Feature Channels: Stem Cells

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Released: 27-Jul-2022 12:00 PM EDT
PAX9 regulates periodontal ligament stem cell-like differentiation of human induced pluripotent stem cells
Preprints

Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda

Released: 26-Jul-2022 12:00 PM EDT
Stem cell therapy for insulin-dependent diabetes: Are we still on the road?
World Journal of Stem Cells

In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,

Released: 26-Jul-2022 12:00 PM EDT
Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles
World Journal of Stem Cells

BACKGROUNDDermal papillae (DP) and outer root sheath (ORS) cells play important roles in hair growth and regeneration by regulating the activity of hair follicle (HF) cells. AIMTo investigate the effects of human mesenchymal stem cell-derived

Released: 26-Jul-2022 12:00 PM EDT
Prodigious therapeutic effects of combining mesenchymal stem cells with magnetic nanoparticles
World Journal of Stem Cells

Mesenchymal stem cells (MSCs) have gained wide-ranging reputation in the medical research community due to their promising regenerative abilities. MSCs can be isolated from various resources mostly bone marrow, Adipose tissues and Umbilical cor

Released: 26-Jul-2022 12:00 PM EDT
Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications
World Journal of Stem Cells

For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (M

Released: 26-Jul-2022 12:00 PM EDT
Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways
World Journal of Stem Cells

BACKGROUNDBronchopulmonary dysplasia (BPD) is not merely a chronic lung disease, but a systemic condition with multiple organs implications predominantly associated with hyperoxia exposure. Despite advances in current management strategies, lim

Released: 26-Jul-2022 12:00 PM EDT
Metabolic-epigenetic nexus in regulation of stem cell fate
World Journal of Stem Cells

Stem cell fate determination is one of the central questions in stem cell biology, and although its regulation has been studied at genomic and proteomic levels, a variety of biological activities in cells occur at the metabolic level. Metabolom

Released: 26-Jul-2022 12:00 PM EDT
Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles
World Journal of Stem Cells

The use of mesenchymal stem-cells (MSC) in cell therapy has received considerable attention because of their properties. These properties include high expansion and differentiation in vitro, low immunogenicity, and modulation of biological proc

Released: 26-Jul-2022 12:00 PM EDT
Application of exosome-derived noncoding RNAs in bone regeneration: Opportunities and challenges
World Journal of Stem Cells

With advances in the fields of regenerative medicine, cell-free therapy has received increased attention. Exosomes have a variety of endogenous properties that provide stability for molecular transport across biological barriers to cells, as a

Released: 26-Jul-2022 12:00 PM EDT
Stem cell therapy for insulin-dependent diabetes: Are we still on the road?
World Journal of Stem Cells

In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,

Released: 26-Jul-2022 12:00 PM EDT
Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs
Preprints

Kazuhiko Ikeda, Keiji Minakawa, Satoshi Ono, Mao Watanabe, Yuka Sato, Saki Takahashi, Sho Odawara, Kinuyo Kawabata, Koki Ueda, Kenneth Nollet, Hideki Sano, Takayuki Ikezoe, Atsushi Kikuta

Released: 26-Jul-2022 12:00 PM EDT
UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer
Preprints

Khosrow Rezvani, Sanam Sane, Rekha Sriniva, Rashaun Potts, Morgan Eikanger, Diana Zagirova, Jessica Freeling, Casey Reihe, Ryan Antony, Brij Gupta, Douglas Lynch, Jonathan Bleeker, Hassan Turaihi, Angela Pillatzki,

Released: 26-Jul-2022 12:00 PM EDT
Human placental mesenchymal stem cells derived exosomes improved functional recovery via attenuating apoptosis and increasing axonal regeneration after severe spinal cord injury
Preprints

Afsane Soleimani, Mirsepehr Pedram, Fatemeh Saadinam, Mohammad Javad Rasaee, Saeed Oraee Yazdani, Masoud Soleimani

