Mayo Clinic researchers have discovered a series of proteins that could be diagnostic markers to identify bipolar I disorder. If this discovery sample can be validated through replication these markers may help as a diagnostic tool for psychiatrists treating mood disorders.
A team of researchers at Kansas State University, the University of Missouri and global agricultural biotechnology company Genus plc has developed pigs that are resistant to the most devastating disease in the swine industry.
Scientists from The Scripps Research Institute have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action, a technique with significant potential to quickly find drug candidates.
Scientists have long known that when sounds are faint or objects are seen through fog in the distance, repetition of these weak or ambiguous sensory “inputs” can result in different perceptions inside the same brain. Now the results of new research, described in Nature Neuroscience, have identified brain processes in mice that may help explain how those differences happen.
A team of neuroscientists has found new support for MIT linguist Noam Chomsky’s decades-old theory that we possess an “internal grammar” that allows us to comprehend even nonsensical phrases.
Currently, there is no treatment to halt the progression of Huntington’s disease (HD), a fatal genetic disorder that slowly robs sufferers of their physical and mental abilities. Now, researchers at University of California, San Diego School of Medicine have discovered that an existing compound, previously tested for diabetes, offers hope for slowing HD and its symptoms.
In the first study to run a genome-wide analysis of Short Tandem Repeats (STRs) in gene expression, a large team of computational geneticists led by investigators from Columbia Engineering and the New York Genome Center have shown that STRs, thought to be just neutral, or "junk," actually play an important role in regulating gene expression. The work uncovers a new class of genetic variants that modulate gene expression. (Nature Genetics 12/7)
Parkinson’s disease researchers at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo have developed a way to ramp up the conversion of skin cells into dopamine neurons. They have identified – and found a way to overcome –a key obstacle to such cellular conversions.
Scientists devised a new approach that balances attractions between particles and promises to become a useful tool to create designer materials that can repair damage.
Northwestern University neuroscientists now can read the mind of a fly. In a study focused on three of the fruit fly’s sensory systems, the researchers developed a new tool that uses fluorescent molecules of different colors to tag neurons in the brain to see which connections, or synapses, were active during a sensory experience that happened hours earlier. Mapping the pattern of individual neural connections could provide insights into the computational processes that underlie the workings of the human brain.
A new study by UC San Francisco scientists shows that the proportion of normal cells, especially immune cells, intermixed with cancerous cells in a given tissue sample may significantly skew the results of genetic analyses and other tests performed both by researchers and by physicians selecting precision therapies.
Colorado State University chemists have made a completely recyclable, biodegradable polymer, paving a potential new road to truly sustainable, petroleum-free plastics.
Researchers have developed a swallowable device engineered for stability in the stomach, allowing for potential extended drug release or physiological monitoring and subsequent degradation in the small intestine for safe passage out of the body.
Investing in simple diagnostic tests could save lives and end disease epidemics in the developing world, say researchers in a supplement in the journal Nature.
Matter known as ordinary corresponds to only 5% of the Universe. Numerical simulations made it possible to predict that the rest of this ordinary matter should be located in the large-scale structures that form the “cosmic web”. A team led by the University of Geneva observed this phenomenon. The research shows that the majority of the missing ordinary matter is found in the form of a very hot gas associated with intergalactic filaments.
You may believe that you have forgotten the Chinese you spoke as a child, but your brain hasn’t. Moreover, that “forgotten” first language may well influence what goes on in your brain when you speak English or French today.
In a paper published today in Nature Communications, researchers from McGill University and the Montreal Neurological Institute describe their discovery that even brief, early exposure to a language influences how the brain processes sounds from a second language later in life. Even when the first language learned is no longer spoken.
A camera so advanced that it can photograph and film methane in the air around us is now presented by a team of researchers from Linköping and Stockholm Universities. It can be an important part of the efforts to measure and monitor greenhouse gases.
A camera so advanced that it can photograph and film methane in the air around us is now presented by a team of researchers from Linköping and Stockholm Universities. It can be an important part of the efforts to measure and monitor greenhouse gases.
Running sophisticated simulations on a powerful supercomputer, an international research team has glimpsed the unique turbulence that fuels stellar explosions.
Scientists at The Scripps Research Institute (TSRI) have found evidence that a mutant protein responsible for most cases of cystic fibrosis is so busy “talking” to the wrong cellular neighbors that it cannot function normally and is prematurely degraded.
New theoretical physics research shows that swirling particles known as skyrmions, which have been found in magnetic systems, can also exist in ferroelectrics.
New research from The University of Manchester and the Babraham Institute has revealed how gaps between genes interact to influence the risk of acquiring diseases such as arthritis and type 1 diabetes.
• The Weizmann Institute Quantum Optics team has devised a way to pluck a single photon from a pulse of light. This breakthrough can both aid further basic research into the nature of light and help advance quantum communication systems, which will likely be based on single photons.
The Weizmann Institute of Science’s Dr. Ayelet Erez, an MD/PhD who has treated rare childhood diseases, found that a protein that is missing in one such disease is also silenced by many cancers. Looking at how the lack of the protein affects the sick children also provides a “lens” on cancer.
