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Released: 29-Jan-2024 11:30 AM EST
Mount Sinai Leaders Showcase Innovations and Solutions in Health Delivery and Care Quality at Arab Health 2024
Mount Sinai Health System

Mount Sinai Health System leaders will attend and present at Arab Health 2024, the Middle East’s largest healthcare exhibition and congress, on January 29 – February 1

23-Jan-2024 11:05 AM EST
Researchers Discover Why One Type of Chemotherapy Works Best in Bladder Cancer
Mount Sinai Health System

Tisch Cancer Institute researchers discovered that a certain type of chemotherapy improves the immune system’s ability to fight off bladder cancer, particularly when combined with immunotherapy, according to a study published in Cell Reports Medicine in January.

25-Jan-2024 9:00 AM EST
Icahn Mount Sinai School of Medicine Receives Helmsley Charitable Trust Grant for Crohn's Disease Research
Mount Sinai Health System

The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn’s disease before noticeable symptoms develop.

Released: 22-Jan-2024 8:00 AM EST
Spike in Influenza, COVID-19, and Other Respiratory Illnesses Can Lead to Rise in Cardiovascular Complications
Mount Sinai Health System

Mount Sinai cardiologists warn about the risk of heart problems during winter for American Heart Month

Newswise: AI-Driven Study Redefines Right Heart Health Assessment With Novel Predictive Model
Released: 4-Jan-2024 9:00 AM EST
AI-Driven Study Redefines Right Heart Health Assessment With Novel Predictive Model
Mount Sinai Health System

New York, NY [January 4, 2023]—In a milestone study, researchers from the Icahn School of Medicine at Mount Sinai have harnessed the power of artificial intelligence (AI) to enhance the assessment of the heart’s right ventricle, which sends blood to the lungs.

Newswise: Mount Sinai Study Shows That Human Beliefs About Drugs Could Have Dose-Dependent Effects on the Brain
Released: 3-Jan-2024 10:45 AM EST
Mount Sinai Study Shows That Human Beliefs About Drugs Could Have Dose-Dependent Effects on the Brain
Mount Sinai Health System

Mount Sinai researchers have shown for the first time that a person’s beliefs related to drugs can influence their own brain activity and behavioral responses in a way comparable to the dose-dependent effects of pharmacology.

Newswise: Novel Genetic Priority Score Unveiled to Enhance Target Prioritization in Drug Development
2-Jan-2024 1:05 PM EST
Novel Genetic Priority Score Unveiled to Enhance Target Prioritization in Drug Development
Mount Sinai Health System

Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel “genetic priority score” (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score. The findings were described in the January 3 online issue of Nature Genetics [DOI: 10.1038/s41588-023-01609-2]. Studies have shown that drugs have an increased likelihood of success in clinical trials when the genes they target have been demonstrated to have genetic support. The new tool integrates multiple lines of genetic evidence to prioritize these drug targets.

Newswise: Demystifying a Key Receptor in Substance Use and Neuropsychiatric Disorders
Released: 2-Jan-2024 11:05 AM EST
Demystifying a Key Receptor in Substance Use and Neuropsychiatric Disorders
Mount Sinai Health System

Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic medication asenapine, a possible therapeutic target for substance use and neuropsychiatric disorders. This discovery may pave the way for the development of improved medications targeting the same pathway. Their findings, detailed in the January 2 online issue of Nature Communications https://doi.org/10.1038/s41467-023-44601-4, show that a brain protein known as the TAAR1 receptor, a drug target known to regulate dopamine signaling in key reward pathways in the brain, differs significantly in humans compared to the preclinical rodent models on which drugs are typically tested. The study suggests considering species-specific differences in drug-receptor interactions and further investigation into ways asenapine affects the body, as steps toward potential therapeutic improvements.

19-Dec-2023 1:05 PM EST
Where You Live Matters: A First-of-Its-Kind Study Illustrates How Racism Is Interrelated With Poor Health
Mount Sinai Health System

A team of health equity researchers from several institutions has leveraged a complex web of data to test a hypothesis: That structural racism is associated with resources and structures at the neighborhood level that are closely associated with poor health.

Newswise: New Insights Revealed On Tissue-Dependent Roles of JAK Signaling in Inflammation
18-Dec-2023 3:05 PM EST
New Insights Revealed On Tissue-Dependent Roles of JAK Signaling in Inflammation
Mount Sinai Health System

Patient-specific mutation-engineered mouse reveals how sensory neurons may trigger some allergy conditions but block others, suggesting more precise design of JAK inhibitors is necessary.

Newswise: Mount Sinai Receives $1.3 Million From the National Institutes of Health to Support Program That Introduces High School Students to Virus Surveillance
Released: 14-Dec-2023 4:15 PM EST
Mount Sinai Receives $1.3 Million From the National Institutes of Health to Support Program That Introduces High School Students to Virus Surveillance
Mount Sinai Health System

Prestigious grant will allow the New York City Virus Hunters initiative to expand an ongoing collaboration with BioBus that enables young students to keep city safe and help avoid future pandemics.

Newswise: Unlocking the Human Genome: Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants
Released: 14-Dec-2023 9:00 AM EST
Unlocking the Human Genome: Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants
Mount Sinai Health System

In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome.

Newswise: A Type of Allergy Medicine Might Help Treat Lung Cancer, Research Suggests
4-Dec-2023 11:05 AM EST
A Type of Allergy Medicine Might Help Treat Lung Cancer, Research Suggests
Mount Sinai Health System

Researchers at the Icahn School of Medicine at Mount Sinai have identified an allergy pathway that, when blocked, unleashes antitumor immunity in mouse models of non-small cell lung cancer (NSCLC). And in an early parallel study in humans, combining immunotherapy with dupilumab—an Interleukin-4 (IL-4) receptor-blocking antibody widely used for treating allergies and asthma—boosted patients' immune systems, with one out of the six experiencing significant tumor reduction. The findings were described in the December 6 issue of Nature.

Newswise: Traumatic Memories Are Represented Differently Than Regular Sad Memories in the Brains of People With PTSD, New Research Shows
28-Nov-2023 5:05 PM EST
Traumatic Memories Are Represented Differently Than Regular Sad Memories in the Brains of People With PTSD, New Research Shows
Mount Sinai Health System

A new analysis of the brain activity of people with post-traumatic stress disorder (PTSD) is the first to reveal that traumatic memories are represented in the brain in an entirely different way than sad autobiographical memories.



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