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Released: 10-Oct-2022 12:00 PM EDT
UTX inhibition suppresses proliferation and promotes apoptosis in patient-derived glioblastoma stem cells by modulating periostin expression
Preprints

Yan Luan, Yingfei Liu, Jingwen Xue, Ke Wang, Kaige Ma, Haixia Lu, Xinlin Chen, Yong Liu, Zhichao Zhang

Released: 10-Oct-2022 12:00 PM EDT
The Viral Load of Human Cytomegalovirus Infection in Children Following Hematopoietic Stem Cell Transplant by Chip Digital PCR
Preprints

Wen-Jun Wang, Miao Feng, Feng- He, Juan Song, Qin-Qin Song, Dong Xia, Rong Liu, Hai-Lan Yao, Jun Han

Released: 10-Oct-2022 12:00 PM EDT
A cell size threshold triggers commitment to stomatal fate in Arabidopsis
Preprints

Yan Gong, Renee Dale, Hannah F Fung, Gabriel O Amador, Margot Smit, Dominique Bergmann

Released: 10-Oct-2022 12:00 PM EDT
The neuroprotective effects of dental pulp stem cells and erythropoietin in mice hippocampus after ischemia-reperfusion
Preprints

Shahram Mohammad Poor, Amir Johari Moghadam, Ameneh Rezayof, Rana Mehdizade, Mohammad Barbarestani, Rafieh Alizadeh, Naser Abbasi, Majid Katebi, Mansoureh Soleimani

Released: 10-Oct-2022 12:00 PM EDT
PRAMEL7/CUL2 axis regulates NuRD stability to establish ground-state pluripotency in embryonic stem cells
Preprints

Meneka Rupasinghe, Cristiana Bersaglieri, Deena M. Leslie Pedrioli, Patrick G.A. Pedrioli, Michael O. Hottiger, Paolo Cinelli, Raffaella Santoro

Released: 10-Oct-2022 12:00 PM EDT
Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model
Preprints

Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yan Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, Makoto Michikawa

Released: 10-Oct-2022 12:00 PM EDT
Human endometrium derived induced pluripotent stem cells are amenable to directed erythroid differentiation
Preprints

Hyun Kyung Kim, Si Hyun Cho, Young Sik Choi, Byung Seok Lee, Sinyoung Kim, Joo Hyun Park

Released: 9-Oct-2022 12:00 PM EDT
Chromosome territory reorganization through artificial chromosome fusion is negligible to cell fate determination and mouse development.
Preprints

Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou, Yun Zhao

Released: 9-Oct-2022 12:00 PM EDT
2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors
Preprints

Xiao-Min Ren, Richard C Chang, Yikai Huang, Angélica Amorim Amato, Coralie Carivenc, Marina Grimaldi, Angela Y Kuo, Patrick Balaguer, William Bourguet, Bruce Blumberg

Released: 9-Oct-2022 12:00 PM EDT
Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence
Preprints

Venkatesh Mallikarjun, Oana Dobre, Mark R Jackson, Melissa Kidd, Jack Llewellyn, Hamish Tj Gilbert, Stephen M Richardson, Joe Swift

Released: 8-Oct-2022 12:00 PM EDT
Dynamic matrices with DNA-encoded viscoelasticity for advanced cell and organoid culture
Preprints

Yu-Hsuan Peng, Krishna Gupta, Syuan-Ku Hsiao, Andre Ruland, Guenter K Auernhammer, Manfred F Maitz, Susanne Boye, Claudia Gerri, Alf Honigmann, Carsten Werner, Elisha Krieg

Released: 8-Oct-2022 12:00 PM EDT
The RNA m6A reader YTHDF1 promotes hematopoietic malignancy by maintaining oncogenic translation
Preprints

Xiangwei Gao, Zhanghui Chen, Yun-Guang Hong, Zhigang Yang, Yan Chen, Tian Liu, Yuyuan Zheng, Guo-Cai Wu, Yinhui Chen, Juan Xia, Ruiting Wen, Yi Zhao, Jin Chen

Released: 8-Oct-2022 12:00 PM EDT
An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.
Preprints

Andrea D. Thompson, Marcus J. Wagner, Juliani Rodriguez, Alok Malhotra, Steve Vander Roest, Ulla Lilienthal, Hao Shao, Jaime Yob, Benjamin L Prosser, Adam S. Helms, Jason E Gestwicki, David E Ginsburg, Sharlene M. Day

Newswise: Study: Novel Imaging Technique Reveals Excellent Biologic Fixation in Cementless Knee Replacement
Released: 7-Oct-2022 5:45 PM EDT
Study: Novel Imaging Technique Reveals Excellent Biologic Fixation in Cementless Knee Replacement
Geoffrey Westrich, MD

Cementless knee replacement is gaining interest among orthopedic surgeons. Using a novel MRI technique, HSS researchers found that a cementless implant demonstrated excellent biologic fixation, and even improved fixation in some areas in the joint, compared to the standard cemented implant.

