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Released: 13-Jan-2000 12:00 AM EST
Making Breast-Implant Procedures Safer
UT Southwestern Medical Center

An antibiotic solution that may help reduce or eliminate capsular contracture, the most common risk associated with cosmetic and reconstructive breast-implant surgery, has been developed by UTSW plastic surgeons (Plastic and Reconstructive Surgery, 1-00).

Released: 4-Jan-2000 12:00 AM EST
Gene Mutation Alters Feeding Behavior
UT Southwestern Medical Center

University of Texas investigators have reported in the December 24th issue of Science that a tiny transparent worm has enabled a description of the biochemical steps leading from a genetic mutation to a change in behavior.

29-Dec-1999 12:00 AM EST
Method of Synthesizing Antibodies
UT Southwestern Medical Center

UT Southwestern Medical Center at Dallas researchers have discovered a method that may lead to the long-hoped-for efficient and inexpensive production of synthetic antibody substitutes.

Released: 24-Dec-1999 12:00 AM EST
Tumor Index for Diagnosing Ovarian Cancer
UT Southwestern Medical Center

UT researchers have developed a new ovarian tumor index that will help physicians accurately diagnose ovarian tumors as either cancerous or benign.

16-Dec-1999 12:00 AM EST
Vagus Nerve Stimulator Successful for Depression
UT Southwestern Medical Center

A clinical trial has shown Vagus Nerve Stimulation, an electrical stimulation therapy currently used to combat epilepsy, to be a promising new method for treating patients with severe treatment-resistant depression.

10-Dec-1999 12:00 AM EST
Mouse Model of Neurofibromatosis
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center at Dallas have developed a mouse tumor model for the most common genetic disorder in humans, von Recklinghausen disease, or neurofibromatosis type 1 (NF-1). With the aid of this model, investigators have learned more about why and how patients with NF-1 develop malignant tumors.

7-Dec-1999 12:00 AM EST
Human Cancer Cell Death by Inhibiting Telomerase
UT Southwestern Medical Center

Scientists at UT Southwestern Medical Center at Dallas caused the death of human cancer cells by inhibiting telomerase -- the enzyme capable of immortalizing human cells.

3-Dec-1999 12:00 AM EST
Molecular Basis of Childhood Immunodeficiency Disorder
UT Southwestern Medical Center

A rare but fatal genetic disorder in children is caused by defects in the protein perforin, scientists at UT Southwestern Medical Center at Dallas have found.

Released: 23-Nov-1999 12:00 AM EST
Calcium Citrate Trumps Calcium Carbonate in Osteoporosis Studies
UT Southwestern Medical Center

Three studies from UT Southwestern Medical Center at Dallas researchers show that calcium citrate is better absorbed than calcium carbonate and is effective at preventing osteoporosis in early post-menopausal women.

Released: 20-Nov-1999 12:00 AM EST
Blood-Error Reporting System Tracks Medical Mistakes
UT Southwestern Medical Center

The Medical Event Reporting System for Transfusion Medicine seeks to stop blood-transfusion errors before they happen.

Released: 18-Nov-1999 12:00 AM EST
Classification of Child Homicide by Parent
UT Southwestern Medical Center

Investigators at UT Southwestern Medical Center at Dallas are providing insight into a most disturbing crime - the killing of a child by a parent, or filicide.

Released: 11-Nov-1999 12:00 AM EST
Diabetes Complications Treatment also Works as Antioxidant
UT Southwestern Medical Center

A substance used for decades in Europe to treat diabetic neuropathy, or nervous-system complications, also functions as an antioxidant in humans, according to researchers at UT Southwestern Medical Center at Dallas.

Released: 20-Oct-1999 12:00 AM EDT
Cocaine Acts on Heart via Central Nervous System
UT Southwestern Medical Center

UT Southwestern Medical Center at Dallas researchers are a step closer to understanding how cocaine triggers heart attacks and other cardiovascular emergencies.

Released: 13-Oct-1999 12:00 AM EDT
Killing Latent HIV-Infected Cells Using Immunotoxin
UT Southwestern Medical Center

UT Southwestern Medical Center at Dallas researchers linked an antibody to a toxin, killing more than 99 percent of the human cells carrying a latent form of the human immunodeficiency virus (HIV)-1 in a laboratory study.

12-Oct-1999 12:00 AM EDT
Molecule that Repairs Sun and Cigarette Damage
UT Southwestern Medical Center

The crystal structure of an enzyme that hunts down DNA damage caused by sunlight and cigarettes then snaps it up like a Venus' flytrap is described in today's Proceedings of the National Academy of Sciences.

Released: 24-Sep-1999 12:00 AM EDT
Novel Component of Cell-Fate Pathway Identified
UT Southwestern Medical Center

Researchers have identified a new component essential for the proper development of all animals.

Released: 18-Sep-1999 12:00 AM EDT
How a Colon-Cancer Prevention Drug Works
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center at Dallas have discovered how a drug known to help prevent colon cancer inhibits cell growth and prevents inflammation, a discovery that could lead to the design of new cancer pharmaceuticals.

