Newswise — BIRMINGHAM, Ala. – Clinicians should recommend exercise and cognitive training for patients with mild cognitive impairment — a common precursor of Alzheimer’s type dementia — according to new guidelines published in the December 27, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. The panel also suggests there is little evidence that cholinesterase inhibitors — medications used to treat Alzheimer’s dementia— are effective in persons with MCI.

The AAN convened a panel of experts in the field to review literature on the prevalence, prognosis and treatment of MCI, to update the earlier 2001 AAN guidelines. Dan Marson, Ph.D., J.D., professor emeritus in the Department of Neurology, School of Medicine at the University of Alabama at Birmingham, was a member of that panel and is a co-author of the new guidelines.

The panel confirmed that MCI is common in older populations, and its prevalence increases with age and with lower educational level. Persons with MCI are at higher risk of progressing to dementia than are age-matched controls.

“The panel addressed four basic questions,” Marson said. “What is the prevalence of MCI in the general population? What is the prognosis for patients diagnosed with MCI for progression to a diagnosis of dementia, and how does this compare with an age-matched general population? What pharmacologic treatments are effective for patients diagnosed with MCI? And what nonpharmacologic treatments are effective for patients diagnosed with MCI?”

Among the panels’ recommendations:

  • Clinicians should assess for MCI with validated tools in appropriate scenarios.
  • Clinicians should evaluate patients with MCI for modifiable risk factors, assess for functional impairment, and assess for and treat behavioral/neuropsychiatric symptoms.
  • Clinicians should monitor cognitive status of patients with MCI over time.
  • Cognitively impairing medications should be discontinued where possible and behavioral symptoms treated.
  • Clinicians may choose not to offer cholinesterase inhibitors; if offering, they must first discuss lack of evidence.
  • Clinicians should recommend regular exercise.
  • Clinicians may recommend cognitive training.
  • Clinicians should discuss diagnosis, prognosis, long-term planning and the lack of effective medicine options and may discuss biomarker research with patients with MCI and families.

“Care for persons with MCI continues to evolve, with early identification, diagnosis, and education important to patients with MCI and their families,” said Marson. “Where clinicians are not proficient in caring for the cognitive and behavioral or psychiatric needs of persons with MCI, referral to appropriate specialists is an important part of the treatment paradigm in line with the guideline recommendations.”

The AAN panel was led by Ronald C. Petersen, M.D., Ph.D., at the Mayo Clinic. Other panelists represented the University of Pittsburgh, University of Florida, Heart Rhythm Society, Charleston Area Medical Center, University of Kansas, University of Calgary, Washington University, University of Wisconsin and the Cleveland Clinic.

About UAB

Known for its innovative and interdisciplinary approach to education at both the graduate and undergraduate levels, the University of Alabama at Birmingham is the state of Alabama’s largest employer and an internationally renowned research university and academic medical center; its professional schools and specialty patient-care programs are consistently ranked among the nation’s top 50. Find more information at and

EDITOR’S NOTE: The University of Alabama at Birmingham is a separate, independent institution from the University of Alabama, which is located in Tuscaloosa. Please use University of Alabama at Birmingham on first reference and UAB on subsequent references.








Journal Link: Neurology, Dec. 27, 2017