Feature Channels: Stem Cells

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Released: 4-Apr-2022 12:00 PM EDT
Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA
Preprints

Aurelie Carabalona, Henna Kallo, Liliia Andriichuk, MaryAnne Gonzalez, Ellinoora Elomaa, Florence Molinari, Christiana Fragkou, Pekka Lappalainen, Marja Wessels, Juha Saarikangas, Claudio Rivera

Released: 4-Apr-2022 12:00 PM EDT
Methanol fixed feeder layers altered the pluripotency and metabolism of bovine pluripotent stem cells
Preprints

Wenqiang Xu, Ruifeng Hao, Jing Wang, Lingna Gao, Xuejie Han, Chen Li, Hui Zhang, Xueling Li

Released: 4-Apr-2022 12:00 PM EDT
Therapeutic options and clinical outcomes of 1261 patients with mantle cell lymphoma in China: a real-world retrospective multicenter analysis from Chinese Hematologist and Oncologist Innovation Cooperation of the excellent (CHOICE)
Preprints

Qingqing Cai, Dongfeng Zeng, Yu Fang, Yue Fei, Rong Liang, Haige Ye, Yun Liang, Xiuhua Sun, Michael Wang, Huiqiang Huang, Lugui Qiu, Tiejun Gong, Donglu Zhao, Yuxuan Che, Jinni Wang, Panpan Liu, Yi Wang, Tao Pan, Yao Lv, Panruo Jiang, Xuzhao Zhang, Jintai Deng, Shuhua Yi, Yizi He, Ling Xiao, Huijuan Lv, Jiangfang Feng, Huan Xie, Jiacheng Qian, Huilai Zhang, Hui Zhou

Released: 3-Apr-2022 12:00 PM EDT
Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
Preprints

Nan Wang, Jing He, Xiaoyu Feng, Shengyou Liao, Yi Zhao, Fuchou Tang, Kehkooi Kee

Released: 1-Apr-2022 12:00 PM EDT
Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma
Preprints

Lorenz Nierves, Jian Guo, Siyuan Chen, Janice Tsui, Anuli C Uzozie, Jonathan W Bush, Tao Huan, Philipp F Lange

Released: 1-Apr-2022 12:00 PM EDT
Fyn interrupts telomere maintenance in stem cells by phosphorylating menin at tyrosine 603
Preprints

Souren Paul, Preston McCourt, Le Thi My Le, Joohyun Ryu, Wioletta Czaja, Ann Bode, Rafael Contreras-Galindo, Zigang Dong

Released: 1-Apr-2022 12:00 PM EDT
CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder
Preprints

Serena Tamura, Andrew D Nelson, Perry We Spratt, Henry Kyoung, Xujia Zhou, Zizheng Li, Jingjing Zhao, Stephanie S Holden, Atehsa Sahagun, Caroline M Keeshen, Congyi Lu, Elizabeth C Hamada, Roy Ben-Shalom, Jen Q Pan, Jeanne T Paz, Stephan J Sanders, Navneet Matharu, Nadav Ahituv, Kevin J Bender

Released: 1-Apr-2022 12:00 PM EDT
Dynamic tissue-specific H2Bub1 is required for human and mouse cardiogenesis
Preprints

Syndi Barish, Jeffrey Drozd, Kathryn Berg, Isabella Berglund-Brown, Labeeqa Khizir, Lauren Wasson, Christine Seidman, Jonathan Seidman, Sidi Chen, Martina Brueckner

Released: 1-Apr-2022 9:00 AM EDT
In-vivo T-cell depleted reduced-intensity conditioned allogeneic haematopoietic stem-cell transplantation for patients with acute lymphoblastic leukaemia in first remission: results from the prospective, single-arm evaluation of the UKALL14 trial
The Lancet

Background The outcome of chemotherapy in patients older than 40 years with acute lymphoblastic leukaemia is poor and myeloablative allogeneic haematopoietic stem-cell transplantation (HSCT) has a high transplant-related …

Released: 31-Mar-2022 4:00 AM EDT
Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence
Stem Cell Reports