Released: 7-Oct-2022 12:00 PM EDT
Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
Preprints

Denise Ragusa, Chun Wai Suen, Gabriel Torregrosa Cortes, Liza Dijkhuis, Connor Byrne, Giulia-Andreea Ionescu, Joana Cerveira, Kamil R Kranc, Anna Bigas, Jordi Garcia-Ojalvo, Alfonso Martinez Arias, Cristina Pina

Released: 7-Oct-2022 12:00 PM EDT
Candidate stem cell isolation and transplantation in Hexacorallia
Preprints

Benyamin Rosental, Shani Talice, Shany Barkan, Grace Snyder, Aner Ottolenghi, Shir Eliachar, Ronit Ben-Romano, Shelly Oisher, Ton Sharoni, Magda Lewandowska, Eliya Sultan, Oron Goldstein, Reuven Aharoni, Uzi Hadad,

Released: 7-Oct-2022 12:00 PM EDT
Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo
Preprints

Dennis May, Sangwon Yun, David Gonzalez, Sangbum Park, Yanbo Chen, Elizabeth Lathrop, Biao Cai, Tianchi Xin, Hong-Yu Zhao, Siyuan Wang, Lauren E Gonzalez, Katie Cockburn, Valentina Greco

Released: 7-Oct-2022 12:00 PM EDT
Iron Chelation Improves Ineffective Erythropoiesis and Iron Overload in Myelodysplastic Syndrome Mice
Preprints

Wenbin An, Maria Feola, Srinivas Aluri, Marc Ruiz-Martinez, Ashwin Sridharan, Maayan Levy, Eitan Fibach, Xiaofan Zhu, Amit K Verma, Yelena Ginzburg

Released: 7-Oct-2022 12:00 PM EDT
Stromal STAT5-mediated trophic activity regulates hematopoietic multipotent progenitor niche factors
Preprints

Zhengqi Wang, Grace Emmel, Hong Seo Lim, Wandi Zhu, Astrid Kosters, Eliver Ghosn, Peng Qiu, Kevin Bunting

Released: 7-Oct-2022 12:00 PM EDT
Circular RNAs arising from synaptic host genes are modulated by SFPQ RNA-binding protein and increased during human neuronal differentiation
Preprints

Michelle E Watts, Marika Oksanen, Sanna Lejerkrans, Francesca Mastropasqua, Myriam Gorospe, Kristiina Tammimies

Released: 7-Oct-2022 12:00 PM EDT
Engineering human spinal microphysiological systems to model opioid-induced tolerance
Preprints

Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo

Newswise: New Center for Experimental Therapeutics in Cancer advances promising treatments
Released: 7-Oct-2022 6:05 AM EDT
New Center for Experimental Therapeutics in Cancer advances promising treatments
UC Davis Health

UC Davis Comprehensive Cancer Center has launched a Center for Experimental Therapeutics in Cancer to accelerate promising cancer therapies from the lab to the bedside. The idea is to advance precision medicine that leads to more effective, less toxic cancer therapies.

Released: 6-Oct-2022 12:00 PM EDT
The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
Preprints

Luke D Roberts, Amanda K. E. Hornsby, Alanna Thomas, Martina Sassi, Aimee Kinzett, Nathan Hsiao, Bethan R David, Mark Good, Timothy Wells, Jeffrey S Davies

Released: 6-Oct-2022 12:00 PM EDT
PEDF peptide stimulates chondrocyte regeneration in rats with monoiodoacetate-induced articular cartilage injury
Preprints

Yung-Chang Lu, Tsung-Chuan Ho, Chang-Hung Huang, Shu-I Yeh, Show-Li Chen, Yeou-Ping Tsao

Released: 6-Oct-2022 12:00 PM EDT
Muscle hypertrophy and neuroplasticity in the small bowel in Short Bowel Syndrome
Preprints

Rasul Khasanov, Daniel Svoboda, María Ángeles Tapia-Laliena, Martina Kohl, Silke Maas-Omlor, Cornelia Irene Hagl, Lucas M. Wessel, Karl-Herbert Schäfer

Released: 6-Oct-2022 12:00 PM EDT
Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencing
Preprints

Ryan N. Ptashkin, Mark D. Ewalt, Gowtham Jayakumaran, Iwona Kiecka, Anita S. Bowman, Jinjuan Yao, Jacklyn Casanova, Yun-Te David Lin, Kseniya Petrova-Drus, Abhinita S. Mohanty, Ruben Bacares, Jamal Benhamida, Satshil Rana, Anna Razum

