Researchers at UT Southwestern Medical Center have discovered that the protein SMAC may lead to the development of drugs that eliminate cancerous cells. The protein, second mitochondria-derived activator of caspases, promotes apoptosis, or cell death (Nature, 8-24-00).
Eric J. Nestler has been appointed chairman of psychiatry at UT Southwestern. Formerly director of molecular psychiatry at Yale University School of Medicine, his basic-science focus brings an added dimension to the Department of Psychiatry.
Nobel laureate Dr. Alfred Gilman, chairman of pharmacology at UT Southwestern Medical Center at Dallas, will lead a $10 million-per-year project allowing researchers around the world to pool their efforts in studying one of the biggest unsolved problems in biomedicine -- how cells interact with, or signal, each other.
Researchers at UT Southwestern Medical Center at Dallas have uncovered a potential explanation for how cyclosporine and related anti-rejection drugs can elevate blood pressure and cause hypertension in organ-transplant recipients.
A new way to deliver a schizophrenia drug that may help curtail the problem of patients not taking their medication, which is common in people with schizophrenia, is being tested by UT Southwestern Medical Center psychiatry researchers.
LASIK surgery is far better at correcting farsightedness than photorefractive keratectomy, ophthalmologists at UT Southwestern Medical Center at Dallas have discovered (Transactions of the American Ophthalmological Society).
A high intake of vitamin E can help reduce heart disease and stroke risk in type II diabetics, UT Southwestern researchers have found (Circulation, 7-11-00).
Brain scans of veterans who returned from the Gulf War sick show evidence of significant brain-cell loss, according to UT Southwestern Medical Center researchers.
UT Southwestern Medical Center researchers have developed an easy, inexpensive index to measure the severity of Alzheimer's disease (Journal of Neurology, 5-24-00).
In a national study of 681 chronically depressed patients, psychotherapy combined with the antidepressant Serzone improved mood in 85 percent of patients after only three months of treatment, reported a research team, which included UT Southwestern Medical Center, in NEJM (5-18-00).
A very high intake of dietary fiber, mostly from fruits and vegetables, lowers blood glucose levels in diabetics, shows a study by UT Southwestern Medical Center researchers (NEJM, 5-11-00).
A number of incontinent women diagnosed with overactive bladder may have bladder obstructions their doctors miss, a study by UT Southwestern Medical Center urologists showed (Journal of Urology, 6-00).
UT Southwestern Allied Health Sciences School is collaborating with the University of Arkansas for Medical Sciences to support online instruction for students interested in earning a bachelor's degree in nuclear medicine technology.
An NIMH $1.6 million grant will fund a research project, led by an associate professor of psychiatry at UT Southwestern Medical Center at Dallas, which will involve seriously depressed patients who have suffered at least two major depressive episodes during their lives.
In medical tests analyzing brain function, Gulf War veterans who complain of dizziness showed results similar to those of victims of the Toyko subway nerve gas attack, according to a University of Texas Southwestern Medical Center study (Otolaryngology-Head and Neck Surgery, 3-00).
A resurgence in interest in the high-protein, low-carbohydrate diet has prompted UT Southwestern Medical Center doctors to zero in on the fad diet to see if it increases the risk of kidney stones and loss of bone.
Sedentary white rabbits have given UT Southwestern Medical Center researchers a glimpse of the molecular changes that alter the structure and function of muscles following exercise training (Applied Physiology, 3-00).
Myogen and UT Southwestern Medical Center have announced a new patent and technology-licensing agreement and the establishment of collaborative research programs targeted at developing drugs to treat heart failure.
An innovative method of physical therapy in use at the University of Texas Southwestern Medical Center is helping some disabled individuals trade in their wheelchairs for walkers.
A study of genetically obese rats has revealed that an overabundance of fat can collect in heart cells and cause them to die, UT Southwestern Medical Center researchers report (Proceedings of the National Academy of Sciences, 2-14-00).
The higher a man's prostate specific antigen level is, the more likely his prostate will continue to grow abnormally, report UT Southwestern Medical Center researchers (Journal of Urology, 1-00).
By studying the crystal structure of a protein molecule, UT Southwestern Medical Center scientists have discovered an important cell-regulation process that impacts cancer development and may lead to the development of cancer-fighting drugs(Science, 12-99).
A new $4 million grant will allow UT Southwestern Medical Center at Dallas researchers to offer the latest and most advanced treatments under investigation to people infected with human immunodeficiency virus (HIV), the virus that causes AIDS.
