Ludwig’s Webster Cavenee received today the 2014 Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research. Issued by the American Association for Cancer Research (AACR), the award recognizes a single researcher’s sustained contributions to the prevention and cure of cancer.
As more parents consider whether it’s safe for adolescents to play football, a new Tulane University study of high school players found no link between years of play and any decline in neurocognitive function.
While many overweight patients intend to lose weight after joint replacement, a study at Hospital for Special Surgery finds that although some are able to achieve this goal, equal numbers of patients actually gain weight after hip or knee replacement. Patients who lose weight have better joint replacement outcomes in terms of function and activity level two years down the road.
Mindfulness-based meditation could lessen some symptoms associated with cancer in teens, according to the results of a clinical trial intervention led by researchers at the University of Montreal and its affiliated CHU Sainte-Justine children’s hospital.
A study by researchers at Hospital for Special Surgery finds that electromyography (EMG) testing to determine the quality of donor nerves can improve the outcome of nerve transfer surgery to restore function in patients with a brachial plexus injury.
Total knee replacement for patients with rheumatoid arthritis (RA) presents greater challenges, as RA patients generally have more health concerns than patients with osteoarthritis. However, researchers at Hospital for Special Surgery found that same-day bilateral knee replacement surgery is safe for select patients with rheumatoid arthritis.
Preliminary studies point to adherent stromal cells derived from human placenta appear promising as a readily available cell source to aid tendon healing and regeneration.
Researchers at the Barbra Streisand Women’s Heart Center at the Cedars-Sinai Heart Institute have found that emotional stressors – such as those provoking anger – may cause changes in the nervous system that controls heart rate and trigger a type of coronary artery dysfunction that occurs more frequently in women than men. They will describe their findings at the American Psychosomatic Society’s annual meeting on March 13 in San Francisco.
Some of the nation's top regenerative medicine scientists gather to discuss the latest research in 3D printing, military medicine, wound care, tissue engineering, stem cells and more.
University of Adelaide researchers say new insights into how the human brain responds to chronic pain could eventually lead to improved treatments for patients.
Elaine Fuchs, Ph.D., will receive the 2014 Pezcoller Foundation-American Association for Cancer Research (AACR) International Award for Cancer Research at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9, in recognition of her seminal work contributing to the understanding of mammalian skin, skin stem cells, and skin-related diseases, particularly cancers, genetic diseases, and proinflammatory disorders.
The American Association for Cancer Research (AACR) will award the Eighth Annual AACR Team Science Award to the Duke University/Johns Hopkins University/National Cancer Institute (NCI) Malignant Brain Tumor Team at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9. The award will be presented during the opening ceremony, Sunday, April 6, 8:15 a.m. PT.
After hip replacement surgery, many patients are anxious to resume driving. A new study using a sophisticated interactive driving simulator finds that patients can safely get back behind the wheel after four weeks, challenging the conventional wisdom that they should wait six weeks.
One of the biggest concerns of patients considering knee replacement is the amount of pain they will have after surgery. Although it is a very successful operation overall to relieve arthritis pain and restore function, persistent postoperative pain can be a problem for some individuals. Researchers determined which patients were at highest risk for increased postoperative pain based on demographic and surgical variables.
People who sustain the most common type of hip fracture are at increased risk of complications. A special type of MRI developed at Hospital for Special Surgery can show a detailed image following fracture repair, without the distortion caused by metal surgical screws that are problematic in standard MRIs.
Major League Baseball players who undergo Tommy John surgery are less likely to regain the performance level they had before surgery, according to a Henry Ford Hospital study. The study is the first to show a link between the surgery and declining pitching performance at the professional level. It also involved the largest cohort of professional pitchers to date to examine the issue.
As more people in the United States become severely obese, bariatric surgery has grown in popularity as a corrective measure; however, serious neurologic complications can result immediately after surgery or even years later (Juhasz-Pocsine et al, Neurology 2007;68(21):1843-50).
Stem cell transplant was viable and effective in halting or reversing degenerative disc disease of the spine, a meta-analysis of animal studies showed, in a development expected to open up research in humans. Recent developments in stem cell research have made it possible to assess its effect on intervertebral disc (IVD) height, Mayo Clinic researchers reported in a scientific poster today at the 30th Annual Meeting of the American Academy of Pain Medicine.
Not only are neuropathic pain symptoms quite common in knee osteoarthritis (OA), but scientists can predict who will respond to treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) by assessing the nervous system’s own capacity to regulate pain, new research suggests. Patients whose tests had indicated superior conditioned pain modulation (CPM) had less pain and fewer neuropathic symptoms at study’s end, in results reported in a scientific poster today at the 30th Annual Meeting of the American Academy of Pain Medicine.
Two hormones credited with reducing pain and need for opioid analgesics when released naturally during pregnancy and childbirth worked similarly when administered simultaneously to patients with intractable pain, research shows.