Released: 26-Jul-2022 12:00 PM EDT
Pipsqueak family genes dan/danr antagonize nuclear Pros and prevent premature decommission of neural stem cells in Drosophila third instar larval brains
Preprints

Huanping An, Yue Yu, Xuming Ren, Minghua Zeng, Yu Bai, Tao Liu, Huimei Zheng, Rong Sang, Fan Zhang, Yu Cai, YongMei Xi

Released: 26-Jul-2022 12:00 PM EDT
An archaeal compound as a driver of Parkinson’s disease pathogenesis
Preprints

Paul Wilmes, Jean-Pierre Trezzi, Velma Aho, Christian Jäger, Sebastian Schade, Annette Janzen, Oskar Hickl, Benoit Kunath, Mélanie Thomas, Kristopher Schmit, Pierre Garcia, Alessia Sciortino, Camille Martin-Gallausiaux, Rashi Halder,

Released: 26-Jul-2022 12:00 PM EDT
miR-3682-3p directly targets FOXO3 and stimulates tumor stemness in hepatocellular carcinoma via a positive feedback loop involving FOXO3/PI3K/AKT/c-Myc
World Journal of Stem Cells

BACKGROUNDCancer stem cells (CSCs) have been implicated in tumorigenesis and tumor recurrence and metastasis are key therapeutic targets in cancer treatment. MicroRNAs display therapeutic potential by controlling the properties of CSCs; however

Released: 25-Jul-2022 12:00 PM EDT
In silico analysis of genes and pathways related to acute myeloid leukemia presenting leukopenia
Preprints

Ajeet Kumar, Ravi Bhushan, Pawan K. Dubey, Vijai Tilak, Vineeta Gupta, Nilesh Kumar, S. V.S Raju, Akhtar Ali

Released: 25-Jul-2022 12:00 PM EDT
Detection of second primary lymphoma in late diffuse large B-cell lymphoma recurrences
Preprints

Madeleine Berendsen, Diede van Bladel, Eva Hesius, Fleur de Groot, Leonie Kroeze, Jos Rijntjes, Jeroen Luijks, Brigiet Hoevenaars, Altuna Halilovic, Peet Nooijen, Ellen van der Spek, Joost Vermaat, Corine Hess, Konnie Hebeda,

Released: 25-Jul-2022 12:00 PM EDT
Non metastasis protein 2 (NME2) is a potential target for leukemia-specific immunotherapy
Preprints

Tobias Däbritz, Sabine Tschiedel, Michael Cross, Dietger Niederwieser

Released: 25-Jul-2022 12:00 PM EDT
Methylation genome wide profiling in lowly and highly efficient adipose somatic cell nuclear transfer in pigs
Preprints

Maciej Grzybek, Krzysztof Flisikowski, Tom Giles, Marta Dyjak, Rafal Ploski, Piotr Gasperowicz, Richard D Emes, Pawel Lisowski

Released: 25-Jul-2022 12:00 PM EDT
mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis
Preprints

Marie Clémot, Cecilia D'Alterio, Alexa C. Kwang, D. Leanne Jones

Released: 25-Jul-2022 12:00 PM EDT
Application of Shear Stress for Enhanced Osteogenic Differentiation of Mouse Induced Pluripotent Stem Cells
Preprints

Phoonsuk Limraksasin, Praphawi Nattasit, Jeeranan Manokawinchoke, Watcharaphol Tiskratok, Naruephorn Vinaikosol, Hiroko Okawa, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus, Prasit Pavasant, Thanaphum Osathanon, Hiroshi Egusa

Released: 25-Jul-2022 12:00 PM EDT
Cancer Stem Cells and Competing Endogenous RNAs
Preprints

Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

Released: 25-Jul-2022 12:00 PM EDT
Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells
Preprints

Kotaro Sasaki, Yasunari Seita, Keren Cheng, John McCarrey, Nomesh Yadu, Ian Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana-Toro, Li-Hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann

Released: 25-Jul-2022 12:00 PM EDT
Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2
Preprints

Marija Zivaljic, Mathieu Hubert, Ludivine Grzelak, Giulia Sansone, Uwe Maskos, Olivier Schwartz

Released: 24-Jul-2022 12:00 PM EDT
Cell cycle and temporal transcription factors regulate proliferation and neuronal diversity of dedifferentiation-derived neural stem cells
Preprints

Louise Cheng, Kellie Veen, Francesca Froldi, Qian Dong, Edel Alvarez-Ochoa, Phuong-Khanh Nguyen, Kieran F Harvey, John P D McMullen, Owen J. Marshall, Patricia R Jusuf

Released: 24-Jul-2022 12:00 PM EDT
Dynamic changes in the niche and transcription trigger early murine and human pluripotent stem cell-derived liver organogenesis
Preprints

Ogechi Ogoke, Daniel Guiggey, Sarah Thompson, Alexander Chiang, Tram Hoang Anh Nguyen, Daniel Berke, Cortney Ott, Allison Kalinousky, Claire Shamul, Peter Chen, Shatoni Ross, Zhaowei Chen, Pooja Srivastava, Supriya D Mahajan,

Released: 24-Jul-2022 12:00 PM EDT
Hydrogel Assisted Double Molding of 3D-Print Enables Prestress Regulation of Micro-Heart Muscle Physiology
Preprints

Daniel W. Simmons, David R. Shuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Mary K. Munsell, Brennan Kandalaft, Missy Pear, Nathaniel Huebsch

Released: 23-Jul-2022 12:00 PM EDT
Self-organized anteroposterior regionalization of early midbrain and hindbrain using micropatterned human embryonic stem cells
Preprints

Abstract: To develop into the central nervous system, neuroepithelial cells must first form a neural tube consisting of a series of patterned neural progenitor cells along the anterior-posterior (AP) axis. Based on studies using model organisms, it has been revealed that AP spatial regionalization is dominated by gradients of morphogens that regulate retinoic acid (RA), sonic hedgehog (SHH), bone morphogenetic proteins (BMPs), and Wingless/int1 (WNT) signaling pathways.

Released: 22-Jul-2022 12:00 PM EDT
Screening of single nucleotide polymorphisms within HLA region related to hematopoietic stem cell transplantation using MassARRAY technology
Preprints

Abstract: A growing number of studies showed that single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA)-related genes were associated with the outcome of hematopoietic stem cell transplantation (HSCT).

Released: 22-Jul-2022 12:00 PM EDT
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived mesenchymal stem cells via miR-143-3p/ADD3 axis
Preprints

Background Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long non-coding RNAs (lncRNAs) reportedly play essential roles in stem cell aging. However, the mechanisms by which lncRNAs influence mesenchymal stem cell aging have not been investigated.

Released: 22-Jul-2022 12:00 PM EDT
Differentially expressed circRNA and mRNA profiles of neural stem cells with radiation treatment
Preprints

Jiacong Hong, Shan Wang, Zhaopeng Cai, Peng Wang, Zhongyu Xie, Keng Chen

Released: 22-Jul-2022 12:00 PM EDT
The presence of BBB hastens neuronal differentiation of cerebral organoids - the potential role of endothelial derived BDNF
Preprints

Giorgia Fedele, Alessandra Cazzaniga, Sara Castiglioni, Laura Locatelli, Antonella Tosoni, Manuela Nebuloni, Jeanette A.M. Maier

Released: 22-Jul-2022 12:00 PM EDT
Molecular Underpinnings and Environmental Drivers of Spontaneous Loss of Heterozygosity in Drosophila Intestinal Stem Cells
Preprints

Lara Al Zouabi, Marine Stefanutti, Nick Riddiford, Natalia Rubanova, Mylene Bohec, Nicolas Servant, Allison J Bardin

Released: 21-Jul-2022 1:05 PM EDT
Lighting up the B cells
Institute for Basic Science

Our immune system is essential for our survival, as our bodies are constantly being exposed to bacteria, viruses, parasites, and other pathogens.

