Like bad neighbors who decide to go wreck another community, prostate and breast cancer usually recur in the bone, according to a new University of Michigan study.
A long term study reports about the effectiveness of replacing bone marrow, purposely destroyed by chemotherapy, with autologous (self) stem cell rescue for people with aggressive forms of multiple sclerosis (MS). The study is published in the March 22, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
The International Society for Stem Cell Research will launch a series of topical conferences focused on bringing leading stem cell research to scientists in more areas of the world.
Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved “clean” technique.
Proteins in fluids bathing the brain are essential for building the brain, discover scientists in a report published March 10 in the journal Neuron. The finding promises to advance research related to neurological disease, cancer and stem cells.
Stem cells derived from a patient’s own bone marrow were safely used in pediatric patients with traumatic brain injury (TBI), according to results of a Phase I clinical trial at (UTHealth) published in Neurosurgery.
Rensselaer Polytechnic Institute Assistant Professor of Biomedical Engineering Deanna Thompson is utilizing more than $300,000 in New York state funding as part of the state stem cell research program, NYSTEM, to study adult neural stem cells. The NYSTEM program is New York’s $600 million publicly funded grant program to advance scientific discovery in the area of stem cells.
Ordinary human cells reprogrammed as induced pluripotent stem cells may revolutionize personalized medicine by creating new and diverse therapies unique to individual patients. But important and unanswered questions have persisted about the safety of these cells, in particular whether their genetic material is altered during the reprogramming process. A new study finds that the genetic material of reprogrammed cells may in fact be compromised, and suggests that extensive genetic screening of hiPSCs become standard practice.
For children with severe traumatic brain injury (TBI), transplantation of stem cells derived from the patients' own bone marrow is a "logistically feasible and safe" treatment procedure, reports the March issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.
Unique computer model calculates how long a blood stem cell will live, information that could predict the outcome of bone marrow transplants.
Pluripotent stem cells have been generated from horses by a team of researchers. The findings will help enable new stem-cell based regenerative therapies in veterinary medicine, and because horses’ muscle and tendon systems are similar to our own, aid the development of preclinical models.
An essential protein for normal stem cell renewal also promotes the growth of breast cancer stem cells when it's overproduced in those cells, researchers at The University of Texas MD Anderson Cancer Center reported in Cancer Cell.
In an opinion piece published Feb. 10 in the journal Science, a team of scholars led by a Johns Hopkins bioethicist urges the scientific community to act collectively to stem the negative effects of the patenting and privatizing of stem cell lines, data and pioneering technologies. This means grappling with the ambiguity of several fundamental distinctions typically made in ethics, law and common practice, the experts insist.
Research from The University of Texas Health Science Center at Houston (UTHealth) and Athersys reveals that a novel stem cell therapy provided multiple benefits when administered in preclinical models of ischemic stroke.
Researchers at Johns Hopkins have found a better way to create induced pluripotent stem (iPS) cells—adult cells reprogrammed with the properties of embryonic stem cells—from a small blood sample. This new method, described last week in Cell Research, avoids creating DNA changes that could lead to tumor formation.
By coaxing healthy and diseased human bone marrow to become embryonic-like stem cells, a team of Wisconsin scientists has laid the groundwork for observing the onset of the blood cancer leukemia in the laboratory dish.
Reprogramming adult cells to recapture their youthful “can-do-it-all” attitude appears to leave an indelible mark, found researchers at the Salk Institute for Biological Studies. When the team, led by Joseph Ecker, PhD., a professor in the Genomic Analysis Laboratory, scoured the epigenomes of so-called induced pluripotent stem cells base by base, they found a consistent pattern of reprogramming errors.
New technique removes several hurdles in generating induced pluripotent stem (iPS) cells, smoothing the way for disease research and drug development.
Fifty years ago today, two young, unknown scientists at the fledgling Ontario Cancer Institute (OCI) published accidental findings that proved the existence of stem cells – cells that can self-renew repeatedly for different uses.
Breakthrough discovery offers hope for new therapies for range of diseases.
Among stem cell biologists there are few better-known proteins than nestin, whose very presence in an immature cell identifies it as a "stem cell," such as a neural stem cell. As helpful as this is to researchers, until now no one knew which purpose nestin serves in a cell.
The Hinxton Group, an international consortium of stem cell scientists, bioethicists and experts in law and public policy, called urgently today for specific measures designed to counter secrecy and self interest. The recommended measures focus on the sharing of data, materials and collective management of intellectual property related to stem cells.
Do genetic variations in DNA determine the outcome and success in patients who undergo stem-cell transplantation to treat blood cancers and predict complications? The National Heart, Blood and Lung Institute of the National Institutes of Health has awarded a $4.3 million, four-year grant to Fred Hutchinson Cancer Research Center to help find out.
Cancer scientists led by Dr. John Dick at the Ontario Cancer Institute (OCI) and collaborators at St Jude Children’s Research Hospital (Memphis) have found that defective genes and the individual leukemia cells that carry them are organized in a more complex way than previously thought.
Scientists coax stem cells (created from skin cells of a patient with an inherited heart disease) into cardiac cells. Method holds promise for personalized medicine, and for studying diseased cells that can’t be easily biopsied.
