Higher levels of a key inflammatory marker were related to older breast cancer survivors reporting cognitive problems, researchers found in one of the first long-term efforts to examine the potential link between chronic inflammation and cognition in older breast cancer survivors.
New UCLA-led research suggests certain gut bacteria -- including one that is essential for a healthy gut microbiome – differ between people who go on to acquire HIV infection compared to those who have not become infected. The findings, published in the peer-reviewed journal eBioMedicine, suggest that the gut microbiome could contribute to one’s risk for HIV infection, said study lead Dr.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA center members discovered how to create more accurate, consistent brain organoids to develop treatments for neurological disorders.
Researchers at UCLA’s Jonsson Comprehensive Cancer Center and collaborating organizations report successful results from an experimental cancer-detection system that appears to have overcome some of the challenges of the "liquid biopsy" in a novel, cost-effective way.
FINDINGS Women with COVID in pregnancy who are subsequently vaccinated after recovery, but prior to delivery, are more likely to pass antibodies on to the child than similarly infected but unvaccinated mothers are. Researchers who studied a mix of vaccinated and unvaccinated mothers found that 78% of their infants tested at birth had antibodies.
The National Cancer Institute has awarded a five-year, $13.3 million grant to a collaborative study on sequential combinations of targeted inhibitors and immunotherapies against cancer.
The research projects, part of the NIH's BRAIN Initiative, aim to shed light on the developing brain’s cellular infrastructure to better understand brain disorders.
An automated process that combines natural language processing and machine learning identified people who inject drugs (PWID) in electronic health records more quickly and accurately than current methods that rely on manual record reviews.
Jack Schlosser, a healthcare management veteran with more than four decades in the field, has been named Executive-in-Residence at the UCLA Fielding School of Public Health’s UCLA Center for Healthcare Management for the 2022-23 academic year.
The UCLA Clinical AIDS Research and Education (CARE) Center today announced its participation in STOMP (Study of Tecovirimat for Human Monkeypox Virus), or A5418, a phase 3, randomized, placebo-controlled, double-blind trial evaluating the safety and efficacy of tecovirimat for the treatment of human monkeypox. STOMP, which is being led by the AIDS Clinical Trials Group (ACTG), has been designed to learn as much as possible in a broad population of people with monkeypox.
Dr. Daniel Geschwind was awarded the National Academy of Medicine’s top annual prize in mental health in recognition of his pioneering research and leadership in autism genetics.
Data suggests a previously unobserved relationship between body temperature and REM sleep, with REM sleep appearing to act like a "thermostatically controlled brain heater.”
The David Geffen School of Medicine at UCLA has been awarded a $13.6 million grant from the Centers for Disease Control and Prevention to continue to study the effectiveness of COVID-19 vaccines and the long-term impact of infection among U.S. health care workers. The new yearlong grant project follows the 2020–21 Preventing Emerging Infections Through Vaccine Effectiveness Testing study, or PREVENT I, which was among the first to demonstrate the real-world benefit of mRNA vaccines in preventing symptomatic infection following their authorization by the Food and Drug Administration.
Dr. Timothy Miller was honored with the Congressional Medal of Honor Distinguished Citizen Award for his work reconstructing the faces of veterans severely disfigured during the wars in Iraq and Afghanistan.
Analyzing genetic ancestry data from a large genomic repository – the UCLA ATLAS Precision Health Biobank – researchers have found a highly diverse patient population that’s consistent with the global diversity of Los Angeles – one of the most ethnically diverse cities in the world and an ideal location to pursue personalized, precision medicine for underrepresented populations.
Amid growing scrutiny of breast implant safety, a pair of UCLA scientists are developing a lab test aimed at detecting silicone implant ruptures which they think may also help explain why many women who received implants have later reported a constellation of systemic symptoms.
UCLA research finds that a refundable State-level Earned Income Tax Credit (SEITC) of 10% or above the Federal EITC was associated with a 21% relative risk reduction in reported behavior that could put single mothers at high risk for becoming infected with HIV during the previous year. Also, a 10 percentage-point increase in SEITC was linked to a 38% relative reduction in the same reported high-risk behavior the previous year.
The pilot study is one of the first to indicate that neurofeedback could help address cognitive deficits of cancer patients experiencing “chemo brain."
A new UCLA-led study has identified multiple new risk genes for Alzheimer’s disease and a rare, related brain disorder by using a combination of new testing methods allowing for mass screening of genetic variants in a single experiment.
A warming planet doesn’t just mean more people may find it harder to get quality sleep: There is also evidence suggesting that sleep disturbance could make it harder for the body to fend off infection, a UCLA professor writes.
UCLA researchers who oversaw a long-running mental health response program after a devastating 1988 earthquake in Armenia offer lessons learned in disaster response that are especially important amid the COVID-19 pandemic, a plague of gun violence, and the increasing threat of climate-related disasters.
New study suggests that readily available PET scanning could enable a whole-body analysis of the effects of systemic STING-activating therapy in humans, potentially providing a diagnostic tool to guide clinical development of this treatment approach.
