Johns Hopkins scientists have developed a simplified, cheaper, all-purpose method they say can be used by scientists around the globe to more safely turn blood cells into heart cells. The method is virus-free and produces heart cells that beat with nearly 100 percent efficiency, they claim.
A new study has demonstrated no significant benefit of taking the drug bosentan for idiopathic pulmonary fibrosis (IPF).
Hawaii Governor Neil Abercrombie has issued a state proclamation declaring the week of April 9-16, 2011, as “Brain Health Awareness Week” in the Aloha state. The proclamation coincides with two large events in Honolulu; the Brain Health Fair Saturday, April 9, and the American Academy of Neurology’s Annual Meeting at the Hawaii Convention Center April 9-16, which is the world’s largest meeting of neurologists with more than 9,000 attendees.
Workshop Coincides with the American Academy of Neurology Annual Meeting, Largest in World
A researcher determined to manipulate the activation of certain enzymes will present new findings about a previously unknown cellular process that the pancreas uses to selectively detect and gobble up activated enzymes before they can digest the organ, avoiding disease progression.
The first of its kind, an effectiveness study by Newswise has shown that 93% of research news releases and 77% of feature news releases get at least 5 news clips in major media outlets. The study also explored the reach and relevance of web search results duplicating the original news release.
Experts on metabolism will convene for a thematic program to discuss scientific advances in understanding the links between metabolic function and the onset of disease.
The program will showcase the work of scientists from all over the world who have their sights set on reversing the epidemic of obesity by laying bare and manipulating, to mankind’s advantage, its molecular underpinnings. Nine 25-minute talks and numerous other shorter talks about groundbreaking obesity studies.
A thematic program will bring together researchers from across the country to discuss recent developments in DNA replication, recombination and repair and the importance of these activities in cancer and gene therapy.
Two dozen researchers will go public about their ongoing work aimed at improving our understanding of biological systems and contributing to our cache of healing compounds.
Today, The Endocrine Society released a new Clinical Practice Guideline (CPG) for the evaluation and treatment of pituitary incidentalomas. The CPG is published in the April 2011 issue of the Journal of Clinical Endocrinology & Metabolism (JCEM), a publication of The Endocrine Society.
It turns out that exercising during pregnancy might be the earliest intervention strategy available to mothers for improving their child’s heart health after birth.
Familiar voices, magnetic stimulation being tested in two clinical trials. One study is a double-blind, randomized trial in which family members and loved ones of the patients play very important roles.
The United States should pay close attention to how the United Kingdom carries out plans to assess a new drug’s worth using factors that go beyond clinical and cost effectiveness, according to researchers at the Johns Hopkins Berman Institute of Bioethics. In a commentary to appear in the April 7 issue of the New England Journal of Medicine, the bioethicists detail and discuss a new, “value-based pricing” policy proposed by the British government.
New research suggests that workers exposed to welding fumes may be at risk for developing brain damage in an area of the brain also affected in Parkinson’s disease. The study is published in the April 6, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Johns Hopkins researchers report the discovery of a molecular switch that regulates the behavior of a protein that, when altered, is already known to increase human susceptibility to schizophrenia and mood disorders.
MIT cancer biologists have identified a genetic change that makes lung tumors more likely to spread to other parts of the body. The findings, to be published in the April 6 online issue of Nature, offers new insight into how lung cancers metastasize and could help identify drug targets to combat metastatic tumors, which account for 90 percent of cancer deaths.
Following years of futile attempts, new research from the Monell Center demonstrates that living human taste cells can be maintained in culture for at least seven months. The findings provide scientists with a valuable tool to learn about the human sense of taste and how it functions in health and disease.
Oncologists can use colorectal cancer patients’ own immune system to boost the effects of chemotherapy and increase progression-free survival, according to Phase III study results presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.
Breast cancer survivors with poor physical health scores had an elevated risk of poorer cancer outcomes, including recurrence and death, according to the results of an observational study presented at the AACR 102nd Annual Meeting 2011, held April 2-6.
Freeze-dried strawberries may be an alternative to drugs for the prevention of esophageal cancer, according to research presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.
Experts from The Cancer Institute at NYU Langone Medical Center presented new research findings at the American Association for Cancer Research 102nd Annual Meeting 2011 held April 2-6, 2011 in Orlando, Florida. NYU Cancer Institute researchers discussed various breakthroughs such as a novel test for early-stage asbestos-related pulmonary cancer, a promising treatment strategy for glioblastomas, genome-wide mapping of nickel-related cancer and greater understanding of melanoma and bladder cancer.
While there is an increasing equality in terms of the likelihood that children from communities and families across the socioeconomic spectrum will be diagnosed with autism, a new study finds that such factors still influence the chance of an autism diagnosis, though to a much lesser extent than they did at the height of rising prevalence.
Modifying a protein from a plant much favored by science, researchers at the University of California, San Diego School of Medicine and colleagues have created a new type of genetic tag visible under an electron microscope, illuminating life in never-before-seen detail.
Meditation produces powerful pain-relieving effects in the brain, according to new research published in the April 6 edition of the Journal of Neuroscience.
Investigators have attempted to replicate 2009 findings that associated the XMRV retrovirus with Chronic Fatigue Syndrome. However those studies have been performed on blood. The current study focuses instead on cerebrospinal fluid, given the syndrome's impact on nervous system function.