An antibiotic solution that may help reduce or eliminate capsular contracture, the most common risk associated with cosmetic and reconstructive breast-implant surgery, has been developed by UTSW plastic surgeons (Plastic and Reconstructive Surgery, 1-00).
University of Texas investigators have reported in the December 24th issue of Science that a tiny transparent worm has enabled a description of the biochemical steps leading from a genetic mutation to a change in behavior.
UT Southwestern Medical Center at Dallas researchers have discovered a method that may lead to the long-hoped-for efficient and inexpensive production of synthetic antibody substitutes.
UT researchers have developed a new ovarian tumor index that will help physicians accurately diagnose ovarian tumors as either cancerous or benign.
A clinical trial has shown Vagus Nerve Stimulation, an electrical stimulation therapy currently used to combat epilepsy, to be a promising new method for treating patients with severe treatment-resistant depression.
Researchers at UT Southwestern Medical Center at Dallas have developed a mouse tumor model for the most common genetic disorder in humans, von Recklinghausen disease, or neurofibromatosis type 1 (NF-1). With the aid of this model, investigators have learned more about why and how patients with NF-1 develop malignant tumors.
Scientists at UT Southwestern Medical Center at Dallas caused the death of human cancer cells by inhibiting telomerase -- the enzyme capable of immortalizing human cells.
A rare but fatal genetic disorder in children is caused by defects in the protein perforin, scientists at UT Southwestern Medical Center at Dallas have found.
Three studies from UT Southwestern Medical Center at Dallas researchers show that calcium citrate is better absorbed than calcium carbonate and is effective at preventing osteoporosis in early post-menopausal women.
The Medical Event Reporting System for Transfusion Medicine seeks to stop blood-transfusion errors before they happen.
Investigators at UT Southwestern Medical Center at Dallas are providing insight into a most disturbing crime - the killing of a child by a parent, or filicide.
A substance used for decades in Europe to treat diabetic neuropathy, or nervous-system complications, also functions as an antioxidant in humans, according to researchers at UT Southwestern Medical Center at Dallas.
UT Southwestern Medical Center at Dallas researchers are a step closer to understanding how cocaine triggers heart attacks and other cardiovascular emergencies.
UT Southwestern Medical Center at Dallas researchers linked an antibody to a toxin, killing more than 99 percent of the human cells carrying a latent form of the human immunodeficiency virus (HIV)-1 in a laboratory study.
The crystal structure of an enzyme that hunts down DNA damage caused by sunlight and cigarettes then snaps it up like a Venus' flytrap is described in today's Proceedings of the National Academy of Sciences.
Researchers have identified a new component essential for the proper development of all animals.
Researchers at UT Southwestern Medical Center at Dallas have discovered how a drug known to help prevent colon cancer inhibits cell growth and prevents inflammation, a discovery that could lead to the design of new cancer pharmaceuticals.
An international team led by researchers at UT Southwestern Medical Center at Dallas has located the gene for a rare fat-developmental disorder called congenital generalized lipodystrophy.
The National Institutes of Health has awarded researchers at UT Southwestern Medical Center at Dallas a four-year, $1.8 million grant to study lipodystrophy syndrome, a fat distribution disorder that more and more HIV-infected patients are developing.
A new study from UT Southwestern Medical Center at Dallas found both selective and nonselective beta-blockers equally effective in reducing the risk of sudden death in patients with congestive heart failure.
The recent discovery of four genes that can halt lupus, an incurable and potentially fatal autoimmune disease that affects about 1.5 million Americans, could lead to the development of preventive drugs.
The discovery by UT Southwestern Medical Center at Dallas researchers that an enzyme deficiency is responsible for some infant deaths attributed to Sudden Infant Death Syndrome (SIDS) could lead to new postnatal testing to identify those at risk.
Using an infrared, nighttime video camera to study genetically engineered mice lacking a molecule known to affect appetite, UT Southwestern researchers unexpectedly discovered they had created a rodent with the sleep disorder narcolepsy.
Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.
UT Southwestern Medical Center at Dallas scientists have used genetically altered mice to help explain two types of human blindness, one that occurs in children and another that develops in approximately one in four adults over 65.
Scientists at UT Southwestern Medical Center at Dallas have found, in mice, that a hormone is involved in the regulation of testicular descent.
Investigation of two important cell systems has revealed that a large protein complex, previously thought to mainly regulate protein degradation, also plays a significant role in sensitivity to cancer-causing ultraviolet light.
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