Feature Channels: Biotech

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Released: 3-Nov-2022 12:00 PM EDT
Preparation of Cell-Loaded Microbeads as Stable and Injectable Delivery Platforms for Tissue Engineering
Preprints

Mehmet Ali Karaca, Derya Dilek Kancagi, Ugur Ozbek, Ercument Ovali, Ozgul Gok

Released: 3-Nov-2022 12:00 PM EDT
Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutations
Preprints

Yara Hussein, Utkarsh Tripathi, Ashwani Choudhary, Ritu Nayak, David Peles, Idan Rosh, Jose Djamus, Ronen Spiegel, Tali Garin-Shkolnik, Shani Stern

Released: 3-Nov-2022 12:00 PM EDT
HB-EGF and zinc activate EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures
Preprints

Oier Pastor-Alonso, Irene Dura, Sara Bernardo-Castro, Emilio Varea, Teresa Muro-Garcia, Soraya Martin-Suarez, Juan Manuel Encinas-Perez, Jose Ramon Pineda

Released: 3-Nov-2022 11:05 AM EDT
New ‘smart tattoos’ tackle tech challenges of on-skin computing
Cornell University

Researchers at Cornell University have come up with a reliable, skin-tight computing system that’s easy to attach and detach, and can be used for a variety of purposes – from health monitoring to fashion.

Newswise: Artificial Intelligence Makes Enzyme Engineering Easy
Released: 3-Nov-2022 10:25 AM EDT
Artificial Intelligence Makes Enzyme Engineering Easy
Osaka University

You can't expect a pharmaceutical scientist to switch labs to the facilities available in a television studio and expect the same research output.

Released: 3-Nov-2022 5:00 AM EDT
Glioblastoma Stem Cell HISTArionics
Cell Stem Cell

Glioblastomas are lethal malignancies that possess a rapidly evolving microenvironment containing necrotic/hypoxic areas, aberrant microvasculature, and glioblastoma stem cells (GSCs) that promote tumor growth, recurrence, and treatment resistance. C

Released: 3-Nov-2022 5:00 AM EDT
Reciprocal Regulation of Mesenchymal Stem Cells and Immune Responses
Cell Stem Cell

The reciprocal regulation between mesenchymal stem/stromal cells(MSCs)and immune responses is complex and critical for designing cell therapies. Wang et al. discuss the characteristics and functions of MSCs under different pathophysiological cond

Released: 3-Nov-2022 5:00 AM EDT
Uncovering the Emergence of HSCs in the Human Fetal Bone Marrow by Single-Cell RNA-Seq Analysis
Cell Stem Cell

Zheng et al. provide a transcriptomic landscape of hematopoietic stem and progenitor cells and microenvironment in human fetal bone marrow and spleen. They uncover the precise timepoint at which hematopoietic stem cells (HSCs) seed fetal bone marrow

Released: 3-Nov-2022 5:00 AM EDT
A Single-Cell Transcriptome Atlas of Glial Diversity in the Human Hippocampus Across the Postnatal Lifespan
Cell Stem Cell

Su et al. performed single-nucleus RNA-sequencing analysis to map diversity, molecular properties, disease relevance, and age-dependent dynamics of glial subpopulations in the human hippocampus across the postnatal lifespan. The resulting glial refe

Released: 3-Nov-2022 5:00 AM EDT
Functional Renal Collecting Ducts From Human PSCs
Cell Stem Cell

Collecting ducts in the kidney control the balance of water and electrolytes, as well as pH of the urine to maintain body homeostasis. Shi et al.1 recently reported in Nature Biotechnology a protocol to generate functional collecting duct cells from

Released: 3-Nov-2022 5:00 AM EDT
Vade-MECOM: How to Peel Back the Layers of Hematopoiesis
Cell Stem Cell

A recent study1 demonstrates how hematopoietic stem cells (HSCs) contribute minimally to blood and immune cell production during development and only become active postnatally. The work also reveals how Mecom expression can be used to distinguish rar

Released: 2-Nov-2022 3:40 PM EDT
In the Latest Human vs. Machine Match, Artificial Intelligence Wins by a Hair
Rutgers University-New Brunswick

Vikas Nanda has spent more than two decades studying the intricacies of proteins, the highly complex substances present in all living organisms.

Newswise: Patient-Specific Cancer Tumours Replicated in 3D Bioprinting Advance
Released: 2-Nov-2022 12:55 PM EDT
Patient-Specific Cancer Tumours Replicated in 3D Bioprinting Advance
University of Bristol

Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models. The University of Bristol-led advance, published in Biofabrication, would allow clinicians to treat the models, known as spheroids, with chemotherapy drugs and radiation to help them understand an individual patient’s resistance to therapies.

Released: 2-Nov-2022 12:00 PM EDT
Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland
Preprints

Valeria Scagliotti, Maria Lillina Vignola, Thea L Willis, Mark Howard, Eugenia Marinelli, Carles Gaston-Massuet, Cynthia Lilian Andoniadou, Marika Charalambous

Released: 2-Nov-2022 12:00 PM EDT
AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion
Preprints

Anita E M Kneppers, Marine Theret, Sabrina Ben Larbi, Linda Gsaier, Audrey Saugues, Carole Dabadie, Arnaud Ferry, Kei Sakamoto, Rémi Mounier

Newswise: MIRRI and USCCN Enhance Their Cooperation to Promote the Valorization of Microbial Resources and Innovation in Biotechnology
Released: 2-Nov-2022 9:00 AM EDT
MIRRI and USCCN Enhance Their Cooperation to Promote the Valorization of Microbial Resources and Innovation in Biotechnology
International Phytobiomes Alliance

Leading culture collection networks in the EU and the U.S. announced today the signing of a Memorandum of Understanding to enhance their cooperation to promote microbial resources and innovation in biotechnology.

