A first-of-its-kind study of gene therapy in the treatment of Parkinson’s disease determined that half of all patients who received the treatment had “clinically meaningful improvements” of their symptoms within six months of surgery, says study lead author and co-principal investigator Peter LeWitt, M.D.
A multi-center gene therapy trial for patients with advanced Parkinson’s disease demonstrated reduced symptoms of the progressive movement disorder, according to a new study published in Lancet Neurology.
It is no surprise to scientists that the largest social network on the web is called Facebook. Identifying people by their face is fundamental to our social interactions, one of the primary reasons vision researchers are trying to find out how our brain processes facial identity. In a study recently published in the Journal of Vision, scientists used an original approach — a method that “shakes” the brain gently and repeatedly by making an image appear and disappear at a constant rate — to evaluate its sensitivity to perceiving facial identity. The technique is called steady-state visual evoked potential (SSVEP).
Dr. Olivier Collignon of the University of Montreal’s Saint-Justine Hospital Research Centre compared the brain activity of people who can see and people who were born blind, and discovered that the part of the brain that normally works with our eyes to process vision and space perception can actually rewire itself to process sound information instead.
A 65-year-old woman with Parkinson’s disease became the first patient in the United States to receive a new device for deep brain stimulation (DBS) therapy.
Researchers at Missouri University of Science and Technology are trying to get proteins to create the sticky plaque often associated with neurological diseases like Alzheimer’s, Parkinson’s and even Mad Cow. If successful, the study would better equip researchers to prevent or find a cure for these diseases.
A new center combining academic research with the treatment of adults with Down syndrome – one of the first in the country – has opened at the University of California, San Diego School of Medicine. A primary focus of the new Down Syndrome Center for Research and Treatment (DSCRT) will be investigating the connection between Down syndrome and Alzheimer’s disease.
People who have a stroke are more likely to be dependent if they are depressed, older or have other medical problems, according to a study published in the March 15, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Proteins in fluids bathing the brain are essential for building the brain, discover scientists in a report published March 10 in the journal Neuron. The finding promises to advance research related to neurological disease, cancer and stem cells.
Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at (UTHealth) published in Neurosurgery.
A light-sensing receptor that’s packed inside the eye’s photoreceptor cells has an altogether surprising role in cells elsewhere in the body, Johns Hopkins scientists have discovered. Using fruit flies, they showed that this protein, called rhodopsin, also is critical for sensing temperature.
Neena Singh, MD, PhD and colleagues at Case Western Reserve University School of Medicine have identified the first disease-specific biomarker for sporadic Creutzfeldt-Jakob disease (sCJD), a universally fatal, degenerative brain disease for which there is no cure.
Just when children are faced with intensifying peer pressure to misbehave, regions of the brain are actually blossoming in a way that heighten the ability to resist risky behavior, report researchers at three West Coast institutions.
A devastating vascular disorder of the brain called CADASIL, which strikes young adults and leads to early dementia, often is misdiagnosed as multiple sclerosis, Loyola University Health System researchers report.
Patients with epilepsy worry more than their physicians do about the patients’ potential memory loss accompanying their seizure disorder, according to a recent study.
Stroke survivors who have an irregular heartbeat called atrial fibrillation may be at higher risk of developing dementia than stroke survivors who do not have the heart condition, according to research published in the March 8, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Scientists have blocked harmful immune cells from entering the brain in mice with a condition similar to multiple sclerosis (MS). The disease is believed to be caused by immune cells that enter the brain and damage myelin, an insulating material on the branches of neurons that conduct nerve impulses.
All our daily activities, from driving to work to solving a crossword puzzle, depend on signals carried along the body's vast network of neurons. Propagation of these signals is, in turn, dependent on myriad small molecules within nerve cells -- receptors, ion channels, and transmitters -- turning on and off in complex cascades. Until recently, the study of these molecules in real time has not been possible, but researchers at the University of California at Berkeley and the University of Munich have attached light-sensing modules to neuronal molecules, resulting in molecules that can be turned on and off with simple flashes of light.