Released: 6-Oct-2022 12:00 PM EDT
Long-term survivors demonstrate superior quality of life after haploidentical stem cell transplantation to matched sibling donor transplantation
Preprints

Xiaoyu Zhang, Jiao Wang, Yuqiu Liu, Jie Liu, Bei Wang, Qiuhui Zhang, Wei Guan, Huijuan Zhang, Li Xu, Guiying Liu, Ping Zhang, Yi He, Sizhou Feng, Mingzhe Han, Changping Li,

Released: 6-Oct-2022 12:00 PM EDT
Emergency hematopoiesis proceeds without contribution of hematopoietic stem cells
Preprints

Clara Marie Munz, Nicole Dressel, Minyi Chen, Tatyana Grinenko, Axel Roers, Alexander Gerbaulet

Released: 6-Oct-2022 12:00 PM EDT
Distinct modes of heat shock transcription factor interactions with mitotic chromosomes
Preprints

Rachel M Price, Marek A Budzyński, Junzhou Shen, Jennifer E. Mitchell, James Z.J. Kwan, Sheila S. Teves

Released: 6-Oct-2022 12:00 PM EDT
Prediction of diabetes mellitus development after kidney transplantation using patient-specific induced pluripotent stem cells
Preprints

Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang

Released: 6-Oct-2022 12:00 PM EDT
α-synuclein fibril and synaptic vesicle interactions lead to vesicle destruction and increased uptake into neurons
Preprints

Amberley D Stephens, Ana Fernandez-Villegas, Chyi Wei Chung, Oliver Vanderpoorten, Dorothea Pinotsi, Ioanna Mela, Edward Nicholas Ward, Thomas M McCoy, Robert Cubitt, Alexander F Routh, Clemens F Kaminski, Gabriele S Kaminski Schierle

Released: 6-Oct-2022 9:30 AM EDT
DOE Funds Pilot Study Focused on Biosecurity for Bioenergy Crops
Brookhaven National Laboratory

The U.S. Department of Energy’s (DOE) Office of Science has selected Brookhaven National Laboratory to lead a new research effort focused on potential threats to crops grown for bioenergy production. Understanding how such bioenergy crops could be harmed by known or new pests or pathogens could help speed the development of rapid responses to mitigate damage and longer-term strategies for preventing such harm.

Released: 6-Oct-2022 5:00 AM EDT
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination
Cell Stem Cell

Fibrosis, the pathological end stage of chronic inflammatory diseases, results from extracellular matrix deposition by fibrogenic fibroblasts. In this issue of Cell Stem Cell, Sobecki et al. (2022) develop a novel vaccination-based immunotherapy aga

Released: 6-Oct-2022 5:00 AM EDT
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures
Cell Stem Cell

Three recent studies from the Zernicka-Goetz and Hanna groups (Amadei et al., 2022; Tarazi et al., 2022; Lau et al., 2022) report the development of mouse embryo-like structures from stem cells. Using a combination of stem cell-derived sources, th

Released: 6-Oct-2022 5:00 AM EDT
Pervasive donor DNA integration defies precision gene editing of hematopoietic stem cells
Cell Stem Cell

Therapeutic gene editing based on homology-directed repair (HDR) promises to precisely recombine donor template sequences at programmed double-strand break sites. In this issue, Ferrari et al. report that commonly used AAV donors blunt hematopoietic

Released: 6-Oct-2022 5:00 AM EDT
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
Cell Stem Cell

By characterizing the epigenome of direct reprogramming processes, Qian and colleagues discovered common features of direct reprogramming. Particularly, Ascl1, the neuron reprogramming factor, activates a unique set of cardiac genes. Together with As

Released: 5-Oct-2022 12:00 PM EDT
Loss of the MLL3 tumor suppressor accelerates breast tumor onset via HIF1a-induced CCL2-mediated recruitment of CCR2+ regulatory T cells
Preprints

Marie Boutet, Piril Erler, Kenta Nishitani, Nicole Couturier, Zheng Zhang, Emeline Barbieux, Erik Guillen, Masako Suzuki, Gregoire Lauvau, Wenjun Guo

Released: 5-Oct-2022 12:00 PM EDT
Chemical Imaging Reveals Diverse Functions of Tricarboxylic Acid Metabolites in Root Growth and Development
Preprints

Tao Zhang, Sarah E. Noll, Jesus T. Peng, Amman Klair, Abigail Tripka, Nathan Stutzman, Casey Cheng, Richard N Zare, Alexandra Jazz Dickinson



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