Scientists at Washington University School of Medicine in St. Louis have taken one of the first detailed looks into how Alzheimer’s disease disrupts coordination among several of the brain’s networks.
An enzyme that could represent a powerful new tool for combating Alzheimer’s disease has been discovered by researchers at Mayo Clinic in Florida.
Surgery causes a lasting increase in Alzheimer’s pathology in AD mice, via transient activation of brain inflammation. There was a clear and persistent decrement in learning and memory caused by surgery as compared with inhalational anesthesia – but only in the context of a brain made vulnerable by human Alzheimer-associated transgenes.
This week, a strategic roadmap to help to the nation’s health care system cope with the impending public health crisis caused Alzheimer’s disease and related dementia will be published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. The plan aims to link the latest scientific findings with clinical care and bring together patients, families, scientists, pharmaceutical companies, regulatory agencies, and advocacy organizations behind a common set of prioritized goals. The consensus document is the outcome of a June meeting of leading Alzheimer's researchers, advocates and clinicians, who gathered as part of the Marian S. Ware Alzheimer Program at the University of Pennsylvania.
New research shows that professional football players may be at a higher risk of death from diseases that damage the cells in the brain, such as Alzheimer’s disease and ALS (also known as Lou Gehrig’s disease), compared to the general U.S. population. The study is published in the September 5, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Sleep disruptions may be among the earliest indicators of Alzheimer’s disease, scientists at Washington University School of Medicine in St. Louis report Sept. 5 in Science Translational Medicine.
Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer's disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to this form of dementia.
People whose blood sugar is on the high end of the normal range may be at greater risk of brain shrinkage that occurs with aging and diseases such as dementia, according to new research published in the September 4, 2012, print issue of Neurology®, the medical journal of the American Academy of Neurology.
People who are obese and also have high blood pressure and other risk factors called metabolic abnormalities may experience a faster decline in their cognitive skills over time than others, according to a study published in the August 21, 2012, print issue of Neurology®, the medical journal of the American Academy of Neurology.
People who are free of dementia and have high levels of a protein that indicates the presence of inflammation have relatives who are more likely to avoid the disease as well, according to a new study published in the August 15, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Latrepirdine, which failed in U. S. Clinical trials of alzheimer’s disease, is showing new potential in an animal model.
UCLA researchers found that older adults who regularly used a brain fitness program played on a computer demonstrated significantly improved memory and language skills.
The greatest risk factor for Alzheimer’s disease (AD) is advancing age. By age 85, the likelihood of developing the dreaded neurological disorder is roughly 50 percent. But researchers at the University of California, San Diego School of Medicine say AD hits hardest among the “younger elderly” – people in their 60s and 70s – who show faster rates of brain tissue loss and cognitive decline than AD patients 80 years and older.
The physical benefits of the Olympic sports are pretty obvious: strength, endurance and agility, to name a few. But did you know they also can help the brain? Mayo Clinic research shows that any exercise that gets the heart pumping may reduce the risk of dementia and mild cognitive impairment -- and slow those conditions if they start. Aerobic exercise also can boost your mood.
An international team of scientists led by researchers at Mount Sinai School Medicine have discovered that a drug that had previously yielded conflicting results in clinical trials for Alzheimer’s disease effectively stopped the progression of memory deterioration and brain pathology in mouse models of early stage Alzheimer’s disease.
Jianhua Xing, a Virginia Tech assistant professor of biology, and his colleagues recommend further study of how rope-like polymers called microtubules function. They computational comparations of two models of microtubules, a component of cell cytoskeletons.
A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer’s disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can disrupt proteins that regulate an enzyme associated with Alzheimer’s. The paper, published in The Journal of Neuroscience, identifies the complex mechanisms that result in a rapid and robust post-injury elevation of the enzyme in the brain.
Experts from the Comprehensive Center on Brain Aging at NYU Langone Medical Center will present new research at The 2012 Alzheimer’s Association International Conference on Alzheimer’s Disease to be held in Vancouver, British Columbia, Canada, July 14 – July 19.
Problems walking including slow gait and a short stride are associated with an increased risk of cognitive decline, Mayo Clinic researchers have discovered.
Higher levels of a certain fat in the blood called ceramides may increase a person’s risk of developing Alzheimer’s disease, according to a study published in the July 18, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Researchers have provided direct experimental evidence linking diabetes to the onset of Alzheimer’s disease. The study also identified an experimental model that could become an important new tool for AD research.
Metabolic syndrome, a term used to describe a combination of risk factors that often lead to heart disease and type 2 diabetes, seems to be linked to lower blood flow to the brain, according to research by the University of Wisconsin School of Medicine and Public Health.
Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center found that people with a form of mild cognitive impairment (MCI), a risk factor for developing Alzheimer’s disease, have twice the risk of dying compared with cognitively normal people. Those with dementia have three times the risk. The findings are being presented at the Alzheimer’s Association International Conference in Vancouver this week.
Activity lingers longer in certain areas of the brain in those with Alzheimer’s than it does in healthy people, Mayo Clinic researchers who created a map of the brain found. The results suggest varying brain activity may reduce the risk of Alzheimer’s disease. The study, “Non-stationarity in the “Resting Brain’s” Modular Architecture,” was presented at the Alzheimer’s Association International Conference and recently published in the journal PLoS One.
Scientists have assembled the most detailed chronology to date of the human brain’s long, slow slide into full-blown Alzheimer’s disease.