Amyotrophic lateral sclerosis, known as ALS or Lou Gehrig’s disease, is a notorious neurodegenerative condition characterized by the progressive deterioration of brain and spinal cord neurons, resulting in the gradual but catastrophic loss of muscle control and ultimately, death. In a paper, published in the journal Nature Neuroscience, a team of scientists at the UCSD School of Medicine and colleagues describe the profound and pervasive role of a key protein in ALS pathology called TDP-43.
Researchers from Mount Sinai School of Medicine have found that lactate, a type of energy fuel in the brain, plays a critical role in the formation of long-term memory. These findings have important implications for common illnesses like Alzheimer’s disease, other neurodegenerative disorders, aging-related memory impairment and diabetes. The research is published in the March 4th issue of the journal Cell.
The burning, tingling pain of neuropathy may affect feet and hands before other body parts because the powerhouses of nerve cells that supply the extremities age and become dysfunctional as they complete the long journey to these areas, Johns Hopkins scientists suggest in a new study. The finding may eventually lead to new ways to fight neuropathy, a condition that often accompanies other diseases including HIV/AIDS, diabetes and circulatory disorders.
Unexpected results from a Scripps Research Institute and ModGene, LLC study could completely alter scientists’ ideas about Alzheimer’s disease—pointing to the liver instead of the brain as the source of the “amyloid” that deposits as brain plaques associated with this devastating condition. The findings could offer a relatively simple approach for Alzheimer’s prevention and treatment.
Mobility is a challenge for spinal cord injured patients. Infection is another. Adam Thrasher, assistant professor of health and human performance (HHP), says infection is the leading cause of death for people living with spinal cord injuries for two years or more. He and HHP colleague Richard Simpson are investigating why the immune system is blunted after a spinal cord injury.
Johns Hopkins scientists have discovered that PARIS — the protein — facilitates the most common form of Parkinson’s disease (PD), which affects about 1 million older Americans. The findings of their study, published March 4 in Cell, could lead to important new targets for treatment.
New research suggests that ibuprofen may offer protection against developing Parkinson’s disease, according to one of the largest studies to date investigating the possible benefits of the over-the-counter drug on the disease. The study is published in the March 2, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A retrovirus that inserted itself into the human genome thousands of years ago may be responsible for some cases of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), also known as Lou Gherig’s disease. The finding, made by Johns Hopkins scientists, may eventually give researchers a new way to attack this universally fatal condition.
An experimental drug that targets a brain system that controls inflammation might help preserve neurological function in people who survive sudden cardiac arrest, new research suggests.
Researchers at UT Southwestern Medical Center have identified a signaling pathway in the brain that’s sufficient to induce cellular leptin resistance, a problem that decreases the body’s ability to “hear” that it is full and should stop eating.
New research confirms that the genetic roots of autism are highly complicated, but that common biological themes underlie this complexity. Autism-related genes play key roles in synaptic function and neurotransmission.
For children with severe traumatic brain injury (TBI), transplantation of stem cells derived from the patients' own bone marrow is a "logistically feasible and safe" treatment procedure, reports the March issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.
Results from a new study contribute to growing evidence that if one of your parents has Alzheimer’s disease, the chances of inheriting it from your mother are higher than from your father. The study is published in the March 1, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers at the University of California, San Diego School of Medicine, led by Jeffrey D. Esko, PhD, professor in the Department of Cellular and Molecular Medicine, describe the build-up of a novel secondary metabolite in Sanfilippo disease, a discovery that could improve understanding of the pathology of Sanfilippo disease and refine diagnostic techniques.
Anumantha Kanthasamy of ISU's College of Veterinary Medicine has discovered a protein pathway that may hold the secret to understanding Parkinson's disease. He has been working to understand the complex mechanisms of the disease for more than a decade and believes this recent discovery offers hope for the cure.
The American Academy of Neurology Foundation is hosting the first Brain Health Fair on Saturday, April 9, 2011, at the Hilton Hawaiian Village in Honolulu, from 10:00 a.m. to 4:00 p.m. Free registration is open to the public now at http://www.brainhealthfair.com.
