Feature Channels: Digestive Disorders

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A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis (CF) patients who have a single copy of the most common genetic mutation for the disease.

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Pancreatitis causes more than 360,000 hospitalizations each year. Sajan Nagpal, MD, a medical pancreatologist at the University of Chicago Medicine, answers common questions about this painful condition.

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New information published by scientists at Wake Forest Baptist Health suggests that gut bacteria and its interactions with immune cells and metabolic organs, including fat tissue, play a key role in childhood obesity.

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November is national Pancreatic Cancer Awareness month. This year alone, more than 56,000 Americans will be diagnosed with pancreatic cancer. Pancreatic tumors are particularly aggressive and hard to treat "due to a mutational profile that makes it resistant to therapies that work better for other tumor types," explains Angela Alistar, MD, medical director of GI oncology at Morristown Medical Center. Dr. Alistar, an internationally known expert on pancreatic cancer, is now enrolling patients in five clinical trials aimed at pancreatic cancer.

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Cleveland Clinic has successfully performed the Midwest’s first purely laparoscopic living donor surgery for liver transplantation in an adult recipient. The advanced procedure is available at only a few hospitals worldwide, and Cleveland Clinic is the second U.S. academic medical center to offer this approach for living donor liver transplantation.

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What began as a 51-year-old mystery comes down to a single gene, as researchers from the University of Chicago and University of California, San Francisco discovered the cause of a new inherited form of pancreatitis.

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Mayo Clinic physicians will present findings at the American College of Gastroenterologists Annual Scientific Meeting, Oct. 25–30 in San Antonio.

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Gastro Girl, Inc. in partnership with the American College of Gastroenterology announces a joint venture to bring GI OnDEMAND to market as gastroenterology’s virtual care and support platform. Telehealth capabilities will enable providers to get reimbursed for out-of-office patient support.

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Dr. Mark B. Pochapin, a gastroenterologist at NYU School of Medicine/NYU Langone Health, was elected President of the American College of Gastroenterology. Dr. Pochapin's clinical and research interests include prevention, early detection, and treatment of gastrointestinal cancers and quality in endoscopy.

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The American College of Gastroenterology Annual Scientific Meeting features innovative clinical gastroenterology research with implications for patients with digestive and liver diseases. ACG's Public Relations Committee has picked Noteworthy Abstracts and invited investigators to offer Author Insights.

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American College of Gastroenterology announces 2019 SCOPY Award winners (Service Award for Colorectal Cancer Outreach, Prevention, and Year-Round Excellence) to recognize the achievements of ACG members in their community engagement, education and awareness efforts for colorectal cancer prevention

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In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.

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Ciarán P. Kelly, MD, FACG, Professor of Medicine at Harvard Medical School, is available to discuss Celiac Disease: Myths and Mysteries, topic of The American Journal of Gastroenterology Lecture

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The recipients of the Mayo Clinic Distinguished Alumni Award have been named:

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This this report represents an important opportunity to address better training among physicians around eating disorders.

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A study published today in The New England Journal of Medicine found that in patients seen for heartburn unresponsive to treatment with Proton Pump Inhibitors (PPIs), an extensive, systematic workup revealed truly PPI-refractory and reflux-related heartburn in only a minority of cases. In other words, most patients with heartburn unrelieved by PPIs did not have gastroesophageal reflux disease (GERD) causing the symptom. Furthermore, for the selected subgroup identified as having reflux-related, PPI-refractory heartburn, surgery that corrects reflux was significantly superior (67% success rate) to continued medical therapy (28% success rate).

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A multi-center randomized clinical trial evaluating a new artificial pancreas system — which automatically monitors and regulates blood glucose levels — has found that the new system was more effective than existing treatments at controlling blood glucose levels in people with type 1 diabetes.The study showed that the system improved participants’ blood glucose control throughout the day and overnight.

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Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes

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Research shows reintroducing soy into a child’s diet first was a promising treatment strategy for children who have both celiac disease and an associated allergic inflammatory disorder called eosinophilic esophagitis.

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New research suggests a vaccine that blocks a digestive hormone may slow the spread of pancreatic cancer, potentially increasing survival rates. The study, published ahead of print in the American Journal of Physiology—Gastrointestinal and Liver Physiology, was chosen as an APSselect article for October.

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The Center for Medicinal Cannabis Research at University of California San Diego School of Medicine announces $3 million in research grants to explore new applications of cannabis for a number of novel medical applications.