A multidisciplinary treatment plan that combined splint use, physical therapy and discontinuation of bisphosphonates brought excellent results for a 58-year-old woman diagnosed with bisphosphonate-related osteonecrosis of the jaw (BRONJ). The treatment team and study authors highlighted the effectiveness of advanced imaging technology and multidisciplinary collaboration for patient outcomes that included a 90% decrease in pain, improved function and normalized imaging results. They presented study results today in a scientific poster at the 30th Annual Meeting of the American Academy of pain Medicine.
Not only are neuropathic pain symptoms quite common in knee osteoarthritis (OA), but scientists can predict who will respond to treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) by assessing the nervous system’s own capacity to regulate pain, new research suggests. Patients whose tests had indicated superior conditioned pain modulation (CPM) had less pain and fewer neuropathic symptoms at study’s end, in results reported in a scientific poster today at the 30th Annual Meeting of the American Academy of Pain Medicine.
Success rates soared to 75% for patients who waited less than 2 years for a spinal cord stimulator (SCS) implant, compared with 15% for patients whose implants happened 20 years after the onset of pain, according to a retrospective analysis. The length of time patients waited for a referral also varied by specialty, as shown in a scientific poster presented today at the 30th Annual Meeting of the American Academy of Pain Medicine.
Patients who benefited from intradiscal biacuplasty (IDB) to treat discogenic low-back pain maintained initial gains in pain relief and physical function when rechecked at 1 year, a new study showed. Furthermore, patients who were in the sham treatment group and were later offered IDB achieved the same positive results as patients in the original treatment arm, researchers reported in a scientific poster today at the 30th Annual Meeting of the American Academy of Pain Medicine.
Two commonly delivered epidural injection modalities deliver minimal differences in pain relief and function at 1 and 6 months, new research shows. Results presented today at the 30th Annual Meeting of the American Academy of Pain Medicine indicate both injection types were effective for treating unilateral lumbosacral radicular pain (ULSRP).
Determining MRI RF heating safety is a complex process that requires complete understanding of the potential interactions between the MRI system, lead behavior, and individual patient characteristics.1 A comprehensive analysis was performed to evaluate a new MR-compatible SCS lead. Materials and Methods: Anesthetized porcine (Sus scroffa; n = 5) were implanted with leads and temperature probes in the spinal canal (Figure 1) and scanned in a 1.5T MRI system at multiple landmarks. MRI RF heating predictions from animal model simulations were compared to in vivo electrode temperature measurement to confirm model accuracy. Multiple human models were combined with several MRI coils to simulate the electromagnetic effects due to variations in human morphology. Simulations were performed for hundreds of clinical lead paths in each human model and combined with lead characterization analyses to predict the temperature rise at the electrodes in the spinal cord for each patient situation.
Postsurgical pain scores were highly correlated with reports of overall patient satisfaction during hospital stays, in a new finding that was true for some types of surgery more than others. The researchers, who presented results in a scientific poster today at the 30th Annual Meeting of the American Academy of Pain Medicine, stressed the importance of improving patient care in the peri-operative setting in alignment with new federal requirements tying performance to pay.
The spread of close to 80% of injectate to surrounding soft tissues following a nerve block to treat chronic pelvic pain suggests a need to reduce the quantity injected, according to study authors, who presented results in a scientific poster today at the 30th Annual Meeting of the American Academy of Pain Medicine.
Prescriptions for benzodiazepines are rising in primary care, and their frequent combined use with opioid analgesics may be contributing to medication-related deaths, a finding that goes largely unreported, according to Stanford researchers.
A method called molecular subtyping can help doctors better determine which of their breast cancer patients are at high risk of getting breast cancer again, a new study led by the University of South Florida reports.
A Phase I trial conducted at UAB was designed to evaluate the safety, acceptability and drug absorption qualities of an intravaginal ring containing two anti-HIV medications when worn by women for 28 days.
Researchers found initial confirmation that a novel scaffold protein previously unassociated with the mu opioid receptor (MOR) regulates MOR-induced signaling activation. The MOR is the target of opioid drugs like morphine and is an important mechanism for pain regulation in the body. The research approach was designed to open new avenues to the treatment of chronic pain, a serious public health problem with major economic and societal costs.
Ludwig researcher Jedd Wolchok has received the 38th Annual American Association for Cancer Research-Richard and Hinda Rosenthal Memorial Award for his significant and continuing contributions to the development of immunotherapy for melanoma and his application of the strategy to other malignancies.
A new approach to breast reconstruction surgery aimed at helping patients’ bodies get back to normal more quickly cut their postoperative opioid painkiller use in half and meant a day less in the hospital on average, a Mayo Clinic study found. The method includes new pain control techniques, preventive anti-nausea treatment and getting women eating and walking soon after free flap breast reconstruction surgery. It has proved so effective, it is now being used across plastic surgery at Mayo Clinic.
