Feature Channels: Drug Resistance

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A recent study published in the journal Communications Biology shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer.

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University of Maryland School of Medicine (UMSOM)’s Institute of Human Virology (IHV) researchers received funding from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) for $2.7 million to study genetic changes in two genes from the HIV-1 virus that may make it resistant to antiretroviral therapy.

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Demand for new kinds of antibiotics is surging, as drug-resistant and emerging infections are becoming an increasingly serious global health threat. Researchers are racing to reexamine certain microbes that serve as one of our most successful sources of therapeutics: the actinomycetes.

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Dr. Oladele "Dele" Ogunseitan, UC Presidential Chair and Professor of Population Health and Disease Prevention at the University of California, Irvine Program in Public Health, discusses using a One Health approach to combating global antibiotic resistance.

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Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

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Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.

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有越来越多人因抗生素耐药性感染而面临死亡。此类感染是微生物物种通过突变以躲避制药破坏性攻击所引发的。仅2019年，全球便有超过120万人死于抗生素耐药性感染。

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Cada vez mais pessoas estão morrendo por infecções resistentes a antibióticos. Essas infecções são alimentadas por espécies microbianas que estão em mutação para escapar das drogas desenvolvidas para destruí-las.

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Una creciente cantidad de personas muere debido a infecciones resistentes a los antibióticos. Estas infecciones son propiciadas por especies bacterianas que mutan a fin de evadir a los fármacos creados para destruirlas.

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If you’ve been hitting the gym and getting results, you know it’s time to strut your stuff; and it turns out bacteria feel the same way.

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Don't miss these articles in our Staff Picks channel

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A new study found that for telemedicine visits related to acute respiratory infection, contractor-supplied physicians prescribed antibiotics to patients nearly twice as often as emergency physicians employed by the hospital system. As the majority of acute respiratory infections are viral, researchers say the findings highlight concerns of antibiotic stewardship amid growing antibiotic resistance.

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While gene mutations can lead to drug resistance, researchers in the Perelman School of Medicine at the University of Pennsylvania have identified an important, non-genetic adaptation that could also drive resistance to targeted therapy in T cell leukemia, a type of blood cell cancer.

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New research from the University of Georgia found that fungal infections account for $6.7 billion in health care spending in 2018. And that’s just the cases that were directly responsible for inpatient hospital stays.

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The spectacular structure of the protective armour of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.

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Using genomic sequencing techniques and machine learning analysis of patient records, Israeli researchers have developed an antibiotic prescribing algorithm that cuts the risk of emergence of antibiotic resistance by half.

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The Latest Research News in Cardiovascular Health