Among postmenopausal women with prior hysterectomy who had used estrogen therapy for about 6 years and then stopped, longer-term follow-up indicates that the increased risk of stroke seen during the intervention period had dissipated, the decreased risk of hip fracture was not maintained, while the decreased risk of breast cancer persisted, according to a study in the April 6 issue of JAMA.
Higher levels in blood of the protein clusterin, also known as apolipoprotein J, are significantly associated with the prevalence and severity of Alzheimer's disease, but not with the risk of onset of new disease, according to a study in the April 6 issue of JAMA.
In an analysis of opioid prescription patterns and deaths, receiving higher prescribed doses is associated with an increased risk of opioid overdose death, but receiving both as-needed and regularly scheduled doses is not associated with overdose risk, according to a study in the April 6 issue of JAMA.
An analysis of data from 10 studies indicates that the presence of low frequency (also called "minority") human immunodeficiency virus type 1 (HIV-1) drug resistance mutations, particularly those involving nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance, are significantly associated with an increased risk of first-line antiretroviral treatment failure, according to an article in the April 6 issue of JAMA.
An editorial in the April 6 issue of the Journal of the American Medical Association cautions against estrogen-only hormone therapy in women who have had a hysterectomy because of longstanding evidence that it raises the risk of breast cancer.
Soy food consumption did not increase the risk of cancer recurrence or death among survivors of breast cancer, according to the results of a study presented at the AACR 102nd Annual Meeting 2011, held April 2-6.
Research from New Jersey’s only NCI-Comprehensive Cancer Center explores the protein HER2 and the role it plays in breast cancer aggressiveness, poor clinical outcome and chemotherapy resistance. The findings, being presented at the 102 Annual Meeting of the AACR, indicate that under stressful conditions, too much HER2 can cause a decrease in the cell-survival mechanism of autophagy. This decrease can lead to the alteration of other cellular processes and may increase breast cancer metastasis.
Researchers at the University of Pennsylvania School of Medicine may have found a way to turn an adaptive cellular response into a liability for cancer cells by treating a group of patients with several different types of advanced cancers with temsirolimus, a molecularly targeted cancer drug that blocks nutrient uptake, plus hydroxychloroquine, an anti-malarial drug that inhibits autophagy. The regimen halted tumor growth in two-thirds of the patients.
Cardiologists from the Cardiac & Vascular Institute at NYU Langone Medical Center presented new research findings at the American College of Cardiology 60th Annual Scientific Session held April 2-5, 2011 in New Orleans, Louisiana.
Breast cancer survivors who experience extreme weight gain have an increased risk of death after breast cancer diagnosis. Moderate weight gain did not affect breast cancer outcomes. These study results were presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.
Using minute graphite particles 1000 times smaller than the width of a human hair, mechanical engineers at Arizona State University hope to boost the efficiency—and profitability—of solar power plants.
For some people, alcohol is a social lubricant. For others, it's an unpleasant downer. New research shows that a person's response to alcohol can predict their future drinking behavior, including their frequency of binge drinking and the risk of developing an alcohol-use disorder.
Adolescent girls participating in high-impact physical activity, specifically basketball, running and gymnastics/cheerleading, appear to be at increased risk for developing stress fractures, according to a report posted online today that will appear in the August print issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
Having a significant other who exhibits controlling behaviors appears to be associated with increased physical and sexual relationship violence, according to a report in the April issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. However, young women experiencing these behaviors are more hesitant to answer questions about relationship violence.
The prevalence of plagiocephaly, a condition marked by an asymmetrical, flattening of the skull, appears to be increasing in infants and young children, according to a report posted online today that will appear in the August issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
Persons with an addictive-like eating behavior appear to have greater neural activity in certain regions of the brain similar to substance dependence, including elevated activation in reward circuitry in response to food cues, according to a report posted online today that will appear in the August print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
People who migrate to the United States from Mexico have a significantly higher risk of developing depressive or anxiety disorders than family members of migrants who remain in Mexico, according to a report in the April issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Low levels of household income are associated with several lifetime mental disorders and suicide attempts, and a decrease in income is associated with a higher risk for anxiety, substance use, and mood disorders, according to a report in the April issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Fossil teeth of African animals show that during the past 10 million years, different plant-eating critters began grazing on grass at different times as many switched from a salad-bar diet of tree leaves and shrubs, says a University of Utah study.
Scientists from the Morgridge Institute for Research, the University of Wisconsin-Madison, the University of California and the WiCell Research Institute moved gene therapy one step closer to clinical reality by determining that the process of correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells.
A species of algae long known to associate with spotted salamanders has been discovered to live inside the cells of developing embryos, say scientists from the U.S. and Canada, who report their findings in this week's PNAS. This is the first known example of a eukaryotic algae living stably inside the cells of any vertebrate.
Vanderbilt researchers, who helped organize a consortium including the University of Pennsylvania School of Medicine, the University of Miami Miller School of Medicine, and the Boston University School of Medicine, have identified four new genes linked to Alzheimer’s disease. The findings, released today by Nature Genetics, effectively double the number of genes known to contribute to the disease, according to Jonathan Haines, Ph.D., director, Vanderbilt Center for Human Genetics Research.
Judy E. Garber, M.D., M.P.H., was inaugurated today as president of the American Association for Cancer Research at the AACR 102nd Annual Meeting 2011. This year’s meeting theme is “Innovation and Collaboration: The Path to Progress.”
Researchers at McMaster University and Hamilton Health Sciences have found accessing blocked arteries through the forearm compared to groin led to fewer vascular complications and similar success rates for angioplasty.
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