Body odor is a deer hunter’s worst enemy, an alert to animals that an ominous presence is lurking, but the science behind suppressing it to give hunters an edge oddly enough could help researchers develop a life-saving device for diabetes patients. Scientists today presented the latest advances that tie together these two seemingly unrelated fronts at the 247th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
A sweetener created from the plant used to make tequila could lower blood glucose levels for the 26 million Americans and others worldwide who have type 2 diabetes and help them and the obese lose weight, researchers said here today. Their report was part of the 247th National Meeting of the American Chemical Society, the world’s largest scientific society.
A new kind of single-dose vaccine that comes in a nasal spray and doesn’t require refrigeration could dramatically alter the public health landscape — get more people vaccinated around the world and address the looming threats of emerging and re-emerging diseases. Researchers presented the latest design and testing of these “nanovaccines” at the 247th National Meeting & Exposition of the American Chemical Society (ACS), the world’s largest scientific society.
Honey, that delectable condiment for breads and fruits, could be one sweet solution to the serious, ever-growing problem of bacterial resistance to antibiotics, researchers said here today. Their study was part of the 247th National Meeting of the American Chemical Society, the world’s largest scientific society.
As some countries and companies roll out new rules to limit animal testing in pharmaceutical products designed for people, scientists are stepping in with a new way to test therapeutic drug candidates and determine drug safety and drug interactions — without using animals. The development of “chemosynthetic livers,” which could dramatically alter how drugs are made, was presented at the 247th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
Scientists reported today on at least five new experimental substances — based on a tiny protein found in cone snail venom — that could someday lead to the development of safe and effective oral medications for the treatment of chronic nerve pain. They say the substances could potentially be stronger than morphine, with fewer side effects and lower risk of abuse. They presented the research at the 247th National Meeting & Exposition of the American Chemical Society.
The health benefits of eating dark chocolate have been extolled for centuries, but the exact reason has remained a mystery –– until now. Researchers reported here today that certain bacteria in the stomach gobble the chocolate and ferment it into anti-inflammatory compounds that are good for the heart. They presented their study at the 247th National Meeting & Exposition of the American Chemical Society.
While the world’s best athletes competed during last month’s winter Olympics, doctors and scientists were waging a different battle behind the scenes to make sure no one had an unfair advantage from banned performance-enhancing drugs. Here today at the 247th National Meeting & Exposition of the American Chemical Society, researchers unveiled a new weapon — a test for doping compounds that is a thousand times more sensitive than those used today.
When a heart gets damaged, such as during a major heart attack, there’s no easy fix. But scientists working on a way to repair the vital organ have now engineered tissue that closely mimics natural heart muscle that beats, not only in a lab dish but also when implanted into animals. They presented their latest results at the 247th National Meeting & Exposition of the American Chemical Society (ACS), the world’s largest scientific society.
In response to drug-resistant “superbugs” that send millions of people to hospitals around the world, scientists are building tiny, “molecular drill bits” that kill bacteria by bursting through their protective cell walls. They presented some of the latest developments on these drill bits, better known to scientists as antimicrobial peptides (AMPs), at the 247th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
Leftover cigarette smoke that clings to walls and furniture is a smelly nuisance, but now research suggests that it could pose a far more serious threat, especially to young children who put toys and other smoke-affected items into their mouths. Scientists reported today at the 247th National Meeting & Exposition of the American Chemical Society that one of the tobacco-specific nitrosamines newly formed in “third-hand smoke” damages DNA and could potentially cause cancer.
Some children who outgrow one type of food allergy may then develop another type of allergy, more severe and more persistent, to the same food. The more severe allergy is eosinophilic esophagitis (EoE), which has been increasing in recent years.
The American Association for Cancer Research (AACR) will showcase newsworthy research on clinical trials, epidemiology, immunology, epigenetics, laboratory science, and translational medicine at its Annual Meeting, April 5-9.
John F. DiPersio, M.D., Ph.D., will be recognized with the 19th Annual American Association for Cancer Research-Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.
The American Association for Cancer Research (AACR) and the Cancer Research Institute (CRI) will present Robert D. Schreiber, Ph.D., Alumni Endowed Professor of Pathology and Immunology, Professor of Molecular Microbiology, and Director of the Center for Human Immunology and Immunotherapy Programs at Washington University School of Medicine in St. Louis, Mo., with the second annual AACR-CRI Lloyd J. Old Award in Cancer Immunology at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.
The American Association for Cancer Research (AACR) and the American Cancer Society will recognize Curtis C. Harris, M.D., with the 23rd Annual AACR-American Cancer Society Award for Excellence in Cancer Epidemiology and Prevention at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.
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