New research examined the impact of virtual training on the mental-health and suicide-prevention skills of more than 33,000 middle-school educators. The researchers found, overwhelmingly, that those who completed the training had “higher levels of preparedness” in identifying suicide warning signs than participants at the pre-test evaluation.
A new study explores the effect of obesity on non-surgical periodontal care and evaluates potential pathways that may illustrate the connection between obesity and gum disease.
The U.S. Department of Justice awarded a $1 million grant to launch a special court docket for cases involving high-risk domestic offenders. The Cuyahoga County Common Pleas Court is partnering with social sciences researchers at Case Western Reserve University to develop, implement and evaluate the court docket.
Researchers at the Case Western Reserve University School of Medicine have identified that a gene critical to clearing up unnecessary proteins plays a role in brain development and contributes to the development of autism spectrum disorders (ASD) and schizophrenia.
New research at Case Western Reserve University found big gaps in services and continued care for children with autism—and their families—as they transition from adolescence to adulthood.
A team of researchers using the Microsoft HoloLens mixed reality platform has created what is believed to be the first interactive holographic mapping system, expected to have a wide range of scientific, clinical and educational applications and further a collaborative interaction between neuroanatomists and brain-imaging scientists.
“Narwhal: Revealing an Arctic Legend” has been on exhibit at The Smithsonian’s Museum of Natural History since 2017 and is due to go on tour of North America in 2020. Museum visitors can view panoramic Arctic landscape images, touch a cast of a narwhal’s spiral tusk, hear narwhal vocalizations and read Inuit narwhal legends. This Saturday evening, Oct. 26, in a one-night-only debut as part of a family game night at the museum, visitors who don the Microsoft HoloLens headset will be drawn into an infinitely more interactive experience of 3-D images of the sea creatures swimming all around them.
CWRU's W. Henry Boom, MD, and a team of collaborators nationally received the first installment of a seven-year contract, totaling $30 million in its first year from the National Institute of Allergy and Infectious Diseases of the NIH, to establish three immunology research centers to accelerate TB vaccine development.
The U.S. Department of Defense recently awarded researchers from MetroHealth Medical Center and Case Western Reserve University more than $800,000 to study the experiences and needs of veterans and civilians who have suffered spinal cord injuries.
Scientists have made genetic data publicly available for bacteria that might be lurking inside the gut walls of patients chronically affected with severe Crohn’s disease. By studying a surgically removed, damaged bowel from a patient, researchers were able to culture bacteria from a special form of microscopic lesions that they earlier discovered and that can be present within the gut wall of the inflamed bowel in Crohn’s disease. After growing the bacteria in their laboratory, they chose one representative species, and performed a complete genome sequence analysis that could hold clues into how the slow and damaging microlesions form.
An expert team from Case Western Reserve University School of Medicine has received a five-year, $3.6 million grant from the National Institutes of Health for diagnosing Parkinson's disease via an innovative skin testing approach.
Research at Case Western Reserve University sheds new light on how mosquitoes behave and spread disease, adding to evidence that the insects responsible for millions of deaths per year are much more prolific biters than previously thought.
A nurse scientist at Case Western Reserve University is further expanding her research on aging-related health challenges increasingly faced by people living longer with HIV-AIDS.
Charles Rosenblatt, professor of Physics and Macromolecular Science and holder of the Ohio Eminent Scholar endowed chair at Case Western Reserve, was recently awarded a three-year, $497,000 NSF grant for a project entitled "Liquid Crystals as a Paradigm for Chirality and Topological Defects.”
New research at the School of Dental Medicine at Case Western Reserve University looks to change the strategy in identifying seniors’ perception of oral health issues. The idea is to find a correlation between seniors who value dental care and those who seek it out, despite the cost, transportation to appointments and other common barriers.
State spending on transitional housing supports for youth “aging out” of foster care can make a big difference in preventing homelessness, incarceration, substance abuse and early childbirth, according to a new study by social work researchers at Case Western Reserve University.
The brains of potential investors are wired to pay closer attention to entrepreneurs who pitch with passion, according to new research from Case Western Reserve University.
Investigators at Case Western Reserve University School of Medicine, the Case Comprehensive Cancer Center and University Hospitals Cleveland Medical Center developed the test for early detection of Barrett’s esophagus that offers promise for preventing deaths from esophageal adenocarcinoma.
A new study looking at incidence of disease data nationwide from 2000 to 2016 found a shift in obesity-associated cancers (OACs) to younger individuals. Typically, these cancers are diagnosed at higher rates among people older than 65. The most notable findings pertain to increases in these OACs among non-Hispanic Black and Hispanic women and men for whom certain cancers increased by 200-400%.
With a $2.14 million grant from the National Cancer Institute (NCI), researchers from the Frances Payne Bolton School of Nursing at Case Western Reserve University will measure whether an approach that uses simulation or experiential learning can affectively teach family caregivers not only the skills to take better care of their patient, but better care of their own emotional and physical health amid such incredible stress.
The National Academy of Inventors (NAI) has named 54 academic inventors to the Spring 2019 class of NAI Senior Members, including Stanton L. Gerson, MD, Director of the Case Comprehensive Cancer Center (Case CCC).
There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of the disease in its acute phase and managing it in remission. But recently, researchers at Case Western Reserve University School of Medicine identified a pathway in the immune system activated in CD and which holds promise for investigating new treatments.