A study published in the journal, Nature, adds to growing evidence that the people of Europe’s DNA underwent widespread changes, altering their height, digestion, immune system and skin color with the spread of agriculture.
Bombarding and stretching an important industrial catalyst opens up tiny holes on its surface where atoms can attach and react, greatly increasing its activity as a promoter of chemical reactions, according to a study by scientists at Stanford University and the Department of Energy’s SLAC National Accelerator Laboratory.
Study suggests that the common belief that the Earth’s rigid tectonic plates stay strong when they slide under another plate, known as subduction, may not be universal.
A team from the University of York has published research unveiling the 3-D structure of human heparanase, a sugar-degrading enzyme which has received significant attention as a key target in anti-cancer treatments.
Most people probably think that we perceive the five basic tastes—sweet, sour, salty, bitter and umami (savory)—with our tongue, which then sends signals to our brain “telling” us what we’ve tasted. However, scientists have turned this idea on its head, demonstrating in mice the ability to change the way something tastes by manipulating groups of cells in the brain.
Whether you're territorial, a girlfriend stealer, or a cross dresser - when it comes to finding a partner, scientists have discovered that for some birds it's all in the genes. Individual animals usually exhibit flexibility in their behaviour, but some behaviours are genetically determined.
A new type of symmetry operation developed by Penn State researchers has the potential to quicken the search for new advanced materials that range from tougher steels to new types of electronic, magnetic, and thermal materials.
Researchers used a powerful, custom-built X-ray microscope at the Department of Energy's SLAC National Accelerator Laboratory to directly observe the magnetic version of a soliton, a type of wave that can travel without resistance. Scientists are exploring whether such magnetic waves can be used to carry and store information in a new, more efficient form of computer memory that requires less energy and generates less heat.
Scientists have found the "fourth strand" of European ancestry. This population, discovered in the Caucasus mountains of Western Georgia survived for thousands of years, isolated from the rest of Europe due to the Ice Age. A small but significant portion of Europe's genome is derived from this unique population of hunter-gatherers, who came out of hiding, and mixed with the Yamnaya culture, which swept into Western Europe about 5,000 years ago.
Taking genetic engineering to the next level, Colorado State University researchers are creating modular, programmable genetic circuits that control specific plant functions.
An international team of researchers, led by Queen’s University Belfast, has devised a high-precision method of examining magnetic fields in the Sun’s atmosphere, representing a significant leap forward in the investigation of solar flares and potentially catastrophic ‘space weather’.
Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have determined how the body responds during times of emergency when it needs more blood cells. In a study published in Nature, researchers report that when tissue damage occurs, in times of excessive bleeding, or during pregnancy, a secondary, emergency blood-formation system is activated in the spleen.
A new study in Nature Communications by Luis Ossa, Jorge Mpodozis and Alexander Vargas, from the University of Chile, provides a careful re-examination of ankle development in 6 different major groups of birds, selected specifically to clarify conditions in their last common ancestor.
The sensitivity of marine communities to ocean warming rather than rising ocean temperatures will have strong short-term impacts on biodiversity changes associated with global warming, according to new research.
A study at The University of Texas MD Anderson Cancer Center may explain why chemotherapy drugs such as gemcitabine are not effective for many pancreatic cancer patients, and perhaps point to new approaches to treatment including enhancing gemcitabine’s ability to stop tumor growth.
Pediatric oncology researchers have pinpointed a crucial change in a single DNA base that both predisposes children to an aggressive form of the childhood cancer neuroblastoma and makes the disease progress once tumors form. The gene change results in a "super-enhancer" that drives the cancer.
New research led by scientists at Beth Israel Deaconess Medical Center helps explain the role of an immunosuppressive pathway associated with irritable bowel disease, a condition that develops in genetically susceptible individuals when the body's immune system overreacts to intestinal tissue, luminal bacteria or both.
The anticipated melting of the massive West Antarctic Ice Sheet could be slowed by two big factors that are largely overlooked in current computer models, according to a new study.
Scientists at the University of North Carolina School of Medicine (UNC) and University of California, San Francisco (UCSF) have created a general tool to probe the activity of these orphan receptors, illuminating their roles in behavior and making them accessible for drug discovery
Building on wireless technology that has the potential to interfere with pain, scientists have developed flexible, implantable devices that can activate -- and, in theory, block -- pain signals in the body and spinal cord before those signals reach the brain. The researchers, at Washington University School of Medicine in St. Louis and the University of Illinois at Urbana-Champaign, said the implants one day may be used in different parts of the body to fight pain that doesn't respond to other therapies.
Using a high-tech imaging method, a team of biomedical engineers at the School of Engineering & Applied Science at Washington University in St. Louis was able to see early-developing cancer cells deeper in tissue than ever before with the help of a novel protein from a bacterium.
For decades, biologists have been trying to find the crucial sensor protein in nerve endings that translates muscle and tendon stretching into proprioceptive nerve signals. Now, a team led by scientists from The Scripps Research Institute has identified this sensor protein in mice.
Scientists at the University of North Carolina and UC-San Francisco created a general tool to probe the activity of orphan receptors, illuminating their roles in behavior and making them accessible for drug discovery for the first time.