Released: 14-Sep-1999 12:00 AM EDT
Gene Located for Rare Fat Disorder
UT Southwestern Medical Center

An international team led by researchers at UT Southwestern Medical Center at Dallas has located the gene for a rare fat-developmental disorder called congenital generalized lipodystrophy.

Released: 14-Sep-1999 12:00 AM EDT
Lipodystrophy Syndrome in HIV-Infected Patients
UT Southwestern Medical Center

The National Institutes of Health has awarded researchers at UT Southwestern Medical Center at Dallas a four-year, $1.8 million grant to study lipodystrophy syndrome, a fat distribution disorder that more and more HIV-infected patients are developing.

Released: 2-Sep-1999 12:00 AM EDT
Selective and Nonselective Beta-Blockers and Sudden Death
UT Southwestern Medical Center

A new study from UT Southwestern Medical Center at Dallas found both selective and nonselective beta-blockers equally effective in reducing the risk of sudden death in patients with congestive heart failure.

Released: 28-Aug-1999 12:00 AM EDT
Scientists Find Four Genes That Could Prevent Lupus
UT Southwestern Medical Center

The recent discovery of four genes that can halt lupus, an incurable and potentially fatal autoimmune disease that affects about 1.5 million Americans, could lead to the development of preventive drugs.

Released: 28-Aug-1999 12:00 AM EDT
Enzyme Deficiency Identified for Some Sudden Infant Death Cases
UT Southwestern Medical Center

The discovery by UT Southwestern Medical Center at Dallas researchers that an enzyme deficiency is responsible for some infant deaths attributed to Sudden Infant Death Syndrome (SIDS) could lead to new postnatal testing to identify those at risk.

5-Aug-1999 12:00 AM EDT
Researchers Create Mice with Narcolepsy
UT Southwestern Medical Center

Using an infrared, nighttime video camera to study genetically engineered mice lacking a molecule known to affect appetite, UT Southwestern researchers unexpectedly discovered they had created a rodent with the sleep disorder narcolepsy.

Released: 3-Aug-1999 12:00 AM EDT
Engineered Cells May Treat Inflammatory Diseases
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death.

8-Jul-1999 12:00 AM EDT
Mouse Gene Function that Causes 2 Types of Blindness
UT Southwestern Medical Center

UT Southwestern Medical Center at Dallas scientists have used genetically altered mice to help explain two types of human blindness, one that occurs in children and another that develops in approximately one in four adults over 65.

29-Jun-1999 12:00 AM EDT
Hormone Involved in Cryptorchidism
UT Southwestern Medical Center

Scientists at UT Southwestern Medical Center at Dallas have found, in mice, that a hormone is involved in the regulation of testicular descent.

Released: 17-Jun-1999 12:00 AM EDT
Lever Involved in Ultraviolet Sensitivity
UT Southwestern Medical Center

Investigation of two important cell systems has revealed that a large protein complex, previously thought to mainly regulate protein degradation, also plays a significant role in sensitivity to cancer-causing ultraviolet light.

Released: 16-Jun-1999 12:00 AM EDT
Genetic Cause for Gulf War Syndrome
UT Southwestern Medical Center

A genetic trait can predispose people to Gulf War syndrome, a new study has found.

11-Jun-1999 12:00 AM EDT
New Gene Family May Regulate Important Processes
UT Southwestern Medical Center

A newly discovered gene defines a family that appears integral to the creation of cells, UT Southwestern Medical Center at Dallas researchers reported in the July issue of Human Molecular Genetics.

Released: 10-Jun-1999 12:00 AM EDT
Procedure, New Apparatus, Relief from Incontinence
UT Southwestern Medical Center

Imagine planning your life around the location of the nearest restroom or missing out on a nightly walk or tennis match due to the chance of an embarrassing accident.

24-May-1999 12:00 AM EDT
Fast, Controllable Way to Study Molecular Interactions
UT Southwestern Medical Center

A molecule that is extremely sensitive to light has proved a highly efficient way of initiating bonding of two proteins. UT Southwestern Medical Center at Dallas researchers who designed this cross-linking reagent and technique said this will be an important tool in studying multiprotein complexes.

Released: 21-May-1999 12:00 AM EDT
Discovery of a Molecule That Controls Bile Acids
UT Southwestern Medical Center

The discovery that a nuclear receptor controls the production of bile acids and works within a pathway that speeds up destruction of cholesterol may lead to new cholesterol drugs, UT Southwestern researchers reported in today's issue of Science.

Released: 13-May-1999 12:00 AM EDT
Way to Control Gene Activities
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center at Dallas have developed a method to turn off a gene for telomerase, which activates the continuous division of cancer cells. This finding could aid in the creation of new cancer drugs.

Released: 1-May-1999 12:00 AM EDT
Study to test St. John's wort for treatment of depression
UT Southwestern Medical Center

Twenty-eight-year-old artist Leslie Kenegar has a group of her paintings that she hides in her back closet and describes as "just for me - I don't want anybody else to know I've felt that way." On her other walls, however, hang the bright paintings she's done in her sunny moods.