Fast data processing of overdose deaths, which have increased in recent years, is crucial to developing a rapid public health response. But the system now in place lacks precision and takes months. To correct that, UCLA researchers have developed an automated process that reduces data collection to a few weeks.
The four-year award, part of the NIH’s BRAIN Initiative, will support the design, manufacturing and distribution of two types of new "miniscopes" that will allow scientists to peer much deeper into the brain than before.
New research led by UCLA Jonsson Comprehensive Cancer Center investigators suggests that new technology in development may lead to a better way to detect early-stage hepatocellular carcinoma (HCC).
UCLA researchers and colleagues at Emory University and other research centers have combined data simulation and experimental observation to bridge a gap between two major properties of large-scale organization of the human brain – stationary and traveling waves of activity.
UCLA Health is joining a new effort to increase the ability to quickly respond to emerging pathogens by creating the capability to detect all existing and new respiratory RNA viruses in a single test.
The inaugural cohort of innovators has been selected to participate in UCLA Health’s new TechQuity Accelerator.
Key takeaways: • Just like the real thing. The stem cell–derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body. • Tomorrow’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain. • Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.
Peer comparison, a commonly used behavioral intervention comparing primary care physicians' performance to that of their peers, has no statistically significant impact on preventive care performance. It does, however, decrease physicians’ job satisfaction while increasing burnout.
UCLA has received a $59 million Clinical and Translational Science Award from the National Center for Advancing Translational Sciences (NCATS). The five-year award supports the UCLA Clinical and Translational Science Institute (CTSI), a research partnership among UCLA, Charles Drew University of Medicine and Science, the Lundquist Institute at Harbor-UCLA Medical Center, and Cedars-Sinai Medical Center.
A unique study of brain activity in the cerebral cortex of epilepsy patients found there was a robust response to sound during sleep that largely mirrored the brain’s response during wakefulness. However, there was one key difference from wakefulness.
“Veteran Journeys,” an award-winning opera written by Dr. Kenneth Wells, UCLA Fielding School of Public Health professor of health policy and management, that explores the struggles of America’s military veterans, will be performed live for the first time at UCLA July 22 and 24
UCLA Fielding School project shows health effects of extreme heat across California at the community level; tool shows which communities are at greatest risk of harm during extreme heat days.
A UCLA study offers the first evidence that transgender patients who receive gender-affirming facial feminization surgery reported better mental health after their procedures.
Outpatient antibiotic management of selected patients with appendicitis is safe, allowing many patients to avoid surgery and hospitalization, and should be considered as part of shared decision-making between doctor and patient.
HIV has an “early and substantial” impact on aging in infected people, accelerating biological changes in the body associated with normal aging within just two to three years of infection.
Medicare could waste up to $605 million per year on the controversial Alzheimer’s drug aducanumab if it is eventually approved for widespread use because it is supplied in vials containing fixed doses that may not be appropriate for all patients–resulting in the trashing of large volumes of unused drug
Doctors at the UCLA Gender Health Program have developed a technique to reduce an Adam’s apple bump without leaving a scar on the patient’s neck.
A new study from UCLA researchers indicates a previously undocumented impact of the promotion of Covid-19 vaccines on other public health behaviors. Adult flu vaccination rates have declined in states with low rates of Covid-19 vaccination, which the authors say may be a harbinger of declining trust in public health and could make some populations more vulnerable to preventable disease.
A new analysis led by researchers with the University of California has found the top threats to Americans today regarding dementia in old age are obesity, physical inactivity, and lack of a high school diploma.
A research team led by UCLA’s Anusha Kalbasi, MD, has shown that a synthetic IL-9 receptor allows cancer-fighting T cells to do their work without the need for chemotherapy or radiation.
A new study in mice finds that a gene therapy developed by a UCLA researcher appears to correct a rare creatine deficiency disorder that commonly results in intellectual disabilities, problems with speech, involuntary movements and recurrent seizures.
A new study in mice by UCLA scientists reveals how exposure to traffic-related air pollutants causes cellular changes in the placenta that can lead to pregnancy complications and affect the health of both mother and offspring.
New UCLA research published in The Journal of Physiology points to a novel treatment for respiratory depression associated with opioid use that administers electrical pulses to the back of the neck, helping patients regain respiratory control following high dosage opioid use. This could offer an alternative to pharmacological treatments, which can cause withdrawal symptoms, heart problems and can negatively affect the central nervous system.
One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.
A new UCLA study has identified a gene on the Y chromosome that protects against pulmonary hypertension – a rare but fatal disease that occurs four times more often in women than men.
Q&A about monkeypox with Dr. Anne Rimoin, UCLA Fielding School of Public Health professor of epidemiology and the Gordon-Levin Endowed Chair in Infectious Diseases and Public Health, has been studying monkeypox for two decades.
Data from 44 hospitals in 26 states show that suicide or self-injury and depressive disorders were the primary mental health reasons children received emergency department (ED) or hospital inpatient care after statewide school closures were enacted during the first part of the COVID-19 pandemic.
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