Dangers of seniors wandering off and getting lost can often end in tragedy and appear to be more common as evident by the steady announcements of Silver Alerts, similar to Amber Alerts for missing children, across the country. The problem is so widespread that understanding why seniors wander could help keep them safe and avoid tragic consequences, say geriatric experts from the Harris County Hospital District.
CIHR experts available to discuss the scientific basis behind the disease
In light of the Alzheimer’s Association International Conference taking place in Vancouver next July, CIHR wants to give reporters all the background information they need about the state of Alzheimer’s research.
Modern anesthesia is extremely safe. But as risks to heart, lungs and other organs have waned, another problem has emerged in the elderly: post-operative cognitive dysfunction. Mentally, some patients “just aren’t the same” for months or longer after surgery. Other factors play a role, but a small number of patients deteriorate mentally due to anesthesia per se. Those with Alzheimer’s disease suffer exacerbations, and those without the diagnosis may have it unmasked by anesthesia, suggesting some relationship.
Preventing diabetes or delaying its onset has been thought to stave off cognitive decline -- a connection strongly supported by the results of a 9-year study led by researchers at the University of California, San Francisco (UCSF) and the San Francisco VA Medical Center.
The Mount Sinai Medical Center is the first institution in New York State to use in the clinical setting a newly approved imaging technique to detect Alzheimer’s disease (AD) in people who are cognitively impaired. Until now, physicians have been limited in their ability to diagnose AD, guided almost exclusively by a patient’s mental and behavioral symptoms and family history.
Q&A with Glenn E. Smith, PhD.
In a new study published in PLoS Biology this week researchers address an urgent need to find ways to promote beneficial amyloid fiber assembly or to reverse its pathogenic assembly, at will.
Research published in the Genetics Society of America’s June 2012 issue of the journal GENETICS suggests a gene related to Alzheimer’s disease is also involved in the insulin pathway, which may explain the link between Alzheimer’s and diabetes.
A new study shows that changes in walking speed in late life may signal the early stages of dementia known as mild cognitive impairment (MCI). The research is published in the June 12, 2012, print issue of Neurology®, the medical journal of the American Academy of Neurology.
The Lewy Body Dementia Association (LBDA) launched its nationwide October awareness movement, “A Month To Remember.” LBDA invites volunteers to join the movement by “Standing Strong with LBDA” to build awareness for Lewy body dementia in their communities.
The molecular structure of a protein involved in Alzheimer’s disease – and the surprising discovery that it binds cholesterol – could lead to new therapeutics for the disease, Vanderbilt University investigators report in the June 1 issue of the journal Science.
Research demonstrates how dying or damaged brain cells give rise to autoantibodies in blood that can be reliable biomarkers for early AD diagnosis. Key mechanism mirrors process common to autoimmune disorders.
Exposure to solvents at work may be associated with reduced thinking skills later in life for those who have less than a high school education, according to a study published in the May 29, 2012, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Not only is it safe for people with asthma to exercise, but doing so could reduce their risk of asthma symptoms or attacks, according to a new evidence review in The Cochrane Library.
Research suggests a new approach to improving memory and interrupting disease progression in patients with a form of cognitive impairment that often leads to full-blown Alzheimer’s disease.
Depressive symptoms that are present in midlife or in late life are associated with an increased risk of developing dementia, according to a report in the May issue of Archives of General Psychiatry, a JAMA Network publication.
Greater purpose in life may help stave off the harmful effects of plaques and tangles associated with Alzheimer’s disease, according to a new study by researchers at Rush University Medical Center.
A study on a handful of people with suspected mild Alzheimer’s disease (AD) suggests that a device that sends continuous electrical impulses to specific “memory” regions of the brain appears to increase neuronal activity. Results of the study using deep brain stimulation, a therapy already used in some patients with Parkinson’s disease and depression, may offer hope for at least some with AD, an intractable disease with no cure.
Current research does not support the use of smell tests for predicting Alzheimer’s dementia, according to a comprehensive review.
A new study suggests that eating foods that contain omega-3 fatty acids, such as fish, chicken, salad dressing and nuts, may be associated with lower blood levels of a protein related to Alzheimer’s disease and memory problems. The research is published in the May 2, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A highly toxic beta-amyloid – a protein that exists in the brains of Alzheimer's disease victims – has been found to greatly increase the toxicity of other more common and less toxic beta-amyloids, serving as a possible "trigger" for the advent and development of Alzheimer's, researchers at the University of Virginia and German biotech company Probiodrug have discovered.
Scientists now have a better understanding of how precise memories are formed thanks to research led by Prof. Jean-Claude Lacaille of the University of Montreal’s Department of Physiology. “In terms of human applications, these findings could help us to better understand memory impairments in neurodegenerative disorders like Alzheimer's disease,” Lacaille said. The study looks at the cells in our brains, or neurons, and how they work together as a group to form memories.
Mount Sinai School of Medicine researchers have succeeded in developing a biosynthetic polyphenol that improves cognitive function in mice with Alzheimer’s disease (AD). The findings, published in a recent issue of the Journal of Neuroscience, provide insight in determining the feasibility of biosynthetic polyphenols as a possible therapy for AD in humans, a progressive neurodegenerative disease for which there is currently no cure.
Researchers at Mount Sinai School of Medicine have gained insight into the mechanism by which a pathological brain protein called tau contributes to the progression of Alzheimer’s disease (AD) and other neurodegenerative disorders. This finding, published in the most recent issue of the Journal of Biological Chemistry, may provide the basis for future investigations on how to prevent tau from damaging brain circuits involved in cognitive function.
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