Released: 27-Apr-1999 12:00 AM EDT
Cancer-Risk Analysis Program Goes Public
UT Southwestern Medical Center

A UT Southwestern Medical Center at Dallas physician-scientist is offering his interactive, comprehensive computer program for breast-cancer risk assessment at no charge to health professionals providing breast care.

22-Apr-1999 12:00 AM EDT
Size and Morbidity/Mortality in Newborns
UT Southwestern Medical Center

The smallest 3 percent of infants born at term and of the same gestational age are at the greater risk of death or disability - compared to the 10 percent previously believed to be in danger.

21-Apr-1999 12:00 AM EDT
Gender Affects Lung-Cancer Development
UT Southwestern Medical Center

Once again researchers have discovered that men and women may not in fact be equal - at least with respect to the pattern of precancerous lesions in the lungs of current and former smokers.

Released: 13-Apr-1999 12:00 AM EDT
Research into Body-Fat Disorders
UT Southwestern Medical Center

The National Institutes of Health has awarded a $1.6 million grant to researchers at UT Southwestern Medical Center to study rare body-fat diseases.

Released: 8-Apr-1999 12:00 AM EDT
Molecular Effect of Vitamin E on Plaque Formation Identified
UT Southwestern Medical Center

Furthering evidence of the importance of vitamin E, researchers at UT Southwestern Medical Center at Dallas have identified the pathway that may allow the vitamin to block the trigger of arterial plaque formation at the molecular level.

30-Mar-1999 12:00 AM EST
New cell isolation method will aid in studying tumor development
UT Southwestern Medical Center

Investigators at UT Southwestern Medical Center at Dallas have developed a new way to isolate purified cancer cells - an important advance that will help unravel the mysteries of tumor biology and cancer development.

Released: 17-Mar-1999 12:00 AM EST
Primary Progressive MS Patients Sought for Drug Trial
UT Southwestern Medical Center

Physicians at UT Southwestern Medical Center at Dallas will be participating in the first-ever drug trial for patients with the most rare form of multiple sclerosis, primary progressive MS.

Released: 9-Mar-1999 12:00 AM EST
PSA Levels and Prostate Volume Can Predict Prostate Complications
UT Southwestern Medical Center

A routine test already in use to diagnose prostate cancer and enlarged prostate could also predict the likelihood of a patient requiring surgery or developing acute urinary retention.

2-Mar-1999 12:00 AM EST
Percutaneous Electrical Nerve Stimulation and Back Pain
UT Southwestern Medical Center

A recently developed electro-analgesia technique may offer new hope to patients who suffer from chronic, debilitating back pain, according to researchers at UT Southwestern Medical Center at Dallas.

Released: 18-Feb-1999 12:00 AM EST
Researchers Isolate Gene for Heart and Facial Defects
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center at Dallas have isolated the gene they believe is responsible for the most common genetic cause of heart and facial birth defects.

Released: 30-Jan-1999 12:00 AM EST
Understanding How Estrogen Protects Against Heart Disease
UT Southwestern Medical Center

Scientists at UT Southwestern Medical Center at Dallas now have a better understanding of the protective role that estrogen plays in cardiovascular disease.

Released: 26-Jan-1999 12:00 AM EST
Electrical Nerve Stimulation May Help Reduce Chronic Pain in Cancer Patients
UT Southwestern Medical Center

Borrowing from the ancient practice of Chinese acupuncture, a newly developed electrical nerve-stimulation technique may help alleviate pain associated with cancer that has spread to bones, said researchers at UT Southwestern Medical Center at Dallas.

Released: 29-Dec-1998 12:00 AM EST
Immortalizing Enzyme Does Not Make Human Cells Cancerous
UT Southwestern Medical Center

Scientists at UT Southwestern Medical Center at Dallas have shown that human cells grown in the laboratory and immortalized by the introduction of the enzyme telomerase are not transformed into cancer cells.

Released: 17-Dec-1998 12:00 AM EST
Thymus may hold clue to rebuilding immune system after HIV
UT Southwestern Medical Center

Discovery of a marker that allows tracking of thymus function also shows how the adult immune system might repair itself after being damaged by human immunodeficiency virus (HIV), UT Southwestern Medical Center at Dallas scientists reported in today's issue of Nature.

Released: 11-Dec-1998 12:00 AM EST
Gene Discovery; Preventing Bacterial Shock
UT Southwestern Medical Center

Identification of a gene that normally prevents endotoxic shock - which causes at least 20,000 deaths a year in the United States and possibly one million worldwide - was reported by UT Southwestern Medical Center at Dallas researchers in today's issue of Science.

Released: 9-Dec-1998 12:00 AM EST
New Light on Childhood Muscular Dystrophy
UT Southwestern Medical Center

Researchers at UT Southwestern Medical Center at Dallas have made a critical discovery about blood-flow regulation during exercise and, in the process, have uncovered a clue about a culprit behind Duchenne dystrophy, also known as childhood muscular dystrophy.



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