UC San Diego and its collaborating partners have been awarded $10 million from the Howard Hughes Medical Institute to leverage the biomedical promise of viruses known as bacteriophages as new therapeutic agents in the fight against the rising crisis of antibiotic-resistant bacterial infections.
For the first time, researchers at UC San Diego have created an atomic-level computer model of the H1N1 virus that reveals new vulnerabilities, suggesting possible strategies for the design of future vaccines and antivirals against influenza.
Engineers and physicians have developed a wearable ultrasound device that can assess both the structure and function of the human heart. The portable device, which is roughly the size of a postage stamp, can be worn for up to 24 hours and works even during strenuous exercise.
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science study: senior women were less likely to develop mild cognitive impairment or dementia if they did more daily walking and moderate-to-vigorous physical activity.
Researchers at University of California San Diego and UC Riverside have further elucidated the molecular pathway used by the SARS-CoV-2 virus to infect human lung cells, identifying a key host-cell player that may prove a new and enduring therapeutic target for treating COVID-19.
UC San Diego researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth.
Five years after the deadliest and most destructive wildfire in California history, UC San Diego researchers document persistent differences in cognitive function among survivors.
Researchers have developed a new system for developing gene drives for areas ranging from human health to global food supplies. The new “hacking” system converts split gene drives into full drives, offering new flexibility for safely conducting gene drive experiments in a range of applications.
UC San Diego researchers identify mutation that causes excessive folding in human brain’s wrinkly cerebral cortex, resulting in diminished cognitive function.
Publicly available salary information prompts organizations to reduce the gender pay gap, according to a new study from the University of California San Diego’s School of Global Policy and Strategy.
UC San Diego scientists discover a molecular pathway critical to the initiation of pancreatic tumors. The findings may inspire new chemotherapeutic drugs targeting early stages of tumor formation and spread.
Human cells are often a mixture of both abnormal and normal DNA – a mosaic, so to speak, and like the art form, this complex montage is difficult to understand. Neuroscience researchers are training computers to unveil new methods for DNA mosaic recognition.
An international consortium led by UC San Diego has identified at least some of the genetic drivers of a mysterious form of pediatric epilepsy.
From volunteering in a beach cleanup to learning new ways to promote equity, the start of a new year is the perfect time to take steps to help spark positive change. During UC San Diego’s Changemaker Kickoff Week, campus community members can jump into opportunities to continue building the knowledge and skills needed to make the world a better place for all.
UC San Diego researchers suggest that rising levels of manmade chemicals, accumulating in marine plankton, might be used to monitor the impact of human activity on ecosystem health and perhaps study links between ocean pollution and land-based rates of childhood and adult chronic illnesses.
UC San Diego researchers describe a method for teaching a computer how to spot complex “mosaic mutations” using an artificial intelligence approach termed “deep learning.”
UC San Diego study reveals critical insights into the complex biology of tissue-specific T cells, paving the way for a new branch of precision therapeutics in immunity, autoimmunity, and cancer.
For the first time, researchers at UC San Diego have shown that changes in gene expression happen almost entirely during the transcription stage while the cells are growing. The researchers have provided a simple quantitative formula linking regulatory control to mRNA and protein levels.
Researchers at UC San Diego provide new insights into the pathology of limbic predominate age-related TDP-43 encephalopathy, which mimics Alzheimer’s, making it very difficult to identify in living patients.
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science led 70 participants from 14 nations in a discussion on the ways in which a gene drive project registry could both contribute to and detract from the fair development, testing and use of gene-drive modified organisms.
Two years ago, several browsers that prioritize user privacy --- including Safari, Firefox, and Brave --- began to block third-party cookies for all users by default. Advertisers have responded by pioneering a new method for tracking users across the Web, known as user ID (or UID) smuggling, which does not require third-party cookies. But no one knew exactly how often this method was used to track people on the Internet.
UC San Diego scientists identify a new molecular model and potential therapeutic target for gout, the most common form of inflammatory arthritis.
Using models, researchers at UC San Diego School of Medicine, with colleagues elsewhere, describe using RNA-targeting CRISPR/Cas13d technology to develop a new therapeutic strategy that specifically eliminates toxic RNA that causes Huntington’s Disease.
UC San Diego scientists have identified a long-sought carbon dioxide sensor in plants, a discovery that holds implications for trees, crops and wildfires. The researchers found that two proteins work together to form the sensor, which is key for water evaporation, photosynthesis and plant growth.
The California Institute for Regenerative Medicine has awarded UC San Diego researchers $4.8 million to advance a gene therapy to treat Friedreich’s ataxia, a rare but devastating neuromuscular disorder.
Engineers developed a battery-free, pill-shaped ingestible biosensing system that gives scientists the ability to monitor gut metabolites in real time, which wasn’t possible before. The work could lead to a new understanding of intestinal metabolite composition, which significantly impacts human health.