… Autologous limbal stem cell transplantation is highly successful, but impossible in cases of complete bilateral stem cell deficiency. In these … We found that a very low amount of stem cell-like cells remained 4 weeks after the stem cell deficiency model …

Released: 30-Mar-2022 7:00 AM EDT
Cutting the umbilical cord: Cancer stem cell-targeted therapeutics
Life Sciences

… They may arise due to accumulation of mutations in adult stem cells, uptake of mutated DNA from an apoptotic cell, occurrence of a dedifferentiating mutation within a previously differentiated somatic cell, or induction of fusion between a stem …

Released: 30-Mar-2022 7:00 AM EDT
Strategy of Stem Cell Transplantation for Bone Regeneration with Functionalized Biomaterials and Vascularized Tissues in Immunocompetent Mice
ACS Biomaterials Science & Engineering

… To further investigate whether the implanted functionalized sodium alginate hydrogels produced bioactive stem cell transplantation beds, we performed an H&E and a Masson staining of paraffin sections of subcutaneous composite cystic tissues …

Released: 30-Mar-2022 7:00 AM EDT
Modeling PCDH19-CE: From 2D Stem Cell Model to 3D Brain Organoids
International Journal of Molecular Sciences

… Induced pluripotent stem cell (iPSC) technology has provided a complementary experimental approach for investigating the pathogenic mechanisms implicated in PCDH19-CE during neurogenesis and studying the pathology in a more …

Released: 30-Mar-2022 7:00 AM EDT
The Leucine Rich Repeat Kinase 2 Mutation G2019S Leads to a Reduced Antioxidant Response in Induced Pluripotent Stem Cell Derived Neural Stem Cells
ProQuest

… Single cell technology has found a niche in stem cell biology and can be used for studying cellular diversity, identifying subpopulations in heterogeneous culture systems and stem cellbased disease models. There are many methods available for …

Released: 29-Mar-2022 12:00 PM EDT
Dual Specificity Phosphatase 1 (DUSP1) Provides Mechanistic Link Between Melanoma Cellular Plasticity and Drug Resistance
Preprints

Vijayasaradhi Setaluri, Mithalesh K. Singh, Sarah Altameemi, Marcos Lares, Michael A. Newton

Released: 29-Mar-2022 12:00 PM EDT
Identification of RP11-770J1.4-CTXN1 as an immunomodulatory axis in Low-Grade Glioma
Preprints

Qiyuan Zhuang, Chaxian Liu, Yihan Hu, Ying Liu, Yingying Lyu, Yuhen Liao, Liang Chen, Hui Yang, Ying Mao

Released: 29-Mar-2022 12:00 PM EDT
A DEAD-box helicase drives the partitioning of a pro-differentiation NAB protein into nuclear foci
Preprints

Akiko Doi, Gianmarco D. Suarez, Rita Droste, H. Robert Horvitz

Newswise: 2022 Virtual and Combined Regenerative Medicine Essentials Course and World Stem Cell Summit Meeting Set
Released: 29-Mar-2022 10:05 AM EDT
2022 Virtual and Combined Regenerative Medicine Essentials Course and World Stem Cell Summit Meeting Set
Atrium Health Wake Forest Baptist

The Wake Forest Institute for Regenerative Medicine (WFIRM) and the Regenerative Medicine Foundation (RMF) for the second year will join forces for their annual meetings to be held in conjunction and virtually, kicking off on Monday, June 6 - 11. Early Bird Registration ends May 6.

Newswise: Johns Hopkins Researchers Identify a Potential Window for Treating ALS
Released: 29-Mar-2022 9:00 AM EDT
Johns Hopkins Researchers Identify a Potential Window for Treating ALS
Johns Hopkins Medicine

Johns Hopkins Medicine researchers have found a possible window of opportunity during ALS treatment to target astrocyte abnormalities — a subtype of cells in the central nervous system.

