Researchers in the Biomedical Engineering Department at UConn have developed a new cardiac cell-derived platform that closely mimics the human heart, unlocking potential for more thorough preclinical drug development and testing, and model for cardiac diseases.
Today, the US Department of Health and Human Services (HHS) and the American Society of Nephrology (ASN) announced a new prize competition from the Kidney Innovation Accelerator (KidneyX) that seeks to further the development of a fully functional bioartificial kidney.
Researchers and entrepreneurs have developed an implant made of collagen protein from pig’s skin, which resembles the human cornea.
Jianjun Cheng, Daxiong Zeng, Ting Zhang, Lu Zhang, Xiu Han, Peng Zhou, Lin Wang, Jun He, Qingzhen Han
Pasquale Nigro, Maria Vamvini, Jiekun Jackie Yang, Tiziana Caputo, Li-Lun Ho, Danae Papadopoulos, Nicholas Philip Carbone, Royce Colin, Jie He, Hirshman Frederick Michael, Joseph Daniel White, Jacques Robidoux, Robert Hickner, Soeren
Jiansheng Gao, Yuli Liang, Jiabao Chen, Huihui Shen, Hua Liu
Melis Asal, Gamze Koçak, Vedat Sarı, Tuba Reçber, Emirhan Nemutlu, Canan Aslı Utine, Sinan Guven
Malte Loos, Birgit Klampe, Thomas Schulze, Xiaoke Yin, Konstantinos Theofilatos, Bärbel Ulmer, Carl Schulz, Charlotta Behrens, Tessa Van Bergen, Eleonora Adami, Henrike Maatz, Michaela Schweizer, Susanne Brodesser, Boris Skryabin,
Robin Canac, Bastien Cimarosti, Aurore Girardeau, Virginie Forest, Pierre Olchesqui, Jeremie Poschmann, Richard Redon, Patricia Lemarchand, Nathalie Gaborit, Guillaume Lamirault
McMaster researchers create device to replicate conditions in blood vessels after grafts
A University of Minnesota Twin Cities-led team has found that electrical stimulation of the body combined with sound activates the brain’s somatosensory cortex, increasing the potential for using the technique to treat chronic pain and other sensory disorders.
Anusha Vittal, Nehna Abdul Majeed, Elizabeth Garabedian, Jamie Marko, David E Kleiner, Rob Sokolic, Fabio Candotti, Harry Malech, Theo Heller, Christopher Koh
Alexander Chervov, Andrei Zinovyev
Ying Cao
Troy Yi, Jeffrey Steinberg, Scott Olson, Howaida El-Said, Jun Mo, Eric Anderson, Nicholas Gloude, Deborah Schiff
Zijie Wang, Chuying Chen, Jiayi Zhang, Jiangdie He, Lin Zhang, Jiayuan Wu, Zhihui Tian
Qing Li, Fanfei Kong, Rong Cong, Jian Ma, Cuicui Wang, Xiaoxin Ma
Rahul Naithani
Kseniia Sarieva, Theresa Kagermeier, Shokoufeh Khakipoor, Ezgi Atay, Zeynep Yentuer, Katharina Becker, Simone Mayer
Researchers at IRB Barcelona identify critical spots on the genome where gene editing could cause an unwanted response, and they provide recommendations for safer approaches.
Ruisong Wang, Ziyi Qin, Long Huang, Huiling Luo, Han Peng, Xinyu Zhou, Zhixiang Zhao, Mingyao Liu, Pinhong Yang, Tieliu Shi
Joana Rodrigues Dantas, Débora Batista Araújo, Karina Ribeiro Silva, Débora Lopes Souto, Maria De Fátima Carvalho Pereira, RonirRaggio LUIZ, Cesar Claudio-Da-Silva, Carlos Eduardo Barra Couri, Angelo Maiolino, Carmen Lúcia Kuniyoshi Rebelatto, Débora Regina Daga, Alexandra Cristina Senegaglia,
Zesheng Peng, Yuxi Wu, Jiajing Wang, Sujie Gu, Yihao Wang, Bingzhou Xue, Peng Fu, Wei Xiang
Devanjan Dey, Vadanya Shrivastava, Diksha Joshi, Chitra Mohinder Singh Singal, Sagar Tyagi, Muzaffer Ahmed Bhat, Paritosh Jaiswal, Jai Bhagwan Sharma, Jayanth Kumar Palanichamy, Subrata Sinha, Pankaj Seth, Sudip Sen
Vahedeh Hosseini, Mahdi Paryan, Ameneh Koochaki, Henry Manuel Cesaire, Samira Mohammadi-Yeganeh
Fan-Yan Wei, Asuka Inoue, Akiko Ogawa, Seiya Ohira, Tatsuya Ikuta, Yuri Kato, Shota Yanagida, Yukina Ishii, Yasunari Kanda, Motohiro Nishida
A common method of administering drugs is orally, by swallowing a pill or capsule. But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient, because the bioavailability of the drug in the gastrointestinal tract depends on the medication's ingredients and the stomach's dynamic physiological environment. In Physics of Fluids, researchers from employ a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach – a "StomachSim" – to investigate and quantify the effect of body posture and stomach motility on drug bioavailability.
Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers.
Yu-Ki Lee, Yue Hao, Zhonghua Xi, Woongbae Kim, Youngmin Park, Kyu-Jin Cho, Jyh-Ming Lien, In-Suk Choi
Wenjing Wan, Yuyang Miao, Yuwei Niu, Kunyuan Zhu, Yingwan Ma, Menghao Pan, Baohua Ma, Qiang Wei
Yulong Qiao, Qiang Sun, Xiaona Chen, Di Wang, Ruibao Su, Yuanchao Xue, Hao Sun, Huating Wang
Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y. Kwon, Fen-Biao Gao, Raymond Roos, Paschalis Kratsios
Katsuhiro Tomofuji, Jumpei Kondo, Kunishige Onuma, Koki Oyama, Eiji Miyoshi, Ken Fukumitsu, Takamichi Ishii, Etsuro Hatano, Masahiro Inoue
Charlotte Jaloux, Maxime Bonnet, Marie Vogtensperger, Marie Witters, Julie Veran, Laurent Giraudo, Florence Sabatier, Justin Michel, Romaric Lacroix, Corinne Chareyre, Regis Legre, Gaelle Guiraudie Capraz, Francois Feron
The four-year award, part of the NIH’s BRAIN Initiative, will support the design, manufacturing and distribution of two types of new "miniscopes" that will allow scientists to peer much deeper into the brain than before.
Catherine Thieblemont, Bettina Altmann, Fabian Frontzek, Loïc Renaud, Loic Chartier, Nicolas Ketterer, Christian Recher, Viola Poeschel, Olivier Fitoussi, Gerhard Held, René-Olivier Casasnovas, Corinne Haioun, Franck Morschhauser, Be
Fenghua Qian, Brooke E Arner, Shaneice K Nettleford, Robert F Paulson, K. Sandeep Prabhu
Ana Gutierrez-Franco, Mohamed N. Hassan, Loris Mularoni, Mireya Plass
Haruka Miyata, Masakazu Ishii, Fumio Suehiro, Naohiro Komabashiri, Nao Ikeda, Tomoaki Sakurai, Masahiro Nishimura
Lola Reid, Wencheng Zhang, Giacomo Lanzoni, Eliane Wauthier, Sean Simpson, Amanda Allen, Carolyn Suitt, Juan Dominguez-Bendala, Vincenzo Cardinale, Domenico Alvaro, Diletta Overi, Eugenio Gaudio, Guido Carpino, Kyle Mathews,
Xiang Xu, Shidan Li, Wei Xing, Shaochuan Wang, Youbin Li, Hao Jiang, Hanxuan Zheng, XiaoMing Li, Jing Yang, Debin Guo, Xiaoyu Xie, Renqing Jiang, Chao Fan, Lei Li, Jun Fei
Qiang Feng, Yushang Wang, Lihua Wang, Tianyong Sun, Song Shen, Zixuan Li, Xiaomei Ma, Xiufeng Gu, Xiumei Zhang, Ai Peng, Xin Xu
Jian Zhang, Xiao Hu, Qiao Wu, Shangqin Guo
Jing et al. combine a stroma-free differentiation system with EZH1-repression-mediated epigenetic reprogramming to generate developmentally mature iPSC-derived CAR T cells with enhanced antitumor activities.
Talbott et al. discuss the current state of knowledge in fibroblast biology and heterogeneity, primarily focusing on fibroblasts in skin wound repair. They also consider emerging techniques in the field and evaluate limitations of existing methodolo
In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importan
In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes
In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors.
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