Researchers from the Stowers Institute for Medical Research in collaboration with Fred Hutchinson Cancer Research Center researchers have identified an unprecedented genetic survival strategy that would be right at home in an Agatha Christie murder mystery novel.
In a study published in the June 5, 2017, issue of the Proceedings of the National Academy of Sciences, Stowers scientists Bony De Kumar, Ph.D., and Robb Krumlauf, Ph.D., provide evidence of direct cross-regulatory feedback, or cross-talk, between Nanog and Hox genes.
Stop-and-go traffic is typically a source of frustration, an unneccesary hold-up on the path from point A to point B. But when it comes to the molecular machinery that copies our DNA into RNA, a stop right at the beginning of the path may actually be helpful. Recent research from the Stowers Institute for Medical Research shows that this stop prevents another machine from immediately following the first, presumably to better control the traffic and avoid later collisions.
Proteins, those basic components of cells and tissues, carry out many biological functions by working with partners in networks. The dynamic nature of these networks – where proteins interact with different partners at different times and in different cellular environments – can present a challenge to scientists who study them.
A new report from the Stowers Institute for Medical Research chronicles the embryonic origins of planaria, providing new insight into the animal's remarkable regenerative abilities.
The complex process regulating gene expression is often compared to following a recipe. Miss a genetic ingredient, or add it in the wrong order, and you could have a disaster on your hands.
How do you remember what happened today in the weeks and months that follow? Researchers at the Stowers Institute for Medical Research have answered a piece of that question in a recent study.
Researchers at the Stowers Institute have established a definitive link between the makeup of the microbiome, the host immune response, and an organism’s ability to heal itself.
Researchers at the Stowers Institute have identified a key molecule that directs stem cells in the planarian flatworm to make copies of themselves.
Scientists at the Stowers Institute for Medical Research have reported a detailed description of how function-impairing mutations in polr1c and polr1d genes cause Treacher Collins syndrome (TCS), a rare congenital craniofacial development disorder that affects an estimated 1 in 50,000 live births.
The Stowers Institute for Medical Research is pleased to announce that Scientific Director and Investigator Robert Krumlauf, Ph.D., has been elected a member of the National Academy of Sciences (NAS) for his distinguished and continuing achievements in original scientific research.
For the first time, researchers at the Stowers Institute have mapped where recombination occurs across the whole genome of the fruit fly Drosophila melanogaster after a single round of meiosis.
Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality.
In two new studies, researchers in the laboratory of Howard Hughes Medical Institute Investigator Alejandro Sánchez Alvarado, Ph.D., at the Stowers Institute for Medical Research explore the intricate processes at work when stem cells differentiate into planarian skin cells.
During the holidays, we often remember the past and create new memories. But, why do some memories fade away while others last forever? Scientists at the Stowers Institute for Medical Research have identified a possible biochemical mechanism by which the specialized brain cells known as neurons create and maintain a long-term memory from a fleeting experience.
A particular location in DNA, called the Dlk1-Gtl2 locus, plays a critical role in protecting hematopoietic, or blood-forming, stem cells—a discovery revealing a critical role of metabolic control in adult stem cells, and providing insight for potentially diagnosing and treating cancer, according to researchers from the Stowers Institute for Medical Research.
Researchers in the Workman Lab at the Stowers Institute for Medical Research have identified a link between cellular metabolism and gene expression, one with potentially far-reaching implications for cancer risk prediction and treatment.
A team of researchers from the Stowers Institute for Medical Research and the University of Colorado Boulder has devised a novel optical technique — a combination of structured illumination microscopy (SIM) and single-particle averaging (SPA) — to resolve individual components of SPB duplication in living yeast cells.
A new study in Developmental Cell, from Stowers Institute for Medical Research Associate Investigator Tatjana Piotrowski, Ph.D., zeros in on an important component in fish: the support cells that surround centrally-located hair cells in each garlic-shaped sensory organ, or neuromast.
Researchers at the Stowers Institute have shown that a molecule called elongin A assists with transcription.
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