Feature Channels: Stem Cells

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Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

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Kotaro Sasaki, Yasunari Seita, Keren Cheng, John McCarrey, Nomesh Yadu, Ian Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana-Toro, Li-Hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann

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Marija Zivaljic, Mathieu Hubert, Ludivine Grzelak, Giulia Sansone, Uwe Maskos, Olivier Schwartz

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Fuad Gandhi Torizal, Tia Utami, Lau Qiau You, Kousuke Inamura, Masaki Nishikawa, Yasuyuki Sakai

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Louise Cheng, Kellie Veen, Francesca Froldi, Qian Dong, Edel Alvarez-Ochoa, Phuong-Khanh Nguyen, Kieran F Harvey, John P D McMullen, Owen J. Marshall, Patricia R Jusuf

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Ogechi Ogoke, Daniel Guiggey, Sarah Thompson, Alexander Chiang, Tram Hoang Anh Nguyen, Daniel Berke, Cortney Ott, Allison Kalinousky, Claire Shamul, Peter Chen, Shatoni Ross, Zhaowei Chen, Pooja Srivastava, Supriya D Mahajan,

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Daniel W. Simmons, David R. Shuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Mary K. Munsell, Brennan Kandalaft, Missy Pear, Nathaniel Huebsch

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Abstract: To develop into the central nervous system, neuroepithelial cells must first form a neural tube consisting of a series of patterned neural progenitor cells along the anterior-posterior (AP) axis. Based on studies using model organisms, it has been revealed that AP spatial regionalization is dominated by gradients of morphogens that regulate retinoic acid (RA), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), and Wingless/int1 (WNT) signaling pathways.

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Abstract: A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HSCT).

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Background Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long non-coding RNAs (lncRNAs) reportedly play essential roles in stem cell aging. However, the mechanisms by which lncRNAs influence mesenchymal stem cell aging have not been investigated.

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Giorgia Fedele, Alessandra Cazzaniga, Sara Castiglioni, Laura Locatelli, Antonella Tosoni, Manuela Nebuloni, Jeanette A.M. Maier

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Lara Al Zouabi, Marine Stefanutti, Nick Riddiford, Natalia Rubanova, Mylene Bohec, Nicolas Servant, Allison J Bardin

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Jiacong Hong, Shan Wang, Zhaopeng Cai, Peng Wang, Zhongyu Xie, Keng Chen

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Our immune system is essential for our survival, as our bodies are constantly being exposed to bacteria, viruses, parasites, and other pathogens.

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Ryota Mori, Norikatsu Miyoshi, Shiki Fujino, Tsunekazu Mizushima, Ryohei Yukimoto, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi

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Faizzan S. Ahmad, Yongcheng Jin, Alexander D. Grassam-Rowe, Yafei Zhou, Meng Yuan, Xuehui Fan, Rui Zhou, Razik Mu-U-Min, Christopher O'Shea, Ayman M. Ibrahim, Wajiha Hyder, Yasmine Aguib, Magdi Yacoub, Davor Pavlovic

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Fatemeh Eskandari, Samira Zolfaghari, Ayna Yazdanpanah, Rima Manafi Shabestari, Motahareh Rajabi Fomeshi, Peiman B. Milan, Jafar Kiani, Mina Soufi Zomorrod, Majid Safa

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Robyn M Jong, Krystal Ching, Nicholas E Garelis, Alex Zilinskas, Xammy Nguyenla, Sagar Rawal, Bianca Hill, Bridget Luckie, Lillian Shallow, Jeffery S Cox, Gregory Barton, Sarah Stanley

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Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-Ur Rahman, Tim Habboub, Alan C. Mullen

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So Hee Nam, Yan Lee, Hee-Jin Yang, Sung Bae Park

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Rutgers scientists have found more clear-cut evidence of how the destructive proteins linked to Alzheimer’s disease attack human brain cells and destroy surrounding tissue.

