Researchers at the University of Southern California (USC) have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models.
Scientists at the Johns Hopkins Kimmel Cancer Center say they have evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatments.
Stem cells -- popularly known as a source of biological rejuvenation -- may play harmful roles in the body, specifically in the growth and spread of cancer. Amongst the wildly dividing cells of a tumor, scientists have located cancer stem cells. Physician-scientists from Weill Cornell Medical College are studying these cells with hopes of combating malignant cancers in the brain.
The VCU Life Sciences Survey is the first poll to reflect the discovery reported internationally in November that human skin cells can be used to create stem cells or their near equivalents.
Researchers have discovered a key molecular switch that regulates cancer stem cells. This switch, which belongs to a class of molecules called microRNAs, can decrease a cancer stem cell's ability to propagate tumors.
Researchers at UAB and Whitehead Institute report correcting the basic genetic mutation in mouse models of sickle cell anemia through use of induced pluripotent stem cells, iPS cells.
Researchers at the University of Michigan Comprehensive Cancer Center have found a marker that can be used to identify stem cells in breast tumors, suggesting a potential simple test that could help determine the best treatment for breast cancer.
Researchers have discovered that blood stem cells are capable of patrolling the body's organs where they seek out, and respond to, pathogens. They appear to be proactive participants in our innate immune response.
New collaboration created between Southern California institutions for research into stem cells. Institutions include: USC, Childrens Hospital Los Angeles, House Ear Institute, City of Hope, Caltech and UC Santa Barbara.
Engineers at Rensselaer Polytechnic Institute have transformed a polymer found in common brown seaweed into a device that can support the growth and release of stem cells at the sight of a bodily injury or at the source of a disease.
A stem cells' immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for stem cell maintenance. But nothing lasts forever, found scientists at the Salk Institute for Biological Studies. During the aging process, the level of support drops off, diminishing the stem cells' ability to replenish themselves (self-renew) indefinitely.
Patients living with Myasthenia Gravis (MG) may breathe easier thanks to a rare bone marrow transplant procedure performed at The Bone Marrow Transplant Program at University of California, San Diego Medical Center, the only program in the western United States that has attempted this procedure.
The protein Oct4, which helps to maintain embryonic stem cells, has been shown to be virtually absent in adult stem cells. These results question the findings of more than 50 studies that found Oct4 in various adult stem cells, and put claims of pluripotent adult stem cells into perspective.
Anti-cancer treatments often effectively shrink the size of tumors, but some might have an opposite effect, actually expanding the small population of cancer stem cells believed to drive the disease, according to findings presented Sept. 19 by Vasyl Vasko, M.D. Ph.D., a pathologist at the Uniformed Services University of the Health Sciences.
Easily accessed and plentiful, adult stem cells found in a male patient's testicles might someday be used to create a wide range of tissue types to help him fight disease -- getting around the need for more controversial embryonic stem cells.
Engineers at Rensselaer Polytechnic Institute have developed tools to help solve two of the main problems slowing the progress of stem cell research "” how to quickly test stem cell response to different drugs or genes, and how to create a large supply of healthy, viable stem cells to study from only a few available cells.
Researchers from Georgia Tech and Emory University have discovered that gently shaking embryonic stem cells, similar to how an embryo is shaken in the mother's womb, improves their development and could some day even be used to control what type of cell they eventually become.
A consortium of scientists, led in part by USC School of Dentistry researcher Songtao Shi, has identified unique cells within the adult tendon that have stem-cell characteristics--including the ability to proliferate and self-renew. The research team was able to isolate these cells and regenerate tendon-like tissue in the animal model.
A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.
How do adult stem cells protect themselves from accumulating genetic mutations that can lead to cancer?
Scientist can now identify pluripotent stem cells based solely on their physical appearance.
Working with embryonic mouse brains, a team of Johns Hopkins scientists seems to have discovered an almost-too-easy way to distinguish between "true" neural stem cells and similar, but less potent versions. Their finding, reported this week in Nature, could simplify the isolation of stem cells not only from brain but also other body tissues.
Scientists have created breast cancer stem cells in culture by isolating and transforming a particular population of cells from normal human breast tissue. After being injected with just 100 of these transformed cells, mice develop tumors that metastasize.
Scientists with the Institute of Stem Cell Biology and Medicine at UCLA were able to produce from human embryonic stem cells a highly pure, large quantity of functioning neurons that will allow them to create models of and study diseases such as Alzheimer's, Parkinson's, prefrontal dementia and schizophrenia.
A report from researchers at Children's Hospital Boston and the Harvard Stem Cell Institute sheds new light on a now-discredited Korean embryonic stem cell line, setting the historical record straight and also establishing a much-needed set of standards for characterizing human embryonic stem cells. The report was published online August 2 by the journal Cell Stem Cell.