Wenquan Zou, MD, PhD, an expert in prion and degenerative neurological diseases, has received a two-year grant for developing diagnostic tools for Alzheimer’s disease, Parkinson’s disease, and other related brain-based degenerative disorders via an innovative skin test that uses ultrasensitive technology. The new test is much less invasive than evaluating brain tissue, which is the only approach for making a definitive diagnosis today.
Within four hours of a traumatic experience, certain physiological markers—namely, sweating—are higher in people who go on to develop posttraumatic stress disorder (PTSD), according to a new study.
Convelo Therapeutics Inc., a Cleveland company based on the research findings of Paul Tesar and Drew Adams at the Case Western Reserve University School of Medicine, has entered into a strategic partnership with Genentech to develop new therapeutic drugs to repair damaged myelin insulation on nerve cells for patients suffering from neurological disorders such as multiple sclerosis.
The study examined the effects of this technique in a small experimental research study involving 28 preschool-aged children with autism and their parents in Saudi Arabia.
Researchers from Case Western Reserve University School of Medicine have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to draw natural killer immune cells to cancer cells.
Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease. Now, to learn precisely how that fungus interacts with bacteria to trigger CD, Ghannoum has received a five-year, $3M grant from the National Institutes of Health. His investigation will involve innovative molecular and cellular technologies, to delete specific genes in the fungus and note the effects on the inflammation that is a marker for CD using powerful microscopic analysis.
Denaturalization is the revocation of a naturalized immigrant’s U.S. citizenship by the federal government. The practice is becoming more common under the Trump administration.
A new study using a special type of electron microscope using samples cooled to extremely cold temperatures provides critical information for drug developers seeking to reduce nausea and vomiting side effects of cancer treatments.
Riley Tedrow, PhD, a medical entomologist at Case Western Reserve University School of Medicine, has uncovered new findings about malaria transmission in Madagascar. In a recent study published in PLoS Neglected Tropical Diseases, he also describes real-world application of an effective mosquito surveillance strategy using low cost traps and a recently reported tool that simultaneously tests each mosquito for its species, what it fed on, and the presence of malaria parasites.
Case Western Reserve University faculty members have received a two-year grant to provide regulatory recommendations for gene-editing research conducted in non-traditional settings. The aim of this $160,000 grant from the National Human Genome Research Institute at the National Institutes of Health is to protect the public while encouraging creativity and innovation that could benefit many people.
In a recent Journal of Infectious Diseases study, investigators showed using two antibiotic drugs to fight P. aeruginosa in mouse models was significantly more effective than either antibiotic alone. The antibiotics were ceftazidime-avibactam
Not all burning mouths are the result of a medical condition known as “burning mouth syndrome” (BMS) and physicians and researchers need better standards for an appropriate diagnosis, according to new research at the School of Dental Medicine at Case Western Reserve University.
Researchers at Case Western Reserve University have successfully prevented epileptic seizures in animal models by pre-emptively directing a low-frequency stimulus to the nerve fibers in the brain.
The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes.
An Ohio biologist and partners at universities from three different African countries assert that the hardy-but-humble Marama bean could someday rise up as a new alternative crop in the often-arid climates of developing countries, while its drought- and pest-resistant properties may also be able to be transferred to other plant species in need of protection against climate change.
Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout the body—but a recent study shows what happens next. In results published in Cell, researchers outline the timeline of events, including precisely when and how different parts of a GPCR interacts with its G protein signaling partners. The findings provide new insights into the fundamental mechanisms of drug-induced signaling in cells, including ways to identify the most critical portions of GPCRs for targeting development of novel therapeutics.
Why is music composed according to so many rules? Why do we organize sounds in this way to create music? To address that question, a Cleveland, Ohio, physics professor borrows methods from a related question: ‘How do atoms in a random gas or liquid come together to form a particular crystal?” Professor Jesse Berezovsky at Case Western Reserve University contends that “phase transitions” in physics--and music--come about because of a balance between order and disorder, or entropy.
Case Comprehensive Cancer Center has been selected, once again, as a Lead Academic Participating Site by the National Cancer Institute. The renewal comes with a six-year, $8.9 million grant that will enable the center to provide patients with additional access to clinical trials through the National Clinical Trials Network. In this renewal, NCI is committed to improving the resources provided for each patient to cover research costs at levels linked to the complexity of the clinical trial.
Case Western Reserve University researchers and partners, including a collaborator at Cleveland Clinic, are pushing the boundaries of how “smart” diagnostic-imaging machines identify cancers—and uncovering clues outside the tumor to tell whether a patient will respond well to chemotherapy.
The brain is more resilient than previously thought. In a groundbreaking experiment published in this week’s issue of Nature, neuroscientists created an artificial circulation system that successfully restored some functions and structures in donated pig brains—up to four hours after the pigs were butchered at a USDA food processing facility. Though there was no evidence of restored consciousness, brains from the pigs were without oxygen for hours, yet could still support key functions provided by the artificial system. The result challenges the notion that mammalian brains are fully and irreversibly damaged by a lack of oxygen.
The latest social robots can "read" our emotions in real-time, setting up applications in health care, particularly mental health.
Probiotics typically aim to rebalance bacteria populations in the gut, but new research suggests they may also help break apart stubborn biofilms. Biofilms are living microbial communities—they provide a haven for microbes and are often resistant to antibiotics. A new study describes a specific probiotic mix that could help patients with gastrointestinal diseases avoid harmful biofilms that can worsen their symptoms.
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