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Kolby Jardine, Rebecca Dewhirst, Suman Som, Joseph Lei, Eliana Tucker, Robert Young P, Miguel Portillo-Estrada, Yu Gao, Luping Su, Silvano Fares, Cristina Castanha, Jenny Mortimer

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Yihong Li, Ting Cai, Huina Liu, Yun Lei, Shun Zhang, Fuyu Sun, Jie Liu, Shao-Yu Chen, Huadong Fan

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Ophelie Renoult, Catherine Gratas, Noemie Joalland, Melanie Laurent--Blond, Hala Awada, Marine Bourgeois, Lisa Oliver, Sophie Chiavassa, Mikael Croyal, Francois Paris, Claire Pecqueur

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Siqin Bao, Baojiang Wu, Zhiqing Yang, Yijie Liu, Jianwen Li, Chen Chen, Xihe Li

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Amatullah Mir, Isaree Pitaktong, Jason Yusheng He, Katherine Nurminsky, Tyler Dunn, Sarah Koljaka, Olivia Dunn, Stephanie Ran, Daniel Rodgers, Anya Wang, Hiroshi Matsushita, Narutoshi Hibino, Wesley Shih

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Amanda Menzele, Hamida Aboalgasm, Robea Ballo, Asfree Gwanyanya

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Hailin Zou, Juan Luo, Yibo Guo, Peng Li

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell,

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Peng Ding, Chuan Gao, Youshui Gao, Delin Liu, Hao Li, Jun Xu, Xiaoyi Chen, Yigang Huang, Changqing Zhang, Ming Hao Zheng, Junjie Gao

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Wenxuan Wang, Chun Fan, Xinbo Yu, Xu Qiu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Qiuxia Ji

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Tarik Hadid, Ayad Al-Katib, Jose Binongo, Gina M. Berteotti, Salman Fazal, James M. Rossetti, John Lister

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Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Martin J Lohse, Paolo Annibale

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Ao Fang, Yifan Wang, Naiyu Guan, Lingmin Lin, Binjie Guo, Wanxiong Cai, Xiangfeng Chen, Jingjia Ye, Zeinab Abdelrahman, Shuang Jin, Bin Yu, Xiaosong Gu, Xuhua Wang

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Andrew D Duckworth, Cath Eberlein, Victoria Pollard, Richard Bethell, Joseph R Slupsky, Oliver Schon, John F Woolley, Tiffany Thorn

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Brijesh Kumar, Katie Batic, Poornima Bhat-Nakshatri, Maggie M Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J Temm, George Sandusky, Sandra K Althouse, Anna Maria Storniolo, Harikrishna Nakshatri

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Guomin Li, Xu Han, Ye Wu, Wei Wang, Hong-Xia Tang, Mei-Ping Lu, Xue-Mei Tang, Yi Lin, Fan Deng, Jun Yang, Xin-Ning Wang, Cong-Cong Liu, Wen-Jie Zheng, Bing-Bing Wu, Fang Zhou

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Tomoaki Iwayama, Mizuho Iwashita, Kazuya Miyashita, Hiromi Sakashita, Shuji Matsumoto, Kiwako Tomita, Phan Bhongsatiern, Tomomi Kitayama, Kentaro Ikegami, Takashi Shimbo, Katsuto Tamai, Masanori A Murayama, Shuhei Ogawa, Yoichiro Iwa

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Abstract: Background: Clinical and research based genetic testing has uncovered genes that encode chromatin modifying complex components required for organogenesis. Covalent histone modifications play a key role in establishing transcriptional plasticity during development, required for cell fate specification, and have been implicated as a developmental mechanism that accounts for autism spectrum disorder (ASD) and CHD co-occurrence. ASXL3 has been identified as a high confidence ASD gene. ASXL3 is a component of the Polycomb Repressive Deubiquitination (PR-DUB) complex, which deubiquitinates histone H2A. However, the role of ASXL3 in cardiac development remains unknown.

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Neuroinflammation and activated microglia play important role in neuron damage in the traumatic brain injury (TBI). In this study, we determined the effect of human umbilical cord mesenchymal stem cells (UMSCs) combined with monosialotetrahexosy 1 ganglioside (GM1) on the neuroinflammation and polarization of microglia in a rat model of TBI, which was established in male rats using a fluid percussion brain injury device.

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu

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Here, Seong et al. identify an optimal set of epiblast inducers that captures mouse trophectoderm stem cells (TESCs) as a stable and highly self-renewing state reflecting the blastocyst stage. TESCs have enhanced capacity to form blastoids that indu