Newswise: Study Underway to See if Stem Cells Derived from Fat Tissue Can Enhance Healing and Outcomes in Rotator Cuff Surgery
Released: 28-Mar-2022 4:55 PM EDT
Study Underway to See if Stem Cells Derived from Fat Tissue Can Enhance Healing and Outcomes in Rotator Cuff Surgery
Hospital for Special Surgery

Researchers at HSS have launched a study to see if injecting a type of stem cell derived from a patient’s own fat tissue could improve healing and shoulder function after rotator cuff surgery. The cells are extracted from adipose, or fat tissue, in the patient’s abdomen.

Released: 28-Mar-2022 12:00 PM EDT
Effect of oxidative stress-induced autophagy on proliferation and apoptosis of hMSCs
Preprints

Zhijun Liu, Shaojin Liu, Weipeng Zheng, Zhihao Liao, Sheng Chen, Hewei Wei

Released: 28-Mar-2022 12:00 PM EDT
Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in acute myeloid leukemia
Preprints

Xiaoqiang Xu, Xin Jin, Jiaxi Wang, Rui Sun, Meng Zhang, Xia Xiong, Danni Xie, Mingfeng Zhao

Released: 27-Mar-2022 12:00 PM EDT
Scalable Generation of Pseudo-Unipolar Sensory Neurons from Human Pluripotent Stem Cells
Preprints

Tao Deng, Carlos A. Tristan, Claire Weber, Pei-Hsuan Chu, Seungmi Ryu, Vukasin M. Jovanovic, Pinar Ormanoglu, Prisca Twumasi, Jaehoon Shim, Selwyn Jayakar, Han-Xiong Bear Zhang, Sooyeon Jo, Ty C. Voss, Anton Simeonov, Bruce P. Bean, Clifford J Woolf, İlyas Singec

Released: 27-Mar-2022 12:00 PM EDT
A cancer stem cell population underlies a multi-lineage phenotype and drug resistance in prostate cancer
Preprints

Michael L. Beshiri, Brian J. Capaldo, Ross Lake, Anson T. Ku, Danielle Burner, Caitlin M. Tice, Crystal Tran, Julianna Kostas, Aian Neil Alilin, Juanjuan Yin, Supreet Agarwal, Samantha A. Morris, Fatima H. Karzai, Tamara L. Lotan, William L. Dahut, Adam G. Sowalsky, Kathleen Kelly

Released: 27-Mar-2022 12:00 PM EDT
Phase Separation of a Nodulin Sec14-like protein Maintains Auxin Efflux Carrier Polarity at Arabidopsis Plasma Membranes
Preprints

Chen Liu, Andriani Mentzelopoulou, Alexandra Deli, Fotini Papagavriil, Prashanth Ramachandran, Artemis Perraki, Lucas Claus, Sebastian Barg, Peter Doermann, Yvon Jaillais, Philipp Johnen, Eugenia Russinova, Electra Gizeli, Gabriel Schaaf, Panagiotis Nikolaou Moschou

Released: 27-Mar-2022 12:00 PM EDT
A spatial genome aligner for multiplexed DNA-FISH
Preprints

Bojing Blair Jia, Adam P Jussila, J Colin Kern, Quan Zhu, Bing Ren

Released: 27-Mar-2022 12:00 PM EDT
LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer
Preprints

Donatella Delle Cave, Silvia Buonaiuto, Maria Mangini, Bruno Sainz, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina Duran, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida, Eduard Batlle, AnnaChiara De Luca, Enza Lonardo

Released: 27-Mar-2022 12:00 PM EDT
Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism
Preprints

Laura D'Ignazio, Ricardo S. Jacomini, Bareera Qamar, Kynon J.M. Benjamin, Ria Arora, Tomoyo Sawada, Taylor A. Evans, Kenneth E. Diffenderfer, Aimee R. Pankonin, William T. Hendriks, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger, D. Cristopher Bragg, Apua C.M. Paquola, Jennifer A. Erwin

Released: 27-Mar-2022 12:00 PM EDT
Development of a Novel Microfluidic Co-culture model to study Organoid Vascularization
Preprints

