UCLA Study Finds Strategy to Degrade a Key Cancer Cell-Surface Protein to Invigorate Immune Attack on Tumors
University of California, Los Angeles (UCLA), Health SciencesOne powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.