In a study that demonstrates the promise of cell-based therapies for diseases that have proved intractable to modern medicine, a team of scientists from the University of Wisconsin-Madison has shown it is possible to rescue the dying neurons characteristic of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder also known as Lou Gehrig's disease.
International Society for Stem Cell Research (ISSCR) names 2007 Award Winners and discusses success of the 5th ISSCR Annual Meeting.
The International Society for Stem Cell Research (ISSCR) held its 5th Annual Meeting in Cairnes Australia and announced its 2007-2008 Officers. President George Daley talks about his agenda for the upcoming year.
A University of South Florida neuroscientist reports that the cutting-edge research study of human stem cells in primates with Parkinson's disease is compelling on several fronts -- particularly how the transplanted cells did their job of easing disease symptoms. His commentary appears as a companion piece to the study in the online edition of the Proceedings of the National Academy of Sciences.
Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient's own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents.
In a survey of more than one thousand infertility patients with frozen embryos, 60 percent of patients report that they are likely to donate their embryos to stem cell research, a level of donation that could result in roughly 2000 to 3000 new embryonic stem cell lines. Researchers from Johns Hopkins University and Duke University report the startling findings in the July 6, 2007 issue of Science.
At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line "“ established long ago "“ turned out to behave a lot like cancer stem cells.
Researchers found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA.
Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body.
Researchers have manipulated mouse fibroblasts and, without using any eggs or embryos, turned them into cells with such developmental elasticity that they appear identical to embryonic stem cells.
Rats paralyzed due to loss of blood flow to the spine returned to near normal ambulatory function six weeks after receiving grafts of human spinal stem cells (hSSCs), researchers from the UCSD School of Medicine report. The study, led by Martin Marsala, M.D., UC San Diego professor of anesthesiology, is published in the June 29, 2007 issue of the journal Neuroscience, which is now online.
Diabetes researchers, investigating how the body supplies itself with insulin, discovered to their surprise that adult stem cells, which they expected to play a crucial role in the process, were nowhere to be found. Instead, the insulin-producing beta cells themselves divide and replenish their own population. The basic science finding may point to new future diabetes treatments.
Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease.
In the final stage of muscle fiber development, the cell membranes of attached myoblasts open up and fuse together, but the way in which they merge has remained a mystery. Scientists have discovered that a protein called WIP plays a key role in muscle cell fusion. This finding may help design new methods for healing muscle tissue using stem cells.
A newly discovered small molecule called IQ-1 plays a key role in preventing embryonic stem cells from differentiating into one or more specific cell types, allowing them to instead continue growing and dividing indefinitely, according to research performed by a team of scientists who have recently joined the stem-cell research efforts at the Keck School of Medicine of the University of Southern California.
The California Institute for Regenerative Medicine (CIRM) has awarded $2.5 million to Gay M. Crooks, M.D., professor of pediatrics at the Keck School of Medicine of the University of Southern California (USC) and research-scientist at The Saban Research Institute of Childrens Hospital Los Angeles, for research in blood formation from stem cells.
Vanderbilt University Medical Center is the first in the state to perform a novel therapy that uses bone marrow stem cells to stimulate regeneration of the heart muscle after a heart attack.
The University of Wisconsin School of Medicine and Public Health is among the first medical centers in the country taking part in a novel clinical trial investigating if a subject's own stem cells can treat a form of severe coronary artery disease.
Human embryonic stem cells (hESCs) can treat degenerative diseases safely and effectively, and do so by invoking multiple mechanisms. These were a few of a number of conclusions arrived at by an international collaboration led by Evan Y. Snyder, M.D., Ph.D., to be published in Nature Medicine.
A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated organs.
A cannibalistic process called autophagy spurs dying embryonic stem cells to send "eat me" and "come get me" signals to have their corpses purged, a last gasp that paves the way for normal mammalian development, UT Southwestern Medical Center researchers have found.
Mayo Clinic researchers have safely transplanted cardiac preprogrammed embryonic stem cells into diseased hearts of mice successfully regenerating infarcted heart muscle without precipitating the growth of a cancerous tumor -- which, so far, has impeded successful translation into practice of embryonic stem cell research.
UCLA scientists received seven of 72 seed grants awarded today by the state to fund stem cell research, the first money distributed for work on human embryonic stem cells since California voters approved Proposition 71 in November 2004. Seed grant funding totaled $45 million.
Researchers from the University of Southern California (USC) receive approximately $3.4 million from the California Institute for Regenerative Medicine (CIRM) for stem cell research.
Cardiologists are increasingly using adult stem cells in clinical trials to repair hearts following heart attacks, but no one has understood how the therapy actually works. Now, in animal experiments, researchers at The University of Texas M. D. Anderson Cancer Center have deconstructed the process, describing how the stem cells fuse with heart muscle cells to create new cells that repopulate the ailing organ.
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