Embargoed for Release Until: Sunday, November 2, 1997, 6:00 p.m. Contact: Marie Kendra Tehonica (202) 973-1361
Potential Complications from Common Pain Relievers More Likely in the Elderly
November 2, 1997, Chicago, IL -- The use of non-steroidal anti-inflammatory drugs among the elderly is associated with significant complications of gastroesophageal reflux disease, including peptic stricture, a narrowing or obstruction of the esophagus which can result from chronic acid injury and scarring of the lower esophagus, according to a study at the Emory University Swallowing Center presented at the 62nd Annual Scientific Meeting of the American College of Gastroenterology in Chicago.
A research team lead by gastroenterologist J. Patrick Waring, MD studied the relationship between age and complications of chronic acid reflux in a cohort of 79 individuals referred for endoscopic examination for suspected gastroesophageal reflux disease. Patients were considered NSAID users if they were taking low-dose aspirin, or prescription or over-the-counter NSAIDS, more than twice a week for the previous six months. Patients over 65 were considered elderly.
Findings from endoscopic examination revealed that 28 patients had esophageal stricture, and 5 experienced an narrowing of the esophagus called Schatzki's ring. Peptic stricture was significantly more common in elderly patients, and there was a greater likelihood of strictures in patients who took NSAIDS. Statistical analysis showed that the association of peptic strictures with NSAIDS use was stronger than with the patient's age.
Peptic strictures are among the serious complications that can occur when acid reflux disease is not treated. Others include severe chest pain that can mimic a heart attack, bleeding, or a pre-malignant change in the lining of the esophagus called Barrett's esophagus. Symptoms suggesting that serious damage may have already occurred include:
Dysphagia: a difficulty swallowing or a feeling that food is trapped behind the breast bone.
Bleeding: vomiting blood, or having tarry, black bowel movements.
Choking: the sensation of acid refluxed into the windpipe causing shortness of breath, coughing, hoarseness of the voice.
Weight Loss
Patients with peptic stricture complain of food sticking in the lower esophagus. Heartburn symptoms may actually lessen as the esophageal opening narrows down preventing acid reflux. Stretching of the esophagus (a procedure called dilation) and prescription medication are needed to control and prevent peptic strictures.
# # #
The ACG was formed in 1932 to advance the scientific study and medical treatment of disorders of the gastrointestinal tract. The College promotes the highest standards in medical education and is guided by its commitment to meeting the needs of clinical gastroenterology practitioners.
RSS