Feature Channels: Pharmaceuticals

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A group of researchers have identified potential novel drug candidates for the treatment of Malignant Pleural Mesothelioma (MPM).

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The latest expert commentary and research on SCOTUS decisions, including the overturn of Roe v. Wade

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Rensselaer Polytechnic Institute researchers Gaetano Montelione and Christopher Cioffi will use a five-year, $3.5 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to develop a low-dose, oral COVID antiviral drug that can be administered at home.

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Karallief® Inc., a leading nutraceutical ingredient company that researches, develops, and distributes clinically studied herbal extract ingredient formulas, announced today that the United States Patent and Trademark Office (USPTO) has granted U.S. Patent No. 11,364,255 for Karallief® Easy Climb®.

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Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.

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Amy Lynn Seybert succeeds retiring Patricia Kroboth, who served as dean the past two decades

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With the end of the pandemic seemingly nowhere in sight, scientists are still very focused on finding new or alternative drugs to treat and stop the spread of COVID-19. In a first-of-its-kind study, researchers at the University of New Hampshire have found that using an already existing drug compound in a new way, known as drug repurposing, could be successful in blocking the activity of a key enzyme of the coronavirus, or SARS-CoV-2, which causes COVID-19.

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Researchers at The Ohio State University Wexner Medical Center and College of Medicine have developed a novel drug molecule that targets T-cells causing inflammation in heart failure patients, stopping further progression of the disease.

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New guidance published today in Anaesthesia provides actionable steps to mitigate greenhouse gas emissions from inhaled anesthetics, particularly desflurane, which is commonly used in general anesthesia, and nitrous oxide (laughing gas).

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According to a paper published in Frontiers in Oncology, daily use of a unique mushroom extract AHCC® supported the immune system in clearing HPV infections in two-thirds of study participants after six months of supplementation.

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Researchers used mice to develop a mathematical model of a myocardial infarction, popularly known as a heart attack.

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The Rutgers School of Public Health has launched New Jersey’s first Master of Science (MS) in Epidemiology with a concentration in Pharmacoepidemiology degree. This new program will begin enrolling full-time and part-time students for the Fall 2022 semester.

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The cost of brand-name drugs for epilepsy increased by 277% from 2010 to 2018, according to a study published in the June 15, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The cost of generic drugs for epilepsy decreased by 42% over the same period.

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Valproic acid (VPA) keeps nervous system cells from growing and dividing correctly, researchers discovered.

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A “quality management maturity” (QMM) rating system for pharmaceutical manufacturing facilities is viable toward reducing drug shortages and increasing medicine availability, according to research by risk management expert Clifford Rossi at the University of Maryland.

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Harrington Discovery Institute® at University Hospitals in Cleveland, Ohio, and its registered UK charity Fund for Cures UK, Ltd. (Fund for Cures UK) have issued a call for proposals for the 2023 Harrington UK Rare Disease Scholar Award. In addition to grant funding, Harrington Discovery provides guidance and oversight in drug development, while intellectual property is retained by the scholar and their institution.

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Scientists have reported good news on the pandemic preparedness front: A cocktail of four manufactured antibodies is effective at neutralizing a virus from the Henipavirus family, a group of pathogens considered to be a global biosecurity threat.

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A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no differences in relief of mild-to-moderate COVID-19 symptoms between participants taking ivermectin and participants taking a placebo.

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A new study finds overweight and obese people maintained an average weight loss of 10.6% over 3 to 5 years with a program of lifestyle changes in combination with anti-obesity medications. Weight loss of more than 10% provides significant health benefits, according to researchers who are presenting their findings Sunday, June 12 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.

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A longer duration of treatment with puberty-delaying medications among transgender youth is associated with lower bone mineral density, according to a new study that will be presented Sunday at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.

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Two experimental male contraceptive pills appear to effectively lower testosterone without causing unacceptable side effects, according to a new study that will be presented Monday at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.

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An investigational drug taken while undergoing chemotherapy demonstrated superior overall survival compared to chemotherapy alone in adult patients with a common, highly aggressive subtype of acute myeloid leukemia (AML).

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A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

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Irvine, Calif., June 9, 2022 — Cancer starts when cells start dividing uncontrollably. Scientists have known that taking aspirin can help protect against the development of colorectal cancer – cancer afflicting the colon or rectum – but the exact reason aspirin has this effect has been mostly a mystery. In a new study published in the journal eLife, researchers at the University of California, Irvine reveal for the first time that aspirin changes the way colorectal cancer cell populations evolve over time, making them less able to survive and proliferate.

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A new study from the University of Michigan describes one of the first entirely new drug delivery microencapsulation approaches in decades.

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Sepsis, the body’s overreaction to an infection, affects more than 1.5 million people and kills at least 270,000 every year in the U.S. alone. The standard treatment of antibiotics and fluids is not effective for many patients, and those who survive face a higher risk of death. In new research, the lab of Shaoqin “Sarah” Gong at the University of Wisconsin–Madison reported a new nanoparticle-based treatment that delivers anti-inflammatory molecules and antibiotics.

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Combination chemoimmunotherapy with the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib demonstrated improved progression-free survival over standard chemoimmunotherapy for previously untreated mantle cell lymphoma (MCL) in patients 65 and over, researchers from The University of Texas MD Anderson Cancer Center reported today at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting. The study results also were published today in the New England Journal of Medicine.

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The AREDS2 dietary supplement formula not only reduces risk of lung cancer due to beta-carotene, but is also more effective at reducing risk of AMD progression, compared to the original AREDS formula.

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Ketamine is the speedster of antidepressants, working within hours compared to more common antidepressants that can take several weeks. But ketamine can only be given for a limited amount of time because of its many side effects.

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New research demonstrates that by killing essential gut bacteria, antibiotics ravage athletes’ motivation and endurance. The UC Riverside-led mouse study suggests the microbiome is a big factor separating athletes from couch potatoes.

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Researchers at the Icahn School of Medicine at Mount Sinai have been awarded an initial $16 million from the National Institutes of Health (NIH) to discover and develop globally accessible and affordable novel oral antivirals to combat COVID-19 and future pandemics.

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Current advances include new biomarkers to predict chimeric antigen receptor (CAR) T cell therapy outcomes and neurotoxicities, novel treatment targets for pre-cancerous pancreatic lesions and T-cell acute lymphoblastic leukemia, a new approach to improve immunotherapy responses in cold tumors, a profile of synthetic lethal targets for cancers with tumor suppressor loss, and promising clinical data for acute myeloid leukemia and cancers of unknown primary.