Newswise: DNA 'Nanotransporters' to treat cancer
31-Oct-2022 12:00 PM EDT
DNA 'Nanotransporters' to treat cancer
Universite de Montreal

Canadian chemists specializing in nanotechnology draw inspiration from nature to create molecular transporters that optimize the release of therapeutic drugs.

Newswise: A New Control System for Synthetic Genes
Released: 1-Nov-2022 6:40 PM EDT
A New Control System for Synthetic Genes
Massachusetts Institute of Technology (MIT)

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

Newswise: Dissecting the Ecology of Microalgae and Bacteria Across Time and Space
Released: 1-Nov-2022 5:20 PM EDT
Dissecting the Ecology of Microalgae and Bacteria Across Time and Space
Department of Energy, Office of Science

Microalgae play an important role in the Earth’s climate, converting carbon dioxide into solid carbon. This research sought new ways to study these microalgae and their associated bacterial communities across time and space. The researchers created a new co-culture method called a “porous microplate” that passes nutrients and molecules associated with metabolism between culture cells while blocking physical contact between algae in adjacent wells.

Newswise: New Technique Makes Gene Editing at Scale Possible in Animals, Turning Years of Work Into Days and Making New Kinds of Genetic Experiments Possible
Released: 1-Nov-2022 12:15 PM EDT
New Technique Makes Gene Editing at Scale Possible in Animals, Turning Years of Work Into Days and Making New Kinds of Genetic Experiments Possible
University of Oregon

A new gene editing technique developed by University of Oregon researchers compresses what previously would have been years of work into just a few days, making new kinds of research possible in animal models.

Released: 1-Nov-2022 12:00 PM EDT
The cell developmental atlas of human embryonic temporomandibular joint
Preprints

Qianqi Zhu, Miaoying Tan, Chengniu Wang, Yufei Chen, Chenfei Wang, Junqi Zhang, Yijun Gu, Yuqi Guo, Jianpeng Han, Lei Li, Rongrong Jiang, Xudong Fan, Huimin Xie, Liang Wang,

Released: 1-Nov-2022 12:00 PM EDT
Understanding the impact of bioactive coating materials for human mesenchymal stem cells and implications for manufacturing
Preprints

Pedro Silva Couto, Sam A. Molina, Denis O’Sullivan, Liam O'Neill, Alexander M. Lyness, Qasim Rafiq

Released: 1-Nov-2022 12:00 PM EDT
A TDP-43 acetylation-mimic mutation that disrupts RNA-binding drives FTLD-like neurodegeneration in a mouse model of sporadic TDP-43 proteinopathy
Preprints

Julie Necarsulmer, Jeremy Simon, Baggio Evangelista, YouJun Chen, Xu Tian, Sara Nafees, Ariana Marquez Gonzalez, Ping Wang, Deepa Ajit, Viktoriya Nikolova, Kathryn Harper, Jennifer Ezzell, Adriana Beltran, Sheryl Moy,

Released: 1-Nov-2022 12:00 PM EDT
Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells
Preprints

Yuka Sakata, Keren Cheng, Michinori Mayama, Yasunari Seita, Andrea J Detlefsen, Clementina A Mesaros, Trevor M Penning, Kyosuke Shishikura, Wenli Yang, Richard J Auchus, Jerome F Strauss, Kotaro Sasaki

Released: 1-Nov-2022 12:00 PM EDT
Axon guidance pathways modulate neurotoxicity of ALS-associated UBQLN2
Preprints

Sang Hwa Kim, Kye D Nichols, Eric N Anderson, Yining Liu, Nandini Ramesh, Weiyan Jia, Connor J Kuerbis, Mark Scalf, Lloyd M. Smith, Udai Bhan Pandey, Randal S Tibbetts

Newswise: Efficient Nanovaccine Delivery System Boosts Cellular Immunity
Released: 31-Oct-2022 7:40 PM EDT
Efficient Nanovaccine Delivery System Boosts Cellular Immunity
Osaka Metropolitan University

Cancer immunotherapies, such as immune checkpoint inhibition therapy, have been attracting attention in recent years as new methods for treating cancer.

Newswise: Faster Screen of Biologicals for Growth Stimulants, Disease Protection in Wheat and Corn
Released: 31-Oct-2022 6:25 PM EDT
Faster Screen of Biologicals for Growth Stimulants, Disease Protection in Wheat and Corn
University of Johannesburg

Researchers found a much faster way to screen soil bacteria as potential biostimulants and bio-pesticides.

Released: 29-Oct-2022 12:00 PM EDT
miR-223 Plays A Critical Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity
Preprints

Richard C Chang, Erika M. Joloya, Zhuorui Li, Bassem M Shoucri, Toshi Shioda, Bruce Blumberg



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