Scientists at the University of Michigan Comprehensive Cancer Center have identified a potential new way of attacking breast cancer stem cells, the small number of cells in a tumor that fuel its growth and spread.
For years, the majority of research on reactive oxygen species (ROS) – ions or very small molecules that include free radicals – has focused on how they damage cell structure and their potential link to stroke, cardiovascular disease and other illnesses. However, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have shown for the first time that neural stem cells, the cells that give rise to neurons, maintain high levels of ROS to help regulate normal self-renewal and differentiation.
UTHealth and Children's Memorial Hermann Hospital have launched the first Phase I safety study approved by the FDA to investigate the use of a child’s own umbilical cord blood stem cells for pediatric traumatic brain injury.
A close collaboration between researchers at the Salk Institute for Biological Studies and the Institute for Advanced Study found that the tumor suppressor p53, long thought of as the "Guardian of the Genome," may do more than thwart cancer-causing mutations. It may also prevent established cancer cells from sliding toward a more aggressive, stem-like state by serving as a "Guardian against Genome Reprogramming."
States, not the federal government, now fund the majority of human embryonic stem cell research conducted in the United States, according to a recent study in the journal Nature Biotechnology. In addition, much of the research performed in the states could likely have been funded by the National Institutes of Health under federal guidelines established by President Bush in 2001.
Initial experiments suggest a possible new approach to stem cell therapy for spinal cord injuries—using biocompatible "channels" made of chitosan to guide regeneration of new spinal cord tissue, reports the December issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy.
A protein that is crucial for regulating the self-renewal of normal prostate stem cells, needed to repair injured cells or restore normal cells killed by hormone withdrawal therapy for cancer, also aids the transformation of healthy cells into prostate cancer cells, researchers at UCLA have found.
Groundbreaking discovery moves field closer to therapeutic applications.
Breast cancer stem cells, the aggressive cells thought to be resistant to current anti-cancer therapies and which promote metastasis, are stimulated by estrogen via a pathway that mirrors normal stem cell development. Disrupting the pathway, researchers were able to halt the expansion of breast CSCs, a finding that suggests a new drug therapy target. The study, done in mice, is published in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.
Eduardo Marbán, M.D., one of the most prominent cardiac stem cell researchers, will describe the latest advances during the event that begins at 1 p.m. Tuesday, Nov. 16.
A team of researchers at the University of Wisconsin-Madison reports the development of a fully defined culture system that promises a more uniform and, for cells destined for therapy, safer product.
The liver's unique ability among organs to regenerate itself has been little understood. Now Weill Cornell Medical College scientists have shed light on how the liver restores itself by demonstrating that endothelial cells -- the cells that form the lining of blood vessels -- play a key role.
A collaborative effort between researchers at the Salk Institute for Biological Studies and the University of California, San Diego, successfully used human induced pluripotent stem (iPS) cells derived from patients with Rett syndrome to replicate autism in the lab and study the molecular pathogenesis of the disease.
In an important breakthrough, scientists at McMaster University in Hamilton, ON, Canada, have discovered how to make human blood from adult human skin. Published in Nature, their paper has also shown the conversion of stem cells is direct, without translation through a pluripotent stem cell state.
New research shows how a specific protein controls the body's ability to regulate magnesium. Though it is vital to more than 300 biochemical reaction in the body, the molecular mechanism for controlling magnesium were not previously understood.
A study by researchers at the Salk Institute for Biological Studies revealed that stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. When, or if, favorable conditions return, stem cell numbers multiply to accommodate increased demands on the tissue.
Researchers at North Carolina State University have found that the overproduction of a key protein in stem cells causes those stem cells to form cancerous tumors. Their work may lead to new treatments for a variety of cancers.
A team of physicians and scientists from the Cedars-Sinai Regenerative Medicine Institute and Department of Surgery, led by Dan Gazit, DMD, PhD has been awarded a three-year $1.9 million grant from the California stem cell agency to fund research leading to clinical trials for what could become the first biological treatment for the most common type of bone fracture in osteoporosis patients.
The state stem cell agency today awarded grants totaling $10.4 million to three researchers with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA to translate basic science into new and more effective therapies to regenerate bone and treat deadly brain cancers and corneal disorders that result in blindness.
A change in membrane voltage in newly identified "instructor cells" can cause stem cells' descendants to trigger melanoma-like growth in distant pigment cells. This metastatic transformation is due to changes in serotonin transport. Discovery of this novel bioelectric signal and cell type may help fight cancer, vitiligo and birth defects.
Scientists unravel the molecular link between damage-induced inflammation and muscle regeneration.
Biomedical researchers at the University at Buffalo have engineered adult stem cells that scientists can grow continuously in culture, a discovery that could speed development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases.
A new approach to anchor teeth back in the jaw using stem cells has been developed and successfully tested in the laboratory for the first time by researchers at the University of Illinois at Chicago.
The report in the June 4 issue of Cell Stem Cell reveals that an enzyme that changes the way DNA is packaged in cells allows specific genes to be turned on and off, thereby preventing a stem cell from becoming another cell type.
Kansas State University has been a issued a patent for a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord. The patent addresses procedures to isolate, culture and bank stem cells found in Wharton's jelly -- the substance that cushions blood vessels in the umbilical cord. These cells are called cord matrix stems cells and are different than those obtained from the blood cells in umbilical cords.
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