Repair of the tendon enthesis (e.g., after a rotator cuff tear) is a clinical challenge. To motivate novel cell-based treatment strategies for enthesis repair, Fang et al. define enthesis cell transcriptomes and differentiation trajectories. A uniqu
The extracellular matrix (ECM) microenvironment is emerging as a player in early human development. Cesare et al. demonstrate that naive hiPSCs exhibit a self-organized ECM-rich microenvironment in vitro, which sustains their identity. They develop
A life well lived inspires others to aspire. Our friend and mentor Susan L. Solomon crammed several lifetimes of exploration into her 71 years. Susan’s early life was filled with music: her mother was a pianist and her father the co-founder of Vang
In this issue of Cell Stem Cell, Porpiglia et al.1 report on alterations in CD47 and THBS1 expression and function in aged muscle stem cells that disrupt their regeneration capacity. Targeting THBS1-CD47 cross-signaling is sufficient to reverse sarc
As the stem cell community mourns the loss of New York Stem Cell Foundation founder Susan Solomon, we also look to celebrate her legacy. In this Voices, members of the 2022 class of NYSCF Roberston Investigators share how NYSCF community support will
Herdy et al. identify an enriched population of senescent neurons in the Alzheimer’s brain, which can be modeled in vitro using induced neurons (iNs) and eliminated with senotherapeutics. Alzheimer’s iNs present molecular and genetic markers of
Pera and colleagues discuss the nature of recurrent genetic and epigenetic variants in hPSC culture, the methods for their detection, and what is known about their effects on cell behavior in vitro or in vivo. They highlight the key challenges faci
Human cortical organoids transplanted into the somatosensory cortex of rats integrate into the host neural circuits, receive inputs from host cells, and can produce behavioral responses. In a publication in Nature, Revah et al.1 highlight the potent
A roundup of the latest research discoveries and faculty news at Cedars-Sinai.
Molecular biologist Yu Xin (Will) Wang, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Development, Aging, and Regeneration Program to uncover the ways muscle, nerve and immune cells work together to overcome disease.
BACKGROUNDCartilage tissue engineering is a promising strategy for treating cartilage damage. Matrix formation by adipose-derived stem cells (ADSCs), which are one type of seed cell used for cartilage tissue engineering, decreases in the late s
Corneal stem/progenitor cells are typical adult stem/progenitor cells. The human cornea covers the front of the eyeball, which protects the eye from the outside environment while allowing vision. The location and function demand the cornea to m
Ulrich Steidl, M.D., Ph.D., an internationally recognized leader in cancer and stem cell biology, has been named the chair of the department of cell biology at Albert Einstein College of Medicine. Dr. Steidl assumes his new position as Arthur Skoultchi, Ph.D., who has led the department with distinction for 24 years, steps down from departmental leadership. Dr. Steidl is currently professor of cell biology, of oncology, and of medicine; interim director of the Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine; and the Edward P. Evans Endowed Professor for Myelodysplastic Syndromes at Einstein; and deputy director of Montefiore Einstein Cancer Center (MECC) and co-director of MECC’s Blood Cancer Institute.
The UC San Diego Sanford Stem Cell Institute leads its first space launch, sending stem cells into space aboard the International Space Station. The NASA-partnered study will take advantage of the microgravity environment of space to study accelerated aging in stem cells.
UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.
Maud D'Aveni-Piney, Claire Michel, Marie Robin, Stephane Morisset, Didier Blaise, Johan Maertens, Patrice Chevalier, Cristina Castilla-Llorente, Edouard Forcade, Patrice Ceballos, Ibrahim Yakoub-Agha, Xavier Poiré, Martin Carre,
Wen Wang, Xiao Zhang, Ning Zhao, Ze-Hua Xu, Kangxin Jin, Zi-Bing Jin
Feng Wang, Ashmita Chander, Yeonsoo Yoon, Mary Wallingford, Carmen Espejo-Serrano, Francisco Bustos, Greg Michael Findlay, Jesse Mager, Ingolf Bach
Every day, one person in Switzerland is diagnosed with multiple sclerosis. MS is an autoimmune disease in which the body’s own immune system attacks the myelin sheath of the nerve cells in the brain and spinal cord.