Using a sophisticated imaging test to probe for higher-level cognitive functioning in severely brain-injured patients provides a window into consciousness -- but the view it presents is one that is blurred in fascinating ways, say researchers at Weill Cornell Medical College in the Feb. 25 online edition of the journal Brain.
New research shows that Alzheimer’s disease and other dementing illnesses may be easily misdiagnosed in the elderly, according to early results of a study of people in Hawaii who had their brains autopsied after death. The research is being released today and will be presented as part of a plenary session at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
People who speak more than two languages may lower their risk of developing memory problems, according a study released today that will be presented at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
Lack of brain tumor epidemic does not prove safety of cell phones; warning labels needed.
The video entries for the 2011 Neuro Film FestivalSM are in and the public can now begin voting on its “Fan Favorite” video through March 8, 2011. Neuro Film Festival is a contest hosted by the American Academy of Neurology Foundation to help raise awareness through video about brain disorders and the need to support research into preventions, treatments and cures. To view and vote for your favorite video in the Neuro Film Festival contest, visit http://www.neurofilmfestival.com.
Mothers who are depressed respond differently to their crying babies than do non-depressed moms. In fact, their reaction, according to brain scans at the University of Oregon, is much more muted than the robust brain activity in non-depressed moms.
Mayo Clinic was awarded the Gold Seal of Approval for stroke care and re-accredited as an Advanced Primary Stroke Center by The Joint Commission (TJC) following an on-site review conducted Friday, Feb. 18.
Middle-age men and women who have cardiovascular issues, such as high cholesterol and high blood pressure, may not only be at risk for heart disease, but for an increased risk of developing early cognitive and memory problems as well. That’s according to a study released today that will be presented at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
The current focus on medical errors isn’t quite as new as it seems. A Johns Hopkins review of groundbreaking neurosurgeon Harvey Cushing’s notes, made at the turn of the last century, has turned up copious documentation of his own surgical mishaps as well as his suggestions for preventing those mistakes in the future.
New research shows people who have used amphetamines such as benzedrine and dexedrine appear to be at an increased risk of developing Parkinson’s disease, according to a study released today that will be presented at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
Many people want to keep driving after having a stroke, and many can do so safely. Simple tests in the office can help doctors determine who is more likely to be a safe driver after a stroke, according to research published in the February 22, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Mayo Clinic researchers confirmed that patients who receive therapeutic hypothermia after resuscitation from cardiac arrest have favorable chances of surviving the event and recovering good functional status. In therapeutic hypothermia, a patient’s body temperature is cooled to 33 degrees Celsius following resuscitation from cardiac arrest, in order to slow the brain’s metabolism and protect the brain against the damage initiated by the lack of blood flow and oxygenation. This study was published in the December 2010 issue of Annals of Neurology.
Neurosurgeon Lee Eric Tessler, MD is among the first in NY to use a new hand-held CO2 laser for surgeries on tumors buried deep within the base of the skull. The laser allows surgeons to remove these difficult-to-reach tumors in less time, with lower risk of complications, less anesthesia and a smaller possibility of damage to healthy tissue.
People with multiple sclerosis (MS) may find it harder to learn, remember or process information on warmer days of the year, according to new research released today that will be presented at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
Severe head trauma is the most frequent cause of death and severe disability in skiers and snowboarders and accounts for about 15 percent of all skiing and snowboarding related injuries. Although helmet use is apparently increasing, it remains far from universal. A compelling clinical article published online in the March 2011 issue of Journal of Neurosurgery: Pediatrics discusses skull fractures incurred by young skiers and snowboarders and the role helmets play in reducing these head injuries.
Native Hawaiians and Pacific Islanders may be at higher risk for hemorrhagic stroke at a younger age and more likely to have diabetes compared to other ethnicities, according to a study released today that will be presented at the American Academy of Neurology’s 63rd Annual Meeting in Honolulu April 9 to April 16, 2011.
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