UC San Diego researchers identify the PKCα enzyme as a promising therapeutic target in Alzheimer’s disease; a mutation that increases its activity led to biochemical, cellular and cognitive impairments in mice.
Both Democrats and Republicans would rather take away funding from their political party than give money to the other party, reveals a new University of California San Diego Rady School of Management study. The research also assesses people’s preferences regarding two other contentious issues—gun rights and reproductive rights—and finds the same result: people would rather hurt the cause they believe in than support one they oppose.
Nanoengineers at the University of California San Diego’s Jacobs School of Engineering have developed an AI algorithm that predicts the structure and dynamic properties of any material—whether existing or new—almost instantaneously. Known as M3GNet, the algorithm was used to develop matterverse.ai, a database of more than 31 million yet-to-be-synthesized materials with properties predicted by machine learning algorithms. Matterverse.ai facilitates the discovery of new technological materials with exceptional properties.
The University of California San Diego has been named the No. 29 university in the world, climbing five spots globally in the Times Higher Education World Reputation Rankings 2022.
The UC San Diego Sanford Stem Cell Institute leads its first space launch, sending stem cells into space aboard the International Space Station. The NASA-partnered study will take advantage of the microgravity environment of space to study accelerated aging in stem cells.
UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.
UC San Diego researchers discuss how mimicking sleep patterns of the human brain in artificial neural networks may help mitigate the threat of catastrophic forgetting in the latter, boosting their utility across a spectrum of research interests.
UC San Diego researchers used human brain organoids to study the effects of prenatal alcohol exposure on neural development, revealing significant harms in molecular detail.
Engineers and physicians at UC San Diego have developed a device to non-invasively measure cervical nerve activity in humans, a new tool they say could potentially inform and improve treatments for patients with sepsis or post-traumatic stress disorder.
UC San Diego researchers expand and deepen understanding of how genetic aberrations fuel human papilloma virus-negative head and neck cancers and, potentially, provide paths to further refinement and improvement of immune checkpoint inhibitors for HPV-negative head and neck cancers.
The award winners, including San Diego Supercomputer Center at UC San Diego, have been recognized in the annual HPCwire Readers’ and Editors’ Choice Awards, presented at the 2022 International Conference for High Performance Computing, Networking, Storage, and Analysis (SC22), in Dallas, Texas.
Using human brain organoids, an international team of researchers has shown how the SARS-CoV-2 virus that causes COVID-19 infects cortical neurons and specifically destroys their synapses — the connections between brain cells that allow them to communicate with each other.
Uncertainty is bad for business; however, it can be mitigated by trade agreements which help countries become more resilient to economic shocks, according to a new University of California School of Global Policy and Strategy study.
Researchers at UC San Diego School of Medicine and Moores Cancer Center at UC San Diego Health describe the first preclinical model of appendiceal cancer that contains all elements of the tumor, allowing previously stymied investigations to proceed.
Researchers at UC San Diego report that a polygenic hazard score based on 290 genetic variants could be an effective tool for predicting genetic risk of lethal prostate cancer, which kills more than 34,000 men in the U.S. annually.
UC San Diego researchers and others report that more than one-third of the COVID-19 patients who did not receive any treatment experienced complete resolution of symptoms for at least two consecutive days, but then subsequently reported a return of symptoms.
In animal models, UC San Diego researchers found that intensive physical therapy in tandem with implanted neural stem cells increased tissue growth, repair and functionality in spinal cord injuries more than those treatments alone
The University of California San Diego has been ranked among the top 20 universities in the world, according to U.S. News and World Report’s 2022-2023 Best Global Universities.
UC San Diego will be one of multiple sites assessing the safety and efficacy of tecovirimat as a potential treatment for human monkeypox. Marketed as TPOXX, tecovirimat is an antiviral currently approved for treatment of human smallpox in adults and children caused by the variola virus.
Researchers at UC San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs. The discovery opens the possibility of new therapies, including for multiple forms of cancer.
Building upon a long history, the UC San Diego has launched a new Human Milk Institute to accelerate research into the nature, biology and therapeutic potential of human milk to prevent or treat both infant and adult diseases. The new institute is believed to be the first of its kind in the United States.
Using a novel systems biology approach, scientists at UC San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis, a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.
Experts at the San Diego Supercomputer Center at UC San Diego, San Diego State University and California State University, San Bernardino will apply NSF support to train and mentor a cohort of cyberinfrastructure professionals who will work closely with scientists to meet their computational needs.
Victor Nizet, MD, Distinguished Professor of Pediatrics at UC San Diego School of Medicine and Pharmacy at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego, has been elected to the National Academy of Medicine.
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