… d Stem cell frequency of GS5 cells treated with Cas9 and the indicated sgRNAs as determined by limiting dilution assay. e–g Representative flow cytometry images (e) and corresponding quantification (f) (n = 3 biologically independent samples, black …
… The objective of this study is to synthesise the findings of clinical studies in order to derive evidence for use of the mesenchymal stem cell (MSC) therapy in the treatment of neurodegenerative cerebellar ataxias. In order to find relevant studies …
… methylation status, which in turn compromised periodontal stem cell function including a reduction in proliferation and differentiation … co‐regulator, which plays a key role in cell proliferation, differentiation, and stem cell self‐renewal [86]. The …
Micropollutants in water often are hormones that accumulate in the environment and may have negative impacts on humans and animals. Researchers of Karlsruhe Institute of Technology (KIT) and Leibniz Institute of Surface Engineering (IOM) in Leipzig have now developed a process for the photocatalytic degradation of these pollutants when they flow through polymer membranes. It is presented in Nature Nanotechnology. Irradiation with light triggers a chemical reaction, as a result of which steroid hormones are degraded on the membranes coated with titanium dioxide. (DOI: 10.1038/s41565-022-01074-8)
… Allogeneic hematopoietic stem cell transplantation (HSCT) can be a highly effective treatment for patients with hematological malignancies and hereditary blood disorders if a suitable HSC graft can be obtained, ideally from an HLA (human leukocyte …
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). However, defining the best treatment strategy (and in particular …
… hold a patent application for the investigated stem cell product “Stem cell therapy based on adipose-derived stem cells”, WO2017068140. None of the other coauthors declare conflicts of interest. LS is an advisory board member for Takeda and Kyowa …
… In this study, we generate lung cells and macrophages from the same human pluripotent stem cell (hPSC) lines and pair them to establish a co-culture system. This strategy addresses a common concern about histocompatibility when studying …
… ABCC1 encodes the ATPase cassette transporter protein multidrug resistance 1, a stem cell marker and MYCN transcriptional target conferring … 1, 2), suggesting they share a common ependymal stem cell lineage. The mismatch repair gene …
The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell …
… The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury. … Accumulating literature on animal studies suggests that mesenchymal stromal/stem cell (MSC) transplantation …
… We decided to focus on stem cell therapy administered within the acute phase (<2 weeks) of the timing of the TSCI, as this would be the realistic time for administration within humans. It is likely that SC therapy may involve injections within both the …
In this work, the mechanism underlying the anticancer activity of a photoactivatable Ir(III) compound of the type [Ir(CˆN) 2 (dppz)][PF 6 ] where CˆN = 1-methyl-2-(2′-thienyl)benzimidazole (complex 1) was investigated. Complex 1 photoactivated by visible light shows …
… a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. … Taken together, our data describe one mechanism by which a transcription factor controls stem cell …
Annika M Kisch, Karin Bergkvist, Sólveig Adalsteinsdóttir, Christel Wendt, Anette Alvariza, Jeanette Winterling
Sheerien Rajput, Khurram Minhas, Iqbal Azam, Usman Shaikh, El-Nasir Lalani
Toshinobu Nakatake, Makoto Nabetani, Nanae Yutaka, Kaho Suzuki, Ryoichi Hazama, Satoshi Ohnishi, Takashi Hamazaki, Haruo Shintaku, Ran D Goldman
Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao
Hongkui Deng, Jingyang Guan, Guan Wang, Jinlin Wang, Zhengyuan Zhang, Yao Fu, Lin Cheng, GaoFan Meng, Jialiang Zhu, Yanglu Wang, Shijia Liuyang, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen
Tadeusz J. Kaczynski, Elizabeth D. Au, Michael H. Farkas
Lenin D. Ochoa-De la Paz, Nadia Estefanía Gutiérrez-Castañeda, Jessica González-Corona, Ernesto Griego, Emilio J. Galván
GuoYi Dong, Xiaojing Xu, Yue Li, Wenjie Ouyang, Weihua Zhao, Ying Gu, Jie Li, Tianbin Liu, Xinru Zeng, Huilin Zou, Shuguang Wang, Sixi Liu, Hai-Xi Sun, Chao Liu