M. Guy Roukens, Lydia S. Schulla, E. Diana Alupoaie, Leanne De Silva, Debby Gawlitta, Sabine Middendorp, Paul J. Coffer

Released: 27-Mar-2022 12:00 PM EDT
Targeting tumor stemness switch phenotype by activating pathogen induced stem cell niche defense
Preprints

Bikul Das, Seema Bhuyan, Bidisha Pal, Lekhika Pathak, Partha Jyoti Saikia, Shirsajit Mitra, Sukanya Gayan, Reza Bayat Mokhtari, Hong Li, Chilakamarti V Ramana, Debabrat Baishya

Released: 26-Mar-2022 12:00 PM EDT
Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies
Preprints

Pien Goldsteen, Angelica Sabogal Guaqueta, Sophie Bos, Loes Kistemaker, Luke Van der Koog, Manon Eggens, Andrew J Halayko, Amalia Dolga, Reinoud Gosens

Released: 26-Mar-2022 12:00 PM EDT
In vitro induced pluripotency from urine-derived cells in porcine
World Journal of Stem Cells

BACKGROUNDThe generation of induced pluripotent stem cells (iPSC) has been a game-changer in translational and regenerative medicine; however, their large-scale applicability is still hampered by the scarcity of accessible, safe, and reproducib

Released: 26-Mar-2022 12:00 PM EDT
Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation
World Journal of Stem Cells

BACKGROUNDBone marrow (BM) suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to irradiation. Despite concerted efforts, there is no definitive treatment method available. Recent

Released: 25-Mar-2022 12:00 PM EDT
Efficacy and Pharmacokinetic of Human iPSC-derived Cardiomyocytes for Treating Heart Failure in Non-Human Primates
Preprints

Ningxia Liang, Qian Wang, He Zhang, Zhaomin Li, Taotao Chen, FaXiang Xu, Zhixin Guo, Guokai Chen, Huang-Tian Yang, Dongjin Wang, Guangji Wang, Jiaxian Wang

Released: 25-Mar-2022 12:00 PM EDT
A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate
Preprints

Michael J Xiao, Chia-Hua Wu, Graham Meek, Brian Kelly, Lyndsay E.A Young, Sara Martire, Dara Buendia Castillo, Purbita Saha, Altair L Dube, Matthew Gentry, Laura A Banaszynski, Ramon C Sun, Chintan Kikani

Released: 25-Mar-2022 12:00 PM EDT
Catalytic-independent function of PARP-1 is essential in regulating human islet-cell differentiation from stem cells
Preprints

Nidheesh Dadheech, Abhay Srivast, Rashmi G. Shah, Girish M. Shah, Sarita Gupta

Released: 25-Mar-2022 12:00 PM EDT
Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: A novel methods for hair follicle mesenchymal stem cells isolation.
Preprints

Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao

Released: 25-Mar-2022 7:00 AM EDT
Anti-inflammatory effects of mesenchymal stem cell-conditioned media inhibited macrophages activation in vitro
Scientific Reports

… In this study, we hypothesized that several paracrine cytokines exist in stem cell culture media that may facilitate the immunomodulation of macrophages. The IL4 treatment of stem cells could lead to a greater production of those compounds which …

Released: 25-Mar-2022 12:00 AM EDT
Adult neural stem cells and schizophrenia
World Journal of Stem Cells

Schizophrenia (SCZ) is a devastating and complicated mental disorder accompanied by variable positive and negative symptoms and cognitive deficits. Although many genetic risk factors have been identified, SCZ is also considered as a neurodevelo

Released: 25-Mar-2022 12:00 AM EDT
Mesenchymal stem/stromal cells as adjuvant therapy in COVID-19-associated acute lung injury and cytokine storm: Importance of cell identification
World Journal of Stem Cells

Theoretically, mesenchymal stem cells (MSCs) are very promising as adjuvant therapy to alleviate coronavirus disease 2019 (COVID-19)-associated acute lung injury and cytokine storm. Several published studies, which used MSCs to alleviate COVID-



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