The new vaccine was found to be effective against the two most common forms of herpes that cause cold sores (HSV-1) and genital ulcers (HSV-2). Both are known to infect the body’s nerve cells, where the virus can lay dormant for years before symptoms reappear. The new vaccine is the first to prevent this type of latent infection.
Scientists at Janelia Research Campus have identified a neural circuit that connects motor planning to movement.
A new tool developed at the Howard Hughes Medical Institute's Janelia Research Campus lets scientists shine a light on an animal's brain to permanently mark neurons that are active at a particular time. The tool -- a fluorescent protein called CaMPARI that was developed at Janelia -- converts from green to red when calcium floods a nerve cell after the cell fires. The permanent mark frees scientists from the need to focus a microscope on the right cells at the right time to observe neuronal activity.
Howard Hughes Medical Institute scientists have identified a circuit in the brains of mice that regulates thirst. When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully hydrated. A second set of cells suppresses the urge to drink.
A team of researchers at the Howard Hughes Medical Institute’s Janelia Research Campus has won first prize in the 2014 Olympus BioScapes Digital Imaging Competition for their video that captures the early development of a fruit fly embryo.
Researchers at HHMI's Janelia Research Campus have used motion-capture technology to reveal new insight into the sophisticated information processing and acrobatic skills of dragonflies on the hunt.
A new imaging platform developed by Eric Betzig and colleagues at the Howard Hughes Medical Institute's Janelia Research Campus offers another leap forward for light microscopy. The new technology collects high-resolution images rapidly and minimizes damage to cells, meaning it can image the three-dimensional activity of molecules, cells, and embryos in fine detail over longer periods than was previously possible. Betzig was one of three scientists who shared the 2014 Nobel Prize in Chemistry earlier this month.
Scientists at the Howard Hughes Medical Institute's Janelia Research Campus have shown that the brain can temporarily disconnect information about past experience from decision-making circuits, thereby triggering random behavior.
New studies of ancient DNA are shifting scientists' ideas of how groups of people migrated across the globe and interacted with one another thousands of years ago. By comparing nine ancient genomes to those of modern humans, Howard Hughes Medical Institute (HHMI) scientists have shown that previously unrecognized groups contributed to the genetic mix now present in most modern-day Europeans.
By manipulating neural circuits in the brain of mice, scientists have altered the emotional associations of specific memories. The research, led by Howard Hughes Medical Institute investigator Susumu Tonegawa at the Massachusetts Institute of Technology (MIT), reveals that the connections between the part of the brain that stores contextual information about an experience and the part of the brain that stores the emotional memory of that experience are malleable.
The Howard Hughes Medical Institute awards nearly $5 million in research fellowships to 46 predoctoral students from 24 countries.
New technologies for monitoring brain activity are generating unprecedented quantities of information. That data may hold new insights into how the brain works – but only if researchers can interpret it. To help make sense of the data, neuroscientists can now harness the power of distributed computing with Thunder, a library of tools developed at the Howard Hughes Medical Institute's Janelia Research Campus. Thunder speeds the analysis of data sets that are so large and complex they would take days or weeks to analyze on a single workstation – if a single workstation could do it at all. Janelia group leaders Jeremy Freeman, Misha Ahrens, and other colleagues at Janelia and the University of California, Berkeley, report in the July 27, 2014, issue of the journal Nature Methods that they have used Thunder to quickly find patterns in high-resolution images collected from the brains of active zebrafish and mice with multiple imaging techniques.
Researchers at the Howard Hughes Medical Institute’s Janelia Research Campus have developed a new computational method that can rapidly track the three-dimensional movements of cells in such data-rich images. Using the method, the Janelia scientists can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.
The Howard Hughes Medical Institute (HHMI) announced today that 15 leading scientist-educators have been named HHMI professors. Each will receive $1 million over five years to create activities that integrate their research with student learning in ways that enhance undergraduate students’ understanding of science.
The Howard Hughes Medical Institute (HHMI) and the Gordon and Betty Moore Foundation (GBMF) announced the establishment of an Advanced Imaging Center at HHMI’s Janelia Research Campus that will make leading-edge imaging technologies more widely available to the scientific community before the instruments are available commercially.
Every millisecond counts when a fruit fly is being hunted by a damselfly. Janelia scientists find that fruit flies can deploy two escape behaviors, depending on circumstances.
A single-letter change in the genetic code is enough to generate blond hair in humans, in dramatic contrast to our dark-haired ancestors. A new analysis by Howard Hughes Medical Institute (HHMI) scientists has pinpointed that change, which is common in the genomes of Northern Europeans, and shown how it fine-tunes the regulation of an essential gene.
Can the nationally acclaimed Meyerhoff Scholars Program, which has an unparalleled record of advancing diversity in the sciences, be adapted successfully at more universities? That question is at the heart of a new partnership, the Meyerhoff Adaptation Project, between the University of Maryland, Baltimore County (UMBC), the Pennsylvania State University, the University of North Carolina at Chapel Hill (UNC), and the Howard Hughes Medical Institute (HHMI).
Howard Hughes Medical Institute (HHMI) scientists have used an analysis of channelrhodopsin’s molecular structure to guide a series of genetic mutations to the ion channel that grant the power to silence neurons with an unprecedented level of control.
Seventy of the nation’s top medical and veterinary students have been selected to participate in the 26th class of the HHMI Medical Research Fellows Program, a $2.8 million annual initiative to increase the training of future physician-scientists. The students will put their medical studies on-hold for one year to conduct intensive, mentored biomedical research at 32 fellowship institutions across the country.
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