Toru Okubo, Ryuhei Hayashi, Yuji Kudo, Yuki Ishikawa, Andrew J. Quantock
Yufeng Zhang, Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, YaoTing Ji
Marquita Camilleri, Georgios Bekris, Govundeep Sidhu, Caroline Buck, Esme Elsden, Orla McCourt, Jackie Horder, Fiona Newrick, Catherine Lecat, Jonathan Sive, Xenofon Papanikolaou, Rakesh Popat, Lydia Lee, Ke Xu, Charalampia Kyriakou, Neil Rabin, Kwee Yong, Abi Fisher
Biswajit Das, Chinmayee Sethy, Subhajit Chatterjee, Somya Ranjan Dash, Saptarshi Sinha, Subarno Paul, Kunal Goutam, Chanakya Nath Kundu
… stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural stem cell (NSC …
… cells remains eliciting the desired stem cell behavior once transplanted in the body. In their natural environment, stem cell fate is regulated by their … ECM ligands, as well as soluble cues, making MSN-ssDNA based biointerfaces a novel tool to …
… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper stem cell proliferation rate. Thus, our data uncover the underlying mechanism of Aux in stem cell proliferation control and …
… This article briefly introduced the regulatory framework development, the progress in stem cell clinical researches and clinical trials of commercially developed stem cell-based products, as well as the clinical review concerns of stem cell-based products in …
In this review, we will outline dimensions in which outcome of patients with myelofibrosis undergoing curative treatment can be optimized: patient selection, transplant procedure, and posttransplant prevention or treatment of relapse. For …
… of etoposide and cytarabine [8], or intensive chemotherapy followed by autologous stem cell transplantation (IC-ASCT) [9, 10]. Thiotepa-based myeloablative chemotherapy followed by autologous stem cell transplantation (ASCT) …
… Owing to the fact that MSC-derived exosomes can further control stem cell differentiation by carrying and transferring miRNAs, stem cell-based exosome therapeutic regimens have been highlighted as effective means for cardiac …
The widespread clinical application of cord blood (CB) for hematopoietic stem cell (HSC) transplantation is limited mainly by the inadequate number of hematopoietic stem and progenitor cells (HSPCs) in single CB units, which results in unsuccessful or …
… Mesenchymal stem cell-derived EV have been shown to contain a diverse array of bioactive cargo, including proteins, nucleic acids, non-coding RNA and lipids. The lipid bilayer of the EV membrane protects the cargo from degradation and is often …
Mohamadamin Forouzandehmehr, Michelangelo Paci, Jussi Koivumäki, Jari Hyttinen
A pair of Rutgers researchers are teaming up to combat climate change and worldwide hunger at the same time. Yong Mao, associate research professor and lead biologist in the Laboratory for Biomaterials Science at Rutgers School of Arts and Sciences, and Joseph Freeman, professor, director of the Musculoskeletal Regeneration Laboratory, and graduate program director of biomedical engineering in Rutgers School of Engineering, will collaborate with Atelier Meats, a biotechnology company, to develop and produce lab-grown, structured meats.
Yeqing Yang, Junkai Zeng, Chong Jiang, Jiawen Chen, Ming Chen, Buling Wu
Hanan Al-Abboh, Akmal Zahra, Adekunle Adekile
Fei Jiao, Xiao Zhang, Chongyang Ye, Qing Sun, Yan Gao, Chenglin Liu, Bo Huo
Zhen Yu, Shuai Tong, Can Zhang, Yue Bai, Zhijing An, Chang Xu, Fang Wang, Yi Hu, Qinghui Zhuang, Xiaosong Zhong
Rodrigo García-Tejera, Linus Schumacher, Ramon Grima
If you become ill with COVID-19, your smartwatch can track the progression of your symptoms, and could even show how sick you become.
In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause o
(Cell Stem Cell 29, 515–527.e1–e8; April 7, 2022)
Despite the surrounding controversy, quantitative sex-based differences exist in the human brain. In a recent issue of Nature, Kelava et al. shed light on the mechanisms underlying increased brain volume and neuron density in males, while highlighti
Efficient maturation of in vitro-generated cells remains a challenge and the underlying mechanisms are poorly understood. Here Wickramasinghe and colleagues show that PPAR signaling acts in an isoform-specific manner to enhance metabolic and electrop
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right