, someone arrives at UC San Diego Medical Center facing significant life changes because of a split-second accident," said Abrams. "My role as a surgeon is to offer treatment options that deliver satisfying lifelong solutions. You decide what's viable and remove what's not. A finger that is painful, stiff, or with no feeling, may not be worth keeping."
Victor Nizet, M.D., a professor of pediatrics and pharmacy at the University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences, and physician at the Rady Children's Hospital San Diego, has been selected as the 2008 recipient of the most prestigious award in pediatric research by the Pediatric Academic Societies.
Stuart Jamieson, M.D., F.R.C.S, Distinguished Professor of Surgery, Chief, Division of Cardiothoracic Surgery, and Director of the Lung Transplant Program at the UC San Diego Medical Center will receive the Ellis Island Medal of Honor May 10, 2008 in the Great Hall on Ellis Island.
Division of Hospital Medicine at the UCSD Medical Center has received national recognition for a program that protects hospital patients from developing those blood clots. The medical center's Venous Thromboembolism Prevention Team was awarded the Society of Hospital Medicine's first ever Team Approaches in Quality Improvement Award at the Hospital Medicine 2008 meeting in San Diego in April.
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