HHMI Investigator Arul Chinnaiyan is using comprehensive tumor sequencing to better capture the drivers of metastatic cancer and treat the disease more effectively.
A new analysis of genome sequences from the ancient Minoans and Mycenaeans by HHMI investigator and colleagues offers insight into the origins of these Bronze Age cultures.
For some developmental genes one allele must stay silent, otherwise debilitating syndromes and cancers can arise. HHMI Investigator Yi Zhang and his colleagues have uncovered a new imprinting mechanism cells use to keep these genes quiet in mice.
Scientists at HHMI’s Janelia Research Campus created comprehensive brain maps linking different groups of neurons to specific behaviors, using a machine-learning program that annotated more than 225 days of videos of flies – a feat that would have taken humans some 3,800 years.
HHMI has selected 24 schools in the first round of the Inclusive Excellence initiative, a program that aims to help increase the capacity of colleges and universities to effectively engage all students so that they can be successful in science, especially undergraduates who enter four-year institutions via nontraditional pathways.
Janelia Research Campus scientists have uncovered new clues about how fruit flies keep track of where they are in the world. Understanding the neural basis of navigation in flies may reveal how humans accomplish similar feats.
In studies with mice, Janelia researchers discovered that to maintain certain short-term memories, the brain’s cortex relies on connections with the thalamus.
HHMI, the Bill & Melinda Gates Foundation, the Wellcome Trust, and the Calouste Gulbenkian Foundation announce the selection of 41 International Research Scholars, early-career scientists poised to advance biomedical research across the globe.
Hypoxia reverses brain damage caused by mitochondrial dysfunction, HHMI team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders.
Thirteen HHMI scientists have been elected to the National Academy of Sciences.
The Howard Hughes Medical Institute’s (HHMI) Medical Research Fellows Program has selected 79 talented medical and veterinary students to conduct in-depth, mentored biomedical research. Each fellow will spend a year pursuing basic, translational, or applied biomedical research in the U.S.
New research adds to growing evidence that Parkinson's disease may arise in part from neurons’ failure to recycle the materials used to package and transport neurotransmitters.
HHMI scientists develop a much-needed genetic resource that is aiding development of wheat plants with improved traits.
Janelia scientists have developed the first adaptive light-sheet microscope — an instrument that continuously analyzes and adapts to dynamic changes in a specimen and thereby improves spatial resolution.
Using novel computational and biochemical approaches, HHMI scientists have designed and built from scratch 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
An international team of scientists has sequenced the whole genomes and epigenomes of more than 1,000 Arabidopsis thaliana plants, sampled from geographically diverse locations. The collection of 1,001 genomes and 1,001 epigenomes not only illuminates new aspects of its evolutionary history, but also provides a comprehensive, species-wide picture of the interaction between genetic and epigenetic variation in this important model plant.
HHMI scientists have pioneered the use of genome editing to trace lineage in living systems.
New experiments help explain how the brain speeds up or slows down movement.
HHMI scientists have discovered a command center in the brain that controls how much insects eat and how quickly they consume their food.
If you pull an all-nighter or stay up late to binge-watch Game of Thrones, you will probably be grumpy the next day. But if you don’t get enough sleep for weeks or months on end, you may develop depression or other lasting mood problems, and Howard Hughes Medical Institute (HHMI) researchers have now discovered a possible reason why.
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