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Scientists have made genetic data publicly available for bacteria that might be lurking inside the gut walls of patients chronically affected with severe Crohn’s disease. By studying a surgically removed, damaged bowel from a patient, researchers were able to culture bacteria from a special form of microscopic lesions that they earlier discovered and that can be present within the gut wall of the inflamed bowel in Crohn’s disease. After growing the bacteria in their laboratory, they chose one representative species, and performed a complete genome sequence analysis that could hold clues into how the slow and damaging microlesions form.

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An immune cell that helps set the daily rhythms of the digestive system has been identified by researchers at Washington University School of Medicine in St. Louis. The findings open the door to new treatments for digestive ailments targeting such cells.

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Findings showcasing a connection between bacteria in the microbiome and colon cancer, which may be used to screen younger populations at risk, were published in the journal Gastroenterology by researchers from the George Washington University.

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Das Pankreasadenokarzinom (PDAC) ist ein letales Malignom, das am häufigsten gegen eine Chemotherapie resistent ist. Forscher haben nach Möglichkeiten gesucht, die Anfälligkeit der Tumore für krebsbekämpfende Medikamente zu erhöhen.

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L'adénocarcinome du pancréas (PDAC) est une tumeur maligne mortelle qui résiste le plus souvent à la chimiothérapie. Les chercheurs ont cherché des moyens d'accroître la sensibilité des tumeurs aux médicaments anticancéreux.

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胰腺癌(PDAC)是一种致命的恶性肿瘤，通常对化疗具有抗药性。研究人员一直在寻找提高肿瘤对抗癌药物的敏感性的方法。Mayo Clinic今日发布的一项自主研究成果在抗癌战役中开辟了一条新战线。

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O adenocarcinoma pancreático (ACDP) é um carcinoma letal geralmente resistente à quimioterapia. Os pesquisadores têm buscado formas de aumentar a sensibilidade dos tumores aos medicamentos de combate ao câncer.

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Scientists have developed a computer method that may help improve understanding and treatment of Crohn’s disease, which causes inflammation of the digestive tract. The Rutgers-led study, published in the journal Genome Medicine, used artificial intelligence to examine genetic signatures of Crohn’s in 111 people. The method revealed previously undiscovered genes linked to the disease, and accurately predicted whether thousands of other people had the disease.

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The three-drug combination of encorafenib, binimetinib and cetuximab significantly improved overall survival (OS) in patients with BRAF-mutated metastatic colorectal cancer (mCRC), according to results of the BEACON CRC Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

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A new blood test in development has shown ability to screen for numerous types of cancer with a high degree of accuracy, a trial of the test shows.

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Good bacteria that live in the guts of mammals program the metabolic rhythms that govern the body’s absorption of dietary fat.

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Mount Sinai researchers have identified elemental signatures in baby teeth that are unique to attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and cases when both neurodevelopment conditions are present, which suggests that the metabolic regulation of nutrients and toxins play a role in these diseases, according to a study published in Translational Psychiatry in September.

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In the first clinical trial to evaluate two biologic therapies for moderate to severe ulcerative colitis (UC) head to head, Mount Sinai researchers found vedolizumab to be superior to adalimumab in a variety of measures. In a separate study, the investigators reported that ustekinumab is more effective than placebo as an induction and maintenance therapy for UC. The studies were published today in the The New England Journal of Medicine.

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A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute.

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El adenocarcinoma pancreático (PDAC, por sus siglas en inglés) es un cáncer mortal y muy a menudo refractario a la quimioterapia. Por ello, los investigadores buscan maneras de mejorar la sensibilidad tumoral a los fármacos contra el cáncer.

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A scientific team led by Cedars-Sinai has been awarded $10 million from the U.S. Department of Defense to investigate the risk factors and behaviors that contribute to pancreatic diseases and develop potential treatments and lifestyle recommendations to prevent them.

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Within six months of the FDA's move to restrict the label of two immunotherapies, usage of those therapies among oncologists dropped by about 50 percent, according to a new study from researchers in the Abramson Cancer Center at the University of Pennsylvania.

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Expert reports estimate that one in three breast cancer cases could be prevented by lifestyle modifications.

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Value in Health, the official journal of ISPOR—the professional society for health economics and outcomes research, announced today the publication of research demonstrating that discrete choice experiments are able to predict real-world healthcare choices.

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Pathologists are increasingly optimistic about the potential of the human microbiome to help guide diagnosis and monitoring of chronic diseases.

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New research led by the University of South Australia shows just how effective bowel cancer screening is in helping to reduce the number of bowel cancer deaths by up to 45 per cent.