Zeynep Karagoz, Fiona Rosaleen Passanha, Lars Robeerst, Martijn van Griensven, Vanessa LaPointe, Aurelie Carlier
Xiaozhen Zhang, Mengyi Lao, HanShen Yang, Kang Sun, Lihong He, Muchun Li, Honggang Ying, Yan Chen, Xueli Bai, Tingbo Liang
Haruka Wada, Ryo Otsuka, Wilfred Germeraad, Tomoki Murata, Toru Kondo, Ken-Ichiro Seino
Audrey Grain, Jocelyn Ollier, Thierry Guillaume, Patrice Chevallier, Baptiste Le Calvez, Marion Eveillard, Béatrice Clémenceau
Ifedolapo Adejumo, Muyiwa Fageyinbo, Precious Obiekwe, Fortune Ibe-Uba, Ibrahim Oreagba, Esther Agbaje
Kevin Dzobo, Fatemeh Tavakoli Foroushani
Ruolin Zhang, Weibing Mao, Lumeng Niu, Wendai Bao, Yiqi Wang, Zhihao Yang, Yasha Zhu, Haikun Song, Jincao Chen, Guangqiang Li, Meng Cai, Zilong Yuan, Jiawen Dong, Min Zhang,
A new approach to stem cell therapy that uses antibodies instead of traditional immunosuppressant drugs robustly preserves cells in mouse brains and has potential to fast-track trials in humans, a Michigan Medicine study suggests.
Sensory neurons of the peripheral nervous system, which sense touch, temperature, and pain, can be permanently lost during infections, trauma, in response to certain medications, and in diabetic patients with peripheral neuropathy.
Xiaojing Liu, Li Liao, Peng Wang, Yuanxin Ye, Xiangyu Dong, Xiaotao Xing, Zhonghan Li, Qiang Wei, Weidong Tian
Xinlin Yang, Wan'an Xiao, Quang Le, Sang-Hyun Lee, Abhijit Dighe, Jason R Kerrigan, Quanjun Cui
Andrej Thurzo, Paulína Gálfiová, Zuzana Varchulová Nováková, Štefan Polák, Ivan Varga, Martin Strunga, Renáta Urban, Jana Surovková, Ľuboš Leško, Zora Hajdúchová, Jozef Feranc, Marian Janek, Ľuboš Danišovič
Yunqi Yao, Lin Zhang, Fuyi Cheng, Qingyuan Jiang, Yixin Ye, Yushuang Ren, Yuting He, Dongsheng Su, Lin Cheng, Gang Shi, Lei Dai, Hongxin Deng
Heather Wojcik, Harold N Lovvorn, Melinda Hollingshead, Janene Pierce, Howard Stotler, Andrew J Murphy, Suzanne Borgel, Hannah M Phelps, Hernan Correa, Alan O Perantoni
Gou Young Koh, Hyuek Jong Lee, Young-Chan Kim, Jungmo Kim, Myung Jin Yang, Seon Pyo Hong, Jueun Lee, Geum-Sook Hwang
Yasuaki Ikuno, Koichiro Watanabe, Yumi Kakeya, Shinsuke Ikeno, Toshimasa Nakabo, Ayano Narumoto, Yukie Kande, Tomoki Hayashi, Kahori Minami, Kasumi Nobuhiro, Yo Mabuchi, Shiho Nakamura, Hideyuki Okano, Dai Ihara,
Marius E. Moeller, Nathaniel V. Mon Pere, Benjamin Werner, Weini Huang
Johannes Ulrich, Klaus Brehm
Deepti Ramachandran, Nagasuryaprasad Kotikalapudi, David E Maridas, Anton Gulko, Linus T Tsai, Vicki Rosen, Alexander S Banks
Dongdong Jiang, Yongjun Luo, Xiaoshu Wu, Chenyu Huang, Qiaofeng Zhang, Chunzhi Jiang, Qingqiang Yao, Fei Jiang, Pengyu Tang
Karine Rizzoti, Probir Chakravarty, Daniel Sheridan, Robin Lovell-Badge
Yoh Iwasa, Sou Tomimoto, Akiko Satake
Sophie Girardin, Stephan Johannes Ihle, Arianna Menghini, Magdalena Krubner, Leonardo Tognola, Jens Duru, Tobias Ruff, Isabelle Fruh, Matthias Muller, János Vörös
Eldem Sadikoglou, Daniel Domingo-Fernandez, Natalia Savytska, Noemia Fernandes, Patrizia Rizzu, Anastasia Illarionova, Tabea Strauss, Sigrid Schwarz, Alpha Kodamullil, Guenter Hoeglinger, Ashutosh Dhingra, Peter Heutink
Alicia Donval, Cinthia Violeta Hernández Puente, Anaïs Lainé, Diana Roman, Romain Vessely, Julien Leclercq, Muriel Perron, Morgane Locker
Zheng Li, Ying Li, Jinling Bai, Zhijiao Wang, Yingying Zhou
Amin Namjoynik, Asiful Islam, Mohammad Islam
Ziqi Guo, Shiming Pu, Liu Yang, Yaping Liu, Xin Li, Hongxia Zhao, Zuping Zhou, Cheng Yang
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