Released: 21-Jul-2022 12:00 PM EDT
Preclinical investigation of expanded human adipose–derived stem cell dosage and timing for improved defecation function in immunodeficient mice
Preprints

Ryota Mori, Norikatsu Miyoshi, Shiki Fujino, Tsunekazu Mizushima, Ryohei Yukimoto, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi

Released: 21-Jul-2022 12:00 PM EDT
Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists
Preprints

Faizzan S. Ahmad, Yongcheng Jin, Alexander D. Grassam-Rowe, Yafei Zhou, Meng Yuan, Xuehui Fan, Rui Zhou, Razik Mu-U-Min, Christopher O'Shea, Ayman M. Ibrahim, Wajiha Hyder, Yasmine Aguib, Magdi Yacoub, Davor Pavlovic

Released: 21-Jul-2022 12:00 PM EDT
TLR3 stimulation improves the migratory potency of adipose-derived mesenchymal stem cells through the stress response pathway in the melanoma mouse model
Preprints

Fatemeh Eskandari, Samira Zolfaghari, Ayna Yazdanpanah, Rima Manafi Shabestari, Motahareh Rajabi Fomeshi, Peiman B. Milan, Jafar Kiani, Mina Soufi Zomorrod, Majid Safa

Released: 20-Jul-2022 12:00 PM EDT
Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function
Preprints

Robyn M Jong, Krystal Ching, Nicholas E Garelis, Alex Zilinskas, Xammy Nguyenla, Sagar Rawal, Bianca Hill, Bridget Luckie, Lillian Shallow, Jeffery S Cox, Gregory Barton, Sarah Stanley

Released: 20-Jul-2022 12:00 PM EDT
Human liver organoids model progressive inflammatory and fibrotic injury in non-alcoholic fatty liver disease
Preprints

Anja Hess, Stefan D. Gentile, Amel Ben Saad, Raza-Ur Rahman, Tim Habboub, Alan C. Mullen

Newswise: Lymphatics Help ‘Seed’ Early Brain Cells in Zebrafish
Released: 19-Jul-2022 1:55 PM EDT
Lymphatics Help ‘Seed’ Early Brain Cells in Zebrafish
University of Notre Dame

A recent paper in Nature Neuroscience by University of Notre Dame biologist Cody J. Smith demonstrated how lymphatics — which remove waste from the rest of the body — are also associated with microglia and brain development in zebrafish.

   
Newswise: Scientists Develop Blueprint for Turning Stem Cells Into Sensory Interneurons
Released: 19-Jul-2022 1:05 PM EDT
Scientists Develop Blueprint for Turning Stem Cells Into Sensory Interneurons
University of California, Los Angeles (UCLA), Health Sciences

Key takeaways: • Just like the real thing. The stem cell–derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body. • Tomorrow’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain. • Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.

Released: 19-Jul-2022 12:55 PM EDT
Rutgers Scientists Reveal New Evidence of Key Mechanism in Alzheimer’s
Rutgers University-New Brunswick

Rutgers scientists have found more clear-cut evidence of how the destructive proteins linked to Alzheimer’s disease attack human brain cells and destroy surrounding tissue.

   
Released: 19-Jul-2022 12:00 PM EDT
Perfusable Apparatus For Thick-tissue Creation And Growth (patch) Of Cardiac Tissue
Preprints

Amatullah Mir, Isaree Pitaktong, Jason Yusheng He, Katherine Nurminsky, Tyler Dunn, Sarah Koljaka, Olivia Dunn, Stephanie Ran, Daniel Rodgers, Anya Wang, Hiroshi Matsushita, Narutoshi Hibino, Wesley Shih



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